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GTEIEADGRALRFSRRERALAQMEAHDLDMLVLGRQANVRYISGAPQLWVVGTRPFGPICEFVRATGEIH LNSTWDEGIPEEIPHQNLYGFAWNPMTLVGILQSIKGADTVRRVGTDALTPTFAKLLPMAFPHADLVDAE QAMQAARRIKTPEEVQALRRALVVAEEGLAAGVAALRPGIAEKALAGAVLEAEAAGGVSTPATQDAAWVT SKEHPWRRSDGDGLVREGDLVAMSAGVLADGYVAEVARTLYVGDPTDAVRALYRRRDDLWDRLLQACRPG APVSSLLDAYGQAGEPLPAMPVAHGLGLGFDPPVVSPNLRATMEAERLEEGMVLAVTAYVWEQGLGGVFT RDAVLITADGAEILSTAPAYGESVHG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4231 | - | - | 100% (377) | peptidase M24 |
| M. vanbaalenii PYR-1 | Mvan_4232 | - | 1e-17 | 24.94% (393) | peptidase M24 |
| M. vanbaalenii PYR-1 | Mvan_3437 | - | 1e-11 | 27.30% (282) | peptidase M24 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2116c | pepE | 2e-11 | 26.79% (280) | dipeptidase PepE |
| M. gilvum PYR-GCK | Mflv_2421 | - | 0.0 | 87.00% (377) | peptidase M24 |
| M. tuberculosis H37Rv | Rv2089c | pepE | 2e-11 | 26.79% (280) | dipeptidase PepE |
| M. leprae Br4923 | MLBr_00521 | pepQ | 6e-13 | 25.47% (373) | putative cytoplasmic peptidase |
| M. abscessus ATCC 19977 | MAB_2838c | - | 1e-11 | 24.66% (369) | putative cytoplasmic peptidase PepQ |
| M. marinum M | MMAR_4759 | - | 1e-139 | 64.96% (371) | aminopeptidase |
| M. avium 104 | MAV_2971 | - | 1e-138 | 64.78% (372) | peptidase, M24 family protein |
| M. smegmatis MC2 155 | MSMEG_4853 | - | 0.0 | 82.23% (377) | peptidase, M24 family protein |
| M. thermoresistible (build 8) | TH_2275 | - | 1e-105 | 74.00% (250) | peptidase, M24 family protein |
| M. ulcerans Agy99 | MUL_0330 | - | 1e-138 | 64.69% (371) | aminopeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4231|M.vanbaalenii_PYR-1 MGTEIEADGRALRFSRRERALAQMEAHDLDMLVLGRQANVRYISGAPQLW
Mflv_2421|M.gilvum_PYR-GCK MGTEIEADGRALRLSRRERALEQMELHDIDILVLGRQANVRYISGAPQLW
MSMEG_4853|M.smegmatis_MC2_155 MGIDIEADNRALRVSRRERALAQMEAYDLDVLVLGRQANVRYISGAPQLW
MMAR_4759|M.marinum_M MSTEVLPDNRALRCGRRQRALEQMAAHDLDVLVLGRQANVRYVSGTPQLW
MUL_0330|M.ulcerans_Agy99 MSTEVLPDNRALRCGRRQRALEQMAAHDLDVLVLGRQANVRYVSGTPQLW
TH_2275|M.thermoresistible__bu MSTEILPDDRALRHARRNRALAQMAEHDLDILVLGRQANVRYVTGAPQLW
MAV_2971|M.avium_104 MATEVLPDAPALRLARRQRALAAMDEHGLDMLVLGRQANIRYVTGAPQLW
