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TKPKLVFDPVAQEYFDNPYEIYQRMRDEAPIYYDEEGDFYALTRHADVAAALKDHEAFSSARGCDLAMVR SEEGPVKSIIFMDPPEHRHMRSLLNKAFTPRAIQNQHQTVTELVEQYLAKVDPDNFDVVQDFSGPFPVEV ITRMAGVPEDFRQQVRHWIDTSLERQPGQIGWSDKNMQANIDSGVYYYGLVQERRQNPQDDMISRLIAAE IPDENGQMRRLDDIEITGFTSLLGGAGAETVTKLVGSAVVEFARHPDQWQLLLDDRSLIPAAVEELLRYV GPVQYNVRYTVKEAHVPSGTIPAHKPVFLMKAAANRDPRAFDNAETFDITRDRTQAQNLGLGYGIHSCLG AALARMETAVALEHLLDFMPRYEVDFDGLQRVSMQNVAGYHHVPVRVLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2479 | - | - | 100% (400) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_2477 | - | e-151 | 65.84% (401) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4343 | - | e-133 | 60.90% (399) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-69 | 39.15% (401) | cytochrome P450 123 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 1e-69 | 39.15% (401) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-38 | 31.23% (397) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 3e-68 | 38.15% (401) | cytochrome P450 |
| M. marinum M | MMAR_4733 | cyp190A3 | 1e-150 | 64.25% (400) | cytochrome P450 190A3 Cyp190A3 |
| M. avium 104 | MAV_0916 | - | 0.0 | 77.81% (401) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4818 | - | 0.0 | 76.00% (400) | putative cytochrome P450 123 |
| M. thermoresistible (build 8) | TH_2585 | - | 0.0 | 79.13% (393) | PUTATIVE putative cytochrome P450 123 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 9e-67 | 36.55% (394) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_4175 | - | 0.0 | 90.25% (400) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
Mflv_2479|M.gilvum_PYR-GCK -------------------------------MTKPKLVFDPVAQEYFDNP
Mvan_4175|M.vanbaalenii_PYR-1 -------------------------------MTAPELRFDPVSQDYFDNP
MSMEG_4818|M.smegmatis_MC2_155 -------------------------------MTTPQMIFDPFSEQYFENP
TH_2585|M.thermoresistible__bu ------------------------------------VKFDPFSEEFFNDP
MAV_0916|M.avium_104 -------------------------------MTKPKLVFDPYSEDYFNNP
MMAR_4733|M.marinum_M -------------------------------MTTSKVVFDPFSEEFFNGP
MUL_0324|M.ulcerans_Agy99 ----------------------------MTVTAASDVYFDPYDVELNADP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: : .*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
Mflv_2479|M.gilvum_PYR-GCK YEIYQRMRDEAPIYYDEEGDFYALTRHADVAAALKDHEAFSSARGCDLAM
Mvan_4175|M.vanbaalenii_PYR-1 YEIYRRMRDEAPIYYDAEEDFYALTRHEDVAAALKDHEAFSSARGCDLGM
MSMEG_4818|M.smegmatis_MC2_155 FDIYRQMRDDAPLYYDSEQDFYALSRHEDVAAALKDHEAFSSSRGCDLAM
TH_2585|M.thermoresistible__bu FGIYKRMRDEAPIYYDEDEDFYALSRHADVAAALKDHETFSSSRGCDLAM
MAV_0916|M.avium_104 YEIYRRMREEAPLYYDEKEDFYALTRHVDVAAAFKDYETYSSARGCDLAM
MMAR_4733|M.marinum_M WETYRRMQAEAPVYYSEQYDFYALTRHADVAAGLKNFERYSSAYGIDLSM
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
: :: : .*: : ..: . * .: . *. :
Mb0789c|M.bovis_AF2122/97 SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ASFGPHAKL----VMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
