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TSLGLIGLGRIGAFHTETLINLPEVSRLVITDERPGVVGEVAAKYGATPVESVEKLLSSGIDGVVVAAAT PAHAELTLAAVERGLPTFCEKPIASTAAESARVAEIIARSGVPVQVGYQRRFDTAFAAVKQAADSGSLGA LHTVRSTTMDPAPPPMDYIRGSGGIFRDCAVHDFDVIRWVTGQNVVEVYATGSVQGDPLFTEYGDVDTAA IVVRFDGGALGVVSAARYNGRGYDCRLEVHGFDDTVVAGWDQGAPVRNADPANDFPTGQPHHFFMDRFTE AFRTELSSFVDVVEGGPNLGATVADAVEVAWIAEAATESLRRGVPVTIDSVRKEAQQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2613 | - | - | 100% (338) | inositol 2-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2598 | - | 5e-28 | 29.13% (333) | inositol 2-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0624 | - | 3e-10 | 24.34% (189) | oxidoreductase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2612 | - | 2e-13 | 22.41% (348) | putative oxidoreductase |
| M. marinum M | MMAR_2628 | - | 6e-09 | 25.77% (194) | hypothetical protein MMAR_2628 |
| M. avium 104 | MAV_2643 | - | 3e-15 | 23.01% (352) | oxidoreductase family protein, NAD-binding Rossmann fold |
| M. smegmatis MC2 155 | MSMEG_4650 | - | 1e-158 | 80.48% (333) | oxidoreductase YisS |
| M. thermoresistible (build 8) | TH_3104 | - | 1e-09 | 34.09% (88) | PUTATIVE oxidoreductase domain protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3968 | - | 1e-172 | 86.55% (342) | inositol 2-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2613|M.gilvum_PYR-GCK ------MTSLGLIGLGRIG-AFHTETLINLPEVSRLVITDERPGVVGEVA
Mvan_3968|M.vanbaalenii_PYR-1 ------MTTLGLIGLGRIG-AFHAETLTNLPEVSGLVVTDERPEVVSQLA
MSMEG_4650|M.smegmatis_MC2_155 ------MTTLGVIGLGRIG-AFHVDTLSSLDGVDGLVVADERPDAVAAVA
MAV_2643|M.avium_104 -----MTLRVGIIGVGWGA-RVQVPGFRAAKGFEPVALCARTPDRLERAA
TH_3104|M.thermoresistible__bu -------MRVLVIGTGFGR-QAMAPVYRGLG-FDVEVVSPRDESALHRAL
MAB_2612|M.abscessus_ATCC_1997 ------MLKVGIIGAGGVA-RAHARALNTLKSAELVGVLDIDARAAESFT
MMAR_2628|M.marinum_M MTGHGSPLRIGILGAARIAPQALVKPAQGNVEAVVAAVAARDGARAQAFA
: ::* . . :
Mflv_2613|M.gilvum_PYR-GCK AKYGATPVESVEKLLSS--GIDGVVVAAATPAHAELTLAAVERGLPTFCE
Mvan_3968|M.vanbaalenii_PYR-1 TKYGATPANSVQELLAS--GVDGVIVAAATPAHAELTLAAVERGLPTFCE
MSMEG_4650|M.smegmatis_MC2_155 AKHGAKPADSVEELLDS--GVDGVVVAAATPAHAELTLAAVHRGLPTFCE
MAV_2643|M.avium_104 AKLGIEQTSTDWQSFVTRDDLDVISVATPTVLHHEMTIAALAAGKPVLCE
TH_3104|M.thermoresistible__bu NAG-----------------VDLVSVHSPPFLHRQHVTAAVDRGYPVLCD
MAB_2612|M.abscessus_ATCC_1997 DAYGGTPVTDVDALLEL---ADAVVVASPNFTHRDHSLSALRAGRSVLCE
MMAR_2628|M.marinum_M AKHGISRVHSSYEALIADPTLDAVYIPLPNGLHGRWTQAALTAGKHVLCE
* : : . * :*: * .:*:
Mflv_2613|M.gilvum_PYR-GCK KPIASTAAESARVAEIIARSGVPVQVGYQRRFDTAFAAVKQAADSGSLGA
Mvan_3968|M.vanbaalenii_PYR-1 KPIAATAAESARVGEVITRSGVPVQVGYQRRFDAAFAAVKHAVDDGSLGA
MSMEG_4650|M.smegmatis_MC2_155 KPIAATAAESARVAEAIARSGVPVQVGYQRRFDAAFAAAKREVDSGSLGA
MAV_2643|M.avium_104 KPLAGDLEAARHMVRAATDSKLPTACCFENRWNPDWLAVADKVRSGFLGS
TH_3104|M.thermoresistible__bu KPFGRNADEARAMRDHAARRAVPTFLNFELRHQPARAEFKKLADSGVIGT
