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RFILVHGGFHAAWCWERTAAALRALGHDVTAVDLPGHGALADQESTLANRRDAIVAAMQAGDEKCVLVGH SGGGFDATLAADARPDLVSHITYLAAALPREGRTYPEAMAMRDDDNGPVELGEDFDGDVGEMLGYLHFDD TGAMKFADFDGAWKYFYHDCDEETARWAFERLGPERFGDTTVTPVSVPNFWAADLPRSFIVCEQDQAMPR WLADTVARRLGVDQLTIDASHSPFLSRPREFADLLVHATTTTPVAPLRPL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2476 | - | - | 100% (261) | esterase EstC, putative |
| M. gilvum PYR-GCK | Mflv_3566 | - | 2e-09 | 31.82% (110) | hypothetical protein Mflv_3566 |
| M. gilvum PYR-GCK | Mflv_0736 | - | 3e-07 | 32.79% (122) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0046c | - | 5e-05 | 33.68% (95) | hydrolase |
| M. tuberculosis H37Rv | Rv0045c | - | 5e-05 | 33.68% (95) | hydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0554 | - | 7e-07 | 37.78% (90) | alpha/beta family hydrolase |
| M. marinum M | MMAR_0064 | - | 3e-06 | 33.67% (98) | hydrolase |
| M. avium 104 | MAV_2604 | - | 6e-11 | 27.63% (257) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6710 | - | 5e-15 | 28.88% (277) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2893 | - | 7e-21 | 30.49% (246) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2524 | lipV | 2e-06 | 32.54% (126) | lipase LipV |
| M. vanbaalenii PYR-1 | Mvan_4177 | - | 1e-135 | 85.77% (260) | esterase EstC, putative |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2476|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4177|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0046c|M.bovis_AF2122/97 MLSD---DELTGLDEFALLAENAEQAGVNGPLPEVERVQAGA----ISAL
Rv0045c|M.tuberculosis_H37Rv MLSD---DELTGLDEFALLAENAEQAGVNGPLPEVERVQAGA----ISAL
MMAR_0064|M.marinum_M -MTDSFPDDLTGLTEFDLLAENAEQAGVTGPLPEVERIEVGAAETRISAL
MSMEG_6710|M.smegmatis_MC2_155 ------------------------------------------------MN
TH_2893|M.thermoresistible__bu --------------------------------------------------
MAV_2604|M.avium_104 --------------------------------------------------
MUL_2524|M.ulcerans_Agy99 -----------------------------------------MSTDLHVHR
MAB_0554|M.abscessus_ATCC_1997 --------------------------------------MSGMQRDHITDH
Mflv_2476|M.gilvum_PYR-GCK ------MRFILVHGGFHAAWCWERTAAALRA--LGHDVTAVDLPGHGALA
Mvan_4177|M.vanbaalenii_PYR-1 ------MRFVLVHGGFHAAWCWERTIDALQA--LGHDAVAVDLPGHGDRV
Mb0046c|M.bovis_AF2122/97 RWGGSAPRVIFLHGGGQNAHTWD---TVIVG--LGEPALAVDLPGHGHSA
Rv0045c|M.tuberculosis_H37Rv RWGGSAPRVIFLHGGGQNAHTWD---TVIVG--LGEPALAVDLPGHGHSA
