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TAVESVAEFATRARKWLAANMSQIDPLSPPEAPRDDEASWQRARQLQRRPNDGGFAGICFPREYGGQGLA YEYQRAFDEESLHYEMPLILNVPTFTICCATLLDTGSENQKKRHIAAALRGEEVLVQLLSEHSGGSDLAG VLTRAERQGDRWVINGAKTWSTSAFAADYGLCLARTNWDVPKHDGLTMFLVPINHPGITLRRITQVNGST EFCEEFLDSVDVGDDAVVGEVNNGWTVASRQLYHERRAVGIGSEFASGAGSEGGHATPVDYVALAETTGQ AHSDRVREMAGRALVHRAVCEQLIDHVYRSVRDGTLPPAAGTLIRLFHAETVMCEMDTSLAIAGSGGVVG QPGEGLQTGLRYLARQSVAIGGGPTEMARNVIGERMLNFPREFAADRGVSFNQVRRGSPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3854 | - | - | 100% (411) | acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4125 | fadE30 | 8e-42 | 30.18% (391) | acyl-CoA dehydrogenase FadE30 |
| M. ulcerans Agy99 | MUL_3411 | fadE22 | 2e-36 | 36.18% (293) | acyl-CoA dehydrogenase FadE22 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3590c | fadE30 | 1e-41 | 30.36% (392) | acyl-CoA dehydrogenase FADE30 |
| M. gilvum PYR-GCK | Mflv_3794 | - | 1e-159 | 65.94% (411) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3560c | fadE30 | 1e-41 | 30.36% (392) | acyl-CoA dehydrogenase FADE30 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-15 | 28.57% (203) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3122 | - | 2e-38 | 30.52% (367) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3992 | - | 0.0 | 97.81% (411) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1620 | - | 0.0 | 83.42% (404) | acyl-CoA dehydrogenase middle domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2992 | - | 1e-159 | 67.49% (406) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4121 | - | 1e-168 | 70.22% (403) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. vanbaalenii PYR-1 | Mvan_2600 | - | 1e-158 | 66.34% (410) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3590c|M.bovis_AF2122/97 ---------------MQDVEEFRAQVRGWLADNLAG----EFAALKGLGG
Rv3560c|M.tuberculosis_H37Rv ---------------MQDVEEFRAQVRGWLADNLAG----EFAALKGLGG
MAB_3122|M.abscessus_ATCC_1997 ----------------MPVTSSEPSSAGSNALHTSGSSQRDRVAAAAHEV
MUL_3854|M.ulcerans_Agy99 ------------MTAVESVAEFATRARKWLAANMSQID-----PLSPPEA
MMAR_3992|M.marinum_M ------------MTAVESVAEFATRARKWLAANMSQID-----PLSPPEA
MAV_1620|M.avium_104 -------------MTTESVAQFAARARAWLADNMPAID-----RESPPPA
TH_4121|M.thermoresistible__bu MTETTTTSQGRPAEITETVEEFAARARAWLAESMPRID-----PDNPPNA
Mflv_3794|M.gilvum_PYR-GCK --MTETMTSTESTGTVETVEQFAARARTWLAENMPSID-----PDNPPFS
Mvan_2600|M.vanbaalenii_PYR-1 --MTDTMTSTETT---ESVADFAARARTWLAENMPSID-----PDDPPFS
MSMEG_2992|M.smegmatis_MC2_155 --MTETAVSTGTQ---ESVEDFAARARAWLAGNMPRID-----PDNPPFS
MLBr_00737|M.leprae_Br4923 -------MVGWSGNPLFDLFKLPEEHNELRATIRALAE-----KEIAPHA
: . * .
