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VGTEIEADGRALRLSRRERALEQMELHDIDILVLGRQANVRYISGAPQLWVVGTRPFGPICEFVRATGEI HLNSTWDEGIPEEIPHENLYGFAWNPMTLVGILKNIKGADTFRRVGTDALTPTFAKLLPMAFPNAELIDA EQAMQAARRIKTPEEIEALRRALVVAEEGLAAGAAALAPGTTENALAGAVLEAEAAGGVSTPATQDAAWV TSKDHPWRRAGGDGRVRDGDLVAVSAGVLADGYVAEVARTLHVGEPTDAVRALYRRRDDLWDRLIEACRP GRATSGLLDAYEAAGERLPAMPVAHGLGLGFDPPVVSPSLRASADAENLEAGMVLAVTAYVWEEGVGAVF TRDAVLITPDGAEILSSAPAYREAVHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2421 | - | - | 100% (377) | peptidase M24 |
| M. gilvum PYR-GCK | Mflv_2420 | - | 6e-20 | 26.40% (394) | peptidase M24 |
| M. gilvum PYR-GCK | Mflv_3098 | - | 9e-13 | 27.59% (261) | peptidase M24 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2116c | pepE | 1e-12 | 27.56% (283) | dipeptidase PepE |
| M. tuberculosis H37Rv | Rv2089c | pepE | 1e-12 | 27.56% (283) | dipeptidase PepE |
| M. leprae Br4923 | MLBr_01576 | mapB | 2e-10 | 26.71% (277) | methionine aminopeptidase |
| M. abscessus ATCC 19977 | MAB_2192 | - | 1e-11 | 27.57% (272) | dipeptidase PepE |
| M. marinum M | MMAR_4759 | - | 1e-136 | 63.73% (375) | aminopeptidase |
| M. avium 104 | MAV_2971 | - | 1e-138 | 64.25% (372) | peptidase, M24 family protein |
| M. smegmatis MC2 155 | MSMEG_4853 | - | 0.0 | 82.23% (377) | peptidase, M24 family protein |
| M. thermoresistible (build 8) | TH_2275 | - | 1e-104 | 71.60% (257) | peptidase, M24 family protein |
| M. ulcerans Agy99 | MUL_0330 | - | 1e-135 | 63.47% (375) | aminopeptidase |
| M. vanbaalenii PYR-1 | Mvan_4231 | - | 0.0 | 87.00% (377) | peptidase M24 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2116c|M.bovis_AF2122/97 --MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRAET
Rv2089c|M.tuberculosis_H37Rv --MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRAET
MAB_2192|M.abscessus_ATCC_1997 --MAPQRFESDVYADRLRRAAQEAEKVGVTGLVVTPGYDLRYLTGSRAQT
Mflv_2421|M.gilvum_PYR-GCK MGTEIEADGRALRLSRRERALEQMELHDIDILVLGRQANVRYISG-APQL
Mvan_4231|M.vanbaalenii_PYR-1 MGTEIEADGRALRFSRRERALAQMEAHDLDMLVLGRQANVRYISG-APQL
MSMEG_4853|M.smegmatis_MC2_155 MGIDIEADNRALRVSRRERALAQMEAYDLDVLVLGRQANVRYISG-APQL
MMAR_4759|M.marinum_M MSTEVLPDNRALRCGRRQRALEQMAAHDLDVLVLGRQANVRYVSG-TPQL
MUL_0330|M.ulcerans_Agy99 MSTEVLPDNRALRCGRRQRALEQMAAHDLDVLVLGRQANVRYVSG-TPQL
TH_2275|M.thermoresistible__bu MSTEILPDDRALRHARRNRALAQMAEHDLDILVLGRQANVRYVTG-APQL
