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VGVNGADAAEPIAVVGIGCRLAGDISTPGEFFSFLLAGDSAVTEVPPERWEPYLHRDPRNAAVLRETTRW GSFLDDLPGFDAEFFGVSPREAELMDPQQRLALEVSWEALEHAGIPPRSLAGSDTAVLMGVNSDDYGKLI MEDLAGIEAWTGIGTSLCGVANRVSHLLDLRGPSVALDAACAASLVAVHQACQLLRAGETSLALAGGVSA LIGPGLTRVLDVAGATAPDGRCKTFDDAADGYGRGEGAGVVVLKRLADALRDGDRVLAVVRGGAVAQDGR TVGIMSPNGEAQADLFRLACRAAGVSPESVGYLEAHGTGTPTGDPVEVGALSEVYGRADDPCALGSVKPN VGHLEGGAGVVGLIKTVLALHHEMLPPTAGVRTLTTAVDWAGSGLRVPTEAQPWPRGGAPRRAAVCSYGY GGTIAHVLLEEAPITADPDTSTAPTAFIPMSARSEARLAAAADALAGHLREAAFVVDDVAATMWTRRSHD PVRGAVVTDGLSGAQAAEAAVAALDVIAARGRDARVVTGHVVPGAETGAVWVFSGHGSHWAGMGRELLMT EPAFAATIDEVDIVFARELGFSARVALTAEDLGGTDRVQALTFAMQVGLAAVLRSRGVTPAAVIGHSVGE VAACVVSGVFDLAHGAAVACHRARGFRSVMGKGAMALVRLPFDEAERRLAGRTDVVAAISASTESTVVSG TVAAVDGIVDAWTADGMTVRRVNTDVAFHSPAMDALTADLAAMVAQLPQPDSAHIPLYTTALEDPRSTAP RGPDYWAVNLRGRVRFAEAVRAAAEDGHRLFLEVSAHPVVSHSIAETLLGLGFGEHAVLPVLRRDQPERR AVGAAVAGLYCHGAPVAHGLTPTTRWAADLPGTQWQHRRFWRTPTPPPGTAALHDPASHTLLGGVADVTG EVPARVWQTRLDMGNRPYPGDHPVQQTEIVPAAVLLNTFLNAAGAGLADVRLRTPVPPGRTRDIQVVLQG RSLRLSSRLTGTEAVENGWLTHSSAVVATDEEFGEPIDERVWTRCAESLPAGHVVDTLAGVGVAAMGFDW QVRDMRRGSGELVLRVSAQEDGSAPANWAGLLDAATSAASTVFDGPPRLRMPAHIERVHVRADPPAVALL HVRHRGGTATDVTIADESGAVRAFIAGMTFDELESPAGVDLSRMMHHVAWHDTCYDVEARPVEVALVACG DSAEMQRDLLAAGVPVDDHSTVDEVSDTLEPGAVVLLVPPVDAPPEASAELVLNSLKVLHAKGSEARLWV LTRRVHEGANLVHAPLWGLARVAAAEHPHLWGGVLDVADGPLPVGVLASMAGHGVVVFRDGRARTARLTP ARPAGGDAMTCTPGGTYLITGGTGALGLRIAQRLADLGARRLVLLSRSGVPHRSRWADSGDNDAVRAVTA LEERGVTVHIAAVDIGAPGADDQLRTILRELPAVRGVVHAAGVEAGALLLTTSAADLHAAMRPKVAGTLT LHELFPPGQLDWMVLFSSCGYLAGFPGQGAYACANAFLDAAARHRRSLGDRTVSIAWTAWRGLGMGSTSG FVAAQLEALGMGTVGADDAFRALDSAMRGQDPNVVVLPVLPEASAVPMLAEVAPTDQSDGGDVAAGPGDA DLGEWVAQQVIEAVAAELGLSETDVDPRVPLVETGVDSIMTVALRRTLEKRTGLALPPTLLWEHPTAAAV SDRIVELLAPQSEKTGVT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_2690 | - | - | 100% (1698) | beta-ketoacyl synthase |
M. gilvum PYR-GCK | Mflv_3395 | - | 0.0 | 39.08% (1763) | acyl transferase domain-containing protein |
M. gilvum PYR-GCK | Mflv_3391 | - | 0.0 | 34.56% (1788) | beta-ketoacyl synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2956 | ppsA | 0.0 | 36.97% (1780) | phenolpthiocerol synthesis type-I polyketide synthase PPSA |
M. tuberculosis H37Rv | Rv2931 | ppsA | 0.0 | 37.02% (1780) | phenolpthiocerol synthesis type-I polyketide synthase PPSA |
M. leprae Br4923 | MLBr_02357 | - | 0.0 | 36.54% (1776) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_3148c | - | 0.0 | 35.29% (1363) | polyketide synthase Pks5 |
M. marinum M | MMAR_2344 | pks5_1 | 0.0 | 35.57% (1403) | polyketide synthase, Pks5_1 |
M. avium 104 | MAV_2370 | - | 0.0 | 35.37% (1408) | mycocerosic acid synthase |
M. smegmatis MC2 155 | MSMEG_4727 | - | 0.0 | 34.75% (1479) | mycocerosic acid synthase |
M. thermoresistible (build 8) | TH_2454 | - | 0.0 | 67.79% (1751) | PUTATIVE beta-ketoacyl synthase |
M. ulcerans Agy99 | MUL_2016 | ppsD | 0.0 | 38.75% (1187) | phenolpthiocerol synthesis type-I polyketide synthase PpsD |
M. vanbaalenii PYR-1 | Mvan_3852 | - | 0.0 | 78.43% (1711) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MAV_2370|M.avium_104 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_2344|M.marinum_M -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2690|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3852|M.vanbaalenii_PYR-1 -------------------MTDAAWRCARTGPGSSLCANSLCQDVRHVRQ TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2956|M.bovis_AF2122/97 MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLS Rv2931|M.tuberculosis_H37Rv MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLS MLBr_02357|M.leprae_Br4923 MTASIGSEADLCHWLVNYLVTNIGCTPDEVDLNLSLTDLGMSSRDAVVLS MAV_2370|M.avium_104 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 ---------------------------------------------MTQNC MMAR_2344|M.marinum_M ---------------------------------------------MAKSH MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_2016|M.ulcerans_Agy99 ----------------MTSLAERAAQMSPKAREVLAHELVRAGTAFPTDI Mflv_2690|M.gilvum_PYR-GCK ------------------------MGVNGADAA----------------- Mvan_3852|M.vanbaalenii_PYR-1 KLRQGYP----------HRAAASVVALSVAAPA----------------- TH_2454|M.thermoresistible__bu ---------------------MSVDVTAKARPD----------------- Mb2956|M.bovis_AF2122/97 GELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGARNSL Rv2931|M.tuberculosis_H37Rv GELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGARNSL MLBr_02357|M.leprae_Br4923 GELTDLLGKTVSPIDFWEHPTINALAAYLIAPAPDPESESAPRRSVQGAL MAV_2370|M.avium_104 MVPVAVIGMACRLPGAVDSPERLWEALLRGDDFVTEIPPDRWDADEYYDP MSMEG_4727|M.smegmatis_MC2_155 VAPVAIIGMACRLPGAINSPQQLWEALLRGDDFVTEIPTGRWDAEEYYDP MMAR_2344|M.marinum_M VTPVAVIGMACRLPKGIDSPEKFWTALLRGDDLITEIPADRWDADEYYDP MAB_3148c|M.abscessus_ATCC_199 --------MGCRLPGGIESPEQFWQALLRGEDFITEVPPARWDLTEYYDP MUL_2016|M.ulcerans_Agy99 AEPVAVVGIGCRLPGNVSGPDSFWQLLVDGRDAVDEVPADRWDADAFYDP Mflv_2690|M.gilvum_PYR-GCK -EPIAVVGIGCRLAGDISTPGEFFSFLLAGDSAVTEVPPERWEPYLHRDP Mvan_3852|M.vanbaalenii_PYR-1 -APVAIVGIGCRLAGDITTPREFWSFLLTGGSKVTEVPSERWEPYLHRDP TH_2454|M.thermoresistible__bu -DPIAIIGIGCRLAGRITSPEEFWGFLLAGGSNVREIPAERWEPYLRRDP Mb2956|M.bovis_AF2122/97 DEPIAVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQRWQPFEGGPP Rv2931|M.tuberculosis_H37Rv DEPIAVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQRWQPFEGGPP MLBr_02357|M.leprae_Br4923 EEPIAVIGMGCRFPGGISGPEALWQFLCDRRSSIGQVPNERWELFDDGSP :.