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SLNGKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVR DPDSVSAAVAKTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKGRENP HILTLSPPVQLDKKWLKPTAYMMAKFGMTLCALGIAEEMRDEGIASNTLWPRTLVATAAVQNLLGGDEAM GRARKPDVYADAAYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWVEEVNPPGYTQ P*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1333 | - | - | 100% (282) | iron-regulated short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2849 | - | 7e-16 | 26.67% (255) | short-chain type dehydrogenase/reductase |
| M. marinum M | MMAR_2869 | - | 1e-15 | 27.45% (255) | short-chain type dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 1e-145 | 88.17% (279) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4691 | - | 1e-136 | 82.27% (282) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3224 | - | 1e-145 | 88.17% (279) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 9e-08 | 25.64% (195) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_3946c | - | 7e-85 | 57.14% (273) | putative short chain dehydrogenase/reductase |
| M. avium 104 | MAV_4172 | - | 1e-149 | 91.49% (282) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1894 | - | 1e-140 | 85.00% (280) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0664 | - | 1e-140 | 83.69% (282) | POSSIBLE IRON-REGULATED SHORT-CHAIN DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_2546 | - | 1e-161 | 99.65% (282) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1776 | - | 1e-138 | 84.40% (282) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4691|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1776|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MSMEG_1894|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MMAR_1333|M.marinum_M ----------------------------------------------MSLN
MUL_2546|M.ulcerans_Agy99 ----------------------------------------------MSLN
MAV_4172|M.avium_104 ----------------------------------------------MSLN
Mb3251|M.bovis_AF2122/97 ----------------------------------------------MSLN
Rv3224|M.tuberculosis_H37Rv ----------------------------------------------MSLN
Mflv_4691|M.gilvum_PYR-GCK ----------------------------------------------MSLA
Mvan_1776|M.vanbaalenii_PYR-1 ----------------------------------------------MSLA
TH_0664|M.thermoresistible__bu ----------------------------------------------MSLR
MSMEG_1894|M.smegmatis_MC2_155 ----------------------------------------MVRMAQAPLS
MAB_3946c|M.abscessus_ATCC_199 ---------------------------------------------MGSLA
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
*
MMAR_1333|M.marinum_M GKTMFISGASRGIG-------------------LAIAKRAAQ--------
MUL_2546|M.ulcerans_Agy99 GKTMFISGASRGIG-------------------LAIAKRAAQ--------
MAV_4172|M.avium_104 GKTMFISGASRGIG-------------------LAIAKRAAQ--------
Mb3251|M.bovis_AF2122/97 GKTMFISGASRGIG-------------------LAIAKRAAR--------
Rv3224|M.tuberculosis_H37Rv GKTMFISGASRGIG-------------------LAIAKRAAR--------
Mflv_4691|M.gilvum_PYR-GCK GKTMFISGASRGIG-------------------LAIAKRAAA--------
Mvan_1776|M.vanbaalenii_PYR-1 GKTMFISGASRGIG-------------------LAIAKRAAA--------
TH_0664|M.thermoresistible__bu GKTMFISGGSRGIG-------------------LAIAKRVAA--------
MSMEG_1894|M.smegmatis_MC2_155 GKTMFISGASRGIG-------------------LAIAKRAAA--------
MAB_3946c|M.abscessus_ATCC_199 GKTIIMSGGSRGIG-------------------LAIALRAAR--------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
* ::: *.:* ** *.
