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VPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLGADAGVPVIFLHHLGAVLDNWDPRVVDGIAAKHPVVT FDNRGVGASEGQTPDTVTTMADDAIAFVRALGFDQVDLLGFSLGGFVAQVIAQQEPQLVRKIILAGTGPA GGVGIGKVTFGTIRESIKATLTFRDPKELRFFTRTDSGKSAARQFVKRLKERKDNRDKSITVRAFRSQLK AIHAWGTQKPSDLTSIGHPVLIANGDDDTMVPTSNSLDLADRLPDATLRIYPDAGHGGIFQHHAQFVDDA LQFLES
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3177 | - | - | 100% (286) | POSSIBLE PEROXIDASE (NON-HAEM PEROXIDASE) |
| M. tuberculosis H37Rv | Rv0554 | bpoC | 2e-16 | 26.39% (269) | peroxidase BpoC |
| M. tuberculosis H37Rv | Rv2715 | - | 2e-09 | 24.56% (281) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3203 | - | 1e-164 | 100.00% (286) | peroxidase |
| M. gilvum PYR-GCK | Mflv_2561 | - | 7e-12 | 26.52% (264) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_02269 | - | 8e-21 | 28.20% (266) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3934c | - | 3e-12 | 25.09% (287) | alpha/beta fold hydrolase |
| M. marinum M | MMAR_0900 | bpoC | 1e-18 | 27.95% (254) | bromoperoxidase BpoC |
| M. avium 104 | MAV_4589 | - | 4e-18 | 28.24% (255) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_6831 | - | 1e-46 | 38.97% (272) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_3727 | - | 8e-16 | 28.99% (276) | PUTATIVE Chloride peroxidase |
| M. ulcerans Agy99 | MUL_0653 | bpoC | 8e-18 | 27.56% (254) | bromoperoxidase BpoC |
| M. vanbaalenii PYR-1 | Mvan_0974 | - | 1e-12 | 26.48% (253) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3177|M.tuberculosis_H37Rv MPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLG----ADAGVPVIFLHH
Mb3203|M.bovis_AF2122/97 MPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLG----ADAGVPVIFLHH
MSMEG_6831|M.smegmatis_MC2_155 -------MIHSPSTQAQTQYVQGRLARFAYRRFG----SGAGVPLVLALR
MMAR_0900|M.marinum_M ------------------------MINLAYDDKG------TGEPVLFIAG
MUL_0653|M.ulcerans_Agy99 ------------------------MINLAYDDKG------TGEPVLFIAG
MLBr_02269|M.leprae_Br4923 ------------------------MINLAYEDRG------TGEPVVFIAG
MAV_4589|M.avium_104 ------------------------MINLAYDDRG------SGEPVVFIAG
Mvan_0974|M.vanbaalenii_PYR-1 -------------------------MNLAFDDRG------SGDPVLFIAG
MAB_3934c|M.abscessus_ATCC_199 -----------------MPLANINGIQISYDDRGPLALGASGDPVVFISG
Mflv_2561|M.gilvum_PYR-GCK ------------MTMITAYRGPLRSTDLHVDDSGG-----DGRPVVLIHG
TH_3727|M.thermoresistible__bu ------------MATITTSDG----VEIFYRDWG------SGQPIVFSHG
: * * *:::
Rv3177|M.tuberculosis_H37Rv LGAVLDNWDPRVVDGIAAK-HPVVTFDNRGVG-ASEGQTPDTVTTMADDA
Mb3203|M.bovis_AF2122/97 LGAVLDNWDPRVVDGIAAK-HPVVTFDNRGVG-ASEGQTPDTVTTMADDA
MSMEG_6831|M.smegmatis_MC2_155 FRGTMDHWDPAFLDRLAAT-HDVVVFDNVGHS-KSTGTPPTTMAELAGGL
MMAR_0900|M.marinum_M RGGAGRTWQPHQVPAFLAAGYRCITFDNRGIG-ATENAEGFTTQTMVNDT
MUL_0653|M.ulcerans_Agy99 RGGAGRTWQPHQVPAFLAAGYRCITFDNRGIG-ATENAEGFTTQTMVNDT
MLBr_02269|M.leprae_Br4923 RGGAGRTWQPHQVPAFLAAGYRVITFDNRGIG-ATENTEGFTTQTMVADT
MAV_4589|M.avium_104 HGGAGRTWHPYQVPAFLAAGYRVITFDNRGIG-ATENAQGFTTETMVADT
Mvan_0974|M.vanbaalenii_PYR-1 RGGAGRTWHLHQVPVFTRAGYRCVTFDNRGIG-ATENASGFTTETMVGDT
MAB_3934c|M.abscessus_ATCC_199 RGGAGRSWHLHQVPAFRAAGYRTITFNNRGIPPTTESADGFTLQDMVDDT
Mflv_2561|M.gilvum_PYR-GCK WPLHSDSWAH-QVDALRDAGYRVITYDRRGFGRSDKPLIGYTYESLSDDL
TH_3727|M.thermoresistible__bu WPLTADDWDP-QMLFFLNAGYRVIAHDRRGHGRSSPVPDGHDMDHYADDL
* : : : :..:. * .