**:. : * :: * . : ::* **: * MAV_2370|M.avium_104 EPGVPGRSVSRWGAFIDDVAGFDPEFFGINEREATAMDPQHRLLLETSWE MSMEG_4727|M.smegmatis_MC2_155 EPGVPGRSVSKWGAFLDDPAAFDPEFFGITEREAAAIDPQHRLLLETAWE MMAR_2344|M.marinum_M EPGVPDHSVSRWGGFLDDVAGFDPEFFGISEREAIAIDPQHRLLLQTSWE MAB_3148c|M.abscessus_ATCC_199 ESGVPGKSPSKWGAFLEDVGGFDADFFSINEREAVSIDPQHRVLLETSWQ MUL_2016|M.ulcerans_Agy99 DPRAPGRMTTKWGGFIDDVAGFDADFFGITPREAVAMDPQQRVLLEVAWE Mflv_2690|M.gilvum_PYR-GCK RNAAVLRETTRWGSFLDDLPGFDAEFFGVSPREAELMDPQQRLALEVSWE Mvan_3852|M.vanbaalenii_PYR-1 RNAALLRETTRWGTFLDDLAGFDAEFFGVSPREAELMDPQQRLALEVSWE TH_2454|M.thermoresistible__bu RNAAVLREITPWGTFLDDLAGFDAEFFGVSPREAELTDPQQRLALEVSWE Mb2956|M.bovis_AF2122/97 EVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQRLLLEVAWE Rv2931|M.tuberculosis_H37Rv EVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQRLLLEVAWE MLBr_02357|M.leprae_Br4923 EVKALLARTTRWGSFLEDIDAFDSEFFEISPSEADKMDPQQRLLLEVAWE . : ** *: * .**.:** :. ** ***:*: *:.:*: MAV_2370|M.avium_104 AMEHAGLTEERVADSRTGVFIGLTHGDYQLLAADTRSVEGAYGFSGSNFS MSMEG_4727|M.smegmatis_MC2_155 AVEHSGLNPAGLAGSATGVFMGLTHNDYAHLAADAKALEGPYGFTGTSFS MMAR_2344|M.marinum_M AVEHAGMPPMSLSGSLTGVFVGMCHDDYAFVTDDAGALGDAYAFTGTAFS MAB_3148c|M.abscessus_ATCC_199 AVEHAGIDPRALAGSQTGVFVGVTHNDYQLVAADAADLGGPYGFAGTNFC MUL_2016|M.ulcerans_Agy99 ALEHAGLPPDSLSGTRTAAVMGLSAWDYTIVNLERRAEIDAYISTGNPHS Mflv_2690|M.gilvum_PYR-GCK ALEHAGIPPRSLAGSDTAVLMGVNSDDYGKLIMEDLAGIEAWTGIGTSLC Mvan_3852|M.vanbaalenii_PYR-1 ALEHAGISPRALVGSDTAVLMGVNSDDYGKLLMEDIAGIEAWTGIGTSLC TH_2454|M.thermoresistible__bu ALEHAGVPPRSLAGTDTAVLMGVNSDDYGRLLMEDLPGIEAWTGIGTSLC Mb2956|M.bovis_AF2122/97 ALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLSQVDGWSNSGGAMS Rv2931|M.tuberculosis_H37Rv ALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLSQVDGWSNSGGAMS MLBr_02357|M.leprae_Br4923 ALEHAGISSNSLRRSQTGVFAGSCLSEYGAIASTDLSQVDGWSNTGGAMS *:**:*: : : *... * :* : : * . MAV_2370|M.avium_104 LASGRIAYALGVHGPALTVDTACSSGLTAIHLACRSLHEGESDLALAGGA MSMEG_4727|M.smegmatis_MC2_155 LASGRIAYALGVHGPAITVDTACSSSLSAIHMACRSLHDGESDVALAGGV MMAR_2344|M.marinum_M MASGRVSYALGLRGPAMTVDTACSSSLLAVHMACRSLDGGESELALAGGC MAB_3148c|M.abscessus_ATCC_199 MASGRISYALGVHGPSLTVDAGCAAGLATVHMGCQSLAAGESDLVLAGGV MUL_2016|M.ulcerans_Agy99 AAVGRISYLLGLRGPAVAVDTACSSSLVALHLACQSLRLRESDVALAGGV Mflv_2690|M.gilvum_PYR-GCK GVANRVSHLLDLRGPSVALDAACAASLVAVHQACQLLRAGETSLALAGGV Mvan_3852|M.vanbaalenii_PYR-1 GVANRVSHLLDLRGPSVALDAACAASLVAVHQACQLLRAGETSLALAGGV TH_2454|M.thermoresistible__bu GIANRVSHLLDLRGPSVALDAACAASLVAVHNACQLLRAGETGLAIAGGV Mb2956|M.bovis_AF2122/97 IIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTQDCHLAIAAGV Rv2931|M.tuberculosis_H37Rv IIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTQDCHLAIAAGV MLBr_02357|M.leprae_Br4923 IIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTADANLAIAAGV .*::: *.::**::::*:.*::.* ::* .*: * : :.:*.* MAV_2370|M.avium_104 TLALDPRKFSAGSAEGMLSPTGRCHAFDVAADGFVGGEGSVMLLLKRLND MSMEG_4727|M.smegmatis_MC2_155 SVLLEPRKAAGGSAAGMLSPTGHCHAFDTAADGFVSAEGCVVLTLKRLDD MMAR_2344|M.marinum_M MLMLEPDVFSSASAQGMLSPTGRCRTFDASADGFVRSEGCAMLVLKRLPD MAB_3148c|M.abscessus_ATCC_199 NLVLEPRRYVGASQQRMLSPTGRCHTFTGEADGFVMSEGCVMVLLKRLDD MUL_2016|M.ulcerans_Agy99 QLMLSPFTSIALSKWSALSPTGRCKTFDALADGFVRSEGCGVVVLKRLVD Mflv_2690|M.gilvum_PYR-GCK SALIGPGLTRVLDVAGATAPDGRCKTFDDAADGYGRGEGAGVVVLKRLAD Mvan_3852|M.vanbaalenii_PYR-1 SALIGPGLTRVLDVAGATAPDGRCKTFDDDADGYGRGEGAAVVVLKLLDD TH_2454|M.thermoresistible__bu SALIGPGLTRVLDKAGATAPDGRCKSFDASADGYGRGEGAAVVILKRLPD Mb2956|M.bovis_AF2122/97 NLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGAGVVVLKRLTD Rv2931|M.tuberculosis_H37Rv NLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGAGVVVLKRLTD MLBr_02357|M.leprae_Br4923 NLLLSPAVFRGFDQVGALSPTGCCRAFDAAADGFVRGEGAGVVVLKRLTD : * . :* * *::* ***: .**. :: ** * * MAV_2370|M.avium_104 ALRDGDRILAVVRGTAANQDGHTVNIATPSKTAQTAVYRAALAAAGVDAG MSMEG_4727|M.smegmatis_MC2_155 AVADGDRILAVIRGTATNQDGRTVNIATPSADAQAKVYRMALKAAGVEPG MMAR_2344|M.marinum_M AVRDGDRVLAVLRGSATNQDGRTDNISTPSPDAQVAAYRAALAVAGVDAD MAB_3148c|M.abscessus_ATCC_199 AVRDGDRILAVVRGTASNQDGRTVNQSTPSSEAQAAACRTALAVAGVEAD MUL_2016|M.ulcerans_Agy99 AVRDGDRVLAVVRGSAINQDGRSNGMTAPNAAAQRDVIGTALKLADATAD Mflv_2690|M.gilvum_PYR-GCK ALRDGDRVLAVVRGGAVAQDGRTVGIMSPNGEAQADLFRLACRAAGVSPE Mvan_3852|M.vanbaalenii_PYR-1 AVRDGDRVLAVVRGGAVAQDGRTVGIMSPNGQAQEDLFRIACRAAGVTPA TH_2454|M.thermoresistible__bu ALRDGDRVIAVIRGGAVAQDGRTVGIMSPNGAAQRDLFRHTCEITGTSPA Mb2956|M.bovis_AF2122/97 AQRDGDRVLAVICGSAVTQDGRSNGLMAPNPAAQMAVLRAAYTNAGMQPS Rv2931|M.tuberculosis_H37Rv AQRDGDRVLAVICGSAVNQDGRSNGLMAPNPAAQMAVLRAAYTNAGMQPS MLBr_02357|M.leprae_Br4923 AQRDGDRVLAIIRGSAVNQDGRSNGLMAPNPAAQVAVLRTAYANAAMPPT * ****::*:: * * ***:: . :*. ** : : . MAV_2370|M.avium_104 TVGMVEAHGPGTPVGDPIEYASLAEVYGIDG-----PCALASVKTNFGHA MSMEG_4727|M.smegmatis_MC2_155 TVGLVEAHGTGTPVGDPLEFSSLAEVYGTDG-----PCALGSIKTNFGHT MMAR_2344|M.marinum_M TVGMIEAHGTGTPVGDPIEFSSLAQVYGSNGN----PCAVGSAKSSVGHT MAB_3148c|M.abscessus_ATCC_199 TVGLIEAHGTGTPVGDPIEYTGLAQVYGVDG-----PCAVGSVKTNFGHT MUL_2016|M.ulcerans_Agy99 SVNYVETHGTGTVLGDPIEFEALAATYGLGKDKGADSCALGSVKTNLGHL Mflv_2690|M.gilvum_PYR-GCK SVGYLEAHGTGTPTGDPVEVGALSEVYG----RADDPCALGSVKPNVGHL Mvan_3852|M.vanbaalenii_PYR-1 SVGYLEAHGTGTPTGDPVEIGALSAVYGRG--RADNPCAVGSVKPNTGHL TH_2454|M.thermoresistible__bu TVDFVEAHGTGTPTGDPVELDALAAVYGAAH-GPDDPCRVGSVKPNTGHL Mb2956|M.bovis_AF2122/97 EVDYVEAHGTGTLLGDPIEARALGTVLGRGR-PEDSPLLIGSVKTNLGHT Rv2931|M.tuberculosis_H37Rv EVDYVEAHGTGTLLGDPIEARALGTVLGRGR-PEDSPLLIGSVKTNLGHT MLBr_02357|M.leprae_Br4923 AIDYVETHGTGTLLGDPIEARALGAVLGRGR-AEDSPLLIGAVKTNLGHL :. :*:**.