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VTRPTLIRLTAVALGTLLVASAGVIAAARLFPPTTLTAIFANANAIYPGDDVRIAGVRVGTITAIEADGT QTVFTLQVDHGVRIAADVKAVVVAQNLVSARFVALTPRGGSGPVAESGAVIPRERTAVPVEWDEVKERID RLAADLGPTAELTTGSVGRFVDSAADAMAGNGQKLRTAITQLAGISRVIAEGSGDITEMLSHLQTFVAVL RDSNEQIVRFEERLATLSSVLDGSRGDLDAALIHLAEAVGEVQRFVAGTRDRTGEQVARLAGVTQNLVDH RADLEQVLHVAPSAMANAYNMMDPRTGGASGVFVLNNMADPTAFFCGMLGALANVTAPESSKLCAQYLGP GLDTVNFNYLPFPVNPLLTPIPSDSKLIYSEPDLRPGGPGTRSGPTAIAPGDSAYQAQQPTVPQMLLPAE RPTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4163 | - | - | 100% (424) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2511 | - | e-121 | 55.17% (406) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4535 | - | e-120 | 53.07% (407) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 1e-64 | 35.71% (420) | MCE-family protein MCE4D |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 1e-64 | 35.71% (420) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 5e-59 | 34.94% (395) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 7e-61 | 35.16% (364) | MCE-family protein |
| M. marinum M | MMAR_4707 | - | 1e-117 | 51.90% (420) | MCE-family protein |
| M. avium 104 | MAV_0951 | - | 1e-119 | 54.46% (415) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_4787 | - | 1e-126 | 55.07% (414) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4516 | - | 1e-126 | 53.30% (439) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_3921 | mce3D_1 | 2e-70 | 36.88% (423) | MCE-family protein Mce3D_1 |
| M. vanbaalenii PYR-1 | Mvan_2854 | - | 1e-122 | 54.16% (421) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3526c|M.bovis_AF2122/97 ------MMGRVAMLTGSRGLRYATVIALVAALVGG-VYVLSSTGNKRTIV
Rv3496c|M.tuberculosis_H37Rv ------MMGRVAMLTGSRGLRYATVIALVAALVGG-VYVLSSTGNKRTIV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
MSMEG_4787|M.smegmatis_MC2_155 -------------MNRKRIAKGLAVGLVVLLVAGAAVLVRQVFLAPRTFQ
TH_4516|M.thermoresistible__bu -------------MTRRRLTTWLAVGFVVLLVAGGGLLLRQVVYAPRTFE
MMAR_4707|M.marinum_M -------MMRLEGAARSKVKAVLAVALVGLVVVGTGVALRNTFFRPTTIT
MAV_0951|M.avium_104 --------MSPR-VPRNRLAALAAVVLVGLILAGTAVLVRNTFFGQKTIT
Mvan_2854|M.vanbaalenii_PYR-1 --------MTVRGGSLRPARALLVVALTVLAVAGSGVLVYQHFFSPKTIV
Mflv_4163|M.gilvum_PYR-GCK -------------MTRPTLIRLTAVALGTLLVASAGVIAAARLFPPTTLT
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MUL_3921|M.ulcerans_Agy99 -------------MIRRTKTWLAVLLVGLLAAGVVVLLRTTEVVNRTNVV
. ..
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
Rv3496c|M.tuberculosis_H37Rv GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
MSMEG_4787|M.smegmatis_MC2_155 ALFTSATGIYPGDDVRVSGVKVGTIEAITPEGTQTRLTLKVDRGVPIPAD
TH_4516|M.thermoresistible__bu AIFTSATGIYPGDEVRVSGVAVGSIDSITPEGTHTRMVLKVDRDVPIPAD
MMAR_4707|M.marinum_M AYFPTATAIYPGDDVRVSGMKVGTIAAIRPDGTKAKMILHVDHNVPIPAD
MAV_0951|M.avium_104 AYFTTATAIYPNDEVRVSGVKVGNIKSIEPQGTQAKMTLKVDHDVPIPAD
Mvan_2854|M.vanbaalenii_PYR-1 AYFRSATAIYAGDEVRVAGVRVGTIEAIEPQGTRAKMTLAVDRGVPIPAD
Mflv_4163|M.gilvum_PYR-GCK AIFANANAIYPGDDVRIAGVRVGTITAIEADGTQTVFTLQVDHGVRIAAD
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MUL_3921|M.ulcerans_Agy99 AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVRVSFWYDSKYIVPAD
* : .::..*.*:: *: .* * : . . : :. .