Mb3590c|M.bovis_AF2122/97 PGREHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYA
Rv3560c|M.tuberculosis_H37Rv PGREHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYA
MAB_3122|M.abscessus_ATCC_1997 LAKHPPATTPVTDLLGAVYDAGLAWVHFPVGLGGLDAPPALQAVSDTILR
MUL_3854|M.ulcerans_Agy99 PRDDEASWQRARQLQRRPNDGGFAGICFPREYGGQGLAYEYQRAFDEESL
MMAR_3992|M.marinum_M PRDDEASWQRARQLQRRLHDGGFAGICFPREYGGQGLAYEYQRAFDEESL
MAV_1620|M.avium_104 PRDDERAWRRARELQKRLYDGGFAGICFPREYGGLGLDYEYQKAFDAESL
TH_4121|M.thermoresistible__bu DRGEEEPWLRARELQKRLYEGGFAGICFPREYGGLGLPYEYQKAFDAETA
Mflv_3794|M.gilvum_PYR-GCK VRADQESWDRAKELQKRLYEGGFAGICFPREYGGLGLDYAYQRAFNAECR
Mvan_2600|M.vanbaalenii_PYR-1 VRAEQSSWDRAMELQKRLYEGGFAGICFPREYGGLGLDHAYQKAFNAECR
MSMEG_2992|M.smegmatis_MC2_155 VRADQESWDRAKELQKRLYQGGFAGICFPREYGGLGLDHAYQRAFNAEAR
MLBr_00737|M.leprae_Br4923 ADVDQRARFP-EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVA
. . .*: : * ** .
Mb3590c|M.bovis_AF2122/97 RADAPD--KVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYS
Rv3560c|M.tuberculosis_H37Rv RADAPD--KVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYS
MAB_3122|M.abscessus_ATCC_1997 AAGVPDPLFVNVIGYGMAAPTVLAHGQPELIRRILRPLFTGEELWCQLFS
MUL_3854|M.ulcerans_Agy99 HYEMPL--ILNVPTFTICCATLLDTGSENQKKRHIAAALRGEEVLVQLLS
MMAR_3992|M.marinum_M HYEMPL--ILNVPTFTICCATLLDTGSESQKKRHIAAALRGEEVLVQLLS
MAV_1620|M.avium_104 DYEMPL--ILNTPTFTICCATLLDTGSEQQKKQHIAAALRGEEILVQLLS
TH_4121|M.thermoresistible__bu EYELPL--ILNTPTFTICCATILDTGSEQQKRKHISAAIRGDEVLVQLLS
Mflv_3794|M.gilvum_PYR-GCK SYEMPL--ILNVPTFTICAATILDMGTEDQKRDRISAAVRGDEILCQLLS
Mvan_2600|M.vanbaalenii_PYR-1 CYEMPL--ILNVPTFTICAATILDMGSEAQKRDRISAAIRGDEILCQLLS
MSMEG_2992|M.smegmatis_MC2_155 CYEMPL--ILNTPSFTICAATILDMGSEQQKRDRIGAAIRGEEILVQLLS
MLBr_00737|M.leprae_Br4923 RVDASAS--LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALS
. : : :: * : : : *
Mb3590c|M.bovis_AF2122/97 EPGAGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGS
Rv3560c|M.tuberculosis_H37Rv EPGAGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGS
MAB_3122|M.abscessus_ATCC_1997 EPGAGSDLAGLATRAVRDGDEWVINGQKVWTSGAHQARWALLVARSNPDV
MUL_3854|M.ulcerans_Agy99 EHSGGSDLAGVLTRAERQGDRWVINGAKTWSTSAFAADYGLCLARTNWDV
MMAR_3992|M.marinum_M EPSGGSDLAGVLTRAERQGDRWVINGAKTWSTSAFAADYGLCLARTNWDV
MAV_1620|M.avium_104 EPSGGSDLAGVLTRAERRGDRWIINGAKTWSTSAFAADYGLCLARTNWDV
TH_4121|M.thermoresistible__bu EPSGGSDLAGVITRADRRGDKWVINGAKTWSTSAFAADYGLLLARTNWDV