Rv3177|M.tuberculosis_H37Rv IAFVRALGFDQVDLLGFSLG-GFVAQVIAQQEPQLVRKIILAGTGPAGGV
Mb3203|M.bovis_AF2122/97 IAFVRALGFDQVDLLGFSLG-GFVAQVIAQQEPQLVRKIILAGTGPAGGV
MSMEG_6831|M.smegmatis_MC2_155 IDFVGALGLDEIDLLGWSLG-GIVVQEVALQRPELVRRLVVAGSSPGGGV
MMAR_0900|M.marinum_M AALIESLGIGPVRIVAVSMG-SFIAQELMVVRPELVNSAVLMATR-----
MUL_0653|M.ulcerans_Agy99 AALIESLGIGPVRIVAVSMG-SFIAQELMVVRPELVNSAVLMATR-----
MLBr_02269|M.leprae_Br4923 AVLIESLGAVPARIVGVSMG-SFIAQELMVARPELVRAAVLMATR-----
MAV_4589|M.avium_104 AALIEGLNAAPARIVGMSMG-AFIAQELMLARPELVSAAVLMGTR-----
Mvan_0974|M.vanbaalenii_PYR-1 AALIEHLGLAPVRIVALSMG-SYIAQELMVARPELVKSAVLMATR-----
MAB_3934c|M.abscessus_ATCC_199 AALIEQLGAAPARLVGFSMG-ALIAQELTLTRPELVTAAVFMGTR-----
Mflv_2561|M.gilvum_PYR-GCK SAVLEELDLTDVTLVGFSMGGGEVAAYCARKGVERIRSVVFASSVTPFMS
TH_3727|M.thermoresistible__bu AALVEHLGLRDAVHVGHSTGGGVVVRYLARHGEERTAKAVLIAAVPPLMV
.: *. :. * * . :. : :. .:
Rv3177|M.tuberculosis_H37Rv GIGKVTFGTIRESIKATLTFRDPK---ELRFFTRTDSGKSAARQFVKRLK
Mb3203|M.bovis_AF2122/97 GIGKVTFGTIRESIKATLTFRDPK---ELRFFTRTDSGKSAARQFVKRLK
MSMEG_6831|M.smegmatis_MC2_155 PGMPEPDPRIWQVATKPVNDDEDF---LYLFFPETEPGRKLGVESLRRLD
MMAR_0900|M.marinum_M GRLDRARKFFHDAEAELYDSGARM---PSTYDVKDRLLENFSRKTLNDDA
MUL_0653|M.ulcerans_Agy99 GRLDRARKFFHDAEAELYDSGARM---PSTYDVKDRLLENFSRKTLNDDA
MLBr_02269|M.leprae_Br4923 GRLDRTRQFFHAAEAEFHDSGIQL---PSGYNAKVRLLENLSRKTLNDDV
MAV_4589|M.avium_104 GRMDRARQFFRDAEAELADGGVAL---PASYEAKIRLLENFSRKTLNDDT
Mvan_0974|M.vanbaalenii_PYR-1 GRHDRTRDFFWQGERALAESGIEL---PIEFEAKVRLLESFSPNTLNDDN
MAB_3934c|M.abscessus_ATCC_199 GREDATRSFFRKAELELSASGVEV---PAAYQAAMRLLLNFSPKTLNNDA
Mflv_2561|M.gilvum_PYR-GCK ARKDNPEGPLGKLEAARMAASLTTDQDAFFEQFMTDVFSADGELQVTEQE
TH_3727|M.thermoresistible__bu RTDANPGG-LPKSVFDDFQAQLAANRSEFYRALASGPFYGFNRDGVEPSE
. : :
Rv3177|M.tuberculosis_H37Rv ERKDNRDKS-ITVRAFRSQLKAIHAWG--TQKPSDLTSIGHPVLIANGDD
Mb3203|M.bovis_AF2122/97 ERKDNRDKS-ITVRAFRSQLKAIHAWG--TQKPSDLTSIGHPVLIANGDD
MSMEG_6831|M.smegmatis_MC2_155 RRTTAPDHVPVSAETMTAQLKVIASTG--SRIWDRLNDITVPVLVANGAH