Mflv_2479|M.gilvum_PYR-GCK VR-SEEGP-----VKSIIFMDPPEHRHMRSLLNKAFTPRAIQNQHQTVTE
Mvan_4175|M.vanbaalenii_PYR-1 VR-SEDGP-----VKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETVIE
MSMEG_4818|M.smegmatis_MC2_155 VK-GDEPP-----QKSIIFMDPPEHRHMRSLLNKAFTPRAVQAQRDTVVE
TH_2585|M.thermoresistible__bu VR-SEERP-----QKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRDTVIE
MAV_0916|M.avium_104 VR-RGISPE----QKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETIIE
MMAR_4733|M.marinum_M VR-SGQKP-----PQSIIFMDPPDHRHMRSLLNKVFTPRAIQAQRQTVID
MUL_0324|M.ulcerans_Agy99 IK-ANIDIP----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * *:.: *:*: :. . :
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIREL
Mflv_2479|M.gilvum_PYR-GCK LVEQYLA-KVDPDN---FDVVQDFSGPFPVEVITRMAGVPEDFRQQVRHW
Mvan_4175|M.vanbaalenii_PYR-1 LVEHYLS-KVDPDN---FDVVQDFSGPFPVEVITRMAGVPEEFRQQVRHW
MSMEG_4818|M.smegmatis_MC2_155 QVEHYLG-QIDSDE---FDVVQDFSGPFPVEVITRMAGVEPEYRQQVRHW
TH_2585|M.thermoresistible__bu LVRKYLG-AVKSDE---FDVVQDFSGPFPVEVITRMAGVPEEYRQQVRHW
MAV_0916|M.avium_104 VVDKYLS-AADPDN---FDVVQDFSGPFPVEVITRMAGVPEEYRQQVRHW
MMAR_4733|M.marinum_M KIDKYLG-ALDPEG---FDAVQEFSGPFPVEVITTMLGVPERHAQQVRHW
MUL_0324|M.ulcerans_Agy99 FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
* ** : : . :.: ** : **
Mb0789c|M.bovis_AF2122/97 ADAVLH------REDGV-ADVPPPAMAASIELMRYYADLIAEFRRRPANN
Rv0766c|M.tuberculosis_H37Rv ADAVLH------REDGV-ADVPPPAMAASIELMRYYADLIAEFRRRPANN
MAB_1216c|M.abscessus_ATCC_199 ADGVMH------REDGL-ADVPPEAIQASFDLMTYYIEMVRERRRRPTED
Mflv_2479|M.gilvum_PYR-GCK IDTSLE------RQPGQ-IGWSDKNMQANIDSGVYYYGLVQERRQNPQDD
Mvan_4175|M.vanbaalenii_PYR-1 IDKGLE------RKPGQ-IEWSDENMQANIDSGVYYYGLVQERRRNPQDD
MSMEG_4818|M.smegmatis_MC2_155 IDTSLS------REPGQ-VAYSEAGMKANIDTAMYYYSLVQKRRENPQDD
TH_2585|M.thermoresistible__bu IDTSLH------REPGQ-IEATEAGMQANIDTAMFYYDLVQKRRQEPQDD
MAV_0916|M.avium_104 IDTSLH------HEPGQ-IEVSEAGMQANIDTAMYYFGLVQERRQNPQDD
MMAR_4733|M.marinum_M IDESLT------REPGQ-VEVGEQGMQANINTAMLYYDLVKQRRDDPRDD
MUL_0324|M.ulcerans_Agy99 ATAQLR------TEAGKPMKASADGMVS----GDFFAHYIDWRAEHPSSD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
: * : : : * .:
Mb0789c|M.bovis_AF2122/97 LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199 LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
Mflv_2479|M.gilvum_PYR-GCK MISRLIAAEIPDENGQMRRLDDIEITGFTSLLGGAGAETVTKLVGSAVVE
Mvan_4175|M.vanbaalenii_PYR-1 MISRLIAAEIPGENGEMRKLDDIEITGFTSLLGGAGAETVTKLLGSAVVE
MSMEG_4818|M.smegmatis_MC2_155 MISRLIAAEIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLIGTAMVT
TH_2585|M.thermoresistible__bu MISRLIAAEIPDEDGGMRRLDDIEICGFATLLGGAGAETVTKLIGTAVVN
MAV_0916|M.avium_104 MISRLIAAEIPGENGQMRKLDDIEITGFATLLGGAGAETVTKLLGNAAVI
MMAR_4733|M.marinum_M LFTKLINAEIEREDGQVTNLDDLEIAGFATLLGGAGAETVTKLVGNAAVV
MUL_0324|M.ulcerans_Agy99 IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
MLBr_02088|M.leprae_Br4923 LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
: : *: : : .* *: :: ** **...*:. *
