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VTTSTHSGVTQIARTGYTWLDIPTEPDFARMRREVGVRLHAAMSDQGVDALVLLGNGNVMYATGISWPLA DAGLSHVERPIAVVLADDEHPHLFLPFREGAAMESDLPDDHLHGPVYLEFDEGVSEFGKILARLIPAGAT IATDELTGAMRRAGTALFPSAPVDAAPVVGAAKLVKTVDQIACVRRACQITEEAVAEIQKSLAPGARQID LSAEFVRRTFELGATTNMFDSIWQAMPASKADSTWTTTGDLALPLLTTERELSQGDVLWTDVSIAYHGYC SDHGRTWIVGQDPTAAQQRQFEKWAEIVDAVLAVTKAGATCGDLGRAATAAAGGHKPWLPHFYLGHGIGT GAAEMPMIGTDLGQEWDDNFVFPDGMLLVFEPVVWEDGTGGYRGEEIVVVTDGGWMPLTSYPYDPYEVTG GN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2420 | - | - | 100% (422) | peptidase M24 |
| M. gilvum PYR-GCK | Mflv_2421 | - | 6e-20 | 26.40% (394) | peptidase M24 |
| M. gilvum PYR-GCK | Mflv_3098 | - | 9e-16 | 25.07% (383) | peptidase M24 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2116c | pepE | 1e-16 | 25.00% (380) | dipeptidase PepE |
| M. tuberculosis H37Rv | Rv2089c | pepE | 1e-16 | 25.00% (380) | dipeptidase PepE |
| M. leprae Br4923 | MLBr_00521 | pepQ | 6e-13 | 29.03% (279) | putative cytoplasmic peptidase |
| M. abscessus ATCC 19977 | MAB_2192 | - | 8e-17 | 25.40% (374) | dipeptidase PepE |
| M. marinum M | MMAR_4760 | - | 1e-165 | 66.99% (409) | dipeptidase |
| M. avium 104 | MAV_2970 | - | 1e-172 | 71.11% (398) | peptidase, M24 family protein |
| M. smegmatis MC2 155 | MSMEG_4854 | - | 0.0 | 86.94% (421) | peptidase, M24 family protein |
| M. thermoresistible (build 8) | TH_2276 | - | 1e-177 | 73.76% (404) | peptidase, M24 family protein |
| M. ulcerans Agy99 | MUL_0331 | - | 1e-158 | 67.44% (387) | dipeptidase |
| M. vanbaalenii PYR-1 | Mvan_4232 | - | 0.0 | 90.52% (422) | peptidase M24 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2420|M.gilvum_PYR-GCK ---MTTSTHSGVTQIARTGYTWLDIPTEPDFARMRREVGVRLHAAMSDQG
Mvan_4232|M.vanbaalenii_PYR-1 ---MTTSTQSGVTQIARTGYSWLDIPAEPDFARLRREVGVRLHAAMADQG
MSMEG_4854|M.smegmatis_MC2_155 MTPATTFTNSGVTQIARTGLRWLDIPAEPDFARLRRDVSARLHTAMSEQG
MAV_2970|M.avium_104 -----------MTASAR--GSVIDIPDEPDWARMRAETGARLRGAMADHG
TH_2276|M.thermoresistible__bu -----------MTTSLDTADTGLRIPDEPDRGRMYAEVGARLRETMKDKG
MMAR_4760|M.marinum_M -----------MTTFARPPSPEMQIPERPDLTRMRRETGARLRRAMADRG
MUL_0331|M.ulcerans_Agy99 ---------------------------------MRRETGARLRRAMADRG
Mb2116c|M.bovis_AF2122/97 ------------------------MGSRRFDAEVYARRLALAAAATADAG
Rv2089c|M.tuberculosis_H37Rv ------------------------MGSRRFDAEVYARRLALAAAATADAG
MAB_2192|M.abscessus_ATCC_1997 ------------------------MAPQRFESDVYADRLRRAAQEAEKVG
MLBr_00521|M.leprae_Br4923 --------------------------------MTHSQRRDNLKSQIATTG
*
Mflv_2420|M.gilvum_PYR-GCK VDALVLLGNGNVMYATGISWPLADAGLSHVERPIAVVLADDEHPHLFLPF
Mvan_4232|M.vanbaalenii_PYR-1 VDALVLLGNGNVMYATGISWPLADAGLSHVERPVAVVLADDEHPHLFLPF
MSMEG_4854|M.smegmatis_MC2_155 VDALVLLGNSNVMYATGISWPLADAGLSHVERPVAVVLADDEHPHLYLPS
MAV_2970|M.avium_104 VDALILLMNGYVGYATGASWPLLDAGLSHVERPVAVVLADDEHPHLFMPF
TH_2276|M.thermoresistible__bu VDALVLLNNGNVVYATGASWPFLDAGLSHVERPVAVVLADDEHPHLFLPF
MMAR_4760|M.marinum_M VDAMILLGNSAVVYATGASWPLGDAGLSYVERPVAVVLAGDPWPHLFLPF
MUL_0331|M.ulcerans_Agy99 VDAMILLGNSAVVYATGASWPLGDAGLSYVERPVAVVLAGHPWPHLFLPF
Mb2116c|M.bovis_AF2122/97 LAGLVITPGYDLCYLIGS-------RAETFERLTALVLPAAGAPAVVLPR
Rv2089c|M.tuberculosis_H37Rv LAGLVITPGYDLCYLIGS-------RAETFERLTALVLPAAGAPAVVLPR
MAB_2192|M.abscessus_ATCC_1997 VTGLVVTPGYDLRYLTGS-------RAQTFERLTALVVPATGQPTVVAPR
MLBr_00521|M.leprae_Br4923 LDAMLVTCLINVRYLSGFTGSNGALLVFADERGAVLATDGRYRTQAAQQV
: .::: : * * ** .:. .
