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KIRFGVGLGAEVAPPELPAVVDRLESTGVDSLWLSELVYSSAVEPFVGMAHALGRTSRLKVGTSVAVLPG RHPVLVAKQLASLAALAPKRVLPVFGLRSAMPAEREAFVVPAGRRGAVFDESLRLLRASLEGPTTFSGEF FSVRDVEVLPKPASHLDIWLGGSSRAGYRRIGELGDGWLGSFVTPDEARDAVRTIRAFAEAAGREVPEDH YGINLAVGDGDLPAPVIAAIRTRRPDLDPEELVARDWAQLHRRLDRYIDAGLTKFVIRPAGRGSIDAFLD AFVTELLPREN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3246 | - | - | 100% (292) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_4839 | - | 3e-18 | 28.85% (253) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_1590 | - | 1e-17 | 29.94% (177) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0965c | - | 1e-17 | 34.48% (174) | oxidoreductase |
| M. tuberculosis H37Rv | Rv0940c | - | 1e-17 | 34.48% (174) | oxidoreductase |
| M. leprae Br4923 | MLBr_00269 | - | 9e-09 | 22.49% (338) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0366 | - | 7e-21 | 36.46% (181) | hypothetical protein MAB_0366 |
| M. marinum M | MMAR_0393 | - | 6e-17 | 34.18% (158) | hypothetical protein MMAR_0393 |
| M. avium 104 | MAV_2830 | - | 1e-115 | 72.35% (293) | hypothetical protein MAV_2830 |
| M. smegmatis MC2 155 | MSMEG_3544 | - | 1e-108 | 65.41% (292) | hypothetical protein MSMEG_3544 |
| M. thermoresistible (build 8) | TH_2945 | - | 1e-18 | 30.69% (202) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_1043 | - | 2e-17 | 34.81% (158) | hypothetical protein MUL_1043 |
| M. vanbaalenii PYR-1 | Mvan_5167 | - | 5e-19 | 30.54% (203) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3246|M.gilvum_PYR-GCK -------------MKIRFGVGLGAEVAPPELPAVVDRLESTGVDSLWLSE
MAV_2830|M.avium_104 -------------MKIRFGVGLGADNAPAELGAIVDHLESTGVDSLWFSE
MSMEG_3544|M.smegmatis_MC2_155 -----MPGMTSIEGKVRFGVGLGADTTPEDLPGIVDYLESSGADSVWFSE
MMAR_0393|M.marinum_M -------MRFIITHPMHSHPYHPELASGAGVAAVAAAAERAGFHGFGFTD
MUL_1043|M.ulcerans_Agy99 ---------------MHSHPYHPELASGAGVAAVAAAAERAGFHGFGFTD
TH_2945|M.thermoresistible__bu -MKFTFALPHMMELDAMMQPWEMAVT-GADQTRMARRAEELGFDMIAVPE
Mvan_5167|M.vanbaalenii_PYR-1 -MRLVFALPHMLRLPAMSQPWEASVT-GADQTRMARCADQWGYDMIAVPE
Mb0965c|M.bovis_AF2122/97 -----MRFSYAEAMTDFTFYIPLAKAAEAAGYSSMTIPDSIAYPFESDSK
Rv0940c|M.tuberculosis_H37Rv -----MRFSYAEAMTDFTFYIPLAKAAEAAGYSSMTIPDSIAYPFESDSK
MAB_0366|M.abscessus_ATCC_1997 MKIGVVAPVELGVTAEPDKILEFARAAERLGFSEISVVEHAVVIGDTQST
MLBr_00269|M.leprae_Br4923 -----------MAELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSD
: .