Mb0789c|M.bovis_AF2122/97 AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MAB_1216c|M.abscessus_ATCC_199 GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKI
Mflv_2479|M.gilvum_PYR-GCK FARHPDQWQLLLDDRSLIPAAVEELLRYVGPVQYNVRYTVKEAHVPSGTI
Mvan_4175|M.vanbaalenii_PYR-1 FARHPEQWQMLLDDRNLIPDAVEELLRYVGPVQYNVRYTVKEAHVPSGTI
MSMEG_4818|M.smegmatis_MC2_155 FAKFPDQWQKLLDDRSKVPAAVEELLRYEGPVQYNVRYTLKEARVPSGTI
TH_2585|M.thermoresistible__bu FARFPDQWQKLLDDRSKIPAAVEELLRYEGPVQYNVRYTLKEAHVPSGTI
MAV_0916|M.avium_104 FARHPDQWQKLQDDRDKIPGAVEELLRYEGPVQYNVRYTLKEAHVSGGVI
MMAR_4733|M.marinum_M FARNPEQWQKLLDDRSKVPAAVEELLRYEAPSQYQVRRAMEDVELHGVTI
MUL_0324|M.ulcerans_Agy99 LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSV
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
. * * : : . * *** *** . * . .: :
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIG-CKLVSFGSGAHFCLG
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIG-CKLVSFGSGAHFCLG
MAB_1216c|M.abscessus_ATCC_199 PAGDILLLLPGSANRDDRVFD-DADQYRIGREIG-AKLVSFGSGAHFCLG
Mflv_2479|M.gilvum_PYR-GCK PAHKPVFLMKAAANRDPRAFD-NAETFDITRDRTQAQNLGLGYGIHSCLG
Mvan_4175|M.vanbaalenii_PYR-1 PAHKPVFLMKAAANRDPRAFD-NAETFDITRDRTQAQNLGLGYGIHSCLG
MSMEG_4818|M.smegmatis_MC2_155 PAGKPVFLLKASANRDERAWT-DPDVFDIDRDRTEAQNLGLGYGIHSCLG
TH_2585|M.thermoresistible__bu PAGKPVFLLKASANRDERAWT-DADRFDIDRDRTESPNLALGYGIHSCLG
MAV_0916|M.avium_104 PAGKPVFLCGAAANRDPEAFT-DADTFDIERDQTEAQHLGLGYGIHSCLG
MMAR_4733|M.marinum_M PAGKPVFLINGAANRDPHAWT-DPDKFDIDRDPHEATNLGFGYGIHSCLG
MUL_0324|M.ulcerans_Agy99 PEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPH--QHLTFSVGTHYCLG
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSS--RHLAFAVGSHFCLG
. . :.: .:**** : : : * : :. * * ***
Mb0789c|M.bovis_AF2122/97 AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
Rv0766c|M.tuberculosis_H37Rv AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
MAB_1216c|M.abscessus_ATCC_199 AHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLR
Mflv_2479|M.gilvum_PYR-GCK AALARMETAVALEHLLDFMPRYEVDFDGLQRVSMQNVAGYHHVPVRVLR-
Mvan_4175|M.vanbaalenii_PYR-1 AALARTETAIALEHLLDFMPRFEVDFSGLQRVNMQNVAGYHHVPVKVLR-
MSMEG_4818|M.smegmatis_MC2_155 AALARLESTIALERLLDFMPRYEVKWDGLQRVHMQNVAGYSHVPVKVLR-
TH_2585|M.thermoresistible__bu AALARLESTIALEHLLDFMPRYEVKWDGLRRVTMQNVGGYSHVPVKVLR-
MAV_0916|M.avium_104 AALARLESRIALERLLDFMPRYEVDWAGCRRVTMQNVAGWKNVPVKVLR-
MMAR_4733|M.marinum_M AALARMESAIALEKLLDFMPAFEVDWAGCKRVHMQNVAGWQSVPVRVLR-
MUL_0324|M.ulcerans_Agy99 SALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD--
MLBr_02088|M.leprae_Br4923 AALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV---
: *** * ::* : : :: : * :* .
Mb0789c|M.bovis_AF2122/97 ---
Rv0766c|M.tuberculosis_H37Rv ---
MAB_1216c|M.abscessus_ATCC_199 EGR
Mflv_2479|M.gilvum_PYR-GCK ---
Mvan_4175|M.vanbaalenii_PYR-1 ---
MSMEG_4818|M.smegmatis_MC2_155 ---
TH_2585|M.thermoresistible__bu ---
MAV_0916|M.avium_104 ---
MMAR_4733|M.marinum_M ---
MUL_0324|M.ulcerans_Agy99 ---
MLBr_02088|M.leprae_Br4923 ---