Mflv_2420|M.gilvum_PYR-GCK REGAAMESDLPDDHLHGPVYLEFDEGVSEFGKILARLIPAGATIATDELT
Mvan_4232|M.vanbaalenii_PYR-1 REGAAMESGVPTDHLHGPVYLEFDEGVGEFATILAGLIPAGATIATDELT
MSMEG_4854|M.smegmatis_MC2_155 REGAAMESGVPDDHLHGPVYLEFDEGVEQFGKILAGLVRAGATIAVDELT
MAV_2970|M.avium_104 RSGASAESPVPDDHLHGPAYLEFDHGVQDFARTLADLVPPRGRIAVDELT
TH_2276|M.thermoresistible__bu REGSAFDTEVPADHVHPPLYLEFDEGVEEFGRILSGLITPGAVVAVDELT
MMAR_4760|M.marinum_M REGASQESELPSDHLHGPVYLEFDEGVENFARLLSELIPPAATIAVDELT
MUL_0331|M.ulcerans_Agy99 REGASQESELPSDHLHGPVYLEFDEGVENFARLLSELIPPAATIAVDELT
Mb2116c|M.bovis_AF2122/97 LELAALKQSAAAELGLR--VCDWVDGDDPYGLVSAVLGGAPVATAVTDSM
Rv2089c|M.tuberculosis_H37Rv LELAALKQSAAAELGLR--VCDWVDGDDPYGLVSAVLGGAPVATAVTDSM
MAB_2192|M.abscessus_ATCC_1997 MELAALRDSAIGDLNIP--ISDWVDGENPYELVRAALG-TAGTVAVTESM
MLBr_00521|M.leprae_Br4923 PELEVAIEQSCGRYLAG---RAADDGVCILGFESHVVTVDGLDALTGELE
. .* : . :
Mflv_2420|M.gilvum_PYR-GCK GAMRRAGTALFPS-APVDAAPVVGAAKLVKTVDQIACVRRACQITEEAVA
Mvan_4232|M.vanbaalenii_PYR-1 GAMRRAGSALFPS-APVDAAPVIGAAKLVKTIDQIACIRRACQITEQAVA
MSMEG_4854|M.smegmatis_MC2_155 GAMRRAGTALFPQ-APVDAAATIGAAKIVKTVDQISALRRATQITEQAVA
MAV_2970|M.avium_104 GAMRRAAVTLFPSGPPTDAATVLGAAQLVKTRDELSCLRRAARITEEAIV
TH_2276|M.thermoresistible__bu GAMRRAHDRLFAT-PPQDAGPVVSTAKLVKTPDQIACVRRACRITEEAVV
MMAR_4760|M.marinum_M GAMARAAKLLFPSGAPVDASAVVSAAKVIKTPDELACIRNAVRITDAAMV
MUL_0331|M.ulcerans_Agy99 GAMARAAKLLFPSGAPVDASAVVSAAKVIKTSDELACIRNAVRITDEAMV
Mb2116c|M.bovis_AF2122/97 PALHMLPLADALGVLPVLATDVLRRLRMVKEETEIDALRKAGAAIDRVHA
Rv2089c|M.tuberculosis_H37Rv PALHMLPLADALGVLPVLATDVLRRLRMVKEETEIDALRKAGAAIDRVHA
MAB_2192|M.abscessus_ATCC_1997 PALHLLPLAQLVGTVPVLATGVLRRLRMVKDASEIDALRKAGAAIDRVHA
MLBr_00521|M.leprae_Br4923 GRHTEL----------VRAPGTVEVLREVKDAGELALLRLAAEAADAALT
* .: : :* :: :* * : . .