MAB_2612|M.abscessus_ATCC_1997 KPLALSRVEAKEMVAAAGEIASPALVGFNYRHLPVVTELRRRLQHGDFGT
MMAR_2628|M.marinum_M KPFTANAAEADEIAQLAATTDRVVMEAFHYRYHPLTLRIEQILASGELGT
**: : : . :. * . * :*:
Mflv_2613|M.gilvum_PYR-GCK LHTVRST-------TMDPAPPPMDYIRG-SGGIFRDCAVHDFDVIRWVTG
Mvan_3968|M.vanbaalenii_PYR-1 LHTVRST-------TMDPAPPPMDYIKG-SGGIFRDCAVHDFDVIRWVTG
MSMEG_4650|M.smegmatis_MC2_155 LHTVRST-------TMDPAPPSMDYIKG-SGGIFRDCAVHDFDALRWITG
MAV_2643|M.avium_104 QYLARVSRSASYWHPSHPLQAHWMYDREQGGGYLAGMLVHDLDFLTSLLG
TH_3104|M.thermoresistible__bu PRHLSWTFFG---AGLRGRPHGWINERDTGGGWIGANGAHLIDYTRYLFG
MAB_2612|M.abscessus_ATCC_1997 ICAVELGFRKDSAYRRKNHTWRDSGRSNGTSGALGDLGVHLLDLLTYISG
MMAR_2628|M.marinum_M LQRVETS-----MCFPLPKFSDIRYNYALAGGATMDAGCYAVHMARTFGG
.* : .. . *
Mflv_2613|M.gilvum_PYR-GCK QNVVEVYATGSVQGDPLFTEYG------DVDTAAIVVRFDGGALGVVSAA
Mvan_3968|M.vanbaalenii_PYR-1 QNVVDVYATGSVQGDPRFAEYG------DVDTAAVVVRFDGGALGVVSAA
MSMEG_4650|M.smegmatis_MC2_155 QNAVEVYATGTVQGDPRFTEYG------DVDTAAVVVRFDGGALGIVSAA
MAV_2643|M.avium_104 RPVSVCAEVRTSDPVRELPDGGTLP-VTADDTAALLMRMESGVTVILSLS
TH_3104|M.thermoresistible__bu SEITGCGGVARIEDPHRPDPQGRPRRATAEDAYSAWFVTENGCTATHDTA
MAB_2612|M.abscessus_ATCC_1997 GRILVDECQARITTHVTNKSDE---AVEVDDHAEIYGRLSTGSIFTLVAS
MMAR_2628|M.marinum_M GTPEVVSAQAKRRDSE------------VDRAMTAELRFPAGHSGRIQCS
* :
Mflv_2613|M.gilvum_PYR-GCK RYN-GRGYDCRLEVHGFDDTVVAGWDQG---APVRNADP-----ANDFPT
Mvan_3968|M.vanbaalenii_PYR-1 RYN-GRGYDCRLEVHGFDDTVVAGWDQG---APVRNADPDFSS-PGAFPA
MSMEG_4650|M.smegmatis_MC2_155 RYN-ARGYDCRLEVHGFDNSIVAGWDQG---TPLQNMDP-----RNDFPT
MAV_2643|M.avium_104 VMG-AHADHYRLELFGSDGTIIGDGDLR---SAAYSLGAATDAGLSPLTV
TH_3104|M.thermoresistible__bu FAA-AVALPPRMVLTGSAGALELIGDSR---LIVHRADADP--MTHEFPP
MAB_2612|M.abscessus_ATCC_1997 KAAPAADCGFSIRIVGTNAVFRYHTADPGRYLVSRGADTETVDLARTLLS
MMAR_2628|M.marinum_M MWS-SHLLNMSARVVGDRGELRVLNPVVP--QLFHRLTVQS-------AI
. : * .
Mflv_2613|M.gilvum_PYR-GCK GQPHHFFMDRFT--------EAFRTELSSFVDVVEGG----PNLGATVAD
Mvan_3968|M.vanbaalenii_PYR-1 GPPHHFFMDRFT--------EAFRAELRAFVDVVEGG----PIRGATVAD
MSMEG_4650|M.smegmatis_MC2_155 GPYHHFFMDRFT--------EAFRSELAGFVEVVKGN----PIPGATVAD
MAV_2643|M.avium_104 DEREPAHPERLPGGLAGHASRAMALMLQDWLPAFDGG----PSGAATFED
TH_3104|M.thermoresistible__bu APPRSFYEPALT------------PWLEQVADALRTG----RPATPSFDD
MAB_2612|M.abscessus_ATCC_1997 DPDNEVHGWSDS----------FRSEIDHWSRLVAVGGGANRQALATFDD
MMAR_2628|M.marinum_M GRRVERFPRRAS----------YAYQLDAFTGAILRG----EAVKTTPQD
. . : . . .: *
Mflv_2613|M.gilvum_PYR-GCK AVEVAWIAEAATESLRRGVPVTIDSVRKEAQQ--
Mvan_3968|M.vanbaalenii_PYR-1 AVEVAWIAEAATESLRRGVPVTIESVRKETQQ--
MSMEG_4650|M.smegmatis_MC2_155 AVEVAWMAEAATESLRRGAPVRIEEVRNR-----
MAV_2643|M.avium_104 GLLSLAVIDAAHRSAEGGGWEQVQV---------
TH_3104|M.thermoresistible__bu GVAVAEVMDRLRANVIEQVMQ-------------
MAB_2612|M.abscessus_ATCC_1997 GLAAQEVLESLLRGSKPQPERLPVEHTLPTPAEL
MMAR_2628|M.marinum_M AVQNMTVIDAIYRAAGLPLRNPS-----------
.: : :