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TATDLVFDPFSEEFFNGPWEIYRRMRSEAPVYYNAEYDFYALSRHEDVAAAYKDFETYSSAYGLDLATVR SDEPIPAKMIIIMDPPEHRQMRSLVNKVFTPRAIEALRPMVTETIDRYLSQVDRDSFDVVQDFSALFPVQ VITQMLGVPEEYRKQVGEWVDTSLRREPGQIDMSDEGMQAVGELMGLYYSIIQQRREDPRDDMFSRLIAA EITREDGEKESLDDFEIAGFATLLGGAGAETVTKLVGNAAVTFARHPDQWQKLLDDRSKIPAAVEELLRF EAPNQYNVRRSMKDVELHGVTIPEGKPVFLLAGSANRDPDAFTDADTFDIDRDRSEAQNLGFGYGVHSCL GAALARMESAIALDRLLDFMPRYEVLFDECRRVSAQNVAGWSHVPVRVLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2477 | - | - | 100% (401) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4343 | - | e-164 | 70.12% (405) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2479 | - | e-151 | 65.84% (401) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-76 | 41.31% (397) | cytochrome P450 123 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-76 | 41.31% (397) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-41 | 32.36% (343) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 5e-72 | 38.71% (403) | cytochrome P450 |
| M. marinum M | MMAR_4733 | cyp190A3 | 1e-166 | 70.07% (401) | cytochrome P450 190A3 Cyp190A3 |
| M. avium 104 | MAV_0916 | - | 1e-160 | 67.58% (401) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4818 | - | 1e-158 | 67.58% (401) | putative cytochrome P450 123 |
| M. thermoresistible (build 8) | TH_2856 | - | 1e-167 | 70.75% (400) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 3e-74 | 39.55% (397) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_2001 | - | 1e-169 | 73.92% (395) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
Mflv_2477|M.gilvum_PYR-GCK --------------------------MTATDL-----VFDPFSEEFFNGP
Mvan_2001|M.vanbaalenii_PYR-1 --------------------------MAVVDVGRDPVVFDPFSEEFYRDP
MMAR_4733|M.marinum_M --------------------------MTTSKV-----VFDPFSEEFFNGP
TH_2856|M.thermoresistible__bu --------------------------MTTTKL-----IFDPFSEDFFNGP
MAV_0916|M.avium_104 --------------------------MTKPKL-----VFDPYSEDYFNNP
MSMEG_4818|M.smegmatis_MC2_155 --------------------------MTTPQM-----IFDPFSEQYFENP
MUL_0324|M.ulcerans_Agy99 --------------------------MTVTAAS--DVYFDPYDVELNADP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
. : . .*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
Mflv_2477|M.gilvum_PYR-GCK WEIYRRMRSEAPVYYNAEYDFYALSRHEDVAAAYKDFETYSSAYGLDLA-
Mvan_2001|M.vanbaalenii_PYR-1 QGCYPRLRAEAPVYYNATYDFYALSRHADVAAGLKDFATYSSAYGVDLG-
MMAR_4733|M.marinum_M WETYRRMQAEAPVYYSEQYDFYALTRHADVAAGLKNFERYSSAYGIDLS-
TH_2856|M.thermoresistible__bu YETYRRMREEAPVYYSEEYDFYALSRHADVAAAFKDFETYSSARGVDLA-
MAV_0916|M.avium_104 YEIYRRMREEAPLYYDEKEDFYALTRHVDVAAAFKDYETYSSARGCDLA-
MSMEG_4818|M.smegmatis_MC2_155 FDIYRQMRDDAPLYYDSEQDFYALSRHEDVAAALKDHEAFSSSRGCDLA-
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILE-
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
: : .*: : ..: . * . . *. :
Mb0789c|M.bovis_AF2122/97 ----SSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv ----SSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ----ASFGPHAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
