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STEVLPDNRALRCGRRQRALEQMAAHDLDVLVLGRQANVRYVSGTPQLWVAGTRPFGPTCVLVRATGAIH LLSTWDEGVPDDIPHENLYGISWNPMNTISVLERIDGAATARRVGTDALSPVFAQLLPQAFPNAELVDGE LAMRAARRIKTDEEVVALRAAIAVAESGLAAAVAELRTGVSEQLLAGVLVEAVAAGGVSTPSNQDVAWVT SREHPWRRASGDRRVRSGDLVAFSAGVLAGGYIGEVGRTWPADGVAGAAPLYQRWAKLWEGLLLACQPGV GAGELLNAYRQAGEPAPPMPVARGLGMGFDPPVISAQLPATAANDRLEPGMVLAVTGYVWEAGVGAVFGR EAVLVNADGPEVLTASPMWQA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4759 | - | - | 100% (372) | aminopeptidase |
| M. marinum M | MMAR_4760 | - | 4e-21 | 25.44% (397) | dipeptidase |
| M. marinum M | MMAR_2180 | pepQ | 1e-05 | 23.31% (356) | cytoplasmic peptidase PepQ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2564c | pepQ | 9e-07 | 22.62% (367) | putative cytoplasmic peptidase PEPQ |
| M. gilvum PYR-GCK | Mflv_2421 | - | 1e-136 | 63.73% (375) | peptidase M24 |
| M. tuberculosis H37Rv | Rv2535c | pepQ | 9e-07 | 22.62% (367) | cytoplasmic peptidase PepQ |
| M. leprae Br4923 | MLBr_00521 | pepQ | 4e-07 | 23.28% (378) | putative cytoplasmic peptidase |
| M. abscessus ATCC 19977 | MAB_2838c | - | 1e-11 | 26.90% (368) | putative cytoplasmic peptidase PepQ |
| M. avium 104 | MAV_0892 | - | 1e-177 | 80.75% (374) | peptidase, M24 family protein |
| M. smegmatis MC2 155 | MSMEG_4853 | - | 1e-142 | 67.39% (371) | peptidase, M24 family protein |
| M. thermoresistible (build 8) | TH_2275 | - | 1e-105 | 73.41% (252) | peptidase, M24 family protein |
| M. ulcerans Agy99 | MUL_0330 | - | 0.0 | 98.39% (372) | aminopeptidase |
| M. vanbaalenii PYR-1 | Mvan_4231 | - | 1e-139 | 64.96% (371) | peptidase M24 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4759|M.marinum_M MSTEVLPDNRALRCGRRQRALEQMAAHDLDVLVLGRQANVRYVSGTP---
MUL_0330|M.ulcerans_Agy99 MSTEVLPDNRALRCGRRQRALEQMAAHDLDVLVLGRQANVRYVSGTP---
MAV_0892|M.avium_104 MSVEVCPDERTLRSGRRRRALDQMAAHDLDVLVLGRQANVRYVSGAP---
Mflv_2421|M.gilvum_PYR-GCK MGTEIEADGRALRLSRRERALEQMELHDIDILVLGRQANVRYISGAP---
Mvan_4231|M.vanbaalenii_PYR-1 MGTEIEADGRALRFSRRERALAQMEAHDLDMLVLGRQANVRYISGAP---
MSMEG_4853|M.smegmatis_MC2_155 MGIDIEADNRALRVSRRERALAQMEAYDLDVLVLGRQANVRYISGAP---
TH_2275|M.thermoresistible__bu MSTEILPDDRALRHARRNRALAQMAEHDLDILVLGRQANVRYVTGAP---
Mb2564c|M.bovis_AF2122/97 ----------MTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSN
Rv2535c|M.tuberculosis_H37Rv ----------MTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSN
MLBr_00521|M.leprae_Br4923 ----------MTHSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTGSN
MAB_2838c|M.abscessus_ATCC_199 ----------------------MLRAEDLDALLVTDLINIRYLTGFTGSA
: .:* ::: *:**::* .