Mflv_2420|M.gilvum_PYR-GCK EIQKS--LAPGARQIDLSAEFVRRTFELGATTNMFDSIWQAMPASKADST
Mvan_4232|M.vanbaalenii_PYR-1 EIQKS--LAPGARQIDLSAEFVRRTFELGATTNMFDSIWQVMPTSKAEGT
MSMEG_4854|M.smegmatis_MC2_155 NIQKS--VAPGVRQIDLSAEFVRRAFELGATTNMFDSIWQVMPASRADGT
MAV_2970|M.avium_104 DVQRA--LRPGVRQIDLSATFVRRAFELGATTNMLEAIWQVMPSSREAGV
TH_2276|M.thermoresistible__bu DVQRS--LAPGVRQIDLSGQFVRRAFELGATTNMLEAIWQVMPSTRAEGM
MMAR_4760|M.marinum_M QVHEA--LAPGIRQIELSARFLRRAFELGATASMLEPIWQVMPASRAEGV
MUL_0331|M.ulcerans_Agy99 QVHEA--LAPGIRQIEVSARFLRRAFELGATASMLAPIWQVMPTSRAEGV
Mb2116c|M.bovis_AF2122/97 RVPEF--LVPGRTEADVAADIAEAIVAEGHS-----EVAFVIVGSGPHGA
Rv2089c|M.tuberculosis_H37Rv RVPEF--LVPGRTEADVAADIAEAIVAEGHS-----EVAFVIVGSGPHGA
MAB_2192|M.abscessus_ATCC_1997 LVPEL--LIPGRTEAQVAADIAEAIVAEGHS-----EVAFIIVGSGPHGA
MLBr_00521|M.leprae_Br4923 ELVARGGVRPGLTEREVGRELEGLMLDHGAD----ALSFETIVAAGPNSA
: : ** : ::. : . * : : .
Mflv_2420|M.gilvum_PYR-GCK WTTTGDLALPLLTTERELSQGDVLWTDVSIAYH-GYCSDHGRTWIVGQDP
Mvan_4232|M.vanbaalenii_PYR-1 WTTTGDLALPLLTTERELQQGDVLWTDVSIAYH-GYCSDHGRTWIVGQDP
MSMEG_4854|M.smegmatis_MC2_155 WTTHGDLALPLLTTERELRHGDVLWTDVSIAYH-GYCSDHGRTWIVGQDP
MAV_2970|M.avium_104 WTTHGDLALPLLPTERELAAGDVLWTDISITYA-GYCSDFGRTWVVGREP
TH_2276|M.thermoresistible__bu WTTHGDLALPLLTTERELSAGDVLWTDVSISYG-GYCSDFGRTWVVGEDL
MMAR_4760|M.marinum_M WTTHGDLALPLLSTERELAAGDVLWTDVSITYQ-GYCSDFGRTWIVGRDP
MUL_0331|M.ulcerans_Agy99 WTTHGDLALPLLSTERELAAGDVLWTDVSITYQ-GYCSDFGRTWIVGRDP
Mb2116c|M.bovis_AF2122/97 DPHHG-------YSDRELREGDIVVVDIGGTYGPGYHSDSTRTYSIG-EP
Rv2089c|M.tuberculosis_H37Rv DPHHG-------YSDRELREGDIVVVDIGGTYGPGYHSDSTRTYSIG-EP
MAB_2192|M.abscessus_ATCC_1997 DPHHE-------CSDRELRTGDIVVVDIGGSYEPGYNSDSTRTYSIG-EP
MLBr_00521|M.leprae_Br4923 IPHHR-------PTDTVLAAGDFVKIDFGALVA-GYHSDMTRTFVLG-PA
. :: * **.: *.. ** ** **: :*
Mflv_2420|M.gilvum_PYR-GCK TAAQQRQFEKWAEIVDAVLAVTKAGATCGDLGRAA--TAAAGGHKPWLPH
Mvan_4232|M.vanbaalenii_PYR-1 TPAQQAQFDKWSGIVDGVLAVTKAGATCGDLGRAA--IAAAGGEKPWLPH
MSMEG_4854|M.smegmatis_MC2_155 TPAQQRQFDRWREIVDAVLSVTKAGATCGDLGRAA--TKAAGGQKPWLPH
MAV_2970|M.avium_104 TPRQQDQFHRWRDILDAVLAVTKAGVTSGDLARAA--IAANGGRKPWLPH
TH_2276|M.thermoresistible__bu TDRQHDQFFKWREILDAVLKVTRAGATSGDLARAA--IAANGGVKPWLPH