** ***:* .*. . * . :.: *.. ** MAV_2370|M.avium_104 QAASGALGMMKAILALQHGVVPRNLHFTQLPDDLARIDTKLFVPQQTTPW MSMEG_4727|M.smegmatis_MC2_155 QSAAGALGVMKAVLALQHNVIPQNLHFTRLPDQMAEIETGLFVPETITPW MMAR_2344|M.marinum_M EAAAGAVGIIKAVLSLQHGLVPPMVHHTRLPDELAEIDSALFVPQAITPW MAB_3148c|M.abscessus_ATCC_199 MSAAGALGLMKIVLAVEHGVVPPNLHFTGIPDKLAPVKTNLFVPQTVIPW MUL_2016|M.ulcerans_Agy99 EAAAGITSFIKATLAVAHGYIPPNLHFSRWNPAIDASSTRLFVPTQGAQW Mflv_2690|M.gilvum_PYR-GCK EGGAGVVGLIKTVLALHHEMLPPTAGVRTLTTAVDWAGSGLRVPTEAQPW Mvan_3852|M.vanbaalenii_PYR-1 EGGAGVVGLIKAALALHHEQLPPTAGVRTLTTAVDWAASGLRVPTEAEPW TH_2454|M.thermoresistible__bu EGGAGVVGLIKAALALQHGVIPPTAGIRELTPAVDWATNGLHVPTTVEPF Mb2956|M.bovis_AF2122/97 EAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDLRMKVVDTQTEW Rv2931|M.tuberculosis_H37Rv EAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDLRMKVVDTQTEW MLBr_02357|M.leprae_Br4923 EAAAGIAGFIKTVLAVQRGQIPPNQRFESPNLHIPFAELRMKVVDKHMEW ..:* ..:* *:: : :* : : * : MAV_2370|M.avium_104 VS-NGGHPRRAAVSSYGLSGTNVHAILEQAPEPAPETVAPEGIS------ MSMEG_4727|M.smegmatis_MC2_155 PV-REGQPRRAAVSAYGLSGTNVHAVLEQAPE-SPAETAAEAISP----- MMAR_2344|M.marinum_M PEGNDRTPRRAAVSSYGMSGSNVHVILEQAPEPAVCRNGAAGLG------ MAB_3148c|M.abscessus_ATCC_199 PG-KAQGPRRAGVSAYGMSGSNVHAVVEQAPPVESSTPPAVESP------ MUL_2016|M.ulcerans_Agy99 PA----GLRRAAVSSFGLSGTNAHVVLEQPPAPAPADQPRSGLS------ Mflv_2690|M.gilvum_PYR-GCK PR--GGAPRRAAVCSYGYGGTIAHVLLEEAPITADP------------DT Mvan_3852|M.vanbaalenii_PYR-1 PR--AAEPRRAAVCSYGYGGTIAHVLLEEAPPAPSR------------ET TH_2454|M.thermoresistible__bu PRR-ADSPRRAAVCSYGYGGTIAHLLLEEAPAVDETPAAAPAPAADAADA Mb2956|M.bovis_AF2122/97 PA--TGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPG----------QG Rv2931|M.tuberculosis_H37Rv PA--TGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPG----------QG MLBr_02357|M.leprae_Br4923 PD--TGHLRRAAVSSFGFGGTNAHVVIEQGPELTPVTE----------CS ***.*.::* .*: .* ::*: MAV_2370|M.avium_104 -AESPLLFPLSSTSADELRRTAGRLADWVHAHGD-------LALPDLAYT MSMEG_4727|M.smegmatis_MC2_155 KAGNALVFPVSASSADALRSTAQHLADWLLRSGDGNGRGPAIDLGDLAYT MMAR_2344|M.marinum_M ---DALLFTVSASSTEALRQTADRLADWVDNHEIS--------PSDLAYT MAB_3148c|M.abscessus_ATCC_199 -LGSQLIFPVSSTSAEELRRTAARLADWVAERPE-------VAPGDVGYT MUL_2016|M.ulcerans_Agy99 ------ALVVSGKTPQRVAAMASALADWVDGPGAQ------TPLADVAHT Mflv_2690|M.gilvum_PYR-GCK STAPTAFIPMSARSEARLAAAADALAGHLRE--AAFVV------DDVAAT Mvan_3852|M.vanbaalenii_PYR-1 VSAQMSFIPLSARSEARLAVQAGALAGHLRP--ADFSV------DELAAT TH_2454|M.thermoresistible__bu NSPRFHVIPVSARSGARLARHAAALRGHLS---AGADL------TAVAAT Mb2956|M.bovis_AF2122/97 LSPAVSTLVVAGKTMQRVSATAGMLADWMEGPGADVAL------ADVAHT Rv2931|M.tuberculosis_H37Rv LSPAVSTLVVAGKTMQRVSATAGMLADWMEGPGADVAL------ADVAHT MLBr_02357|M.leprae_Br4923 SNTAVSTLVVTGKTASRVAAMAGMLADWVEGPGAEVAL------ADVAHT : ::. : : * * . : :. * MAV_2370|M.avium_104 LARRRVHRPVRTAVLAG------DRAQLIEALREVADGDTPYPAAVGRGD MSMEG_4727|M.smegmatis_MC2_155 LARRRGFRAARSAVLAG------DRGTLVEGLRQIADGEAMPQQAVTNDD MMAR_2344|M.marinum_M LARRRSHQPVRAGLVAG------NRTELAHRLRETAAGDTPYPAAVGHDD MAB_3148c|M.abscessus_ATCC_199 LARRRAHRSVRTAVVAD------GADELIDALRGVAEGDAPYPAAVAQDD MUL_2016|M.ulcerans_Agy99 LNHHRARHGKFGAVVAR------DRAGAVEGLRALAAGQPGPGVLGCQDV Mflv_2690|M.gilvum_PYR-GCK MWTRRSHDPVRGAVVTDGLSGAQAAEAAVAALDVIAARGRDARVVTGHVV Mvan_3852|M.vanbaalenii_PYR-1 LWTRRGHEPVRAAVLVD-------DGGVADGLDALATQQRDPRVVTGSVV TH_2454|M.thermoresistible__bu MWQRRSHEPVRAAVIAR------HPGELVAGLDAIATDTRHPAVVAGSVL Mb2956|M.bovis_AF2122/97 LNHHRSRQPKFGTVVAR------DRTQAIAGLRALAAGQHAPGVVN-PAE Rv2931|M.tuberculosis_H37Rv LNHHRSRQPKFGTVVAR------DRTQAIAGLRALAAGQHAPGVVN-PAD MLBr_02357|M.leprae_Br4923 LNHHRSRHAKFGTVVAR------DRIQAVAGLRALAAGKQAPGVVG-QQD : :* ::. * * MAV_2370|M.avium_104 R----GPVWVFSGQGSQWAAMGADLLATEPVFAATVAQAEPLIARESGFS MSMEG_4727|M.smegmatis_MC2_155 R----GPVWVFSGQGSQWASMGAELLDREPAFAAAIAELEPLIAAESDFS MMAR_2344|M.marinum_M L----GPVWVFSGQGSQWATMGADLLANEPVFAATVAELEPLIAAESGFS MAB_3148c|M.abscessus_ATCC_199 R----GPVWLFSGQGSQWAGMGAELLGKEPVFAETIARLEPLIHAESGFS MUL_2016|M.ulcerans_Agy99 QN-QPGTVFVYSGQGSQWVGMGRQLLADEPSFAAAIAELEPDFVAQAGFS Mflv_2690|M.gilvum_PYR-GCK PGAETGAVWVFSGHGSHWAGMGRELLMTEPAFAATIDEVDIVFARELGFS Mvan_3852|M.vanbaalenii_PYR-1 PGAADGAVWVFSGHGSHWPGMGRELLAGEPTFGAVIDEVDQVFRRELGFS TH_2454|M.thermoresistible__bu PAAEAGAVWVFSGHGSHWPGMGRELLEHEPVFAAVIDEIEPVFRAELGFS Mb2956|M.bovis_AF2122/97 GSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFS Rv2931|M.tuberculosis_H37Rv GSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFS MLBr_02357|M.leprae_Br4923 GTPGSGTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFS *.*:::**:**:* ** :** ** * .: . : : . .