MAV_2971|M.avium_104 MATEVLPDAPALRLARRQRALAAMDEHGLDMLVLGRQANIRYVTG-APQL
MLBr_01576|M.leprae_Br4923 -----MPARTALSPGFLSPTLPVPAWIPRPEYVGKPTAQE------GSES
: : * : .:
Mb2116c|M.bovis_AF2122/97 FERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRVCDWVDGD--DP
Rv2089c|M.tuberculosis_H37Rv FERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRVCDWVDGD--DP
MAB_2192|M.abscessus_ATCC_1997 FERLTALVVPATGQPTVVAPRMELAALRDSAIGDLNIPISDWVDGE--NP
Mflv_2421|M.gilvum_PYR-GCK WVVGTRPFGPICEFVRATGEIHLNSTWDEGIPEEIPHENLYGFAWNPMTL
Mvan_4231|M.vanbaalenii_PYR-1 WVVGTRPFGPICEFVRATGEIHLNSTWDEGIPEEIPHQNLYGFAWNPMTL
MSMEG_4853|M.smegmatis_MC2_155 WVVGTRPFGPICTYVRATGEIHLNSTWDEGIPEEIPHENLYGLAWNPMTL
MMAR_4759|M.marinum_M WVAGTRPFGPTCVLVRATGAIHLLSTWDEGVPDDIPHENLYGISWNPMNT
MUL_0330|M.ulcerans_Agy99 WVAGTRPFGPTCVLVRATGAIHLLSTWDEGVPDDIPHENLYGISWNPMNT
TH_2275|M.thermoresistible__bu WVAGTRPFGPVCAMLRS-GEIHLNSTWDEGIPEEIGHDHLYGLAWNPMTL
MAV_2971|M.avium_104 WIAGTRPFGPMCVLVRATGDIYLNSTDDEGVPEEIDHDHLYGLAWNPVTL
MLBr_01576|M.leprae_Br4923 WVQTPEVVEKMRVAGRIAAGALTEAG--KAVAPGVTTDELDRIVHEYMVN
: . . : .. : . :
Mb2116c|M.bovis_AF2122/97 YGLVSAVLGGAPVATAVTDSMPALHMLPLADALGVLPVLATD-VLRRLRM
Rv2089c|M.tuberculosis_H37Rv YGLVSAVLGGAPVATAVTDSMPALHMLPLADALGVLPVLATD-VLRRLRM
MAB_2192|M.abscessus_ATCC_1997 YELVRAALG-TAGTVAVTESMPALHLLPLAQLVGTVPVLATG-VLRRLRM
Mflv_2421|M.gilvum_PYR-GCK VGILKNIKGADTFRRVGTDALTPTFAKLLPMAFPNAELIDAEQAMQAARR
Mvan_4231|M.vanbaalenii_PYR-1 VGILQSIKGADTVRRVGTDALTPTFAKLLPMAFPHADLVDAEQAMQAARR
MSMEG_4853|M.smegmatis_MC2_155 IGVLQNIKGTATARRVGTDALTPTFAKLLPMAFPQAELVDGEQAMRDARR
MMAR_4759|M.marinum_M ISVLERIDGAATARRVGTDALSPVFAQLLPQAFPNAELVDGELAMRAARR
MUL_0330|M.ulcerans_Agy99 ISVLERIDGAATARRVGTDALSPVFAQLLPQAFPNAELVDDELAMRAARR
TH_2275|M.thermoresistible__bu IGVLRGIAGADTARRVGTDALTPSFAQLLPMAFPNAELVDAEPAMRAARR
MAV_2971|M.avium_104 IDVLRKVEGAESARRVGTDALTPTFAALLPEAFPNAELVDAEPAMRAARR
MLBr_01576|M.leprae_Br4923 HGAYPSTLGYKGYPKSCCTSLN----EVICHGIPDSTVIADG--------
* :: : . ::
Mb2116c|M.bovis_AF2122/97 VKEETEIDALRKAGAAIDRVHARVPEFLVPGRTEADVAADIAEAIVAEGH
Rv2089c|M.tuberculosis_H37Rv VKEETEIDALRKAGAAIDRVHARVPEFLVPGRTEADVAADIAEAIVAEGH
MAB_2192|M.abscessus_ATCC_1997 VKDASEIDALRKAGAAIDRVHALVPELLIPGRTEAQVAADIAEAIVAEGH
Mflv_2421|M.gilvum_PYR-GCK IKTPEEIEALRRALVVAEEGLAAGAAALAPGTTENALAGAVLEAEAAGGV