Mflv_3246|M.gilvum_PYR-GCK LVYSS-----------AVEPFVGMAHALGRTSRLKVGTSVAVLPGRH-PV
MAV_2830|M.avium_104 LVYSP-----------AVDPVVGMAFALARTHRLKVGTSVAVLPGRH-PV
MSMEG_3544|M.smegmatis_MC2_155 LVYSP-----------AVDPFIGMAYTLSRTTRLKAGTSVAILPGRH-PV
MMAR_0393|M.marinum_M HPAPSQRWLEAG-GHDSLDPFVALGFAAAQTTSLRLIPNIVVLPYRN-PF
MUL_1043|M.ulcerans_Agy99 HPAPSQRWLEAG-GHDSLDPFVALGFAAAQTTSLRLIPNIVVLPYRN-PF
TH_2945|M.thermoresistible__bu HIVMPREHVDLS-GGHWLHSTIAQAYFAGATERITLNSCVTILPLQH-PL
Mvan_5167|M.vanbaalenii_PYR-1 HFVIPAEHVELS-GPHYLQSTVAQAYLAGATERIRLNSCITVLPLQH-PV
Mb0965c|M.bovis_AF2122/97 YPYTPDGNREFMDGKPFIETFVLTAALGAVTTRLRFNFFVLKLPIRP-PA
Rv0940c|M.tuberculosis_H37Rv YPYTPDGNREFMDGKPFIETFVLTAALGAVTTRLRFNFFVLKLPIRP-PA
MAB_0366|M.abscessus_ATCC_1997 YPYSPTGQSHLPDDIDIPDPLELLSFVAAATTTLGLSTGVLVLPDHH-PV
MLBr_00269|M.leprae_Br4923 HFQPWRHQGG-----HASFSLSWMTAVGERTNRILLGTSVLTPTFRYNPA
. * : : . : *
Mflv_3246|M.gilvum_PYR-GCK LVAKQLASLAALAPKRVLPVFGLRSAMPAEREAFV---VPAGRRGAVFDE
MAV_2830|M.avium_104 LVAKQLASLAAVAPKRVLPVFGLRSAIPAEREVFV---VPDGERAAVFDE
MSMEG_3544|M.smegmatis_MC2_155 LVAKQVASLAALAPRRVLPAFGLHSALTAERDVFT---VPRGRRGAVFDE
MMAR_0393|M.marinum_M VVAKSAATLDLLSGGRFILAVGVG-YLKREFAALG---VDHAERAELFEE
MUL_1043|M.ulcerans_Agy99 VVAKSAATLDLLSGGRFILAVGVG-YLKREFAALG---VDHAERAELFDE
TH_2945|M.thermoresistible__bu VTAKALATADWLSGGRMMVTFGVG-WLQREFELLG---VPFRKRGRIADE
Mvan_5167|M.vanbaalenii_PYR-1 VLAKALATADWMSGGRMMVTFGVG-WLQGEFEALG---VPFRERGRMADE
Mb0965c|M.bovis_AF2122/97 LVAKQAGSLAALIGNRVGLGVGTS-PWPEDYELMG---VPFAKRGKRIDE
Rv0940c|M.tuberculosis_H37Rv LVAKQAGSLAALIGNRVGLGVGTS-PWPEDYELMG---VPFAKRGKRIDE
MAB_0366|M.abscessus_ATCC_1997 VLAKRLATLDRLSRGRLRICAGVG-WMREEIEACG---GDFDRRGRAADE
MLBr_00269|M.leprae_Br4923 VIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQGAWPEFKERFARLRE
: .: .: : *. * .* *
Mflv_3246|M.gilvum_PYR-GCK SLRLLRAS-LEGPTT-FSGEFFSVRDVEVLPKPASH--LDIWLGGSSRAG
MAV_2830|M.avium_104 SLRLLRAALVEDSAT-FTGRYFSVTGAAVTPKPAPP--LDIWLGGSAPAA
MSMEG_3544|M.smegmatis_MC2_155 SLELLNAVLRGRDVS-FDGEFFKVRSANVQPVPAKP--VDIWLGGSGPVA
MMAR_0393|M.marinum_M ALQVIRAVWTSDDIS-FEGRHFSARGITAHPRPASNPYPPIWVGGNTAAA
MUL_1043|M.ulcerans_Agy99 ALQVIRAVWTSDDIS-FEGRHFSARGITAHPRPASNPYPPIWVGGNTAAA
TH_2945|M.thermoresistible__bu YLAAIIELWTQDEPS-FAGQFVSFEDVVFEPKPIQQPHPPIWIGGDSDAA
Mvan_5167|M.vanbaalenii_PYR-1 YLAVIKELWTSDAPS-FEGKYVSFREVAFEPKPVQKPHLPIWIGGDADAA
Mb0965c|M.bovis_AF2122/97 CIEIVRGLTTGDYFE-FHGEFYDIPKTKMTPAPTQP--IPILVGGHADAA
Rv0940c|M.tuberculosis_H37Rv CIEIVRGLTTGDYFE-FHGEFYDIPKTKMTPAPTQP--IPILVGGHADAA
MAB_0366|M.abscessus_ATCC_1997 AIAVMRALWSTDGPTSHDGEFYSFRNAYSYPKPVRPQGVPLYIGGHSKAA
MLBr_00269|M.leprae_Br4923 SVRLMRELWRGDRVD-FDGDYYQLKGASIYDVPEGG--VPIYIAAGGPEV
: : . * . . * : :..