Mflv_3794|M.gilvum_PYR-GCK EPSGGSDLAGVITRADKQGDTWIINGAKTWSTSAFAADYGLLLARTDWTV
Mvan_2600|M.vanbaalenii_PYR-1 EPSGGSDLAGVITRAERNGDKWIINGAKTWSTSAFAADYGLLLARTDWTV
MSMEG_2992|M.smegmatis_MC2_155 EPSGGSDLAGVITRADRVGDKWVINGAKTWSTSAFAGDYGLMLARTNWDV
MLBr_00737|M.leprae_Br4923 EREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPD-
* .*** *.: * * ** *::** * * : . . : :* ::
Mb3590c|M.bovis_AF2122/97 QRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADLVV
Rv3560c|M.tuberculosis_H37Rv QRHAGLSYLLVPLDQPGVQIRPIVQITGT--AEFNEVFFDDARTDADLVV
MAB_3122|M.abscessus_ATCC_1997 AKHRGLTYFVVDMTDPGVEVRPLRQMTGD--AEFNEVYLTDVRIPDAHRL
MUL_3854|M.ulcerans_Agy99 PKHDGLTMFLVPINHPGITLRRITQVNGS--TEFCEEFLDSVDVGDDAVV
MMAR_3992|M.marinum_M PKHDGLTMFLVPINHPGITLRRITQVNGS--TEFCEEFLDGVDVGDDAVV
MAV_1620|M.avium_104 PKHEGLTMFLVPINHPGITLRRITMLSGS--TEFCEEFLDGVDVGDDAVV
TH_4121|M.thermoresistible__bu PKHEGLTMFLVPLDAPGITMRRIKQVDGG--NEFCEEFFDNVEVGDDAVV
Mflv_3794|M.gilvum_PYR-GCK PKHEGLTMFLVPLDSPGITMRRIKEVNGN--EEFCEEFFDGLELGADAVV
Mvan_2600|M.vanbaalenii_PYR-1 PKHEGLTMFLVPLNAPGITMRRIKEVNGN--EEFCEEFFDGLELGDDAVV
MSMEG_2992|M.smegmatis_MC2_155 PKHEGLTMFLVPLKAPGITMRRIKEVNGN--EEFCEEFFDNLELGDDAVV
MLBr_00737|M.leprae_Br4923 KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRII
*:: ::* *. : * * :: :
Mb3590c|M.bovis_AF2122/97 GAPGDGWRVAMATLTFERGVSTLGQQIVYAR-------ELSNLVELARRT
Rv3560c|M.tuberculosis_H37Rv GAPGDGWRVAMATLTFERGVSTLGQQIVYAR-------ELSNLVELARRT
MAB_3122|M.abscessus_ATCC_1997 GNEGDGWRVSMTTLMNER--SALGGAFDHGRGG----GSIGNALNLWKQR
MUL_3854|M.ulcerans_Agy99 GEVNNGWTVASRQLYHERRAVGIGSEFASGAGSEGGHATPVDYVALAETT
MMAR_3992|M.marinum_M GEVNNGWTVASRQLYHERRAVGMGSEFASGAGSEGGHATPVDYVALAETT
MAV_1620|M.avium_104 GEVNGGWAVASRQLYHERRAVGQGSEFASGGGSEGGHTIPVDYVSLAEKT
TH_4121|M.thermoresistible__bu GEVDKGWEVASRQLYHERRAVGGGSEFASGIGAEGSTDQPVDYVALLAAT
Mflv_3794|M.gilvum_PYR-GCK GEVNKGWEVATRQLHHERRAVGGGSEFASGTAAENASEMPPDHVGLAEAT
Mvan_2600|M.vanbaalenii_PYR-1 GEVNKGWEVATRQLHHERRAVGGGSEFASGTAAENASEMPPDHVGLARAT
MSMEG_2992|M.smegmatis_MC2_155 GKVDDGWTVASRQLFHERRAVGGGSEFASGTGAENANEMPPDHVGLAEAL
MLBr_00737|M.leprae_Br4923 GEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESI
* . *: .: * * : :
Mb3590c|M.bovis_AF2122/97 AAADDPLIRERLTRAWTGLRAMRSYALATMEGPAVEQPGQD--NVSKLLW
Rv3560c|M.tuberculosis_H37Rv AAADDPLIRERLTRAWTGLRAMRSYALATMEGPAVEQPGQD--NVSKLLW