MMAR_1333|M.marinum_M ---DGANIALIAKTAEPHPKLPG-------------------TVYTAAKE
MUL_2546|M.ulcerans_Agy99 ---DGANIALIAKTAEPHPKLPG-------------------TVYTAAKE
MAV_4172|M.avium_104 ---DGANIALIAKTAEPHPKLPG-------------------TVYTAAKE
Mb3251|M.bovis_AF2122/97 ---DGANIALIAKTAEPHPKLPG-------------------TVFTAAKE
Rv3224|M.tuberculosis_H37Rv ---DGANIALIAKTAEPHPKLPG-------------------TVFTAAKE
Mflv_4691|M.gilvum_PYR-GCK ---DGANIALVAKTAEPHPKLPG-------------------TVYTAAEE
Mvan_1776|M.vanbaalenii_PYR-1 ---DGANIALVAKTAEPHPKLPG-------------------TVYTAAKE
TH_0664|M.thermoresistible__bu ---DGANVALVAKSAEPHPKLPG-------------------TIYTAAKE
MSMEG_1894|M.smegmatis_MC2_155 ---DGANIALIAKTAEPHPKLEG-------------------TIYTAAEE
MAB_3946c|M.abscessus_ATCC_199 ---DGANVAIMAKTAEPHPKLPG-------------------TIYTAAEE
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
**.:*:: :.:.:* * ..:..* :
MMAR_1333|M.marinum_M LEEAGGQALPIVGDVRDPD----SVSAAVAKTVEQFGGIDICVNNASAIN
MUL_2546|M.ulcerans_Agy99 LEEAGGQALPIVGDVRDPD----SVSAAVAKTVEQFGGIDICVNNASAIN
MAV_4172|M.avium_104 LEEAGGQALPIVGDVRDPE----SVEAAVAKTVEQFGGIDICVNNASAIN
Mb3251|M.bovis_AF2122/97 LEEAGGQALPIVGDIRDPD----AVASAVATTVEQFGGIDICVNNASAIN
Rv3224|M.tuberculosis_H37Rv LEEAGGQALPIVGDIRDPD----AVASAVATTVEQFGGIDICVNNASAIN
Mflv_4691|M.gilvum_PYR-GCK IEEAGGQALPIVGDVRDGD----SVVAAVAQAVEKFGGIDICVNNASAIN
Mvan_1776|M.vanbaalenii_PYR-1 IEEVGGQALPIVGDVRDGD----SVAAAVAKTVEQFGGIDMCVNNASAIN
TH_0664|M.thermoresistible__bu IEEAGGQALPIVGDIRDGD----AVAAAVAKTVEQFGGIDICVNNASAIN
MSMEG_1894|M.smegmatis_MC2_155 IEDAGGQALPIVGDVRDGD----SVAAAVTKAVEQFGGIDICVNNASAIN
MAB_3946c|M.abscessus_ATCC_199 IEAAGGHALPLLGDVRDDE----VVASAVAQTVEKFGGIDIVVNNASALN
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
. *: ..: : :*:: .* : *. : :: ** :
MMAR_1333|M.marinum_M LGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKGRENPHILTLSPPVQ
MUL_2546|M.ulcerans_Agy99 LGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKGRENPHILTLSPPVQ
MAV_4172|M.avium_104 LGPITEVPMKRFDLMNGIQVRGTYAVSQACIPHLKGRENPHILTLSPPVL
Mb3251|M.bovis_AF2122/97 LGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPIL
Rv3224|M.tuberculosis_H37Rv LGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPIL
Mflv_4691|M.gilvum_PYR-GCK LGSIEDVPLKRFDLMNGIQVRGTYAVSQACIPHMKGRDNPHILTLSPPIL
Mvan_1776|M.vanbaalenii_PYR-1 LGSIEEVPLKRFDLMNGIQVRGTYAVSQACIPHMKGRDNPHILTLSPPIL
TH_0664|M.thermoresistible__bu LGSIEEVPLKRFDLMNGIQVRGTYAVSQSCIPHMKGRDNPHILTLSPPIR
MSMEG_1894|M.smegmatis_MC2_155 LGSIEEVPLKRFDLMNGIQIRGTYAVSQACIPHMKGRENPHILTLSPPVR
MAB_3946c|M.abscessus_ATCC_199 LAPSESISMKAYDLMQDINARGSFSLSTSAIGALKEADNPHILTLSPPIT
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQG-GHADILVNNAGIT
: * .: .: : : :..**. .. :
MMAR_1333|M.marinum_M LDKKWLK--PTAYMMAKFGMTLCALGIAEEMRDEGIASNTLWPRTLVATA
MUL_2546|M.ulcerans_Agy99 LDKKWLK--PTAYMMAKFGMTLCALGIAEEMRDEGIASNTLWPRTLVATA
MAV_4172|M.avium_104 LGKEWLK--PTAYMMAKFGMTLCALGIAEEMREAGIASNTLWPRTLVATA