** MAV_2370|M.avium_104 VAEAMSAPQTVTGQDRVQPTLFTMQVALAATMKAHGVRPGAVIGHSLGEA MSMEG_4727|M.smegmatis_MC2_155 VTEALTASETVTGIDRVQPTIFAVQVALAAAMRSHGVVPGAVIGHSMGEV MMAR_2344|M.marinum_M VTEAMTAMEPVTGIDRVQPTLFAIQVALAQTMRSYGVHPGAVIGHSLGEV MAB_3148c|M.abscessus_ATCC_199 VTDAISAPETVTGIDRVQPTLFAMQVSLAATLASYGVRPGAVIGHSMGEV MUL_2016|M.ulcerans_Agy99 LQQTLTEGREVVGIDRIQPVLVGIQLALTALWRSHGVTPDAVVGHSMGEV Mflv_2690|M.gilvum_PYR-GCK ARVALTAE-DLGGTDRVQALTFAMQVGLAAVLRSRGVTPAAVIGHSVGEV Mvan_3852|M.vanbaalenii_PYR-1 ARGALASG-ELGGTDRVQALTFATQVGLAAVLRERGVAPAAVIGHSVGEV TH_2454|M.thermoresistible__bu PRQALQSG-ELGGTDRVQALTFAVQAGLAAVLRDRGVKPAAVIGHSVGEV Mb2956|M.bovis_AF2122/97 LHDVLANGEELVGIEQIQLGLIGMQLALTELWCSYGVQPDLVIGHSMGEV Rv2931|M.tuberculosis_H37Rv LHDVLANGEELVGIEQIQLGLIGMQLALTELWCSYGVRPDLVIGHSMGEV MLBr_02357|M.leprae_Br4923 LHDVLANGKELVGIEQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEV .: : * :::* . * *: ** * *:***:**. MAV_2370|M.avium_104 AAAVVAGALSLEDGARVICRRSRLMSRVAGTGATASVELPAQQVLSELTA MSMEG_4727|M.smegmatis_MC2_155 AASVVSGALSLEDGVKVICRRTRLMTRIAGSGAMAMVELPAQQVLSELAS MMAR_2344|M.marinum_M AAAVVAGALLLADGVKVICRRSRLCTRLAGSGAMASVELPAARVREDLVR MAB_3148c|M.abscessus_ATCC_199 AAAVVSEALSLEDGVKVICRRSQLMLRISGAGAMASVDLPAQQVVSELAD MUL_2016|M.ulcerans_Agy99 SAAVVAGALTPADGFKVIATRSRLMARLAGQGAMALLELDSDAAEALIAD Mflv_2690|M.gilvum_PYR-GCK AACVVSGVFDLAHGAAVACHRARGFRSVMGKGAMALVRLPFDEAERRLAG Mvan_3852|M.vanbaalenii_PYR-1 AACVVAGVFDLAHGASIACYRARGFLSVAGDGAMALARLPFDEAERRLGG TH_2454|M.thermoresistible__bu AACVAAGVFDLARGAAVACYRARGFRSVAGKGAMALVGLPFEDARQRLGE Mb2956|M.bovis_AF2122/97 AAAVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIAD Rv2931|M.tuberculosis_H37Rv AAAVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIAD MLBr_02357|M.leprae_Br4923 AAAVVAGALTAAEGLRVTATRSRLMAPLSGQGGMALLELDAVETEALIVD :*.*.: .: * : . *:: : * *. * * . : MAV_2370|M.avium_104 RGISDVVVAVVASPQSTVIAGAAPTVRDLVTAWQERGVMAREVPTDVAFH MSMEG_4727|M.smegmatis_MC2_155 RGVDDVVLSVVASPQSTVVGGATASVRELIEMWESRGVMAREIAVDVASH MMAR_2344|M.marinum_M HRAKDVVVAVVASPQSTVIGGATDTVRELVAAWGEREVMAREVAVDVASH MAB_3148c|M.abscessus_ATCC_199 RDIHDVVLAVVASPQSTVVGGATETVRQLIAEWSDRGLMAREVAVDVASH MUL_2016|M.ulcerans_Agy99 Y--PQVTLAVHASPHQSVVAGPPESVDAVIAAVAGQNRLARRIEVDVASH Mflv_2690|M.gilvum_PYR-GCK RT--DVVAAISASTESTVVSGTVAAVDGIVDAWTADGMTVRRVNTDVAFH Mvan_3852|M.vanbaalenii_PYR-1 RT--DVVAAISASTESTVVSGTVAAVDEIVEAWTASGVMVRRVNTDVAFH TH_2454|M.thermoresistible__bu RT--DVVAAISASPLSTVISGTVDAVGEVSAAWAEQGVMVRKVNTDVAFH Mb2956|M.bovis_AF2122/97 FP--QVTLGIYNSPRQTVIAGPTEQIDELITRVRARDRFASRVNIEVAPH Rv2931|M.tuberculosis_H37Rv FP--QVTLGIYNSPRQTVIAGPTEQIDELIARVRAQNRFASRVNIEVAPH MLBr_02357|M.leprae_Br4923 YS--QVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQNRFASRVNIEVAPH :*. .: *. .:*:.*. : : . .: :** * MAV_2370|M.avium_104 SPQVDPIMDDLTDALAEIS-PRPPEVPYYSATLFDPREQPVCDARYWANN MSMEG_4727|M.smegmatis_MC2_155 SPQVDPILDDLIEALADLD-PAEPEIPYYSATLYDPRDYADYDAYYWADN MMAR_2344|M.marinum_M TPQVEPILGELSELLADVE-PLAPQLPYYSATSFDPRERPRCDARYWVDN MAB_3148c|M.abscessus_ATCC_199 SPQVDPILDDLADALEDLT-PRTPVVPLYSSVSFDPRERPIMDADYWVDN MUL_2016|M.ulcerans_Agy99 HPIIDPILPDLRSALADLT-PQPPAIPMITTTCEQP--QPVLDADYWAAN Mflv_2690|M.gilvum_PYR-GCK SPAMDALTADLAAMVAQLPQPDSAHIPLYTTALEDPRSTAPRGPDYWAVN Mvan_3852|M.vanbaalenii_PYR-1 SPAMDGLTGELGRLVAALPAPGRARVPLYTTALEDPRSEAARDEHYWVAN TH_2454|M.thermoresistible__bu SPAMDALTAELARLTSTLT-PKPAAVPLYSTALADPRSTAARDEHYWVAN Mb2956|M.bovis_AF2122/97 NPAMDALQPAMRSELADLT-PRTPTIGIISTTYADLHTQPVFDAEHWATN Rv2931|M.tuberculosis_H37Rv NPAMDALQPAMRSELADLT-PRTPTIGIISTTYADLHTQPVFDAEHWATN MLBr_02357|M.leprae_Br4923 NPAMDALQPQMRSELADVA-PRTPTIPILSTTYADLGSCPVFDAQHWATN * :: : : : * . : ::. : . . :*. * MAV_2370|M.avium_104 MRRMVRFATAVQAALEDG---YRVFAELAPHPLLVRALEQTARSREIPMA MSMEG_4727|M.smegmatis_MC2_155 LRHTVRFSAAVQAALEDG---HRVFAELSPHPLLTHPVEQTARSLDMPLA MMAR_2344|M.marinum_M LRHAVRFSAAVRAALDDG---YRVFGELSPHPLLTRAVEQTAASLDIPAA MAB_3148c|M.abscessus_ATCC_199 LRHTVRFAAAVQAALDDG---YRVFGELAPHPLLVYPAEQTARSLDIPMV MUL_2016|M.ulcerans_Agy99 LRNPVRFHQAITTAGAQ----HHTFVEISPHPLLTHAITDTLAAADSRTR Mflv_2690|M.gilvum_PYR-GCK LRGRVRFAEAVRAAAEDG---HRLFLEVSAHPVVSHSIAETLLGLGFGEH Mvan_3852|M.vanbaalenii_PYR-1 LRGRVRFAEAVEAAARDG---HRLFLEVSAHPVVSHSIVETLTSLGMDDH TH_2454|M.thermoresistible__bu LRGRVRFAEAVTAAAEDG---HRLFLEVSAHPVVCHSMAETLALAEVGEH Mb2956|M.bovis_AF2122/97 MRNPVHFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSAQPGAR Rv2931|M.tuberculosis_H37Rv MRNPVRFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSAQPGAR MLBr_02357|M.leprae_Br4923 MRNPVHFQQAIMTAGT----DHRTFIEISAHPLLTQAITDTLH----GTR :* *:* *: :* :: * *::.**:: . :* MAV_2370|M.avium_104 ALAG--MRRGQALPHGLRGFVADLHNAGAAVDFSVLYPTGRLVDAPLPTW MSMEG_4727|M.smegmatis_MC2_155 VFAA--MRRQQEMPHGLLGFVADLHSAGAAVDFSVLYPTGRLLDAPLPAW MMAR_2344|M.marinum_M ALPA--MRRNQPLPHGLRGLVADLHSAGAAVDFATLYPDGQLVDAPLPVW MAB_3148c|M.abscessus_ATCC_199 ALAG--MRREQELPHGLRDFVGDLYTAGGAVDFSVLYPTGQLVDVPLPSW MUL_2016|M.ulcerans_Agy99 LITA--TLQRD--GDDAITFHTNLAAVGKKPADAVT---GQLADIPVTPW Mflv_2690|M.gilvum_PYR-GCK AVLP-VLRRDQPERRAVGAAVAGLYCHGAPVAHGLTPTTRWAADLPGTQW Mvan_3852|M.vanbaalenii_PYR-1 AVLP-VLRRDQPQRRAVAAAVGALYCHGAPVAHGFTATMPWAADLPGTQW TH_2454|M.thermoresistible__bu AVLP-VLRREQPELPAVAAVVGALYCHGAPVRPAFPPGTRWATGLPGTQW Mb2956|M.bovis_AF2122/97 YTSLGTLQRDTDDVVTFRTNLNKAHTIHPPHTPHPPEPH---PPIPTTPW Rv2931|M.tuberculosis_H37Rv YTSLGTLQRDTDDVVTFRTNLNKAHTIHPPHTPHPPEPH---PPIPTTPW MLBr_02357|M.leprae_Br4923 CISIGTLQRDADDTVTFHTNLNNVHTVHPPHTPHPAEPH---VTIPSTPW : * . * MAV_2370|M.avium_104 THRRLWLTDGGLESPTHGGCTVAVHPLLGPHVH---LQEEPERHLWQADV MSMEG_4727|M.smegmatis_MC2_155 THSTLLLDR-ELESSAPGVPSVSVHPLLGSHVV---LPQEPEEHLWQGDV MMAR_2344|M.marinum_M ANRRLLLATADARRHG-CANSVAAHPLLGAHVD---LLEEPERHAWQSEI MAB_3148c|M.abscessus_ATCC_199 TRRSYLLDLSAQAQQGHGTHTVAVHPLLGAHVR---LAEEPERHIWQADV MUL_2016|M.ulcerans_Agy99 QHTQFWVED-----RSGISELVAAHPLLGVHIE---VPSG-HDHVWQADV Mflv_2690|M.gilvum_PYR-GCK QHRRFWRTP-TPPPGTAALHDPASHTLLGGVAD---VTGEVPARVWQTRL Mvan_3852|M.vanbaalenii_PYR-1 QHRRFWRTP-TPPPNTRALHDPSSHTLLGGVVD---VTGEVPARVWQTRL TH_2454|M.thermoresistible__bu QHRRFWRTP-GTPPGGVGVHDVDSHTLLGGRID---VAGAVPARVWQTRL Mb2956|M.bovis_AF2122/97 QHTRHWITT-KYPAGSVGSA-PRAGTLLGQHTTVATVSASPPSHLWQARL Rv2931|M.tuberculosis_H37Rv QHTRHWITT-KYPAGSVGSA-PRAGTLLGQHTTVATVSASPPSHLWQARL MLBr_02357|M.leprae_Br4923 QHTRHWIPR-KRSVNSIGLA-PQVGTLLGQHT---AVSGILPIHLWQARL . .