MMAR_4759|M.marinum_M -QLWVAGTRPFGPTCVLVRATGAIHLLSTWDEGVPDDIPHENLYGISWNP
MUL_0330|M.ulcerans_Agy99 -QLWVAGTRPFGPTCVLVRATGAIHLLSTWDEGVPDDIPHENLYGISWNP
MAV_0892|M.avium_104 -QLWVAGTRPFGPTCVLVRETGAVHLLSTWDEGVPEDIPHENLYGISWNP
Mflv_2421|M.gilvum_PYR-GCK -QLWVVGTRPFGPICEFVRATGEIHLNSTWDEGIPEEIPHENLYGFAWNP
Mvan_4231|M.vanbaalenii_PYR-1 -QLWVVGTRPFGPICEFVRATGEIHLNSTWDEGIPEEIPHQNLYGFAWNP
MSMEG_4853|M.smegmatis_MC2_155 -QLWVVGTRPFGPICTYVRATGEIHLNSTWDEGIPEEIPHENLYGLAWNP
TH_2275|M.thermoresistible__bu -QLWVAGTRPFGPVCAMLRS-GEIHLNSTWDEGIPEEIGHDHLYGLAWNP
Mb2564c|M.bovis_AF2122/97 GALLVFAD----ERDAVLATDGRYRTQAASQAPDLEVAIERAVGRYLAGR
Rv2535c|M.tuberculosis_H37Rv GALLVFAD----ERDAVLATDGRYRTQAASQAPDLEVAIERAVGRYLAGR
MLBr_00521|M.leprae_Br4923 GALLVFAD----ERGAVLATDGRYRTQAAQQVPELEVAIEQSCGRYLAGR
MAB_2838c|M.abscessus_ATCC_199 AALWVAAGDGPEEKATVLCTDGRYRTQAAAQVPDLRALIDR---RYGAAL
* * . : * : :: : .
MMAR_4759|M.marinum_M MNTISVLERIDGAATARRVGTDALSPVFAQLLPQAFPNAELVDGELAMRA
MUL_0330|M.ulcerans_Agy99 MNTISVLERIDGAATARRVGTDALSPVFAQLLPQAFPNAELVDDELAMRA
MAV_0892|M.avium_104 ANTVAALRRIDGTQTARRVGTDALSPVFAQLLPTVFPNAQLVDGELAMRA
Mflv_2421|M.gilvum_PYR-GCK MTLVGILKNIKGADTFRRVGTDALTPTFAKLLPMAFPNAELIDAEQAMQA
Mvan_4231|M.vanbaalenii_PYR-1 MTLVGILQSIKGADTVRRVGTDALTPTFAKLLPMAFPHADLVDAEQAMQA
MSMEG_4853|M.smegmatis_MC2_155 MTLIGVLQNIKGTATARRVGTDALTPTFAKLLPMAFPQAELVDGEQAMRD
TH_2275|M.thermoresistible__bu MTLIGVLRGIAGADTARRVGTDALTPSFAQLLPMAFPNAELVDAEPAMRA
Mb2564c|M.bovis_AF2122/97 AGEAGVGKLGFESHVVTVDGLDALAG------ALEGKNTELVRASGTVES
Rv2535c|M.tuberculosis_H37Rv AGEAGVGKLGFESHVVTVDGLDALAG------ALEGKNTELVRASGTVES
MLBr_00521|M.leprae_Br4923 AADDGVCILGFESHVVTVDGLDALTG------ELEGRHTELVRAPGTVEV
MAB_2838c|M.abscessus_ATCC_199 VAHAPAGRAGFESHVVTVDGFDKLAE------AAT--DVELVRAPNRIEK
: . * * *: ..:*: :.