Mb3251|M.bovis_AF2122/97 LEKKWLR--PTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATA
Rv3224|M.tuberculosis_H37Rv LEKKWLR--PTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATA
Mflv_4691|M.gilvum_PYR-GCK LESKWLR--PTPYMMAKFGMTLCALGIAEELRDARVASNTLWPRTMVATA
Mvan_1776|M.vanbaalenii_PYR-1 LESKWLR--PTPYMMAKFGMTLCALGIAEEMRDAGIASNTLWPRTMVATA
TH_0664|M.thermoresistible__bu LEPKWLR--PTPYMMAKYGMTLCALGIAEELRDAGIASNTLWPRTTVATA
MSMEG_1894|M.smegmatis_MC2_155 LEPEWLK--PTAYMMAKFGMTLCALGIAEEMREHGIASNTLWPRTLVATA
MAB_3946c|M.abscessus_ATCC_199 LEPKWFERTTTAYTISKFSMSLVAIGLAAELRQYGIASNALWPRTTIDTA
MLBr_02565|M.leprae_Br4923 RDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMA
. : * . :: : *: . *
MMAR_1333|M.marinum_M AVQN-------------LLGGDEAMGR----------ARKPDVYADAAYV
MUL_2546|M.ulcerans_Agy99 AVQN-------------LLGGEEAMGR----------ARKPDVYADAAYV
MAV_4172|M.avium_104 AVQN-------------LLGGDEAMGR----------ARKPEVYSDAAYV
Mb3251|M.bovis_AF2122/97 AVQN-------------LLGGDEAMAR----------SRKPEVYADAAYV
Rv3224|M.tuberculosis_H37Rv AVQN-------------LLGGDEAMAR----------SRKPEVYADAAYV
Mflv_4691|M.gilvum_PYR-GCK AVQN-------------LLGGDESMAR----------SRKPEVYSDAAYA
Mvan_1776|M.vanbaalenii_PYR-1 AVQN-------------LLGGDESMAR----------SRKPEVYSDAAYA
TH_0664|M.thermoresistible__bu AVQN-------------LLGGDEAMAR----------SRKPEVYADAAYV
MSMEG_1894|M.smegmatis_MC2_155 AVQN-------------LLGGDEAMAR----------ARKPQVYADAAYA
MAB_3946c|M.abscessus_ATCC_199 AIRN-------------ILG-AELVAR----------CRSAQIMADAAYE
MLBr_02565|M.leprae_Br4923 GIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTA
.: . ::* : :. . . .
MMAR_1333|M.marinum_M ILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWVEEVNP
MUL_2546|M.ulcerans_Agy99 ILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWVEEVNP
MAV_4172|M.avium_104 ILNKPAREFTGNMLLCEDVLVESGVTDLSVYNCVPGSQLGVDFWVDGVNP
Mb3251|M.bovis_AF2122/97 IVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANP
Rv3224|M.tuberculosis_H37Rv IVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANP
Mflv_4691|M.gilvum_PYR-GCK ILTKPSS-FTGNTLLCEDVLLEAGVTDLSVYDCVPGSELGVDFWVDSANP
Mvan_1776|M.vanbaalenii_PYR-1 VLTKPSS-FTGHTLLCEDVLLESGVTDLSVYDCVPGSDLGVDFWVEGANP
TH_0664|M.thermoresistible__bu VLNKPSS-YTGNTLLCEDVLLESGVTDLSVYDCVPGSELGVDLWVDSPNP
MSMEG_1894|M.smegmatis_MC2_155 VFTKPAREFTGNTLLCEDVLLDSGVTDLSVYDCVPGGELGVDLWVDTPNP
MAB_3946c|M.abscessus_ATCC_199 ILTKPSREVSGNCFIDDEVLREAGVTDFSQYRECAEEDLELDFWMERA--
MLBr_02565|M.leprae_Br4923 AIPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQ
. : . : .*:: * . . :
MMAR_1333|M.marinum_M PGYTQP
MUL_2546|M.ulcerans_Agy99 PGYTQP
MAV_4172|M.avium_104 PGYTGP
Mb3251|M.bovis_AF2122/97 PGYLPA
Rv3224|M.tuberculosis_H37Rv PGYLPA
Mflv_4691|M.gilvum_PYR-GCK PGYTGP
Mvan_1776|M.vanbaalenii_PYR-1 PGYTGP
TH_0664|M.thermoresistible__bu PGYTGP
MSMEG_1894|M.smegmatis_MC2_155 PGYTGP
MAB_3946c|M.abscessus_ATCC_199 ------
MLBr_02565|M.leprae_Br4923 AMLGA-