MMAR_0064|M.marinum_M RWGGRAPRVIFLHGGGQNAHTWD---TVIVG--LGEPALAVDLPGHGHSA
MSMEG_6710|M.smegmatis_MC2_155 DSRNSGTLAVLVHGAWHSSLHWAAAQRGLAR--RGVASIAVDLPGHGLDA
TH_2893|M.thermoresistible__bu ----MAKPILLVHGAFSGSWVWDQVVAELAS--CGVQARTVELSSRKPDG
MAV_2604|M.avium_104 ---MALPDLVLVHGGEHAGDCWDLVIAELRRQEPGLRTLAVDLPGHGNKP
MUL_2524|M.ulcerans_Agy99 YGPEEPVRVLTIHGVTEHGQSWEYLAGYLPE----VNIAAPDLLGHGRSS
MAB_0554|M.abscessus_ATCC_1997 GGHADGPTLVLVHGLMGRGTTWSRQLPWLRG---LGRVYTYDAPWHRGGD
: :** . * : : : :
Mflv_2476|M.gilvum_PYR-GCK DQE----STLAN-----------------RRDAIVAAMQAGD--EKCVLV
Mvan_4177|M.vanbaalenii_PYR-1 DEE----STLAN-----------------RREAVVAAMQAGG--GKCVLV
Mb0046c|M.bovis_AF2122/97 WREDGNYSPQLN-----------------SETLAPVLRELAP--GAEFVV
Rv0045c|M.tuberculosis_H37Rv WREDGNYSPQLN-----------------SETLAPVLRELAP--GAEFVV
MMAR_0064|M.marinum_M WRQDGDYSPQHN-----------------ADALVPALRELAS--EAEFVV
MSMEG_6710|M.smegmatis_MC2_155 PVPSGYLTAGQPGLETEKSALADITMDDLADAVVDALAEVRSRFARVLLV
TH_2893|M.thermoresistible__bu TLAR------------------------DAHVVRDALKQFDQ---PAVLV
MAV_2604|M.avium_104 GDLATVTIADWV------------------DSVIADIEEAGLG--DIVIV
MUL_2524|M.ulcerans_Agy99 WAAPWSIDANVS-------------------ALAALLKDQADG--PVVVV
MAB_0554|M.abscessus_ATCC_1997 VRDAQPVSTERY-----------------VDALAEAVRSVGA---PVVLI
. .::
Mflv_2476|M.gilvum_PYR-GCK GHSGGGFDATLAADARP-DLVSHITYLAAALPREGRTYPEAMAMRDDDNG
Mvan_4177|M.vanbaalenii_PYR-1 GHSGGGFDATLAADARP-DLVHHIVYLAAALPREGRTYPEAMAMRDAEQG
Mb0046c|M.bovis_AF2122/97 GMSLGGLTAIRLAAMAP-DLVGELVLVDVTPS----ALQRHAELTAEQRG
Rv0045c|M.tuberculosis_H37Rv GMSLGGLTAIRLAAMAP-DLVGELVLVDVTPS----ALQRHAELTAEQRG
MMAR_0064|M.marinum_M GMSLGGLTAIRLGALAP-ELVDELVLIDVTPS----ALQRHAEMTAEQRG
MSMEG_6710|M.smegmatis_MC2_155 AHSAGGGPASLAAEKAP-ELVDHLVYLAAFVP---AARPRFTDYINAPEN
TH_2893|M.thermoresistible__bu GHSYGG-AVITEASADN-DHVAHLIYVCAALP-------------QAGES
MAV_2604|M.avium_104 GHSMAGVTVPGVVAKLGSSRVREMVLATAFVP-----------------P
MUL_2524|M.ulcerans_Agy99 GHSFGGAVALQLAAAHP-DLVAALILLDPAIG----------LDGSRVRE
MAB_0554|M.abscessus_ATCC_1997 GHSMGGLHSWCLAAQRP-DLVSALVVEDMAPD------------------
. * .* . * :
Mflv_2476|M.gilvum_PYR-GCK PVELGEDFDGDVGEMLGYLHFDDTGAMKFADFDGAWKYFYHDCDEETARW
Mvan_4177|M.vanbaalenii_PYR-1 PAELGDEFDGDVGEMLGYLNFDEDGAMTFADFEGAWKYFYHDCDEATARW
Mb0046c|M.bovis_AF2122/97 TVALMHG-EREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNW
Rv0045c|M.tuberculosis_H37Rv TVALMHG-EREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNW
MMAR_0064|M.marinum_M TVALMHG-EREFPSFQAMLDLTVAAAPHREVKALRRGVFHNSRRLENGNW
MSMEG_6710|M.smegmatis_MC2_155 ADVVALPIFSDP-ANLGAHRLNPLSSDAIEVDAIRRAFLTDMPPDAPEGW
TH_2893|M.thermoresistible__bu VSDVLARDPDPQGDLAPALEVREDGTATMKRDAARQALFN-DATEEQFES
MAV_2604|M.avium_104 QGSAIADTLGGPLAVFARRAARIGRPMKIPAPAARWAFCNGMTAAQR-RL
MUL_2524|M.ulcerans_Agy99 VVDAMVAFPDYTDPAEARMERAYGAWADVDPAVLDAELDEHLITLPNGRY
MAB_0554|M.abscessus_ATCC_1997 -FVGGTTGPWEPWLYSWPEVFTSAGEFTARFGEIAGRYFREAFDRVDDGW
Mflv_2476|M.gilvum_PYR-GCK AFERLGPERFGDTT-----VTPVSVPNFWAADLPRSFIVCEQDQAMPRWL
Mvan_4177|M.vanbaalenii_PYR-1 AFERLGPERFGDTT-----VTPVSVPDFWAADLPRSFIVCEQDRSMPRWL
Mb0046c|M.bovis_AF2122/97 VWRYDAIRTFGDFAGLWDDVDALSAPITLVRGGSSGFVTDQDTAELHRRA
Rv0045c|M.tuberculosis_H37Rv VWRYDAIRTFGDFAGLWDDVDALSAPITLVRGGSSGFVTDQDTAELHRRA
MMAR_0064|M.marinum_M AWRYDAIRAFPDFAVLWDDVDALAAPVTLVRGGKSGFVSDEDIAELRGRA
MSMEG_6710|M.smegmatis_MC2_155 RHLLHPDEPYASLS------APVPVTPRRWGRIPRTYIRLDGDRALAPTT
TH_2893|M.thermoresistible__bu VVDKLGPHAMGTLS--------EPVTGLGWQQHPATYVIALRDQMFSVAL
MAV_2604|M.avium_104 TMSKLQAESARVPG-------EPVDRSGLPADVPRTWILTTRDRALSVAS
MUL_2524|M.ulcerans_Agy99 SWRISLPAMVCYWS------ELARDAALPPPGIATTLVRAVRADPQYVSD
MAB_0554|M.abscessus_ATCC_1997 RLHGPIEEWISTAAEWG-----VRDFWDQWRAVQCPALLLEADDTVTPAG
:
Mflv_2476|M.gilvum_PYR-GCK ADTVARRLG-------VDQLTIDASHSPFLSRPREFADLLVHATTTTPVA
Mvan_4177|M.vanbaalenii_PYR-1 ADTVARRLG-------VEQLTIDASHSPFLSRPRELAELLVRATTTTPVS
Mb0046c|M.bovis_AF2122/97 THFRG------------VHIVEKSGHSVQSDQPRALIEIVRGVLDTR---
Rv0045c|M.tuberculosis_H37Rv THFRG------------VHIVEKSGHSVQSDQPRALIEIVRGVLDTR---
MMAR_0064|M.marinum_M KGFRG------------AQTVENSGHSVQSDQPRVLVEILRGVLGGR---
MSMEG_6710|M.smegmatis_MC2_155 QNLMIAEADRLTPDNPFGVRSLPGDHSPMVHRPGELADLLAGI-------
TH_2893|M.thermoresistible__bu QEEFASHVG--------TVAKIDTGHGPMATRPAELAEIIATAAR-----
MAV_2604|M.avium_104 QHASIAALG-----GVETVIPVDACHEVMFSHPERLAQILIERCRLRGVG
MUL_2524|M.ulcerans_Agy99 ELIAALRERLG---ADFALREFECGHMVPQAKPTEVATLIREQLKTP---
MAB_0554|M.abscessus_ATCC_1997 QMQKMSEIG----RRTTYFKIAGSGHLMHDDSPKLYRSAVSDFLAAPGAP
* * :
Mflv_2476|M.gilvum_PYR-GCK PLRPL-
Mvan_4177|M.vanbaalenii_PYR-1 PLVPH-
Mb0046c|M.bovis_AF2122/97 ------
Rv0045c|M.tuberculosis_H37Rv ------
MMAR_0064|M.marinum_M ------
MSMEG_6710|M.smegmatis_MC2_155 ------
TH_2893|M.thermoresistible__bu ------
MAV_2604|M.avium_104 IR----
MUL_2524|M.ulcerans_Agy99 ------
MAB_0554|M.abscessus_ATCC_1997 GASVVA