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TAEISTPRRRSEKSRVAIVDATRGLLLERGFDKLTIEAVAARAGVGKQTIYRWWPSRHALVADVILEDAD RILRPIDHTDDVAADVCAWATGLAKALTTARGNAMLRILTAAGMEHPDTAARLQAGFSVPLHDTVRNRLA ASGFTDRAVQDGADAIVGGIVYAILNEGRAFESRRAESISRAVLAGISAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2374 | - | - | 100% (191) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3225 | - | 2e-16 | 31.21% (173) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1535 | - | 1e-11 | 31.02% (187) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3192c | - | 7e-09 | 33.33% (132) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3167c | - | 7e-09 | 33.33% (132) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00717 | - | 4e-06 | 30.99% (71) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3462c | - | 9e-15 | 31.09% (193) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0088 | - | 5e-08 | 26.97% (152) | transcriptional regulator |
| M. avium 104 | MAV_5267 | - | 4e-62 | 63.24% (185) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6564 | - | 4e-61 | 63.64% (187) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3283 | - | 9e-11 | 28.25% (177) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_2482 | - | 6e-08 | 32.58% (132) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4272 | - | 9e-79 | 74.87% (191) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2374|M.gilvum_PYR-GCK ---------MTAE---ISTPRRRSEKSRVAIVDATRGLLLERGFDKLTIE
Mvan_4272|M.vanbaalenii_PYR-1 ---------MATD---IAAPRRRSEKSRTAIVEATRKLLMERGFDKLTIE
MAV_5267|M.avium_104 ---------MPTDPNGPAAPRRRSEKSRTAIVTATRELLLERGFDGLTIE
MSMEG_6564|M.smegmatis_MC2_155 ---------MTTA----EAPRRRSEKSRVAIVEATRALLLERGFDGLSIE
Mb3192c|M.bovis_AF2122/97 -----MKADLPSLDKAPGAGRPRDPRIDSAILSATAELLVQIGYSNLSLA
Rv3167c|M.tuberculosis_H37Rv -----MKADLPSLDKAPGAGRPRDPRIDSAILSATAELLVQIGYSNLSLA
MUL_2482|M.ulcerans_Agy99 -----MKADPSSLDKAPGAGRPRDPRIDFAILSATMELLVQIGYSNLSLA
TH_3283|M.thermoresistible__bu --------MPGSGARSP--GRPRDPALDDAIRAAARDVVVEHGYDATTLA
MAB_3462c|M.abscessus_ATCC_199 MNETVGPGEVDTPRRHFGNRHGRSEAAREAVLHAADDLLVARGYAGVTME
MMAR_0088|M.marinum_M --MTIGEQVPEGPVESVPSTERKGQRTRRRILDAARAVFAEVGYERATIR
MLBr_00717|M.leprae_Br4923 --------------MTTARRRLSPEDRRAELLALGAEVFGKRPYDEVRID
. : :. : :
Mflv_2374|M.gilvum_PYR-GCK AVAARAGVGKQTIYRWWPSRHALVADVILEDADRILRPI---DHTDDVAA
Mvan_4272|M.vanbaalenii_PYR-1 AVAARAGVGKQTIYRWWPSRHALVADVTLEDADRILRPV---ARTDDVAA
MAV_5267|M.avium_104 AVAARAGVGKQTIYRWWPTRPALVADVMLEDADRLLASV---EHSGDLAA
MSMEG_6564|M.smegmatis_MC2_155 AVAAKAGVGKQTIYRWWPSRHALVADVLLEDADKILARM---PKTDDVTA
Mb3192c|M.bovis_AF2122/97 AVAERAGTTKSALYRRWSSKAELVHEAAFPAAPTALQ-----AAAGDIAA
Rv3167c|M.tuberculosis_H37Rv AVAERAGTTKSALYRRWSSKAELVHEAAFPAAPTALQ-----AAAGDIAA
MUL_2482|M.ulcerans_Agy99 AVAERAGTTKSALYRRWSSKAELVHEAAFPVTPSALS-----APAGDFAG
TH_3283|M.thermoresistible__bu LIADRAGVSVPTIYRRWQHKHELIEEAVLHLDTFELP-----EPTGDLEA
MAB_3462c|M.abscessus_ATCC_199 GIAKAAGVAKQTVYRWWSSKVDVLMDVFLEDAACQLDP----PDLGGLEA
MMAR_0088|M.marinum_M GIAAAAGVDKSSIIKYFGTKQALFHEAVHWDIPVAELT------TDDAGQ
MLBr_00717|M.leprae_Br4923 EIAERAGVSRALMYHYFPDKRAFFAAVVKDEADRLYAATNIPPPAGLTMF
:* **. : : : : .. . .