*** : : ** : MAV_2370|M.avium_104 GTAAQPWLADHQIRNVVVLPGAAYCEMALAAARSVLG---ATAEVRDIRF MSMEG_4727|M.smegmatis_MC2_155 GTEAHPWLSDHRVHQVAVLPGAAYCEMALAAVTPVLG---DTGEVHDLKF MMAR_2344|M.marinum_M GTATLPWLGDHQVNSVAALPGAAYCEMALAAANTVFG---NPSEVGDIGF MAB_3148c|M.abscessus_ATCC_199 GTVGQPWIADHQVRHVAVYPGAAYCEMALSAAAAVFG---EGSAVQSISF MUL_2016|M.ulcerans_Agy99 GTKACPWLGDHKVFGQAIMPAAGFAEIALAAASEAFDLPVDALSINQLEI Mflv_2690|M.gilvum_PYR-GCK DMGNRPYPGDHPVQQTEIVPAAVLLNTFLNAAG---------AGLADVRL Mvan_3852|M.vanbaalenii_PYR-1 DMGSRPYPGDHPVRETEIVPAAVLLNTFLTAAG---------SGLTDVRL TH_2454|M.thermoresistible__bu DLSTRPYPGDHPVQGTEIVPAAVLLNTFLTAAG---------SDIADVRL Mb2956|M.bovis_AF2122/97 APDAKPYQGGHRFHQVEVVPASVVLHTILSAATELGY-----SALSEVRF Rv2931|M.tuberculosis_H37Rv APDAKPYQGGHRFHQVEVVPASVVLHTILSAATELGY-----SALSEVRF MLBr_02357|M.leprae_Br4923 APQAKPYRGWHRVHGVEVVPASIVLRTILCAAAELGY-----STLFEIRF *: . * . *.: . * *. : .: : MAV_2370|M.avium_104 EQALLLDEQTTVDASASVSSPGVLHFTVQSHQGGEQ-------------- MSMEG_4727|M.smegmatis_MC2_155 HDMLLLDDATPVWVSAAVTAPGTAEFGVETHQSGDR-------------- MMAR_2344|M.marinum_M HEMLLLDDQTAAGAVALVEAPGIASFAVDTVRGGEK-------------- MAB_3148c|M.abscessus_ATCC_199 EQLLTLGESTPISATATAKSADILEFVVETHDEGDV-------------- MUL_2016|M.ulcerans_Agy99 EQMLDLDEHTQVTTQLTRRADDKTRIEIYSRSASGW-------------- Mflv_2690|M.gilvum_PYR-GCK RTPVPPGRTRDIQVVLQGRSLRLSSRLTGTEAVENG-------------- Mvan_3852|M.vanbaalenii_PYR-1 RTPVPPGRVRDIQVVLQDGSLRISSRLAD-GGDGNG-------------- TH_2454|M.thermoresistible__bu RTPVAPARTRDVQVVLQDRALALASRIVGEDTTARATAGRDTTDRDTTAC Mb2956|M.bovis_AF2122/97 EQPIFADRPRLIQVVADNRAISLASSPAAGTPSDR--------------- Rv2931|M.tuberculosis_H37Rv EQPIFADRPRLIQVVADNRAISLASSPAAGTPSDR--------------- MLBr_02357|M.leprae_Br4923 EQPIFANLPRLIQVVVDNQLISLASSPATETPQHR--------------- . : . MAV_2370|M.avium_104 ----------------ARHASAVLGAATD-EQPAAHDLSALLTAHPHDDD MSMEG_4727|M.smegmatis_MC2_155 ----------------TQRATAVLRGDVDAERPAAHSIDALLAAHPNRVD MMAR_2344|M.marinum_M ----------------VRRSTALLRAVERDSQPAGYDIEALLAAHACRLD MAB_3148c|M.abscessus_ATCC_199 ----------------VKRATAVLGNGGDVDMPIAYDLSALRAEHPHRES MUL_2016|M.ulcerans_Agy99 ----------------RRHAVAKAETSTPSAAPVLEERTSRQDETDIKP- Mflv_2690|M.gilvum_PYR-GCK ---------------WLTHSSAVVATDEE-FGEPIDERVWT--------R Mvan_3852|M.vanbaalenii_PYR-1 ---------------WLTHSSAVVATDED-FEGELNELMGGGVGADTQAR TH_2454|M.thermoresistible__bu DTTDRDTTACDDPGVWLTHCTARVADDHVGAEGVLDEEAIR-------AR Mb2956|M.bovis_AF2122/97 ---------------WTRHVTAQLSSSPSDSASSLNEHHRANGQP---PE Rv2931|M.tuberculosis_H37Rv ---------------WTRHVTAQLSSSPSDSASSLNEHHRANGQP---PE MLBr_02357|M.leprae_Br4923 ---------------WTRHVTAQLSSASARSAVPSDHPDQING-----HL : * MAV_2370|M.avium_104 GDEVRRRMDRRGVQYGPAFAGLGAVHSGDETG-TVLAEVALPRQIRSQQA MSMEG_4727|M.smegmatis_MC2_155 GDELRAGFGTVGIGHGAAFAGLSEAYVATAAEPTVVAAVALPGPLRSGQR MMAR_2344|M.marinum_M GDELREWFAKTGIHYGPAFTGLAAAHVCERGSDAVLAEISLPGSMRTQQA MAB_3148c|M.abscessus_ATCC_199 GDDLRASFDERGVQYGPAFQGLAAAYRGDETVRSVLAEVTLPRDVRAQQG MUL_2016|M.ulcerans_Agy99 -ADLYALLRQAGQNHGPAFAALTRILR--RPDGSVETEITLSDEAPRHQG Mflv_2690|M.gilvum_PYR-GCK CAESLPAGHVVDTLAGVGVAAMGFDWQVRDMRRG-SGELVLRVSAQEDGS Mvan_3852|M.vanbaalenii_PYR-1 CAEQLPPGHVIDTLAGVGVAAMGFGWQVLDIGRG-AGELLLRVRAEADGS TH_2454|M.thermoresistible__bu CPQPLPAGHVVDTLAGLGVAAMGFGWEVLELHRG-EGELFARVAAEPDKS Mb2956|M.bovis_AF2122/97 RAHRDLIPDLAELLAMRGIDGLPFSWTVASWT---QHSSNLTVAIDLPEA Rv2931|M.tuberculosis_H37Rv RAHRDLIPDLAELLAMRGIDGLPFSWTVASWT---QHSSNLTVAIDLPEA MLBr_02357|M.leprae_Br4923 EVISDPIPDVASLLALCGVDGLPFEWSVKSWAKKTQQSTSRTVEIEFPDT .. .: MAV_2370|M.avium_104 AYGAHPALLDACFQSVEAHPAVRALG--DGALGLVLGIRRLRAYGAARNA MSMEG_4727|M.smegmatis_MC2_155 GYTVHPALLDACFQSVIAHPEVQNIA--SGML-LPLGVRRLRAYGSTRNV MMAR_2344|M.marinum_M GYLVHPALLDACFQSVLAHPVVREMG--NGGLLLPLGVRRLRSHASTRNA MAB_3148c|M.abscessus_ATCC_199 SYIVHPALLDACFQSVIALPDVQEAS--KDALPLPKGVRSLHAYESARAT MUL_2016|M.ulcerans_Agy99 -YRIHPAMLDAALQSLAAAVPNDEFAGSAEASYLPVSFETLRVYSNPGRH Mflv_2690|M.gilvum_PYR-GCK APANWAG-LLDAATSAASTVFDGPPR-----LRMPAHIERVHVRADPP-- Mvan_3852|M.vanbaalenii_PYR-1 TPRSWAG-LLDAATSAASTVFDGPPR-----LRMPARIERVHVCGDPP-- TH_2454|M.thermoresistible__bu APATWAG-LIDAATSTASTIFDGPPR-----LRMPARIERVHVRDKPP-- Mb2956|M.bovis_AF2122/97 LPEGSTGPLLDAAVHLAALSDVADSR-----LYVPASIEQISLGDVVTGP Rv2931|M.tuberculosis_H37Rv LPEGSTGPLLDAAVHLAALSDVADSR-----LYVPASIEQISLGDVVTGP MLBr_02357|M.leprae_Br4923 LPDGAIAPLLDAAILIPALADVTETQ-----FYVPASIKQVWLGDTATGP . * . : : .. : MAV_2370|M.avium_104 HYCYTRVTKADTSGVEAD--IDVLDEHGAVLLAVQGLRVGTSASESGT-- MSMEG_4727|M.smegmatis_MC2_155 RYCLSRIVKADSFGVEAD--LELLDADGTVLLSAMGLQLGTGNSDKAE-- MMAR_2344|M.marinum_M RFCYTRVTACG-HDAEAD--IDVLDEHGTVLLAVRGLLMGTGLSELAD-- MAB_3148c|M.abscessus_ATCC_199 QYCYTRVTKVVGNEVEAD--IDLLDETGSVLIAVRGFRFGTGSSDDEQ-- MUL_2016|M.ulcerans_Agy99 ARCRAQLTNLNDGGAGKLGRITLTDDAGNVTVEITDIYLRR--VERRS-- Mflv_2690|M.gilvum_PYR-GCK --AVALLHVRHR-GGTATD-VTIADESGAVRAFIAGMTFDELES------ Mvan_3852|M.vanbaalenii_PYR-1 --AVALLHVRRR-QGTATD-VAIADESGAVRASITAMTFEELES------ TH_2454|M.thermoresistible__bu --AIALLHVRRRPEGTVTD-VTIAEESGAVSVTLTGMGFEELEN------ Mb2956|M.bovis_AF2122/97 RSSVTLNRTAHDDDGITVD-VTVAAHGEVPSLSMRSLRYRALDFGLDVGR