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TLRIGVLGASRIAEAAIVEPARELGFRLVAVAARDPQRANIFADTYGVERVVPTYQDVVTDPEVDVVYNP LANSLHAPWNLAAVAAGKPVLSEKPFARNRAEAARVASAADAAGVTVMEGFHYLFHPVTQRALALAGDGT LGELRRVEVRMGMPEPKPDDPRWSLELAGGALMDLGCYGVHVLRRFGVPSILSATAVQRSAGVDATLDAE VVFPSGLTGLTANSMVQDDFSFTLRLIGSRGEAFVHNFIKPRDDDRLTVQTDDGTRVERFGTRASYTYQL EFFARHVLHGAPLPLDTTDAVENMAVIDEIYRAAGLPVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2611 | - | - | 100% (320) | oxidoreductase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0624 | - | 2e-10 | 28.41% (176) | oxidoreductase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0542 | - | 2e-10 | 28.41% (176) | oxidoreductase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1781 | - | 6e-10 | 40.91% (88) | hypothetical protein Mb1781 |
| M. tuberculosis H37Rv | Rv1752 | - | 6e-10 | 40.91% (88) | hypothetical protein Rv1752 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2306c | - | 5e-25 | 32.46% (228) | putative oxidoreductase |
| M. marinum M | MMAR_2628 | - | 2e-74 | 48.14% (322) | hypothetical protein MMAR_2628 |
| M. avium 104 | MAV_2987 | - | 2e-76 | 48.14% (322) | NAD binding oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4652 | - | 1e-121 | 66.06% (327) | D-oliose 4-ketoreductase |
| M. thermoresistible (build 8) | TH_3104 | - | 7e-05 | 28.08% (146) | PUTATIVE oxidoreductase domain protein |
| M. ulcerans Agy99 | MUL_3103 | - | 7e-35 | 47.67% (172) | hypothetical protein MUL_3103 |
| M. vanbaalenii PYR-1 | Mvan_3970 | - | 1e-148 | 79.38% (320) | oxidoreductase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2611|M.gilvum_PYR-GCK --------MT-LRIGVLGASRIAEAAIVEP-ARELGFRLVAVAARDPQRA
Mvan_3970|M.vanbaalenii_PYR-1 --------MS-LRIGILGASRIAASAIVEP-ARELGHRLIAVAARDPLRT
MSMEG_4652|M.smegmatis_MC2_155 --------MTGLRIGILGASRIAEKAIVGP-AEDLGHRLVAVAARDRRRA
Mb1781|M.bovis_AF2122/97 --------------------------------------------------
Rv1752|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2628|M.marinum_M ----MTGHGSPLRIGILGAARIAPQALVKPAQGNVEAVVAAVAARDGARA
MUL_3103|M.ulcerans_Agy99 --------------------------------------------------
MAV_2987|M.avium_104 MSAMAEVHAPKLRIGILGAARIAPLALIKPSAENPDVVVAAVAARDASRA
MAB_2306c|M.abscessus_ATCC_199 -------MPESIRWGIVGPGRIAG-NVARDFPLTPRAELAAVASRSLPRA
TH_3104|M.thermoresistible__bu -----------MRVLVIGTG--FGRQAMAPVYRGLGFDVEVVSPRD----
Mflv_2611|M.gilvum_PYR-GCK NIFADTYGVERVVPTYQDVVTDPEVDVVYNPLANSLHAPWNLAAVAAGKP
Mvan_3970|M.vanbaalenii_PYR-1 QAFADKYGVERVLASYQDVVTDPQVDIVYNPLANALHAPWNLAAVAAGKP
MSMEG_4652|M.smegmatis_MC2_155 EAFAEKYGVQRVLDSYRDVVEDPDVDMVYNPLANGLHAPWNLAAIAAGKP
Mb1781|M.bovis_AF2122/97 --------------------------------------------------