Mb2116c|M.bovis_AF2122/97 --MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRA--
Rv2089c|M.tuberculosis_H37Rv --MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRA--
MLBr_00521|M.leprae_Br4923 ----------MTHSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTG--
MAB_2838c|M.abscessus_ATCC_199 ----------------------MLRAEDLDALLVTDLINIRYLTGFTG--
.: ::: :: *: *
Mvan_4231|M.vanbaalenii_PYR-1 VVGTRPFGPICEFVRATGEIHLNSTWDEGIPEEIPHQNLYGFAWNPMTLV
Mflv_2421|M.gilvum_PYR-GCK VVGTRPFGPICEFVRATGEIHLNSTWDEGIPEEIPHENLYGFAWNPMTLV
MSMEG_4853|M.smegmatis_MC2_155 VVGTRPFGPICTYVRATGEIHLNSTWDEGIPEEIPHENLYGLAWNPMTLI
MMAR_4759|M.marinum_M VAGTRPFGPTCVLVRATGAIHLLSTWDEGVPDDIPHENLYGISWNPMNTI
MUL_0330|M.ulcerans_Agy99 VAGTRPFGPTCVLVRATGAIHLLSTWDEGVPDDIPHENLYGISWNPMNTI
TH_2275|M.thermoresistible__bu VAGTRPFGPVCAMLRS-GEIHLNSTWDEGIPEEIGHDHLYGLAWNPMTLI
MAV_2971|M.avium_104 IAGTRPFGPMCVLVRATGDIYLNSTDDEGVPEEIDHDHLYGLAWNPVTLI
Mb2116c|M.bovis_AF2122/97 ETFERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRVCDWVDGDDP
Rv2089c|M.tuberculosis_H37Rv ETFERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRVCDWVDGDDP
MLBr_00521|M.leprae_Br4923 SNGALLVFAD----ERGAVLATDGRYRTQAAQQVPELEVAIEQSCGRYLA
MAB_2838c|M.abscessus_ATCC_199 SAAALWVAAGDGPEEKATVLCTDGRYRTQAAAQVPDLRALIDRRYGAALV
: .
Mvan_4231|M.vanbaalenii_PYR-1 GILQSIKGADTVRRVGTDALTPTFAKLLPMAFPHADLVDAEQAMQAARRI
Mflv_2421|M.gilvum_PYR-GCK GILKNIKGADTFRRVGTDALTPTFAKLLPMAFPNAELIDAEQAMQAARRI
MSMEG_4853|M.smegmatis_MC2_155 GVLQNIKGTATARRVGTDALTPTFAKLLPMAFPQAELVDGEQAMRDARRI
MMAR_4759|M.marinum_M SVLERIDGAATARRVGTDALSPVFAQLLPQAFPNAELVDGELAMRAARRI
MUL_0330|M.ulcerans_Agy99 SVLERIDGAATARRVGTDALSPVFAQLLPQAFPNAELVDDELAMRAARRI
TH_2275|M.thermoresistible__bu GVLRGIAGADTARRVGTDALTPSFAQLLPMAFPNAELVDAEPAMRAARRV
MAV_2971|M.avium_104 DVLRKVEGAESARRVGTDALTPTFAALLPEAFPNAELVDAEPAMRAARRI
Mb2116c|M.bovis_AF2122/97 YGLVSAVLGGAPVATAVTDSMPALHMLPLADALGVLPVLATDVLRRLRMV
Rv2089c|M.tuberculosis_H37Rv YGLVSAVLGGAPVATAVTDSMPALHMLPLADALGVLPVLATDVLRRLRMV
MLBr_00521|M.leprae_Br4923 GRAADDGVCILGFESHVVTVDGLDALTGELEGRHTELVRAPGTVEVLREV
MAB_2838c|M.abscessus_ATCC_199 AHAPAG---RAGFESHVVTVDGFDKLAEAAT--DVELVRAPNRIEKLREV
. . : :. * :