Mflv_2477|M.gilvum_PYR-GCK ----TVRSDEPIPAKMIIIMDPPEHRQMRSLVNKVFTPRAIEALRPMVTE
Mvan_2001|M.vanbaalenii_PYR-1 ----MVRRGEKVPAKMIISIDPPEHRAMRSLVNKVFTPRAIEALRTMVTD
MMAR_4733|M.marinum_M ----MVRSGQKPPQ-SIIFMDPPDHRHMRSLLNKVFTPRAIQAQRQTVID
TH_2856|M.thermoresistible__bu ----MVRNPEPPPHRSIIMMDPPEHRHMRSLLNRVFTPRAIQSLRSMVEE
MAV_0916|M.avium_104 ----MVRRGISPEQKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETIIE
MSMEG_4818|M.smegmatis_MC2_155 ----MVK-GDEPPQKSIIFMDPPEHRHMRSLLNKAFTPRAVQAQRDTVVE
MUL_0324|M.ulcerans_Agy99 ----FIKANIDIPAGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * *:.: *:*: :. . :
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIREL
Mflv_2477|M.gilvum_PYR-GCK TIDRYLS-QVDRDS---FDVVQDFSALFPVQVITQMLGVPEEYRKQVGEW
Mvan_2001|M.vanbaalenii_PYR-1 TVTRFLS-AVRGDS---FDVVQDFSVYFPVDVITQMLGVPEKYRQQVRLW
MMAR_4733|M.marinum_M KIDKYLG-ALDPEG---FDAVQEFSGPFPVEVITTMLGVPERHAQQVRHW
TH_2856|M.thermoresistible__bu VVDDCLA-AVDPAG---FDAVQDFSALFPIEIISRMLGVPTEYRQQMRLW
MAV_0916|M.avium_104 VVDKYLS-AADPDN---FDVVQDFSGPFPVEVITRMAGVPEEYRQQVRHW
MSMEG_4818|M.smegmatis_MC2_155 QVEHYLG-QIDSDE---FDVVQDFSGPFPVEVITRMAGVEPEYRQQVRHW
MUL_0324|M.ulcerans_Agy99 FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
* ** : : . :.: :* : **
Mb0789c|M.bovis_AF2122/97 ADAVLH------REDGV-ADVPPPAMAASIELMRYYADLIAEFRRRPANN
Rv0766c|M.tuberculosis_H37Rv ADAVLH------REDGV-ADVPPPAMAASIELMRYYADLIAEFRRRPANN
MAB_1216c|M.abscessus_ATCC_199 ADGVMH------REDGL-ADVPPEAIQASFDLMTYYIEMVRERRRRPTED
Mflv_2477|M.gilvum_PYR-GCK VDTSLR------REPGQ-IDMSDEGMQAVGELMGLYYSIIQQRREDPRDD
Mvan_2001|M.vanbaalenii_PYR-1 IDESLH------REPGQ-IDMSEAGMQAMAETWLMYYDLIKQRRADPRDD
MMAR_4733|M.marinum_M IDESLT------REPGQ-VEVGEQGMQANINTAMLYYDLVKQRRDDPRDD
TH_2856|M.thermoresistible__bu VDDFLH------REPGE-VEMSRRGVQAATEMAVYLYKLTKQRRHDLGDD
MAV_0916|M.avium_104 IDTSLH------HEPGQ-IEVSEAGMQANIDTAMYYFGLVQERRQNPQDD
MSMEG_4818|M.smegmatis_MC2_155 IDTSLS------REPGQ-VAYSEAGMKANIDTAMYYYSLVQKRRENPQDD
MUL_0324|M.ulcerans_Agy99 ATAQLR------TEAGKPMKASADGMVS----GDFFAHYIDWRAEHPSSD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
: * : : .:
Mb0789c|M.bovis_AF2122/97 LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199 LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
Mflv_2477|M.gilvum_PYR-GCK MFSRLIAAEITREDGEKESLDDFEIAGFATLLGGAGAETVTKLVGNAAVT
Mvan_2001|M.vanbaalenii_PYR-1 MISALIAAEVEREDGTVDRLKDSEIAGFATLLGGAGAETVTKLVGSAVVT
MMAR_4733|M.marinum_M LFTKLINAEIEREDGQVTNLDDLEIAGFATLLGGAGAETVTKLVGNAAVV
TH_2856|M.thermoresistible__bu LLSRLITAEIERENGKRGPLDNVEITQFAMLLGGAGAETVTKLIGNAAVV
MAV_0916|M.avium_104 MISRLIAAEIPGENGQMRKLDDIEITGFATLLGGAGAETVTKLLGNAAVI
MSMEG_4818|M.smegmatis_MC2_155 MISRLIAAEIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLIGTAMVT
MUL_0324|M.ulcerans_Agy99 IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
MLBr_02088|M.leprae_Br4923 LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