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYTGG-----AVLPDNGRIDLDRTAVPVEW
Rv3496c|M.tuberculosis_H37Rv VQAVIMSPNLVAARFIQLTPVYTGG-----AVLPDNGRIDLDRTAVPVEW
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDG-----KALQDGASLGLDKTAVPIEW
MSMEG_4787|M.smegmatis_MC2_155 AKAVIVAQNLVAARYVQLAPAYRSE----GPTLPDDAVIGLDRTAVPVEW
TH_4516|M.thermoresistible__bu VKAVIVAPNLVAARYVQLTPAYRSSE--GGPTLPDNAVIDLDRTAVPVEW
MMAR_4707|M.marinum_M AKAVIVAQNLVAARYVQLTPAYRSS----GPVMADGAVIPIERTAVPVEW
MAV_0951|M.avium_104 AKAVIVASNLVSARYVQLSPAYRDS----GPVMPDGAVIPVERTAVPVEW
Mvan_2854|M.vanbaalenii_PYR-1 AEAIIVAPNLVSARYVQLTPAWGASPETSGPTMADGGEIGQDRTAVPVEW
Mflv_4163|M.gilvum_PYR-GCK VKAVVVAQNLVSARFVALTPRGGSG-----PVAESGAVIPRERTAVPVEW
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGG-----PALGDNAVIPLERTQVPVEW
MUL_3921|M.ulcerans_Agy99 AKAAILSPTLVTSRAIQLTPAYTGG-----PAMSDNAVIPRQRTAVPVEW
..* :: .**::* : * * . ... : ::* **:**
Mb3526c|M.bovis_AF2122/97 DEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRE
Rv3496c|M.tuberculosis_H37Rv DEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRE
MAB_4150c|M.abscessus_ATCC_199 DEVKTELAKLSDSLGPQ-GQSKGPVSDFINQAATTFD-GNGDSFRNAVRE
MSMEG_4787|M.smegmatis_MC2_155 DEVKEQLTRLATELGPRSGVDGTSMARFIETTADAME-GNGEKLRNTISQ
TH_4516|M.thermoresistible__bu DEVKEQLMRLATDLGPQRGVDDTSVSRFIETAADAME-GNGAKLRETITQ
MMAR_4707|M.marinum_M DEVKDQLMRLATELGPNSKVSSPSISRFIDSAADALGNGNGDKLRQTLAE
MAV_0951|M.avium_104 DEVKTQLMRLATDLGPKSGVSGTSVGRFIDSAANALD-GNGDKLRQTLAQ
Mvan_2854|M.vanbaalenii_PYR-1 DEIKEQLTRLAAELGPASGVSGTSLGRFIDTTADAMA-GNGEKLRETIAQ
Mflv_4163|M.gilvum_PYR-GCK DEVKERIDRLAADLGPTAELTTGSVGRFVDSAADAMA-GNGQKLRTAITQ
MLBr_02592|M.leprae_Br4923 DELRDSITKIISKLGPTKEQPKGPFGDVIESFADGLA-GKGKQINATLDS
MUL_3921|M.ulcerans_Agy99 DDVRAQLAKLTKELQPTEPGGVSPLGSVINTAADNLR-GEGANIRDTVIK
*::: : :: .* * ... :: * : *:* .:. :: .
Mb3526c|M.bovis_AF2122/97 LAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVL
Rv3496c|M.tuberculosis_H37Rv LAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVL
MAB_4150c|M.abscessus_ATCC_199 LSQAAGRLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVL
MSMEG_4787|M.smegmatis_MC2_155 LSGVARILAEGSGNIVDIIKNLQTFVTALRDSNQQVVAFQNRLATLTSVV
TH_4516|M.thermoresistible__bu LSGVARVLAEGSGNVVDIIRNLQTFVTTLRDSNEQVMVFQNRLATLTSVI
MMAR_4707|M.marinum_M LSGVGRILANGSGNIVDIIKNLQTFIGALRDSNVQIVQFNDRLASLTSVL
MAV_0951|M.avium_104 LSGVGRILANGSGNIVDIIKNLQTFVGALRDSNVQIVQFNDRLATLTSVV
Mvan_2854|M.vanbaalenii_PYR-1 LSGVGRILGEGSGDIVEVIQNLQIFVTALRDSNTQIVQFQDRLADVTSVV
Mflv_4163|M.gilvum_PYR-GCK LAGISRVIAEGSGDITEMLSHLQTFVAVLRDSNEQIVRFEERLATLSSVL
MLBr_02592|M.leprae_Br4923 LSRALTALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRL
MUL_3921|M.ulcerans_Agy99 LSQAFSALGDHSTDIFSTVKNLAILVSALQDSTNLMRQLNQNLATVTGLL
*: : : :. : * :: .* . . : .:* .: :
Mb3526c|M.bovis_AF2122/97 ADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLS--D
Rv3496c|M.tuberculosis_H37Rv ADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLS--D