Rv2931|M.tuberculosis_H37Rv RSSVTLNRTAHDDDGITVD-VTVAAHGEVPSLSMRSLRYRALDFGLDVGR MLBr_02357|M.leprae_Br4923 CGAVTLNRTACDDDGITVD-VTVADGSGVPLALMRSLRYRALDLDNAQQD . : : : : MAV_2370|M.avium_104 -----------RDRVLTERLLNIEWRQRELPEPE---HADAASWLLIGT- MSMEG_4727|M.smegmatis_MC2_155 -----------EERLLDERLLTIEWQQRELPRPEGSETVDAGSWLVILAG MMAR_2344|M.marinum_M -----------QDRLMSRHLLGTEWQQRELPQPQ---APNPESWLLVGI- MAB_3148c|M.abscessus_ATCC_199 -----------RDQLLNNRLLAIEWQQQRLPESV---SGAPRRWLLVST- MUL_2016|M.ulcerans_Agy99 -----------VPLPLAQKIFDTEWVEKSIAGAD--QPDAPGSWLVLTDA Mflv_2690|M.gilvum_PYR-GCK ------PAG----VDLSRMMHHVAWHDTCYDVEARPVEVALVACG--DSA Mvan_3852|M.vanbaalenii_PYR-1 ------ATG----ADPSRMLHHVAWHVTPFCADDRPTEVAVIGGGV-DID TH_2454|M.thermoresistible__bu ------PGGGGSSGDLTGMLHHLRWHPVDWPDTDPPAAVVLVGGDARTRA Mb2956|M.bovis_AF2122/97 AQPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAII Rv2931|M.tuberculosis_H37Rv AQPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAII MLBr_02357|M.leprae_Br4923 YSTVFVESHVDALTDARNFVHAIDWQPRTDLDCSN---TPVASSGSVAVI : * MAV_2370|M.avium_104 TATADVLASTLADTLKNHGAQCTTMAWPQQADHTAHAEQLRNQWRGDGFT MSMEG_4727|M.smegmatis_MC2_155 DDDENPRAAGVVSALIGAGMPTTTMAWSHDADHDAQAAALTARLDEQPLA MMAR_2344|M.marinum_M SETADRLTTRLAEALKSLGTDCITTSWHLQADHITDAERFRDQLRDHRFA MAB_3148c|M.abscessus_ATCC_199 GESVDPWAAELIDSLKVRESEVSLIQWRPNTDRVAALKLLYDQLESGTFD MUL_2016|M.ulcerans_Agy99 KSNADEFVARWSSPQRR----VITADLGDEAAMLAAFAETAGDPE-RLPV Mflv_2690|M.gilvum_PYR-GCK EMQRDLLAAGVPVDDHSTVDEVSDTLEPGAVVLLVPPVDAPPEAS----- Mvan_3852|M.vanbaalenii_PYR-1 PVVRDLSDAGVPHRVYGSPGQVPGDTGERSVVLLLP-RDDSPEAA----- TH_2454|M.thermoresistible__bu FVTRDLDEARVAHRSYADPAALPPDLTAGTVVLVLPRTAARPAAS----- Mb2956|M.bovis_AF2122/97 GDDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFA Rv2931|M.tuberculosis_H37Rv GDDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFA MLBr_02357|M.leprae_Br4923 GDARAGFGLLLKEAGYTLAAPADGVSEVRYVVYVADPHPATTAETDVDFA . MAV_2370|M.avium_104 GVVVLTG-PKNGDNDQESALLSR-------DHVQHLVRIARELT-DLPGE MSMEG_4727|M.smegmatis_MC2_155 GVAVIVGDSETGTDAHDVGADARR----GADHVRHLVRIARTLA-DAVGE MMAR_2344|M.marinum_M GVVVMTG----------TGCSSPV----TSDYVRHVVRVVRELP-EIMGE MAB_3148c|M.abscessus_ATCC_199 GVLVVTAPGSEG----GADRVVLQ----GADQVRHLVRITRELV-DLPGE MUL_2016|M.ulcerans_Agy99 GVVVFVGGAGNNSGTADDGRISYDGLIQSRDTVWQISTVVRAIVGTWHGR Mflv_2690|M.gilvum_PYR-GCK --------------------------------AELVLNSLKVLHAKGSE- Mvan_3852|M.vanbaalenii_PYR-1 --------------------------------AEQVLDTLKHLCDNNSQ- TH_2454|M.thermoresistible__bu --------------------------------AQLVLHTLQRLSATNSG- Mb2956|M.bovis_AF2122/97 -----------------------------VRICTEITGLVRTLAERDADK Rv2931|M.tuberculosis_H37Rv -----------------------------VRICTEITGLVRTLAERDADK MLBr_02357|M.leprae_Br4923 -----------------------------VRITAEISDLVRALAKREPGK : : : MAV_2370|M.avium_104 PPRLYVVTRNAQTVLPNDVPNLGQAGLRGLVRVIGMEHPQLGAGQIDVDE MSMEG_4727|M.smegmatis_MC2_155 PPRLYVVTHRSQHVLDTDEPYLEHSGLRGLIRVVGMEHPRLRATQIDVDD MMAR_2344|M.marinum_M APRLFVVTRGAQTVLGGESANLEQAGLRGLLRVIGAEYPHLHTTHVDVDE MAB_3148c|M.abscessus_ATCC_199 PPRLFVVTRNAQTVVDGDITNLEQAGLRGLVRVIGAEYPHLRVTHIDVDR MUL_2016|M.ulcerans_Agy99 APRLWLVTEGGLVVHD-KPGRPAIGALQGLVRVLAYEHPELRATLVDLDT Mflv_2690|M.gilvum_PYR-GCK -ARLWVLTR--RVHE---GANLVHAPLWGLARVAAAEHPHLWGGVLDVAD Mvan_3852|M.vanbaalenii_PYR-1 -ARLWVLTN--RVHE---GGNLVHAPLWGMSRIAAAEHPQLWGGVLDVAC TH_2454|M.thermoresistible__bu -ARLWVLTR--GVHE---GTDPGHGPLWGLARVAAAEHPQLWGGLLDIGE Mb2956|M.bovis_AF2122/97 PAALWILTR--GVHESVAPSALRQSFLWGLAGVIAAEHPELWGGLVDLAI Rv2931|M.tuberculosis_H37Rv PAALWILTR--GVHESVAPSALRQSFLWGLAGVIAAEHPELWGGLVDLAI MLBr_02357|M.leprae_Br4923 PVALWIVTR--GVYESVASSALRQSFLWGFGGVIAAEHPEMWGGLVDLAA *:::*. . * *: : . *:*.: :*: MAV_2370|M.avium_104 STDAQ----------ALARQLLAGSEE----DETAWRDGAWYTARLCPAP MSMEG_4727|M.smegmatis_MC2_155 STAHE----------ALVRQLLSGSPE----DETAWRDGQWYAARLCPSP MMAR_2344|M.marinum_M HSGSE----------VVARQLLSGSEE----DETAWRCGQWYTARLSPMP MAB_3148c|M.abscessus_ATCC_199 HTAAQ----------NVAGELVSGSEE----DETAWREDHWYRARLNLGP MUL_2016|M.ulcerans_Agy99 GADAVT---------RLAGELSSPRDDPNYDDVVAWRDGHRYVTQLCRAI Mflv_2690|M.gilvum_PYR-GCK G-------------PLPVGVLASMAGH----GVVVFRDGRARTARLTPAR Mvan_3852|M.vanbaalenii_PYR-1 G-------------GVPLGVLASLHGH----GVVVARDGVAMTARLSHAQ TH_2454|M.thermoresistible__bu D-------------RLPVRALTALTGH----GVVVVRDGVAHTARLAPAG Mb2956|M.bovis_AF2122/97 N-------DDLGEFGPALAELLAKPSK----SILVRRDGVVLAPALAPVR Rv2931|M.tuberculosis_H37Rv N-------DDLGEFGPALAELLAKPSK----SILVRRDGVVLAPALAPVR MLBr_02357|M.leprae_Br4923 SALGADRDDILDQFGPTLASLLQTPTR----SIVVLRDGVVLAPTLVPIR * . . * . . * MAV_2370|M.avium_104 LLPEERHTAVANHECDGMRLQIRTPGDLESLELVACDRIPPGPGQIEVAV MSMEG_4727|M.smegmatis_MC2_155 LRAAERRTAVADNASEGMRLVVRNPGDLESMELVTFERGTPGPGQIEVAV MMAR_2344|M.marinum_M LRPEERKTTVVEHDTEGMRLQIRTPGDLQTMEFVAFDRVAPGPGQIEVAV MAB_3148c|M.abscessus_ATCC_199 LGPDDWRSTVATPNNEGVRFEVRTPGDLQSLGFVAFDRVAPGPGQIEVSV MUL_2016|M.ulcerans_Agy99 LDPE---------------------------------------------- Mflv_2690|M.gilvum_PYR-GCK PAG----------------------------------------------- Mvan_3852|M.vanbaalenii_PYR-1 SGG----------------------------------------------- TH_2454|M.thermoresistible__bu PGARD--------------------------------------------- Mb2956|M.bovis_AF2122/97 GEP----------------------------------------------- Rv2931|M.tuberculosis_H37Rv GEP----------------------------------------------- MLBr_02357|M.leprae_Br4923 