Mvan_4231|M.vanbaalenii_PYR-1 IKTPEEVQALRRALVVAEEGLAAGVAALRPGIAEKALAGAVLEAEAAGGV
MSMEG_4853|M.smegmatis_MC2_155 IKTPEEIEALRWALSIAEKGLAAGVAEVHAGTSEQALSGAILEAEAAGGV
MMAR_4759|M.marinum_M IKTDEEVVALRAAIAVAESGLAAAVAELRTGVSEQLLAGVLVEAVAAGGV
MUL_0330|M.ulcerans_Agy99 IKTDEEEVALRAAIAVAESGLAAAVAELRTGVSEQLLAGVLVEAVLAGGV
TH_2275|M.thermoresistible__bu VKTVEEVRTLGAALRVAEQAVAAAVAELRPGVTEKTLAGIMLEAEAAGGV
MAV_2971|M.avium_104 IKTPDEITAMGAALRVAEHGLAAALAELAPGAAERTLAGAMMEAMAAGGV
MLBr_01576|M.leprae_Br4923 --------------DIVNIDVTAYIDGVHGDTNATFLSGDVSESHRLLVE
: : : . ::. : *:
Mb2116c|M.bovis_AF2122/97 SEVAFVIVGSGPHGADPHH-GYSDRELREGDIVVVDIGGTYGPGYHSDST
Rv2089c|M.tuberculosis_H37Rv SEVAFVIVGSGPHGADPHH-GYSDRELREGDIVVVDIGGTYGPGYHSDST
MAB_2192|M.abscessus_ATCC_1997 SEVAFIIVGSGPHGADPHH-ECSDRELRTGDIVVVDIGGSYEPGYNSDST
Mflv_2421|M.gilvum_PYR-GCK STPATQDAAWVTSKDHPWRRAGGDGRVRDGDLVAVSAG-VLADGYVAEVA
Mvan_4231|M.vanbaalenii_PYR-1 STPATQDAAWVTSKEHPWRRSDGDGLVREGDLVAMSAG-VLADGYVAEVA
MSMEG_4853|M.smegmatis_MC2_155 STPATQDAAWVTSTEHPWRRAEGDGRVRDGDLVALSAG-VLADGYVAEVA
MMAR_4759|M.marinum_M STPSNQDVAWVTSREHPWRRASGDRRVRSGDLVAFSAG-VLAGGYIGEVG
MUL_0330|M.ulcerans_Agy99 STPSNQDVAWVTSREHPWRRASGDRRVRSGDLVAFSAG-VLAGGYIGEVG
TH_2275|M.thermoresistible__bu STPATQDVAWVTSREHPWRRARTDGRVQEGDLVTFAAG-VLADGYVGEVG
MAV_2971|M.avium_104 STPATQDAAWVTSRERPWRRAGS-GEVRPGDLVAFAAG-ALADGYVAEVG
MLBr_01576|M.leprae_Br4923 RTR--EATMRAINAVKPGRALSIIGRVIES----------YANRFGYNVV
. * : : . : :
Mb2116c|M.bovis_AF2122/97 RTYSIGEPDS-DVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLAE
Rv2089c|M.tuberculosis_H37Rv RTYSIGEPDS-DVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLAE
MAB_2192|M.abscessus_ATCC_1997 RTYSIGEPDP-DVAQRISVLERAQQAAVHAARPGVTAESVDAAARRVLTE
Mflv_2421|M.gilvum_PYR-GCK RTLHVGEPTD-AVRALYRRRDDLWDRLIEACRPGRATSGLLDAYEAAG-E
Mvan_4231|M.vanbaalenii_PYR-1 RTLYVGDPTD-AVRALYRRRDDLWDRLLQACRPGAPVSSLLDAYGQAG-E
MSMEG_4853|M.smegmatis_MC2_155 RTLYVGEPTD-AVRALYRRRDDLWDRLADACRPGRPTSALLDAYEQAG-E
MMAR_4759|M.marinum_M RTWPADG-VA-GAAPLYQRWAKLWEGLLLACQPGVGAGELLNAYRQAG-E
MUL_0330|M.ulcerans_Agy99 RTWPADG-VA-GAAPLYQRWAKLWDGLLLACQPGAGAGELLNAYRQAG-E
TH_2275|M.thermoresistible__bu RTWPVXX----------------XTAVGVPCRDG-AHRTVVVALQHRN-L
MAV_2971|M.avium_104 RTWPAGDTVGGQVRALFGRSNALYDRMLAACRPGASTGDLLAAYRAVD-E
MLBr_01576|M.leprae_Br4923 RHFTGHG-------------------IGTTFHNGLVVLHYDQPFVTTIMQ
* . : * .