MMAR_4759|M.marinum_M ARRIKTDEEVVALRAAIAVAESGLAAAVA--ELRTGVSEQLLAGVLVEAV
MUL_0330|M.ulcerans_Agy99 ARRIKTDEEEVALRAAIAVAESGLAAAVA--ELRTGVSEQLLAGVLVEAV
MAV_0892|M.avium_104 ARRVKTAEEMVALRESIAVAESALAAAVS--ELRPGVSEQALAGVLLEAS
Mflv_2421|M.gilvum_PYR-GCK ARRIKTPEEIEALRRALVVAEEGLAAGAA--ALAPGTTENALAGAVLEAE
Mvan_4231|M.vanbaalenii_PYR-1 ARRIKTPEEVQALRRALVVAEEGLAAGVA--ALRPGIAEKALAGAVLEAE
MSMEG_4853|M.smegmatis_MC2_155 ARRIKTPEEIEALRWALSIAEKGLAAGVA--EVHAGTSEQALSGAILEAE
TH_2275|M.thermoresistible__bu ARRVKTVEEVRTLGAALRVAEQAVAAAVA--ELRPGVTEKTLAGIMLEAE
Mb2564c|M.bovis_AF2122/97 LREVKDAGELALLRLACEAADAALTDLVARGGLRPGRTERQVSRELEALM
Rv2535c|M.tuberculosis_H37Rv LREVKDAGELALLRLACEAADAALTDLVARGGLRPGRTERQVSRELEALM
MLBr_00521|M.leprae_Br4923 LREVKDAGELALLRLAAEAADAALTELVARGGVRPGLTEREVGRELEGLM
MAB_2838c|M.abscessus_ATCC_199 LREVKDDSEVLLLERACAAADTALAALIETGGIRPGRTEREVARDLENLM
*.:* * * : *: .:: : .* :*. :. :
MMAR_4759|M.marinum_M AAGGVSTPSNQDVAWVTSREHPWRRASGDRRVRSGDLVAFSAGVLAGGYI
MUL_0330|M.ulcerans_Agy99 LAGGVSTPSNQDVAWVTSREHPWRRASGDRRVRSGDLVAFSAGVLAGGYI
MAV_0892|M.avium_104 AAGGVSTPSNQDVAWATSRSHPWRRADGDGRIQDGDLVAFSAGVLAGGYV
Mflv_2421|M.gilvum_PYR-GCK AAGGVSTPATQDAAWVTSKDHPWRRAGGDGRVRDGDLVAVSAGVLADGYV
Mvan_4231|M.vanbaalenii_PYR-1 AAGGVSTPATQDAAWVTSKEHPWRRSDGDGLVREGDLVAMSAGVLADGYV
MSMEG_4853|M.smegmatis_MC2_155 AAGGVSTPATQDAAWVTSTEHPWRRAEGDGRVRDGDLVALSAGVLADGYV
TH_2275|M.thermoresistible__bu AAGGVSTPATQDVAWVTSREHPWRRARTDGRVQEGDLVTFAAGVLADGYV
Mb2564c|M.bovis_AF2122/97 LDHGADAVSFETIVAAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYH
Rv2535c|M.tuberculosis_H37Rv LDHGADAVSFETIVAAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYH
MLBr_00521|M.leprae_Br4923 LDHGADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFVKIDFGALVAGYH
MAB_2838c|M.abscessus_ATCC_199 AEHGADGPSFETIVAAGPNSAIPHHRPTGAMLAAGDFVKIDFGALVAGYH
*.. : : . . . . :: . : **:* . *.*. **
MMAR_4759|M.marinum_M GEVGRTWPADG---VAGAAPLYQRWAKLWEGLLLACQPGVGAGELLNAYR
MUL_0330|M.ulcerans_Agy99 GEVGRTWPADG---VAGAAPLYQRWAKLWDGLLLACQPGAGAGELLNAYR
MAV_0892|M.avium_104 GEVGRTWPADKKHAPSGAEALHRRWDALWDKLIAACHPDVRADELMTAYR
Mflv_2421|M.gilvum_PYR-GCK AEVARTLHVGEP--TDAVRALYRRRDDLWDRLIEACRPGRATSGLLDAYE
Mvan_4231|M.vanbaalenii_PYR-1 AEVARTLYVGDP--TDAVRALYRRRDDLWDRLLQACRPGAPVSSLLDAYG