SEP----------------------------------------------- MAV_2370|M.avium_104 SASSINFADVLVAFGRYPAFEGRLPELGTDFAGVVTAVGPDVTDHKVGDH MSMEG_4727|M.smegmatis_MC2_155 KASSINFADVLVAFGRCPSFDGRLPELGSEFGGVVTAVGPGVTTHRVGDR MMAR_2344|M.marinum_M STSSINFADVLVSFGRYNSPDGQMPQLGTDFAGVVTAVGPDVTDHQVGDR MAB_3148c|M.abscessus_ATCC_199 TATSINFADVLNVYGRYSSFEGRQ-ELGVDFAGVVTAVGEGVTQHQVGDR MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2690|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3852|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MAV_2370|M.avium_104 VGGLSANGCWGTFLTCDARLAVTLPPGLADDQAAAVTTAHATAYYGLHEL MSMEG_4727|M.smegmatis_MC2_155 VGGVSANGCWSNFVTCEADLATKLPEGISEHEAAAVGLAYGTVWLGLTEL MMAR_2344|M.marinum_M VGGMSPHGCWATFVTCDGALATPIPAGLTDAQAAAVTTAHATAWYGLHDL MAB_3148c|M.abscessus_ATCC_199 VGGMTPTGAWRSFVVVDANLAATLPAEVPDREAAAVPGAHVTAWYGLHEL MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2690|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3852|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MAV_2370|M.avium_104 ARIGAGDRVLIHSATGGVGQAAIAIARAAGAEIFATAGSEQRRQLLRDMG MSMEG_4727|M.smegmatis_MC2_155 ARMSAGDKILIHSATGGVGQAAIAVARAAGAEIYATAGSEKRRQLLRDWG MMAR_2344|M.marinum_M GRIRAGDKVLIHSGTGGVGQAAIAIARAAGAEIYATAGSPKRRQVLRDMG MAB_3148c|M.abscessus_ATCC_199 ARISAGDKVLIHSGTGGVGQAAIAIARAAGAEIYATAGSPERRDLLRSWG MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2690|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3852|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MAV_2370|M.avium_104 IEHVYDSRTVEFADLIRHDTDGYGVDIVLNSVTGAAQRAGIELLAFGGRF MSMEG_4727|M.smegmatis_MC2_155 IEHVYDSRTTAFADQIRTDTDGYGVDIVLNSVTGPAQRAGLELLAFGGRF MMAR_2344|M.marinum_M IEHVYDSRSIEFAEAIRADTDGYGVDIVLNSLTGAAQRAGLELLAWGGRF MAB_3148c|M.abscessus_ATCC_199 IKHVYDSRSTDFAELIRRDTDGYGVDIVLNSLTGAAQRAGVELLTFGGRF MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2690|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3852|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MAV_2370|M.avium_104 VEIGKRDIYGDTRLGLLPFRRNLTFYALDLALMSFSHPDRLRGLLRTVYR MSMEG_4727|M.smegmatis_MC2_155 VEIGKRDIYADTRLGLFPFRRNLSFYAVDLALMTVTHPQKIRDLLATVYR MMAR_2344|M.marinum_M VEIGKRDIYGDTKMGLFPFRRNLSFYGVDLGMLSITHPRLIRELLTTVYQ MAB_3148c|M.abscessus_ATCC_199 IEIGKRDIYGDTRLGLFPFRRNLSFHAVDLVLVAKTRPEAIYRTLTALYG MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2690|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3852|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MAV_2370|M.avium_104 LTADGALPMPESTHYPLADAASAIRVMSAAQHTGKLVLDVPHAGRSRVVV MSMEG_4727|M.smegmatis_MC2_155 LIADGTLPLPEITHYPLEEAATAIRIMGGAQHTGKLVIDIPDTGQSQVVV MMAR_2344|M.marinum_M HTAEGVLPMPQDTHYPLAEAATAIRVMGAADHTGKLLLDIPRSGRSAVVL MAB_3148c|M.abscessus_ATCC_199 QMAEGVLPLPEISPSPLQEAAESIRVMGAAGHTGKLVLDLPKAGEVSAVI MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2690|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3852|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MAV_2370|M.avium_104 PPAQVRAFRSDGAYIVTGGLGGLGLFLAEKMASPGSRAGCGRIVLCSRAL MSMEG_4727|M.smegmatis_MC2_155 PPEQVPVFRGDGAYVITGGLGGLGLFLAERMAAAG----CGRIVVNSRSA MMAR_2344|M.marinum_M PPEQVPVLRADGSYIITGGLGGLGLFLAEKMATAG----AGRIVLSSRSA MAB_3148c|M.abscessus_ATCC_199 PPSHAPAFRRDGAYVVTGGLGGLGLFLARKLAAAG----VGRIILNGRSA MUL_2016|M.ulcerans_Agy99 -PQRDPVIRPGASYIVTGGLGGLGLVVARWLVDSG----AGRVVLNGRSE Mflv_2690|M.gilvum_PYR-GCK --GDAMTCTPGGTYLITGGTGALGLRIAQRLADLG----ARRLVLLSRSG Mvan_3852|M.vanbaalenii_PYR-1 --GAPMTCTPGGTYLVTGGTGALGLRIAQRLADLG----ARRLVLLSRSG TH_2454|M.thermoresistible__bu SAGEGLRCSPGGTYLITGGTGALGLRLAHRLADLG----ARRLVLVSRSG Mb2956|M.bovis_AF2122/97 -ARKSLQCRPDAAYLITGGLGALGLLMADWLADRG----AHRLVLTGRTP Rv2931|M.tuberculosis_H37Rv -ARKSLQCRPDAAYLITGGLGALGLLMADWLADRG----AHRLVLTGRTP MLBr_02357|M.leprae_Br4923 -VRKSLQCKSDGAYLITGGMGALGLLMADWLADRG----ARRLVLMGRTP ..:*::*** *.*** :* :. * *::: .*: MAV_2370|M.avium_104 PNPKA--------------LATLERIRQMGADIVVERGDIAEAGTAQRLL MSMEG_4727|M.smegmatis_MC2_155 PSTRS--------------SEIIELIRATGADIVVECGDIAEPDTALRLV MMAR_2344|M.marinum_M PSQKA--------------LETIELIRSIGSDVVVECGDIAQPATAARLV MAB_3148c|M.abscessus_ATCC_199 PKPEA--------------LAAIEQIRQGGTEIDVALGDIAEPDTAQRLV MUL_2016|M.ulcerans_Agy99 PSDEQ--------------RKVLAELESR-AEVVVVCGDSATEGVAESLV Mflv_2690|M.gilvum_PYR-GCK VPHRSRWADSGDNDAVR----AVTALEERGVTVHIAAVDIGAPGADDQLR Mvan_3852|M.vanbaalenii_PYR-1 LPHRDQWTDN-QSEAVR----AVAALEERGVSVHVAAIDIGAAGAGDQLR TH_2454|M.thermoresistible__bu MPARDSWGRAGDSDTVA----AITALEERGVSVRVAALDIGAPGAAARLR Mb2956|M.bovis_AF2122/97 LPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEAVAADVGCREDVQALL Rv2931|M.tuberculosis_H37Rv LPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEAVAADVGCREDVQALL MLBr_02357|M.leprae_Br4923 LPPRRDWELDTLDAGLRQKIDAICALEMRGVTVEAVAVDVGHHDDVQALL . : :. : * . * MAV_2370|M.avium_104 DVAT-ATGLPVRGVLHLAAVIEDATLANITDELIER-DWAAKVYGAWNLH MSMEG_4727|M.smegmatis_MC2_155 AAAT-QTGLPLRGVLHAAAVVEDATLANITDELVEH-DWAPKVYGAWNLH MMAR_2344|M.marinum_M ANAT-ATNLPLRGVLHAAAVVEDATLANITDELLDR-DWAPKVYGAWHLH MAB_3148c|M.abscessus_ATCC_199 AAAT-ETGKPVRGVLHAAALVHDATLANITDELIDRGDWRPKVHGAWNLH MUL_2016|M.ulcerans_Agy99 AAAE-DQQRQLRGIVHGAAVIDDSLLFSMTKDSLER-VWAPKAAGALRLH Mflv_2690|M.gilvum_PYR-GCK TILR--ELPAVRGVVHAAGVEAGALLLTTSAADLHA-AMRPKVAGTLTLH Mvan_3852|M.vanbaalenii_PYR-1 AMLR--ELPPVRGVVHAAGVEAGALLLDTSADDIRA-AMRPKVAGTLILH TH_2454|M.thermoresistible__bu EVLA--DLPDVRGVIHAAGVEAGALLTNTTAEDIEA-TMRPKVDGVLALH Mb2956|M.bovis_AF2122/97 AARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVRQ-VMWPKIGGSQVLH Rv2931|M.tuberculosis_H37Rv AARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVRQ-VMWPKIGGSQVLH MLBr_02357|M.leprae_Br4923 AKRDRDGAAPIRGIIHAAGVTNDQLVTNMTDDPVRQ-VMWPKIAGCQVLH :**::* *.: . : : : .