Mflv_3246|M.gilvum_PYR-GCK YRRIGELGDGWLGSFVTP-----------------------DEARDAVRT
MAV_2830|M.avium_104 LRRIGALADGWLGSFLTP-----------------------AEARAGREA
MSMEG_3544|M.smegmatis_MC2_155 LARIGRLADGWLGSFLTP-----------------------VEAGAARRT
MMAR_0393|M.marinum_M RRRVAAHGDGWCPFPAPAP---------LAQTAGTAAIDSADRLAAGIDD
MUL_1043|M.ulcerans_Agy99 RRRVAVHGDGWCPFPAPAP---------LAQTAGTAAIDSADRLAAGIDD
TH_2945|M.thermoresistible__bu LRRAARFASGWFTFLTKP-----------------------EDIAARVDI
Mvan_5167|M.vanbaalenii_PYR-1 LRRAAKYASGWWSFLTPP-----------------------EKLAERLDF
Mb0965c|M.bovis_AF2122/97 LRRAAR-ADGWMHGGGDP--------------------DELDRLIARVKR
Rv0940c|M.tuberculosis_H37Rv LRRAAR-ADGWMHGGGDP--------------------DELDRLIARVKR
MAB_0366|M.abscessus_ATCC_1997 ARRAGRLGSGFQPLGLVG-----------------------DDLTAAVGV
MLBr_00269|M.leprae_Br4923 AKYAGRAGEGFVCTSGKGEELYTEKLIPAVLEGAAVAGRDADDIDKMIEI
. ..*:
Mflv_3246|M.gilvum_PYR-GCK IRAFAEAAGREVPEDHYGINLAVGDGDLPAPVIAAIRTRRPDLDPEELVA
MAV_2830|M.avium_104 IERAAAAAGRHIEPDHFGISLAVADGELPPPAIAAVRRRRPDLDPDELIA
MSMEG_3544|M.smegmatis_MC2_155 IEREAQAAGREIEPDHYGISLAVAAGDIPDDVYDMARRRRPEVDPAELIA
MMAR_0393|M.marinum_M LRRKCDAAGRDFSAIDVTFTNFDGGG-----------PASADFNADAYLG
MUL_1043|M.ulcerans_Agy99 LRRKCDAAGRDFSAIDVTFTNFDGGG-----------PASADFNADAYLG
TH_2945|M.thermoresistible__bu ITSQPEYDGRPFDVMHGLGTNRVGEGHVPT----GDRGAWPGMSAAELID
Mvan_5167|M.vanbaalenii_PYR-1 IKSQPDYDGRPFDVVHGLGTNRVGEGHVAQ----HDPDARPGMSAAEIVD
Mb0965c|M.bovis_AF2122/97 LREEAGKTS-PFEIHVISLDGFTVDG-------------VKRLEDKGVTD
Rv0940c|M.tuberculosis_H37Rv LREEAGKTS-PFEIHVISLDGFTVDG-------------VKRLEDKGVTD
MAB_0366|M.abscessus_ATCC_1997 MRAAAVDAGRDPRGLDLVLGHG-----------------LHRVDQAALDQ
MLBr_00269|M.leprae_Br4923 KMSYDPDPEQALSNIRFWAPLSLAAEQKHSIDDPIEMEKVADALPIEQVA
Mflv_3246|M.gilvum_PYR-GCK RDWAQLHRRLDRYIDAGLTKFV-----IRPAGRGSIDAFLDAFVTELLPR
MAV_2830|M.avium_104 SGWDQLHRKLDAYLDAGLTKFV-----IRPAGTAPWDGFLDRFVTELVGR
MSMEG_3544|M.smegmatis_MC2_155 ADWPTLHRRIDAYVDAGLTKFV-----VRPVGSGDREAFLERFVGELLPR
MMAR_0393|M.marinum_M G-LEKLATLGVTWVHVGLP---------GDGLAHALECIDRFRVQVIEAA
MUL_1043|M.ulcerans_Agy99 G-LEKLAMLGVTWVHVGLP---------GDGLAHALECIDRFRVQVIEAA
TH_2945|M.thermoresistible__bu R-IGALHEHGVTYTSVPIP---------PVRGVEEYLDYSQWVMEEIAPN
Mvan_5167|M.vanbaalenii_PYR-1 R-LSWLGAQGVTVSAVPIP---------KVRGVEEYLDYAQWVIEEIKPQ
Mb0965c|M.bovis_AF2122/97 V-IVGFRVP-YTMGPDTEP---------LQTKIRNLEMFAENVIAKV---
Rv0940c|M.tuberculosis_H37Rv V-IVGFRVP-YTMGPDTEP---------LQTKIRNLEMFAENVIAKV---
MAB_0366|M.abscessus_ATCC_1997 AAHAGAGRMLLSASRRATT---------LEAVLEEMAGCATRLELGGPR-
MLBr_00269|M.leprae_Br4923 KRWIVVSDPDEAVARVGQYVTWGLNHLVFHAPGHNQRRFLELFEKDLAPR
Mflv_3246|M.gilvum_PYR-GCK EN---
MAV_2830|M.avium_104 QN---
MSMEG_3544|M.smegmatis_MC2_155 QN---
MMAR_0393|M.marinum_M -----
MUL_1043|M.ulcerans_Agy99 -----
TH_2945|M.thermoresistible__bu VP---
Mvan_5167|M.vanbaalenii_PYR-1 VP---
Mb0965c|M.bovis_AF2122/97 -----
Rv0940c|M.tuberculosis_H37Rv -----
MAB_0366|M.abscessus_ATCC_1997 -----
MLBr_00269|M.leprae_Br4923 LRRLG