Mb2116c|M.bovis_AF2122/97 AGLAEYFVHRTGHG-IGLCVHEEPYIVAGNDLVLVPGMAFSIEPGIYFPG
Rv2089c|M.tuberculosis_H37Rv AGLAEYFVHRTGHG-IGLCVHEEPYIVAGNDLVLVPGMAFSIEPGIYFPG
MAB_2192|M.abscessus_ATCC_1997 AGMGEAFVHRTGHG-IGLSVHEEPYIVEGNELVLEPGMAFSIEPGVYFPG
Mflv_2421|M.gilvum_PYR-GCK RLPAMPVAHGLGLG-FDPPVVSPSLRASADAENLEAGMVLAVTAYVWEEG
Mvan_4231|M.vanbaalenii_PYR-1 PLPAMPVAHGLGLG-FDPPVVSPNLRATMEAERLEEGMVLAVTAYVWEQG
MSMEG_4853|M.smegmatis_MC2_155 PLPAMPVAHGLGLG-FDPPVVSPALRATADGERFEEGMVLAVTSYVWEAG
MMAR_4759|M.marinum_M PAPPMPVARGLGMG-FDPPVISAQLPATAANDRLEPGMVLAVTGYVWEAG
MUL_0330|M.ulcerans_Agy99 PAPPMPVARGLGMG-FDPTVISAQLPATAANDRLEPGMVLAVTGYVWEAG
TH_2275|M.thermoresistible__bu PEPTVAAAVAVHMQ-HDLKWLSVRRAAVC---------------------
MAV_2971|M.avium_104 PVPPMPVAHGLGLG-FDPPVVSETLAAAGERDRMEAGMVLAITGYVWQRG
MLBr_01576|M.leprae_Br4923 PGMTFTIEPMINLGTLDYEVWDDGWTVVTKDR------------------
. . .
Mb2116c|M.bovis_AF2122/97 RWGARIEDIVIVTEDGAVSVNNCPHELIVVPVS
Rv2089c|M.tuberculosis_H37Rv RWGARIEDIVIVTEDGAVSVNNCPHELIVVPVS
MAB_2192|M.abscessus_ATCC_1997 QWGARIEDIVVITENGCESVNSRPHGLTVVPTR
Mflv_2421|M.gilvum_PYR-GCK VGAVFTRDAVLITPDGAEILSSAPAYREAVHG-
Mvan_4231|M.vanbaalenii_PYR-1 LGGVFTRDAVLITADGAEILSTAPAYGESVHG-
MSMEG_4853|M.smegmatis_MC2_155 IGAVFTRDAVVIGADGPDVLTTVPVYGEAVHG-
MMAR_4759|M.marinum_M VGAVFGREAVLVNADGPEVLTASPMWQA-----
MUL_0330|M.ulcerans_Agy99 VGAVFGREAVLVNADGPEVLTASPMWQA-----
TH_2275|M.thermoresistible__bu ---------------------------------
MAV_2971|M.avium_104 IGAVFRRDTVHITEGGVQVLTASPTWTGPLP--
MLBr_01576|M.leprae_Br4923 KWTAQFEHTLLVTDTGVEILTVQ----------