: : *: : : * *: :: ** **...*:. *
Mb0789c|M.bovis_AF2122/97 AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MAB_1216c|M.abscessus_ATCC_199 GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKI
Mflv_2477|M.gilvum_PYR-GCK FARHPDQWQKLLDDRSKIPAAVEELLRFEAPNQYNVRRSMKDVELHGVTI
Mvan_2001|M.vanbaalenii_PYR-1 FARHPEQWQQLLDDRGKIGVAIEELLRYDAPVQYNVRRSNHPVTLHGVTI
MMAR_4733|M.marinum_M FARNPEQWQKLLDDRSKVPAAVEELLRYEAPSQYQVRRAMEDVELHGVTI
TH_2856|M.thermoresistible__bu FAQHPDQWRLLLEDRSKIPAAVEELLRYEAPAQYNVRCSRREVTLHGVTI
MAV_0916|M.avium_104 FARHPDQWQKLQDDRDKIPGAVEELLRYEGPVQYNVRYTLKEAHVSGGVI
MSMEG_4818|M.smegmatis_MC2_155 FAKFPDQWQKLLDDRSKVPAAVEELLRYEGPVQYNVRYTLKEARVPSGTI
MUL_0324|M.ulcerans_Agy99 LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSV
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
. * * : : :** **:: . * . :
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIG-CKLVSFGSGAHFCLG
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIG-CKLVSFGSGAHFCLG
MAB_1216c|M.abscessus_ATCC_199 PAGDILLLLPGSANRDDRVFD-DADQYRIGREIG-AKLVSFGSGAHFCLG
Mflv_2477|M.gilvum_PYR-GCK PEGKPVFLLAGSANRDPDAFT-DADTFDIDRDRSEAQNLGFGYGVHSCLG
Mvan_2001|M.vanbaalenii_PYR-1 PAGAPVFLLGASANRDPDAWT-APDVFDINRDRTEAQNLGFGYGIHSCLG
MMAR_4733|M.marinum_M PAGKPVFLINGAANRDPHAWT-DPDKFDIDRDPHEATNLGFGYGIHSCLG
TH_2856|M.thermoresistible__bu PAGKPVFLIGGSANRDPRAWT-DPDTFDIERDRTEAQNLGFGYGIHSCLG
MAV_0916|M.avium_104 PAGKPVFLCGAAANRDPEAFT-DADTFDIERDQTEAQHLGLGYGIHSCLG
MSMEG_4818|M.smegmatis_MC2_155 PAGKPVFLLKASANRDERAWT-DPDVFDIDRDRTEAQNLGLGYGIHSCLG
MUL_0324|M.ulcerans_Agy99 PEGSIMMMLIGAANRDHRQFRPDGDVFNIRREP--HQHLTFSVGTHYCLG
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSS--RHLAFAVGSHFCLG
. * :.: .:**** : * : * : :. * * ***
Mb0789c|M.bovis_AF2122/97 AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
Rv0766c|M.tuberculosis_H37Rv AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
MAB_1216c|M.abscessus_ATCC_199 AHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLR
Mflv_2477|M.gilvum_PYR-GCK AALARMESAIALDRLLDFMPRYEVLFDECRRVSAQNVAGWSHVPVRVLR-
Mvan_2001|M.vanbaalenii_PYR-1 AALARLESSIALDMLLDFMPRYGVEWDGCRRVSMQNVSGWANVPVRIL--
MMAR_4733|M.marinum_M AALARMESAIALEKLLDFMPAFEVDWAGCKRVHMQNVAGWQSVPVRVLR-
TH_2856|M.thermoresistible__bu AALARMESAIALERMLDFMPRYEVDWDNCRRVNMQNVAGWQNVPVRMLGR
MAV_0916|M.avium_104 AALARLESRIALERLLDFMPRYEVDWAGCRRVTMQNVAGWKNVPVKVLR-
MSMEG_4818|M.smegmatis_MC2_155 AALARLESTIALERLLDFMPRYEVKWDGLQRVHMQNVAGYSHVPVKVLR-
MUL_0324|M.ulcerans_Agy99 SALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD--
MLBr_02088|M.leprae_Br4923 AALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV---
: ***:*. ::* : : : : * :* .
Mb0789c|M.bovis_AF2122/97 ---
Rv0766c|M.tuberculosis_H37Rv ---
MAB_1216c|M.abscessus_ATCC_199 EGR
Mflv_2477|M.gilvum_PYR-GCK ---
Mvan_2001|M.vanbaalenii_PYR-1 ---
MMAR_4733|M.marinum_M ---
TH_2856|M.thermoresistible__bu ---
MAV_0916|M.avium_104 ---
MSMEG_4818|M.smegmatis_MC2_155 ---
MUL_0324|M.ulcerans_Agy99 ---
MLBr_02088|M.leprae_Br4923 ---