MSMEG_4853|M.smegmatis_MC2_155 AEVARTLYVGEP--TDAVRALYRRRDDLWDRLADACRPGRPTSALLDAYE
TH_2275|M.thermoresistible__bu GEVGRTWPVXXX-----------------TAVGVPCRDG-AHRTVVVALQ
Mb2564c|M.bovis_AF2122/97 SDMTRTFVLGKA--ADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAAAR
Rv2535c|M.tuberculosis_H37Rv SDMTRTFVLGKA--ADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAAAR
MLBr_00521|M.leprae_Br4923 SDMTRTFVLGPA--ADWQLEIYQLVADAQRAGRKALRPGANLRDVDAAAR
MAB_2838c|M.abscessus_ATCC_199 SDMTRTLVLGSA--APWQQEIHELVLTAQAAGRAALAPGASLKNVDAAAR
.:: ** . . : *
MMAR_4759|M.marinum_M QAGEPAPP-MPVARGLGMGFDPPVISAQLPATAANDRLEPGMVLAVTGYV
MUL_0330|M.ulcerans_Agy99 QAGEPAPP-MPVARGLGMGFDPTVISAQLPATAANDRLEPGMVLAVTGYV
MAV_0892|M.avium_104 AAGEPAPP-MPVARGLGMGFDPPVVSQHLPATAAGERLEPGMVLAVTGYV
Mflv_2421|M.gilvum_PYR-GCK AAGERLPA-MPVAHGLGLGFDPPVVSPSLRASADAENLEAGMVLAVTAYV
Mvan_4231|M.vanbaalenii_PYR-1 QAGEPLPA-MPVAHGLGLGFDPPVVSPNLRATMEAERLEEGMVLAVTAYV
MSMEG_4853|M.smegmatis_MC2_155 QAGEPLPA-MPVAHGLGLGFDPPVVSPALRATADGERFEEGMVLAVTSYV
TH_2275|M.thermoresistible__bu HRNLPEPT-VAAAVAVHMQHDLKWLSVRRAAVC-----------------
Mb2564c|M.bovis_AF2122/97 QLIADAGYGEHFGHGLGHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGV
Rv2535c|M.tuberculosis_H37Rv QLIADAGYGEHFGHGLGHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGV
MLBr_00521|M.leprae_Br4923 QLIVDAGYGQQFSHGLGHGVGLEIHEAPGIGTTSAGTLLAGSVVTVEPGV
MAB_2838c|M.abscessus_ATCC_199 DVITAAGYGENFGHGLGHGVGLQIHEAPGIGSTATGTLLAGSAVTVEPGV
. .: . . .
MMAR_4759|M.marinum_M WEAGVGAVFGREAVLVNADG--------------PEVLTASPMWQA----
MUL_0330|M.ulcerans_Agy99 WEAGVGAVFGREAVLVNADG--------------PEVLTASPMWQA----
MAV_0892|M.avium_104 WEEGVGAVFGREAVLITADG--------------PEVLTASPFWQP----
Mflv_2421|M.gilvum_PYR-GCK WEEGVGAVFTRDAVLITPDG--------------AEILSSAPAYREAVHG
Mvan_4231|M.vanbaalenii_PYR-1 WEQGLGGVFTRDAVLITADG--------------AEILSTAPAYGESVHG
MSMEG_4853|M.smegmatis_MC2_155 WEAGIGAVFTRDAVVIGADG--------------PDVLTTVPVYGEAVHG
TH_2275|M.thermoresistible__bu --------------------------------------------------
Mb2564c|M.bovis_AF2122/97 YLPGRGGVRIEDTLVVAG-GTPKMPETAGQT---PELLTRFPKELAIL--
Rv2535c|M.tuberculosis_H37Rv YLPGRGGVRIEDTLVVAG-GTPKMPETAGQT---PELLTRFPKELAIL--
MLBr_00521|M.leprae_Br4923 YLSGRGGVRIEDTLVVAAKGTSETPITSRPTGFIPELLTRFPKELAIL--
MAB_2838c|M.abscessus_ATCC_199 YLPDRGGVRIEDTLVVRP-----------DG---PELLTRFPKELIVID-