MAB_4150c|M.abscessus_ATCC_199 AASTENLGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFS--D
MSMEG_4787|M.smegmatis_MC2_155 DGSRSDLDAALKNLSVAVGEVQRFVAGSRNQTSEQIQRLADVTSNLV--D
TH_4516|M.thermoresistible__bu NGSRTDLDAALQNLSVAVGEVQRFVAGSRDQTSEQLERLANVTRNLL--D
MMAR_4707|M.marinum_M DDNKSDLDAALTDLSSAVGEVQRFIAGSRDATAEQITRLADLTQILV--D
MAV_0951|M.avium_104 NDSKSDLDAALTDLSTAVGEVQRFIAGTRNQTSEQIARLADVTQILV--D
Mvan_2854|M.vanbaalenii_PYR-1 DGSRSDLDSAITTLSEAVGEVRRFVQGSRGQTVEQVQRLANVTQVLS--D
Mflv_4163|M.gilvum_PYR-GCK DGSRGDLDAALIHLAEAVGEVQRFVAGTRDRTGEQVARLAGVTQNLV--D
MLBr_02592|M.leprae_Br4923 AHSDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPE
MUL_3921|M.ulcerans_Agy99 ANDPNEVANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALN--D
. :: :: : : :: *: .. .* . . :
Mb3526c|M.bovis_AF2122/97 QSENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQF-----
Rv3496c|M.tuberculosis_H37Rv QSENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQF-----
MAB_4150c|M.abscessus_ATCC_199 QSDDLEQILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQF-----
MSMEG_4787|M.smegmatis_MC2_155 QRLQVENLLHIAPNAFVNGYNIYNPDSGSPVGQFVFHNMSEPLHF-----
TH_4516|M.thermoresistible__bu NKLEIENVLHIAPNALANAYNIYNPDTGSPVGQFVLNNFSDPVQF-----
MMAR_4707|M.marinum_M NKMALKNVLHVTPNALANAYNDYDPDVGNVRGGVGIQNLTNPVFS-----
MAV_0951|M.avium_104 HHMDLENILHVAPNALGNFFNDYNADTGTIVGGFGIMNFANPTFSGLMVP
Mvan_2854|M.vanbaalenii_PYR-1 DSMVLKNILHAAPNALVNGYNIYNPDTGGPRGSFAMNNFANPVTM-----
Mflv_4163|M.gilvum_PYR-GCK HRADLEQVLHVAPSAMANAYNMMDPRTGGASGVFVLNNMADPTAF-----
MLBr_02592|M.leprae_Br4923 PLNGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQF-----
MUL_3921|M.ulcerans_Agy99 SLDDVKQFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISF-----
:: .** : * : .. * . : *:::*
Mb3526c|M.bovis_AF2122/97 ----ICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYP
Rv3496c|M.tuberculosis_H37Rv ----ICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYP
MAB_4150c|M.abscessus_ATCC_199 ----ICGGVFETGT---KTEYLKRAEICRERMGPVLRRAT------FNYA
MSMEG_4787|M.smegmatis_MC2_155 ----ICGAIGAVEN----VTAPETAKLCAQYLGPALRLLN------FNNV
TH_4516|M.thermoresistible__bu ----ICGAIGAIEN----TTAPETAKLCAQYLGPGLRLLN------FNYL
MMAR_4707|M.marinum_M ----ICSQLGAMEN----VTSVESGKLCGLYLSPALKVFNPLMYFNFNYF
MAV_0951|M.avium_104 LPVPGCTAVGAIEN----ITAVESGKLCSLFLGPGLRVLN------FNNL
Mvan_2854|M.vanbaalenii_PYR-1 ----ICSAIAAVEN----VTAEESGKACAQYLGPALRLMN------FNYL
Mflv_4163|M.gilvum_PYR-GCK ----FCGMLGALAN----VTAPESSKLCAQYLGPGLDTVN------FNYL
MLBr_02592|M.leprae_Br4923 ----ICSAIQAGSR----LGYQESAELCAQYLSPVLDAIK------FNYF
MUL_3921|M.ulcerans_Agy99 ----LCGAIQAASR----LGYEQSAKLCVQYLAPIIKNRQ------YNFL
* . .: * :.* : *
Mb3526c|M.bovis_AF2122/97 PIMFHPLNTITAYKGQIIYDTPATEAKSE-----------------TPVP
Rv3496c|M.tuberculosis_H37Rv PIMFHPLNTITAYKGQIIYDTPATEAKSE-----------------TPVP
MAB_4150c|M.abscessus_ATCC_199 PILLHPINQISAYKGQIIYDTPETEAKSQ-----------------APRE