Rv1752|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2628|M.marinum_M QAFAAKHGISRVHSSYEALIADPTLDAVYIPLPNGLHGRWTQAALTAGKH
MUL_3103|M.ulcerans_Agy99 --------------------------------------------------
MAV_2987|M.avium_104 RAFATRHGIATVHDHYEALIADPDIDAIYNPLPNGLHGRWTRAALAAGKH
MAB_2306c|M.abscessus_ATCC_199 QDFAGAHQIPRAYGSYRELLADPDIDAVYIATPHPQHRQTAIAALTAGKA
TH_3104|M.thermoresistible__bu -----ESALHRALN--------AGVDLVSVHSPPFLHRQHVTAAVDRGYP
Mflv_2611|M.gilvum_PYR-GCK VLSEKPFARNRAEAARVASAADAAGVTVMEGFHYLFHPVTQRALALAGDG
Mvan_3970|M.vanbaalenii_PYR-1 VLTEKPYARDRGEAARVAAAADAAGVTVMEGFHYLFHPVTQRALSLAGDG
MSMEG_4652|M.smegmatis_MC2_155 VLSEKPFARNESEAATVAQAARDAGVPVLEGFHYHFHPVTQRAFAVAAGG
Mb1781|M.bovis_AF2122/97 --------------------------------------------------
Rv1752|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2628|M.marinum_M VLCEKPFTANAAEADEIAQLAATTDRVVMEAFHYRYHPLTLRIEQILASG
MUL_3103|M.ulcerans_Agy99 --------------------------------------------------
MAV_2987|M.avium_104 VLCEKPFTANAAEAREIADLAEHSDRVVMEAFHYRYHPLTLRAEEIIASG
MAB_2306c|M.abscessus_ATCC_199 ILVEKTFTATVSGAQEVIDIARARGVFAMEAMWTRFQPAIVAAKDLVDDG
TH_3104|M.thermoresistible__bu VLCDKPFGRNADEARAMRDHAARRAVPTFLNFELRHQPARAEFKKLADSG
Mflv_2611|M.gilvum_PYR-GCK TLGELRRVEVRMGMPEPKP-DDPRWS-LELAGGALMDLGCYGVHVLRRFG
Mvan_3970|M.vanbaalenii_PYR-1 TLGELTRIEVRMGMPAPQS-DDPRWS-LELAGGALMDLGCYGLHVMRRFG
MSMEG_4652|M.smegmatis_MC2_155 ELGEITRVEVRMAMPSPAD-DDPRWS-LDLAGGAVMDLGCYGIHVMRALG
Mb1781|M.bovis_AF2122/97 -----------------------------------MDAGCYAVHMAHTFG
Rv1752|M.tuberculosis_H37Rv -----------------------------------MDAGCYAVHMAHTFG
MMAR_2628|M.marinum_M ELGTLQRVETSMCFPLPKF-SDIRYN-YALAGGATMDAGCYAVHMARTFG
MUL_3103|M.ulcerans_Agy99 -----------MRFPLPKF-SDIRYN-YALAGGATMDAGCYAVHMARTFG
MAV_2987|M.avium_104 ELGTLQHVEAALCFPLPKF-SDIRYD-YALAGGATMDAGCYAVHMARTFG
MAB_2306c|M.abscessus_ATCC_199 AIGEVRQVQADLGVDRPFDREDRLFN-PALGGGALLDLGVYVVSLAQYFL
TH_3104|M.thermoresistible__bu VIGTPRHLSWTFFGAGLRGRPHGWINERDTGGGWIGANGAHLIDYTRYLF
* : : : :
Mflv_2611|M.gilvum_PYR-GCK --------------VPSILSATAVQRSAGVDATLDAEVVFPSGLTGLTAN
Mvan_3970|M.vanbaalenii_PYR-1 --------------TPSVLAATAVQRTPGVDERFDAELVFPSGLTGLTTN
MSMEG_4652|M.smegmatis_MC2_155 AMRVDGL-----GGEPKVLGARAEERTPGVDAWCEVDFVFPEGGTGVSTN
Mb1781|M.bovis_AF2122/97 ------------GATPEVVSAQAKLRDPAVDRAMTAELKFPGGHTGGIRC
Rv1752|M.tuberculosis_H37Rv ------------GATPEVVSAQAKLRDPAVDRAMTAELKFPGGHTGGIRC
MMAR_2628|M.marinum_M ------------GGTPEVVSAQAKRRDSEVDRAMTAELRFPAGHSGRIQC
MUL_3103|M.ulcerans_Agy99 ------------GGTPEVVSAQAKRRDSEVDRAMTAELRFPAGHSGRIEF
MAV_2987|M.avium_104 ------------GRSPEVVSAQAKLRGPKVDRAMTAELRFPAGHTGRVRC
MAB_2306c|M.abscessus_ATCC_199 G-------------DPAAVVAHGSLFPTGVDAEAGLLLRYDDGRTATLLC
TH_3104|M.thermoresistible__bu GSEITGCGGVARIEDPHRPDPQGRPRRATAEDAYSAWFVTENGCTATHDT
* . . . .: . * :.