MAB_3122|M.abscessus_ATCC_1997 PDLHTPELRAKLTNLFVRSEGNRYGTQMRIAAQGDAPMGPEG-SIGKLMG
MUL_3854|M.ulcerans_Agy99 GQAHSDRVREMAGRALVHRAVCEQLIDHVYRSVRDGTLPPAAGTLIRLFH
MMAR_3992|M.marinum_M GQAHSDRVREMAGRALVHRAVCEQLIDHVYRSVRDGTLPPAAGTLIRLFH
MAV_1620|M.avium_104 GQADDPRVQEMAGRVLVHRAVAEQLIGHVYRSVRDGALPPAAGTLIRLFH
TH_4121|M.thermoresistible__bu GQSDSLRAQELAGRALVHRAVQDQLVEHVYHAVNDGTLPPAGGSIIRVTH
Mflv_3794|M.gilvum_PYR-GCK GQSDNPLVQDLAGRALVRRIVKEQLIDHVFRSITDGSLPPNAGTLIRLFH
Mvan_2600|M.vanbaalenii_PYR-1 GQDGDPRVQDLAGRALVRRIVKEQLIDHVFRSIGNGSLPPNAGTLIRLFH
MSMEG_2992|M.smegmatis_MC2_155 GRADDPFVQDLAGRALVRRAVKTQLIDHVTQAIAAGALPPTAGTLIRLFH
MLBr_00737|M.leprae_Br4923 STFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFIS-AASKCFA
. :
Mb3590c|M.bovis_AF2122/97 ANWHRNLGELAMDVIGKPGMTMP---------DGEFDEWQRLYLFTRADT
Rv3560c|M.tuberculosis_H37Rv ANWHRNLGELAMDVIGKPGMTMP---------DGEFDEWQRLYLFTRADT
MAB_3122|M.abscessus_ATCC_1997 AELNQQIYDFCVELLGIEATLYASYDMRRVVEDDRRADTMWAFLRSKANT
MUL_3854|M.ulcerans_Agy99 AETVMCEMDTSLAIAGSGGVVGQPGE---------GLQTGLRYLARQSVA
MMAR_3992|M.marinum_M AETVMCEMDTSLAIAGSGGVVGQPGE---------GLQTGLRYLARQSVA
MAV_1620|M.avium_104 SETVTTDVDTALAIAGSAGVVGEPGA---------GLETGLRYLSRQTVA
TH_4121|M.thermoresistible__bu AEHIQVEVDTALALAGSGGVVDDSRD---------LFRFGERYLSRQAAA
Mflv_3794|M.gilvum_PYR-GCK AETTELEVDTALAIAGTAGVIDEGSDD--APELSGLLEIGVRYLSRQTGS
Mvan_2600|M.vanbaalenii_PYR-1 AETTELEVDTALAIAGTAGVVDEGSDD--APGLTGLMDVGVRYLSRQTGS
MSMEG_2992|M.smegmatis_MC2_155 AETTELEVDTALAIAGTAGVVDEGGD------FDGMLDIGVRYLSRQTGS
MLBr_00737|M.leprae_Br4923 SDIAMEVTTDAVQLFGGAGYTSD-------------FPVERFMRDAKITQ
:: .: : * . :
Mb3590c|M.bovis_AF2122/97 IYGGSNEIQRNIIAERVLGLPREAKG------------------
Rv3560c|M.tuberculosis_H37Rv IYGGSNEIQRNIIAERVLGLPREAKG------------------
MAB_3122|M.abscessus_ATCC_1997 IEGGTSDVMRNIIGERVLGLPGDIRVDTDKAWKDVPRG------
MUL_3854|M.ulcerans_Agy99 IGGGPTEMARNVIGERMLNFPREFAADRGVSFNQVRRG--SPR-
MMAR_3992|M.marinum_M IGGGTTEMARNVIGERMLNFPREFAADRGVPFNQVRRG--PPR-
MAV_1620|M.avium_104 IGGGTTEMARNVIGERVLGFPREYAADRGVPFNQVRHGQRSDRS
TH_4121|M.thermoresistible__bu LGGGTTEIARNIIAERILGFPREPAADRGMPFKDVKRN----RG
Mflv_3794|M.gilvum_PYR-GCK LGGGSSEMARNVIGERILGFPRELAADKGIPFNEVKRN----KS
Mvan_2600|M.vanbaalenii_PYR-1 LGGGSSEMARNVISERILGFPRELAADKGIPFNQVKRN----KS
MSMEG_2992|M.smegmatis_MC2_155 LGGGSSEMARNVIGERVLGFPREHAADRGVPFREVKRN----KG
MLBr_00737|M.leprae_Br4923 IYEGTNQIQRVVMSRALLR-------------------------
: *..:: * ::.. :*