MSMEG_4787|M.smegmatis_MC2_155 PFPVSPYLMPSANPENLIYSEPNLAPGAG-----------------GGSP
TH_4516|M.thermoresistible__bu PIGIDPFLMPSAKPENIIYSEPRLAPGGG-----------------ANLE
MMAR_4707|M.marinum_M PIPINPILAPAFDLQNVVYTEQRLAPGGE-----------------GPKP
MAV_0951|M.avium_104 PIPINIFLQKSVDPSKILYSEPRLAPGGE-----------------GPKP
Mvan_2854|M.vanbaalenii_PYR-1 PLPFNAYLGPAP--QNVIYSEPGLAPGGG-----------------GTAP
Mflv_4163|M.gilvum_PYR-GCK PFPVNPLLTPIPSDSKLIYSEPDLRPGGP-----------------GTRS
MLBr_02592|M.leprae_Br4923 PFGLNLFSTAEVLPKEVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNT
MUL_3921|M.ulcerans_Agy99 PFGQNLFVGASARPNELTYSEDWLR-------------------------
*: :: *
Mb3526c|M.bovis_AF2122/97 ELTWVPAGGG--APVGN--------------------------------P
Rv3496c|M.tuberculosis_H37Rv ELTWVPAGGG--APVGN--------------------------------P
MAB_4150c|M.abscessus_ATCC_199 DLVWVRPNGAPPPPKPS--------------------------------P
MSMEG_4787|M.smegmatis_MC2_155 QPPETPPVLSAYNPGPPPPPP-------------------FTGRPPGTPP
TH_4516|M.thermoresistible__bu FEPELPPTVSAYEGVPPGPPP-------------------FTGRPPGTPP
MMAR_4707|M.marinum_M IAPELPPAVSAYTGLPGDT----------------------PEAPPPPPP
MAV_0951|M.avium_104 GPPEIPPAVSAYTGLPGD-----------------------PVGPPGAEP
Mvan_2854|M.vanbaalenii_PYR-1 APAETPPAVSAYTGVGDVPPPPGWS---------------DPAHPPGAYA
Mflv_4163|M.gilvum_PYR-GCK GPTAIAPGDSAYQ-------------------------------------
MLBr_02592|M.leprae_Br4923 QPGWIVAPGMQGQQVGPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGP
MUL_3921|M.ulcerans_Agy99 -PDYIPPQAIPPQQA----------------------------------P
.
Mb3526c|M.bovis_AF2122/97 ADLQSLLVPPAP------GPAPAPPA-----------PGAGPGEHG----
Rv3496c|M.tuberculosis_H37Rv ADLQSLLVPPAP------GPAPAPPA-----------PGAGPGEHG----
MAB_4150c|M.abscessus_ATCC_199 QDLSALMLGPDE------VNAPPPPG-----------TEVRPAEPGPVPP
MSMEG_4787|M.smegmatis_MC2_155 PGAAQLLPGAPP------IVPPNVPSSVRDMLAPAGPPPGPVPETGPAPG
TH_4516|M.thermoresistible__bu PGAQQMLPGAPP------VVPPNVRSTLQGMLNPAGTPHGPAPD-GP---
MMAR_4707|M.marinum_M P--ARIPGAAMP-----EPPPPSVPA----------EPSPPP--ANLSDM
MAV_0951|M.avium_104 P--ARIPGAAMP-----LPPPPSTPM----------PPPPPPE-PGVSGM
Mvan_2854|M.vanbaalenii_PYR-1 P--HGLPANPHPALYPDAPIPPGVPP----------PPPARPAPSSIGDM
Mflv_4163|M.gilvum_PYR-GCK ------------------AQQPTVPQ-----------------------M
MLBr_02592|M.leprae_Br4923 PTAYDEHPVPPPIGLQASVPIPSPRPDV----VPGPVAPTPSPAANVGDP
MUL_3921|M.ulcerans_Agy99 PAAAPPAQAPPPA---VGLPLPAEAP------------ATPDPAAGLRGI
*
Mb3526c|M.bovis_AF2122/97 --------------GGG--
Rv3496c|M.tuberculosis_H37Rv --------------GGG--
MAB_4150c|M.abscessus_ATCC_199 GFPVTADDAPPPAIPGAPR
MSMEG_4787|M.smegmatis_MC2_155 PLPAEAPLEPAEGTPPA--
TH_4516|M.thermoresistible__bu PLPAEAP-APAEGTPPA--
MMAR_4707|M.marinum_M LLPAEGPQP----------
MAV_0951|M.avium_104 LLPAQGPQQ----------
Mvan_2854|M.vanbaalenii_PYR-1 LLPAEAAPAPPSTEGTP--
Mflv_4163|M.gilvum_PYR-GCK LLPAERPTP----------
MLBr_02592|M.leprae_Br4923 PLPAELGAGQ---------
MUL_3921|M.ulcerans_Agy99 MVPQGVGS-----------