For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SAETRSSGRRKLPKQERSREMVAKIVQTTAALLIKTEPEQVTTNLIADRAGISKGSIYQYFSDKEEIIEA AVEHLAAQQAPEIEEMLRSVTMSRPEVAMESSIDILIDFTIANRRLIRYLAERPDHVRTFEAISGLNATL LAMATLHMGHYRDQYRDELSPRALAWLFFNMAVATTLRYIEADDPISLDELRSGLKFASTGLLAGAVSGG HVGEPGPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3251 | - | - | 100% (219) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1610 | - | 3e-07 | 31.68% (101) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4953 | - | 8e-07 | 27.05% (122) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0237 | - | 1e-06 | 32.20% (118) | TetR/ACRR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0232 | - | 1e-06 | 32.20% (118) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 3e-06 | 25.32% (158) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2392 | - | 9e-09 | 31.71% (82) | putative transcriptional regulator, TetR |
| M. marinum M | MMAR_0684 | - | 4e-16 | 27.03% (185) | putative regulatory protein |
| M. avium 104 | MAV_4938 | - | 1e-05 | 27.97% (118) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6532 | - | 9e-12 | 28.57% (154) | transcriptional regulatory protein |
| M. thermoresistible (build 8) | TH_1265 | - | 3e-07 | 29.29% (99) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2529 | - | 2e-06 | 24.14% (203) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2968 | - | 5e-92 | 80.68% (207) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3251|M.gilvum_PYR-GCK ------------------MSAETRSSGRRKLPKQERSREMVAKIVQTTAA
Mvan_2968|M.vanbaalenii_PYR-1 ------------------MSSSKHISERRKLPQQQRSREMVAKIVASTAS
Mb0237|M.bovis_AF2122/97 --------------------------MPTVTWARVDP-ARRAAVVEAAEA
Rv0232|M.tuberculosis_H37Rv --------------------------MPTVTWARVDP-ARRAAVVEAAEA
MAV_4938|M.avium_104 --------------------------MPTVTWARVDP-ARRAAIIEAAES
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
MUL_2529|M.ulcerans_Agy99 MSDLAKAAQHRAVRSADRVR-STEGATPKARGNRLPRDERRGQLLIVASD
MMAR_0684|M.marinum_M --------------------MPRKSATFRKVPTQDRSKDTVKRILDAARM
MSMEG_6532|M.smegmatis_MC2_155 -------------------MVVAMSDAPRKKPRQRRSRETVEVVLEAAAQ
TH_1265|M.thermoresistible__bu --------------------------------VTPKGERRRDALISAAAE
MAB_2392|M.abscessus_ATCC_1997 ----------MTRTAGSPARSSTRPQRAERRTQEERSAAMRGRLLDATVD
:: :
Mflv_3251|M.gilvum_PYR-GCK LLIKTEPEQVTTNLIADRAGISKGSIYQYFSDKEEIIEAAVEHLAAQQAP
Mvan_2968|M.vanbaalenii_PYR-1 LLLKTDPDQLTTNLIADKAGVSKGSIYQYFADKDAIINAAIEQLAAQQAP
Mb0237|M.bovis_AF2122/97 EFGAHGFSRGSLNVIARRAGVAKGSLFQYFADKRDLYAFIADIASQRVRS
Rv0232|M.tuberculosis_H37Rv EFGAHGFSRGSLNVIARRAGVAKGSLFQYFADKRDLYAFIADIASQRVRS
MAV_4938|M.avium_104 EFGAHGFSRGSLNVIARKAGVAKGSLFQYFADKRDLYAFIADIGSQRVRG
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
MUL_2529|M.ulcerans_Agy99 VFVDRGYHAAGMDEIAERAGVSKPVLYQHFSSKLELYLAVLNRHVDKLVA
MMAR_0684|M.marinum_M LLEERGYDGTSTNRIAAAAGISPGSLYQYFANKDAILHAVVAEYTQQLLD
MSMEG_6532|M.smegmatis_MC2_155 VFDREG-LAATTNRIAERAGVSIGSLYQYFPNKHALLNALAQRHVQTASA
TH_1265|M.thermoresistible__bu LLCEGGFDAVRHRAVARRAGLPLASTTYYFSSLDDLIVQAVTHIGARETR