Mvan_4231|M.vanbaalenii_PYR-1 KTPEEVQALRRALVVAEEGLAAGVAA--LRPGIAEKALAGAVLEAEAAGG
Mflv_2421|M.gilvum_PYR-GCK KTPEEIEALRRALVVAEEGLAAGAAA--LAPGTTENALAGAVLEAEAAGG
MSMEG_4853|M.smegmatis_MC2_155 KTPEEIEALRWALSIAEKGLAAGVAE--VHAGTSEQALSGAILEAEAAGG
MMAR_4759|M.marinum_M KTDEEVVALRAAIAVAESGLAAAVAE--LRTGVSEQLLAGVLVEAVAAGG
MUL_0330|M.ulcerans_Agy99 KTDEEEVALRAAIAVAESGLAAAVAE--LRTGVSEQLLAGVLVEAVLAGG
TH_2275|M.thermoresistible__bu KTVEEVRTLGAALRVAEQAVAAAVAE--LRPGVTEKTLAGIMLEAEAAGG
MAV_2971|M.avium_104 KTPDEITAMGAALRVAEHGLAAALAE--LAPGAAERTLAGAMMEAMAAGG
Mb2116c|M.bovis_AF2122/97 KEETEIDALRKAGAAIDRVHARVPEF--LVPGRTEADVAADIAEAIVAEG
Rv2089c|M.tuberculosis_H37Rv KEETEIDALRKAGAAIDRVHARVPEF--LVPGRTEADVAADIAEAIVAEG
MLBr_00521|M.leprae_Br4923 KDAGELALLRLAAEAADAALTELVARGGVRPGLTEREVGRELEGLMLDHG
MAB_2838c|M.abscessus_ATCC_199 KDDSEVLLLERACAAADTALAALIETGGIRPGRTEREVARDLENLMAEHG
* * : * : : : .* :* :. : *
Mvan_4231|M.vanbaalenii_PYR-1 VSTPATQDAAWVTSKEHPWRRSDGDGLVREGDLVAMSAG-VLADGYVAEV
Mflv_2421|M.gilvum_PYR-GCK VSTPATQDAAWVTSKDHPWRRAGGDGRVRDGDLVAVSAG-VLADGYVAEV
MSMEG_4853|M.smegmatis_MC2_155 VSTPATQDAAWVTSTEHPWRRAEGDGRVRDGDLVALSAG-VLADGYVAEV
MMAR_4759|M.marinum_M VSTPSNQDVAWVTSREHPWRRASGDRRVRSGDLVAFSAG-VLAGGYIGEV
MUL_0330|M.ulcerans_Agy99 VSTPSNQDVAWVTSREHPWRRASGDRRVRSGDLVAFSAG-VLAGGYIGEV
TH_2275|M.thermoresistible__bu VSTPATQDVAWVTSREHPWRRARTDGRVQEGDLVTFAAG-VLADGYVGEV
MAV_2971|M.avium_104 VSTPATQDAAWVTSRERPWRRAGS-GEVRPGDLVAFAAG-ALADGYVAEV
Mb2116c|M.bovis_AF2122/97 HSEVAFV-IVGSGPHGADPHHGYSDRELREGDIVVVDIGGTYGPGYHSDS
Rv2089c|M.tuberculosis_H37Rv HSEVAFV-IVGSGPHGADPHHGYSDRELREGDIVVVDIGGTYGPGYHSDS
MLBr_00521|M.leprae_Br4923 ADALSFETIVAAGPNSAIPHHRPTDTVLAAGDFVKIDFG-ALVAGYHSDM
MAB_2838c|M.abscessus_ATCC_199 ADGPSFETIVAAGPNSAIPHHRPTGAMLAAGDFVKIDFG-ALVAGYHSDM
. : . . :: : **:* . * . ** .:
Mvan_4231|M.vanbaalenii_PYR-1 ARTLYVGDPTD-AVRALYRRRDDLWDRLLQACRPGAPVSSLLDAYGQAG-
Mflv_2421|M.gilvum_PYR-GCK ARTLHVGEPTD-AVRALYRRRDDLWDRLIEACRPGRATSGLLDAYEAAG-
MSMEG_4853|M.smegmatis_MC2_155 ARTLYVGEPTD-AVRALYRRRDDLWDRLADACRPGRPTSALLDAYEQAG-
MMAR_4759|M.marinum_M GRTWPADG-VA-GAAPLYQRWAKLWEGLLLACQPGVGAGELLNAYRQAG-
MUL_0330|M.ulcerans_Agy99 GRTWPADG-VA-GAAPLYQRWAKLWDGLLLACQPGAGAGELLNAYRQAG-
TH_2275|M.thermoresistible__bu GRTWPVXX----------------XTAVGVPCRDG-AHRTVVVALQHRN-