MMAR_0900|M.marinum_M AVGDWLAMFSMWPIKQTPGLRCQLDAAPLTNRLPAYRNIAAPVLVIGFSD
MUL_0653|M.ulcerans_Agy99 AVGDWLAMFSMWPIKQTPGLRCQLDAAPLTNRLPAYRNIAAPVLVIGFSD
MLBr_02269|M.leprae_Br4923 AVADWIAMFNMWPIKSTPGLRCQTDVAPQNNRLPAYRSIAAPVLVIGFAE
MAV_4589|M.avium_104 AVADWIAMFSTWPVKSTPGMRAQLDVAPYTNRLSAYRSIATPVLVIGFSD
Mvan_0974|M.vanbaalenii_PYR-1 AVRDWIDMFTMWPQKPTPGMRTQLDIAPQGSRLSAYQSVTTPVLVIGFAD
MAB_3934c|M.abscessus_ATCC_199 AIKDWIDMFTLWPEPASGGIDHQRSAIPAPDRPGAYADIKVPSLVIGFTD
Mflv_2561|M.gilvum_PYR-GCK RQEA----LSMCGDADKPATLACMAAFGGTDFREDLPKVTVPSLVIHGDS
TH_3727|M.thermoresistible__bu ALIANWWRQGMMGDAK--AHYDGIVAFSQTDFTEDLTKITVPVLVMHGDD
.: * *:
Rv3177|M.tuberculosis_H37Rv DTMVPT-SNSLDLADRLPDATLRIYPDAGHGGIFQHHAQFVDDALQFLES
Mb3203|M.bovis_AF2122/97 DTMVPT-SNSLDLADRLPDATLRIYPDAGHGGIFQHHAQFVDDALQFLES
MSMEG_6831|M.smegmatis_MC2_155 DRMIDA-YASYAMAGRLPDAKIVLYSDAGHGFLFQHLPDFAREVTEFLAG
MMAR_0900|M.marinum_M DIVTPP-YLGREVADSLPNGRYLQIPDAGHLGFFERPEAVNTAALKFFAG
MUL_0653|M.ulcerans_Agy99 DIVTPP-YLGREVADSLSNGRYLQIPDAGHLGFFERPEAVNTAALKFFAG
MLBr_02269|M.leprae_Br4923 DVVTPP-SLGREVADVLPNGRYLQIPDAGHLGFFERPEAVNAAALQFFAG
MAV_4589|M.avium_104 DVLTPP-YLGREVADALPNGRYVQIPDTGHLGFFERPDAVNAAMLKFFGE
Mvan_0974|M.vanbaalenii_PYR-1 DVVLPS-YLGREVANALPNGRFLEIPGTGHLGFIEKPQVVNTAILNFFAD
MAB_3934c|M.abscessus_ATCC_199 DMTLPP-YLGKEVADAIPGGQYVEISDAGHLGFIERPDEVNRVILEFFAS
Mflv_2561|M.gilvum_PYR-GCK DATVPFEGSGKRTYELLPDGRLHVIAGGPHGIPVSHADEFNAVLLEFLEQ
TH_3727|M.thermoresistible__bu DQVVPYANSGPLTAELLRNAKLKTYQGFPHGMMTTHAEVVNADILEFLRS
* . : .. . * : . :*:
Rv3177|M.tuberculosis_H37Rv --------
Mb3203|M.bovis_AF2122/97 --------
MSMEG_6831|M.smegmatis_MC2_155 NRP-----
MMAR_0900|M.marinum_M TRG-----
MUL_0653|M.ulcerans_Agy99 TRG-----
MLBr_02269|M.leprae_Br4923 VKGEWP--
MAV_4589|M.avium_104 QH------
Mvan_0974|M.vanbaalenii_PYR-1 TL------
MAB_3934c|M.abscessus_ATCC_199 TAQTV---
Mflv_2561|M.gilvum_PYR-GCK DFADGRGR
TH_3727|M.thermoresistible__bu --------