MMAR_4760|M.marinum_M QPRQQQQFDRWREIMSAVVGVARAGATAAELARAA--TAANGGARPWLPH
MUL_0331|M.ulcerans_Agy99 QPRQQQQFDRWREIMSAVVGVARAGATAAELARAA--TAANGGARPWLPH
Mb2116c|M.bovis_AF2122/97 DSDVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLAEAGLAEYFVH
Rv2089c|M.tuberculosis_H37Rv DSDVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLAEAGLAEYFVH
MAB_2192|M.abscessus_ATCC_1997 DPDVAQRISVLERAQQAAVHAARPGVTAESVDAAARRVLTEAGMGEAFVH
MLBr_00521|M.leprae_Br4923 ADWQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLIVDAGYGQQFSH
. . :.*.. .: ** . .* : *
Mflv_2420|M.gilvum_PYR-GCK FYLGHGIGTGAAEMPMIGTDLGQEWDDNFVFPDGMLLVFEPVVWEDGTGG
Mvan_4232|M.vanbaalenii_PYR-1 FYLGHGIGTSAAEMPMIGTDLGQDWDDNFVFPAGMLLVFEPVVWQDGTGG
MSMEG_4854|M.smegmatis_MC2_155 FYLGHGIGTSAAEMPMIGTDLGQEWDDNFVFPDGMLLVFEPVVWEDGTGG
MAV_2970|M.avium_104 FYLGHGIGTYPAEAPMIGTDLGEEFDDNFVFPPGMVLVLEPVVWEDGTGG
TH_2276|M.thermoresistible__bu FYLGHGIGTNAAEMPMIGTDLGEEFDDNFVFPAGMLLVLEPVVWEDGTGG
MMAR_4760|M.marinum_M FYLGHGIGVNAAEMPMIGTDLGDEFDENFVLEPGMVLVLEPVVWEDGTGG
MUL_0331|M.ulcerans_Agy99 FYLGHGVGVNAAEMPMIGTDLGDEFDENFVLEPGMVLVLEPVVWEDGTGG
Mb2116c|M.bovis_AF2122/97 R-TGHGIGLCVHEEPYIVA------GNDLVLVPGMAFSIEPGIYFPGRWG
Rv2089c|M.tuberculosis_H37Rv R-TGHGIGLCVHEEPYIVA------GNDLVLVPGMAFSIEPGIYFPGRWG
MAB_2192|M.abscessus_ATCC_1997 R-TGHGIGLSVHEEPYIVE------GNELVLEPGMAFSIEPGVYFPGQWG
MLBr_00521|M.leprae_Br4923 G-LGHGVGLEIHEAPGIGT------TSAGTLLAGSVVTVEPGVYLSGRGG
***:* * * * . .: * . .** :: * *
Mflv_2420|M.gilvum_PYR-GCK YRGEEIVVVTDGGW--MPLTSYPYDPYEVTGGN--------
Mvan_4232|M.vanbaalenii_PYR-1 YRGEEIVVVTEDGW--MPLTEYPYDPYEVSSGN--------
MSMEG_4854|M.smegmatis_MC2_155 YRGEEIVVVTEGGW--MPLTAYPYDPYEVSSGN--------
MAV_2970|M.avium_104 YRSEEIVVITEDGY--LPITDYPYAPYGD------------
TH_2276|M.thermoresistible__bu YRSEEIIVVTEDGY--TQLTDYPYDPYGVGR----------
MMAR_4760|M.marinum_M YRSEEVLVITEEGS--TRLTDYPYDPYVD------------
MUL_0331|M.ulcerans_Agy99 YRSEAVRVIAEEGS--TRLTDYPYDPYVD------------
Mb2116c|M.bovis_AF2122/97 ARIEDIVIVTEDGA--VSVNNCPHELIVVPVS---------
Rv2089c|M.tuberculosis_H37Rv ARIEDIVIVTEDGA--VSVNNCPHELIVVPVS---------
MAB_2192|M.abscessus_ATCC_1997 ARIEDIVVITENGC--ESVNSRPHGLTVVPTR---------
MLBr_00521|M.leprae_Br4923 VRIEDTLVVAAKGTSETPITSRPTGFIPELLTRFPKELAIL
* * ::: * :. *