MAV_2971|M.avium_104 GRTWPAGDTVGGQVRALFGRSNALYDRMLAACRPGASTGDLLAAYRAVD-
Mb2116c|M.bovis_AF2122/97 TRTYSIGEPDS-DVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLA
Rv2089c|M.tuberculosis_H37Rv TRTYSIGEPDS-DVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLA
MLBr_00521|M.leprae_Br4923 TRTFVLGPAAD-WQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLIV
MAB_2838c|M.abscessus_ATCC_199 TRTLVLGSAAP-WQQEIHELVLTAQAAGRAALAPGASLKNVDAAARDVIT
** . * : *
Mvan_4231|M.vanbaalenii_PYR-1 EPLPAMPVAHGLGLGFDPPVVSPNLRATMEAERLEEGMVLAVTAYVWEQG
Mflv_2421|M.gilvum_PYR-GCK ERLPAMPVAHGLGLGFDPPVVSPSLRASADAENLEAGMVLAVTAYVWEEG
MSMEG_4853|M.smegmatis_MC2_155 EPLPAMPVAHGLGLGFDPPVVSPALRATADGERFEEGMVLAVTSYVWEAG
MMAR_4759|M.marinum_M EPAPPMPVARGLGMGFDPPVISAQLPATAANDRLEPGMVLAVTGYVWEAG
MUL_0330|M.ulcerans_Agy99 EPAPPMPVARGLGMGFDPTVISAQLPATAANDRLEPGMVLAVTGYVWEAG
TH_2275|M.thermoresistible__bu LPEPTVAAAVAVHMQHDLKWLSVRRAAVC---------------------
MAV_2971|M.avium_104 EPVPPMPVAHGLGLGFDPPVVSETLAAAGERDRMEAGMVLAITGYVWQRG
Mb2116c|M.bovis_AF2122/97 EAGLAEYFVHRTGHGIGLCVHEEPYIVAGNDLVLVPGMAFSIEPGIYFPG
Rv2089c|M.tuberculosis_H37Rv EAGLAEYFVHRTGHGIGLCVHEEPYIVAGNDLVLVPGMAFSIEPGIYFPG
MLBr_00521|M.leprae_Br4923 DAGYGQQFSHGLGHGVGLEIHEAPGIGTTSAGTLLAGSVVTVEPGVYLSG
MAB_2838c|M.abscessus_ATCC_199 AAGYGENFGHGLGHGVGLQIHEAPGIGSTATGTLLAGSAVTVEPGVYLPD
. .
Mvan_4231|M.vanbaalenii_PYR-1 LGGVFTRDAVLITADG--------------AEILSTAPAYGESVHG-
Mflv_2421|M.gilvum_PYR-GCK VGAVFTRDAVLITPDG--------------AEILSSAPAYREAVHG-
MSMEG_4853|M.smegmatis_MC2_155 IGAVFTRDAVVIGADG--------------PDVLTTVPVYGEAVHG-
MMAR_4759|M.marinum_M VGAVFGREAVLVNADG--------------PEVLTASPMWQA-----
MUL_0330|M.ulcerans_Agy99 VGAVFGREAVLVNADG--------------PEVLTASPMWQA-----
TH_2275|M.thermoresistible__bu -----------------------------------------------
MAV_2971|M.avium_104 IGAVFRRDTVHITEGG--------------VQVLTASPTWTGPLP--
Mb2116c|M.bovis_AF2122/97 RWGARIEDIVIVTEDG--------------AVSVNNCPHELIVVPVS
Rv2089c|M.tuberculosis_H37Rv RWGARIEDIVIVTEDG--------------AVSVNNCPHELIVVPVS
MLBr_00521|M.leprae_Br4923 RGGVRIEDTLVVAAKGTSETPITSRPTGFIPELLTRFPKELAIL---
MAB_2838c|M.abscessus_ATCC_199 RGGVRIEDTLVVRPDG--------------PELLTRFPKELIVID--