Mflv_2611|M.gilvum_PYR-GCK SMVQDDFS-FTLRLIGSRGEAFVHN--FIKPRDDDRLTVQTDDGTRVERF
Mvan_3970|M.vanbaalenii_PYR-1 SMVDDEYS-FTLRLIGTRGEAFVHD--FIKPHDDDRLTLHTEDGTTVERH
MSMEG_4652|M.smegmatis_MC2_155 SMVADDYS-FTITITGSDGEAVVHD--FIRPNLDDRLTVMTGSGVRVEHL
Mb1781|M.bovis_AF2122/97 SMRSSDLLNVSARVVGDRGELRVLN--PVVPQLFHRLPPLACVSARRFRC
Rv1752|M.tuberculosis_H37Rv SMRSSDLLNVSARVVGDRGELRVLN--PVVPQLFHRLPPLACVSARRFRC
MMAR_2628|M.marinum_M SMWSSHLLNMSARVVGDRGELRVLN--PVVPQLFHRLTVQSAIGRRVERF
MUL_3103|M.ulcerans_Agy99 SMWSSHLLNMSARVVGDRGELRVLN--PVVPHLFHRLTVQSAIGRRVERF
MAV_2987|M.avium_104 SMWSTRLLQISARVVGEHGELRIVN--PVLPQAFHRLTVRSRDGRRTERF
MAB_2306c|M.abscessus_ATCC_199 SLLHHTPG--QARIFGTEGWIDILP--RFHHPREIVLHRKGAAPEPMVRP
TH_3104|M.thermoresistible__bu AFAAAVALPPRMVLTGSAGALELIGDSRLIVHRADADPMTHEFPPAPPRS
:: : * * : . :
Mflv_2611|M.gilvum_PYR-GCK GTRASYTYQLEFFARHVLHGAPLP--LDTTDAVENMAVIDEIYRAAGLPV
Mvan_3970|M.vanbaalenii_PYR-1 GTRTSYTYQLEAFTDHVERGTPIP--LDTADAVANMALIDEAYRAAGMSP
MSMEG_4652|M.smegmatis_MC2_155 GTRPSYTYQLEAFAAHVRDGAPLP--FGVDDAVTNMAFVDKAYRAAGLAP
Mb1781|M.bovis_AF2122/97 RSAARASGQDDAQG----RGREHE--RDPRDLSGRRAPIAQPELNMVAAS
Rv1752|M.tuberculosis_H37Rv RSAARASGQDDAQG----RGREHE--RDPRDLSGRRAPIAQPELNMVAAS
MMAR_2628|M.marinum_M PRRASYAYQLDAFTGAILRGEAVK--TTPQDAVQNMTVIDAIYRAAGLPL
MUL_3103|M.ulcerans_Agy99 PRRASYVYQLDAFTGAILRGEAVK--TTPQDAVQNMTVIDAIYRAAGLPL
MAV_2987|M.avium_104 ERRASYAYQLDAFAAGVLRGEPVK--TSARDAVDNMTVIDAIYRAAGLPL
MAB_2306c|M.abscessus_ATCC_199 PVGGGYSHELAEVTECLLNGRAQSSVMPLADTLAVQRVLNTACEQLGVDH
TH_3104|M.thermoresistible__bu FYEPALTPWLEQVADALRTGRPAT--PSFDDGVAVAEVMDRLRANVIEQV
* * :
Mflv_2611|M.gilvum_PYR-GCK R-------
Mvan_3970|M.vanbaalenii_PYR-1 R-------
MSMEG_4652|M.smegmatis_MC2_155 R-------
Mb1781|M.bovis_AF2122/97 GSAA----
Rv1752|M.tuberculosis_H37Rv GSAA----
MMAR_2628|M.marinum_M RNPS----
MUL_3103|M.ulcerans_Agy99 RNPS----
MAV_2987|M.avium_104 RYPT----
MAB_2306c|M.abscessus_ATCC_199 TEDPADLD
TH_3104|M.thermoresistible__bu MQ------