MAB_2392|M.abscessus_ATCC_1997 CLVKYGYAGTTTTRVAQRAGVTRGALVHHFQSKSELLGESVRHLAFRQGQ
: :* **:. :* . :
Mflv_3251|M.gilvum_PYR-GCK EIEEMLRSVTMSRPE--VAMESSIDILIDFTIANRRLIRYLAE------R
Mvan_2968|M.vanbaalenii_PYR-1 VIEEMLRSVTLVQPE--AAMQSSIDILIDVTIANRRLIRYLAE------R
Mb0237|M.bovis_AF2122/97 YMEDLIRELDPNRPFF-EFLTDLLDGWVAYFAEHPRERALHAAATL-EVD
Rv0232|M.tuberculosis_H37Rv YMEDLIRELDPNRPFF-EFLTDLLDGWVAYFAEHPRERALHAAATL-EVD
MAV_4938|M.avium_104 YIEQLIRELDPTRPFF-EFLTDLLDGWVAYFADHPHERALHAAATL-EVD
MLBr_00815|M.leprae_Br4923 SVQQALRTTTNNR----QRLHAAVQAFFDFIEHDGQGYRLIFENDN-ITE
MUL_2529|M.ulcerans_Agy99 GVQQALRTTTDNR----GRLYAAVQAFFDFIEHDSQGYRLIFENDY-VTE
MMAR_0684|M.marinum_M QVTGNLASLVRSEHD--VPLSAAIEAQVDAMLERPQILRVISGQLPGRTS
MSMEG_6532|M.smegmatis_MC2_155 RLDAVFAELRHETPEFDQTLRSILAVVVDLHHDRPALHRLMHRVAV--PR
TH_1265|M.thermoresistible__bu QLEQRVAAVARRRRGAETTADVLVDVLVGTASGITATEELISRYER-YIA
MAB_2392|M.abscessus_ATCC_1997 EILSELIALDRDSDAD--FISRCLDALWRMHQG-SMFIATMELWIAARTD
: . :
Mflv_3251|M.gilvum_PYR-GCK PDHVRTFEAISGLNATLLAMATLHMGHYRDQYRDELSPR--ALAWLFFNM
Mvan_2968|M.vanbaalenii_PYR-1 PDYTRTFENISGLNATLLAMATLHMGHYRDQYRHELSPR--ALAWLFFNM
Mb0237|M.bovis_AF2122/97 TDARISVRSVLHRHYLDVLRPLVRDAHARGDLRADSDTGALMSLLLLIFP
Rv0232|M.tuberculosis_H37Rv TDARISVRSVLHRHYLDVLRPLVRDAHARGDLRADSDTGALMSLLLLIFP
MAV_4938|M.avium_104 TEARISVQNVIHRHYLEVLRPLVRDARLRGDLRADSDTDALLSLLLLIFP
MLBr_00815|M.leprae_Br4923 PRVAAQVR-VATESCIDAVFALISADSRLDPHRAR------MVAVGLVGI
MUL_2529|M.ulcerans_Agy99 PEVAAQVR-VATESCIDAVFALISADSGLDPHRAR------MIAVALVSM
MMAR_0684|M.marinum_M ADVLRPLRELMTATIKGYAIAAPDQSIDMDVDAAT----------WIIVQ
MSMEG_6532|M.smegmatis_MC2_155 DDQLAALQEFENRLAGEVAFHLVRCGRVRDPDDAS-------ATARTVVH
TH_1265|M.thermoresistible__bu CARQPALRDIQRQIRKQRTDAVVKVVERSGRAVRP------ELVSALVCA
MAB_2392|M.abscessus_ATCC_1997 AELSAQMDQFEFIVMQQFSTLGQSVSQTDEELRVIRNIT--LTAMDAVRG
. . .
Mflv_3251|M.gilvum_PYR-GCK AVATTLRYIEADDPISLDELRSG-LKFASTGLLAGAVSGGHVGEPGPS--
Mvan_2968|M.vanbaalenii_PYR-1 AVSTTLRYIESDDPISLEELRSG-LKFASAGLLSGSKT------------
Mb0237|M.bovis_AF2122/97 HLALAPYMRGLDPILGLDEPTPEQPALAVRRLVAVLAAAFDAQHPATNSA
Rv0232|M.tuberculosis_H37Rv HLALAPYMRGLDPILGLDEPTPEQPALAVRRLVAVLAAAFDAQHPATNSA
MAV_4938|M.avium_104 HLALAPYMRGLDPVLGLDEPTPEQPALAVRRLVAVLAAAFSPAP--AHFA
MLBr_00815|M.leprae_Br4923 SVDCARYWLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL----------
MUL_2529|M.ulcerans_Agy99 SVDCARYWLDSDRPISKSDAIEGTVQFAWGGLSHVPLARS----------
MMAR_0684|M.marinum_M LLGSTIRYVVDEPPIAKDVFVTEMTRFVMSSPVAWRCSARPAAVPTA---
MSMEG_6532|M.smegmatis_MC2_155 AVDAHLHRVLPHREVTREAAVDDLVDLVERLLRP----------------
TH_1265|M.thermoresistible__bu VDGAVVAALVGDGDGPRATARSTLIDVIDVLAPYA---------------
MAB_2392|M.abscessus_ATCC_1997 ILVNSMTAPQEVRDQRWARAKAMLLNIVESPAVGAPLDSALRTIDPGKLS
.
Mflv_3251|M.gilvum_PYR-GCK --------
Mvan_2968|M.vanbaalenii_PYR-1 --------
Mb0237|M.bovis_AF2122/97 QTRSEEIT
Rv0232|M.tuberculosis_H37Rv QTRSEEIT
MAV_4938|M.avium_104 TPRSEEVT
MLBr_00815|M.leprae_Br4923 --------
MUL_2529|M.ulcerans_Agy99 --------
MMAR_0684|M.marinum_M --------
MSMEG_6532|M.smegmatis_MC2_155 --------
TH_1265|M.thermoresistible__bu --------
MAB_2392|M.abscessus_ATCC_1997 LSD-----