* * ** MAV_2370|M.avium_104 CALQESG-AEQSLDWFCSFSSAAALVGSPGQGAYAAANSWLDAFTRWRRA MSMEG_4727|M.smegmatis_MC2_155 QAVQSGGPATSELDWFCAFSSAAALVGSPGQGAYAAANSWLDAFMQWRRA MMAR_2344|M.marinum_M QAT-----TDQPLDWFCSFSSAAAMLGSPGQGAYAAANSWLDAFTHWRHN MAB_3148c|M.abscessus_ATCC_199 EAT-----ADQPLDWFCSFSSIAALVGSPGQGAYAAANSWLDGFTHWRRA MUL_2016|M.ulcerans_Agy99 DAT-----ATRELDWWLGFSSTASLLGSPGQTAYACASAWLDGLVAWRRA Mflv_2690|M.gilvum_PYR-GCK ELFP-----PGQLDWMVLFSSCGYLAGFPGQGAYACANAFLDAAARHRRS Mvan_3852|M.vanbaalenii_PYR-1 ELFP-----PEQLDWMVLFSSCGYLAGFPGQGAYACANAFLDATARHRCA TH_2454|M.thermoresistible__bu EVFP-----PGRLDWLVLFSSCGYLGGFPGQGAYACGNAYLDAFARYRRA Mb2956|M.bovis_AF2122/97 DAFP-----PGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALARARRQ Rv2931|M.tuberculosis_H37Rv DAFP-----PGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALARARRQ MLBr_02357|M.leprae_Br4923 EAFP-----PGSVDFFYLTSSAAGIFGIPGQGSYAAANSYLDALARTRRQ :*: :* . : * *** :**...::**. * MAV_2370|M.avium_104 RGLKATAIAWGAWAQIGRGAALADSADVAITPDEGAYAFEALLRHDRACT MSMEG_4727|M.smegmatis_MC2_155 QGLPATSIAWGAWGEIGRGTAMAE-GDNAIAPDEGAYAFEAILRHDRVYN MMAR_2344|M.marinum_M QNQPATAIAWGPWAEIGRAIALAESSDAAIAPDEGAYAFQTLLRHNRTYT MAB_3148c|M.abscessus_ATCC_199 QGLPATVIAWGAWSEIGQGTHLAQNAEAAILPDEGAYAFDTVLRHNRAYT MUL_2016|M.ulcerans_Agy99 AGLPAATINWGPWSEVGVAQALVGTPLDPITPAEGLVALDALLAADRGRT Mflv_2690|M.gilvum_PYR-GCK LGDRTVSIAWTAWRGLGMGSTSGFVAAQLEALGMGTVGADDAFRALDSAM Mvan_3852|M.vanbaalenii_PYR-1 LGDRTVSVAWTAWRGLGMGSTSGFVAAQLEALGMGTVGADDAMRALDTAM TH_2454|M.thermoresistible__bu SGDATTSVAWTAWRGLGMGSASDFVAAQLDALGMGTVDVDDAMRALDAAI Mb2956|M.bovis_AF2122/97 QGCHTMSLDWVAWRGLGLAADAQLVSEELARMGSRDITPSEAFTAWEFVD Rv2931|M.tuberculosis_H37Rv QGCHTMSLDWVAWRGLGLAADAQLVSEELARMGSRDITPSEAFTAWEFVD MLBr_02357|M.leprae_Br4923 QGCHTMSIDWVAWRGLGFAANAQIVSDELQRMGSRDITPSEAFTAWEYVD . : : * .* :* . . : MAV_2370|M.avium_104 GYAPITGTPWLTAFAQR------SPFAEAFRANGQSA-----------TG MSMEG_4727|M.smegmatis_MC2_155 GYAPVLGASWLTAFAQR------SPFAELFLADTQGA-----------SE MMAR_2344|M.marinum_M GYTPILGTPWIANLARR------SRFAEAFRYDGVQR-----------SE MAB_3148c|M.abscessus_ATCC_199 AYAPMAGISWLADFVER------SPFAQAFRDAGQNQ-----------TE MUL_2016|M.ulcerans_Agy99 GVARLRSDRALIAFPEIRNLGYFTLVVQELDAAGDGGDW---------AG Mflv_2690|M.gilvum_PYR-GCK RGQDPNVVVLPVLPEASAV----PMLAEVAPTDQSDGG---DVAAG---- Mvan_3852|M.vanbaalenii_PYR-1 RGEEPNVVVLPVLPGAAAV----PMLSDVAPTGRDDDD---VAPVG---- TH_2454|M.thermoresistible__bu RDGDPNVVVLPLSPAAAAV----PMFADVAPADPDADAPGGEVPDGLSDG Mb2956|M.bovis_AF2122/97 GYDVAQAVVVPMPAPAGAD----GSGA-NAYLLPARNWS----------- Rv2931|M.tuberculosis_H37Rv GYDVAQAVVVPMPAPAGAD----GSGA-NAYLLPARNWS----------- MLBr_02357|M.leprae_Br4923 AYDVAQAVVLPVPRSYGSA----GSTAGDSYLVPARNWS----------- MAV_2370|M.avium_104 TSKLRAELEELPPEEWSTRLRRLISDQVSLILRRNVDPDRPLPEYGLDSL MSMEG_4727|M.smegmatis_MC2_155 TRKLRSELAALPREEWPTHLRRLIAEQVGLLLRRTVDPDRPLSEYGLDSL MMAR_2344|M.marinum_M RSQLRAELAELPLDEWPTRLRRLISEQVSLILRRTIDPDRPLTDYGLDSL MAB_3148c|M.abscessus_ATCC_199 TNKFLDELRALPREEWPTRLRKLVAEQVGLVLRRSIDPDRSLPDYGLDSL MUL_2016|M.ulcerans_Agy99 PEALKEMDPAEARQVVTERLHTRIAAVMGYADRSAVDASMPLTELGLDSL Mflv_2690|M.gilvum_PYR-GCK ------PGDADLGEWVAQQVIEAVAAELGLSET-DVDPRVPLVETGVDSI Mvan_3852|M.vanbaalenii_PYR-1 ------PGDADLDEWVAREVAAAVAAELGLPES-EVDPRVPLVEAGVDSI TH_2454|M.thermoresistible__bu FPADGFPDDGDLAEWVHRRVIAAVAGELGLAET-DVDPRLPLVEIGVDSI Mb2956|M.bovis_AF2122/97 -----VMAATEVRSELEQGLRRIIAAELRVPEK-ELDTDRPFAELGLNSL Rv2931|M.tuberculosis_H37Rv -----VMAATEVRSELEQGLRRIIAAELRVPEK-ELDTDRPFAELGLNSL MLBr_02357|M.leprae_Br4923 -----QMEAAEVRKELESGLRTIIAAELRVAEA-ELDTDRPFAELGLNSL . : :: : :*. .: : *::*: MAV_2370|M.avium_104 GGLELLTRIQTETGIRVSPADIAAIGTIRGLADLLRDKLTPAGAAQAERV MSMEG_4727|M.smegmatis_MC2_155 GHLELRTRIETETGVRVSAMDMT---TIRGLAQRLCEMLDTDDAVSAPS- MMAR_2344|M.marinum_M GNLELRTRIETETGIRISSTDIT---TVRGLADHLCKKLTPAEDAPATM- MAB_3148c|M.abscessus_ATCC_199 GNLEIRTRIQADTGVRIGPADVS---TVRSLAAHIYDRLAEQESEVASS- MUL_2016|M.ulcerans_Agy99 MAVRIRNTARADFGVEPPVTLILQGASLHDLTVDVIRQLDLAGDEQTHEH Mflv_2690|M.gilvum_PYR-GCK MTVALRRTLEKRTGLALPPTLLWEHPTAAAVSDRIVELLAPQSEKTGVT- Mvan_3852|M.vanbaalenii_PYR-1 MTVALRRALEKRTGLALPPTLLWEHPTAAAVTDRIVELLTPHPEKADIS- TH_2454|M.thermoresistible__bu MTVALRRQLERQTGLTLPPTLLWEHPTAGAVSDRIVEMLRARG------- Mb2956|M.bovis_AF2122/97 MAMAIRREAEQFVGIELSATMLFNHPTVKSLASYLAKRVAPHDVSQDNQI Rv2931|M.tuberculosis_H37Rv MAMAIRREAEQFVGIELSATMLFNHPTVKSLASYLAKRVAPHDVSQDNQI MLBr_02357|M.leprae_Br4923 MAMAIRREAEQFIGIELSAIMLFNHPTVALLAAYLTKVVAPQHDSQGDEM : : . *: : : :: : : MAV_2370|M.avium_104 ----------------------------- MSMEG_4727|M.smegmatis_MC2_155 ----------------------------- MMAR_2344|M.marinum_M ----------------------------- MAB_3148c|M.abscessus_ATCC_199 ----------------------------- MUL_2016|M.ulcerans_Agy99 VDVVRDRAQQRAAARHGAAMRRKRG---- Mflv_2690|M.gilvum_PYR-GCK ----------------------------- Mvan_3852|M.vanbaalenii_PYR-1 ----------------------------- TH_2454|M.thermoresistible__bu ----------------------------- Mb2956|M.bovis_AF2122/97 SALSSSAGSVLDSLFDRIESAPPEAERSV Rv2931|M.tuberculosis_H37Rv SALSSSAGSVLDSLFDRIESAPPEAERSV MLBr_02357|M.leprae_Br4923 AALSASAGGVLDSLFDRIESTSTEAEGLV