Mflv_2374|M.gilvum_PYR-GCK DVCAWATGLAKALTTARGNAMLRILTAAGMEH------PDTAARLQAGFS
Mvan_4272|M.vanbaalenii_PYR-1 DLCAWAVTLATALTTVRGNAMLRALTTAGVEH------QDTAARLHAGFN
MAV_5267|M.avium_104 DLVGWVGKLVTSLTTPRGSAMLRTLTVACMEH------EDTAVKLRAGFS
MSMEG_6564|M.smegmatis_MC2_155 DLASWAGTLAAALTTRRGHAMLKTLMAASLEH------EDTAARLREGFS
Mb3192c|M.bovis_AF2122/97 DIRMMIAATRDVFTTPVVRAALPGLVADMTAD------AELNARVLAR-F
Rv3167c|M.tuberculosis_H37Rv DIRMMIAATRDVFTTPVVRAALPGLVADMTAD------AELNARVLAR-F
MUL_2482|M.ulcerans_Agy99 DIRMMVAATRDVFTTPVVRAALPGLVADMTAE------ADLNARVLSR-F
TH_3283|M.thermoresistible__bu DLGTWVRLFLTVAMEPAARAAVPGLMSAYSRN------PDDYRRLMTRGE
MAB_3462c|M.abscessus_ATCC_199 DLRHHLSATAQFLAADDAGAVFRALIGQSQHD------GQLADDFRGRYL
MMAR_0088|M.marinum_M TTENYARAMLTAWAADP-NSPMAVLLRTSMTS------EDAADILRRHIT
MLBr_00717|M.leprae_Br4923 EEVRVGVLAYMAYHKQNPEAAWAAYVGLGRSDPVLLGIDDEAKNRQMEHI
: :
Mflv_2374|M.gilvum_PYR-GCK VPLHDTVRNRLAASGFTDRAVQDGAD----AIVG--GIVYAILNEGRAFE
Mvan_4272|M.vanbaalenii_PYR-1 QPIHDAVRGRLTAEGLTAESARDATD----AIVG--GIVYAILSEGRSFD
MAV_5267|M.avium_104 APLHDSVRARLLAEGVDAATAESAAD----AIVG--GVVYPILSGAQRYS
MSMEG_6564|M.smegmatis_MC2_155 RPLIESVRDRLRDEDIDADHAQAAAD----ALLG--AVVNAVLSEGRSYS
Mb3192c|M.bovis_AF2122/97 ADLFAAVRMRLREAVDRGEAHPDVDPDRLIELIGGATMLRMLLYPDDMLD
Rv3167c|M.tuberculosis_H37Rv ADLFAAVRMRLREAVDRGEAHPDVDPDRLIELIGGATMLRMLLYPDDMLD
MUL_2482|M.ulcerans_Agy99 TELFATVRIRLQEAVDRGEAHPDVDPNRMIELIGGATMLRVLLYPDQMLD
TH_3283|M.thermoresistible__bu LPVRAAIAAMLERAKAAGQAAPDCDPDAVFELIRGATFLRALTHSDED-A
MAB_3462c|M.abscessus_ATCC_199 REQQARDQIPIARAVARGELPADVDVAHVAEQLVA-PLYYRVIVTGETVD
MMAR_0088|M.marinum_M AQGVDAVAATIDASDARLRAAVAGAILMGIASQRFILRMPDLVDADIDDI
MLBr_00717|M.leprae_Br4923 MSRIGDVVSVVPESKLHPDIERDLRVIVHGWLAFTFEVCRQRIMDPSTDA
:
Mflv_2374|M.gilvum_PYR-GCK SRRAESISRAVLAGISAR-------------------
Mvan_4272|M.vanbaalenii_PYR-1 PHRAESITRTVIAGITTR-------------------
MAV_5267|M.avium_104 RRRAEHTTRLIVAALTAG-------------------
MSMEG_6564|M.smegmatis_MC2_155 RQRAETSARIIVAGLRP--------------------
Mb3192c|M.bovis_AF2122/97 DAWVDQTTAIVVRGVHRAAPGGSVV------------
Rv3167c|M.tuberculosis_H37Rv DAWVDQTTAIVVRGVHRAAPGGSVV------------
MUL_2482|M.ulcerans_Agy99 EAWVDQTTAILVHGVTR--------------------
TH_3283|M.thermoresistible__bu EAFCTRITEAVLRAVRS--------------------
MAB_3462c|M.abscessus_ATCC_199 AAFVDRIVEDFLRRRE---------------------
MMAR_0088|M.marinum_M LRLVTPLLRSLIDPE----------------------
MLBr_00717|M.leprae_Br4923 DRLADSCAHALLDAIARVPEISKELADAMAIARQPPQ
.: