For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VVTLDRLINVLGGYGIHLKLCSTPRSTELRSVVMHEPGPVVGDVLLAVGAASLADALEWAEAAHAVVVLV RATDEDLTTAPDGIAVMLVEPEVSWSELAAVVYGLVLEGRETESGRGPTDLFALADSLAETVGGSVTIED RRSSVLAYSRLQHDADPARAETILSRQAPERLRTLFAERGVFRHLAESDEPLFVAGDPEQGLTGRMVVAA RAGRELLGSVWVTCAQPLPEANRAALADGARMVAVHLLRSRASADLERQVESDLVIRLLEGAADAATVAS RLALPQTPLRVIALRAHTADEGHSALLLAFERATAGFGWSRPGRSALADNTVYTVLPSPDPDTATTWVAG LRAALPDPVSVVAGVSGPAVAAELVLARREADECLALHEVRHGGAVPVYDEAWDDILLQRLRVAAQSGRA PQRGPVAELRRHDQAHGTHYAPTLQAWLQAQGDLAEAGRMLGVHENTVRYRLRRMAEVTNLELTDPRKRL AMMIQLAASEHLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6290 | - | - | 100% (503) | putative DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_5120 | - | 3e-32 | 27.70% (527) | hypothetical protein MSMEG_5120 |
| M. smegmatis MC2 155 | MSMEG_6198 | - | 4e-32 | 28.21% (521) | DNA-binding protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 2e-33 | 29.51% (488) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_1946 | - | 1e-175 | 66.07% (501) | putative DNA-binding protein |
| M. tuberculosis H37Rv | Rv1186c | - | 2e-33 | 29.51% (488) | hypothetical protein Rv1186c |
| M. leprae Br4923 | MLBr_01652 | - | 2e-05 | 42.11% (57) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_1391 | - | 2e-07 | 34.06% (138) | putative transcriptional regulator |
| M. marinum M | MMAR_4254 | - | 2e-35 | 29.18% (497) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_1987 | - | 0.0 | 67.13% (505) | putative DNA-binding protein |
| M. thermoresistible (build 8) | TH_2137 | - | 0.0 | 65.06% (518) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_0931 | - | 2e-36 | 29.38% (497) | hypothetical protein MUL_0931 |
| M. vanbaalenii PYR-1 | Mvan_4779 | - | 1e-175 | 65.29% (507) | putative DNA-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1218c|M.bovis_AF2122/97 --------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSD
Rv1186c|M.tuberculosis_H37Rv --------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSD
MMAR_4254|M.marinum_M --------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSD
MUL_0931|M.ulcerans_Agy99 --------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSD
MAV_1987|M.avium_104 ------------MITLDRLVNVLGGYGVRLRWSSVPRSTELRSVVIHETP
TH_2137|M.thermoresistible__bu ------------VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALHENA
MSMEG_6290|M.smegmatis_MC2_155 ------------MVTLDRLINVLGGYGIHLKLCSTPRSTELRSVVMHEPG
Mflv_1946|M.gilvum_PYR-GCK MHTAGPGVASTFVITLDRLINVLGGYGARWQGGSADRQTELRSVVLPEVV
Mvan_4779|M.vanbaalenii_PYR-1 ------------MITLDRLINVLGGYGARWHSGSADRQTELRSVVLPEVV
MAB_1391|M.abscessus_ATCC_1997 ------------------MTASLSDRFMRRLPETARRAVDCFAAEVPYYG
MLBr_01652|M.leprae_Br4923 ----------------MNHNHFVPAPPRRLPLELLDTVPDSLLRRLKQYS
: :
Mb1218c|M.bovis_AF2122/97 DVRLGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSD
Rv1186c|M.tuberculosis_H37Rv DVRLGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSD
MMAR_4254|M.marinum_M DVRLGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSD
MUL_0931|M.ulcerans_Agy99 DVRLGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSD
MAV_1987|M.avium_104 ED------RPVVGDVLLAVGAGSLDEAVRWAASARA----AVVVLRDDET
TH_2137|M.thermoresistible__bu GG------LRVTGDVLLAVGAESVAEAVRWAETAQA----VVVLTRAG-P
MSMEG_6290|M.smegmatis_MC2_155 ---------PVVGDVLLAVGAASLADALEWAEAAHA----VVVLVRAT--
Mflv_1946|M.gilvum_PYR-GCK DG------RTVSGDVLLAIGATTTAEAVRWARAARA----VVVLTRGG-G
Mvan_4779|M.vanbaalenii_PYR-1 DG------RTVSGDVLLAVGAASPAEALQWARAARA----VVVLTRGEHA
MAB_1391|M.abscessus_ATCC_1997 ----------------MLPREVLDGEITEFTKQHFR------IFARVMLE
MLBr_01652|M.leprae_Br4923 GR-------------LATEAVTAMQERLPFFADLEA--------SQRASV
: : :
Mb1218c|M.bovis_AF2122/97 SVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDL
Rv1186c|M.tuberculosis_H37Rv SVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDL
MMAR_4254|M.marinum_M AVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDL
MUL_0931|M.ulcerans_Agy99 AVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDL
MAV_1987|M.avium_104 PMTFDGVTDVGAVLVIDPTVSWSAVAAVVYGLVLEGRETE--SGRGPTDL
TH_2137|M.thermoresistible__bu DASRSCSDGAVAVLTVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDL
MSMEG_6290|M.smegmatis_MC2_155 DEDLTTAPDGIAVMLVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDL
Mflv_1946|M.gilvum_PYR-GCK DPEPDTAG--VAVLVVDSAMPWSEFAAIVYGLVMEGRETE--SGRGPTDL
Mvan_4779|M.vanbaalenii_PYR-1 DPELDGAG--VAVVVIDSAMPWSDFAAIVYGLVMEGRETE--SGRGPTDL
MAB_1391|M.abscessus_ATCC_1997 SRAPTDDEFAVSILAASRRAQEDIPLPAVLAVYN----------------
MLBr_01652|M.leprae_Br4923 TLVVQTAVVNFVQWMQNPHSDVSYTAQAFELVPQD---------------
. . . :
Mb1218c|M.bovis_AF2122/97 FGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPE
Rv1186c|M.tuberculosis_H37Rv FGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPE
MMAR_4254|M.marinum_M FGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPE
MUL_0931|M.ulcerans_Agy99 FGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPE
MAV_1987|M.avium_104 FALADSLADGIGNPVVIQDRHLGVLAYS-RLAQADPALVETVLQRQTPEP
TH_2137|M.thermoresistible__bu FALADNLADAVGGPVTIEDRMSRVLAYSQRQQHADPARAQTILARQAPEP
MSMEG_6290|M.smegmatis_MC2_155 FALADSLAETVGGSVTIEDRRSSVLAYSRLQHDADPARAETILSRQAPER
Mflv_1946|M.gilvum_PYR-GCK FALADNLSNAVGGAVVIEDRASQVLAFSRGQLDADPARAKTILARQAPPS
Mvan_4779|M.vanbaalenii_PYR-1 FALADSLAGAVGGAVVIEDRSSQVLAFSRGQQDADPGRIATILARQAPPE
MAB_1391|M.abscessus_ATCC_1997 --VAARVGIETLRELATPDEVDEVLAVSVQLQRYLQLMLPAVTAAYLE--
MLBr_01652|M.leprae_Br4923 LARRIALRHTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLA
: : *:. :
Mb1218c|M.bovis_AF2122/97 HLQWIGQWGIFDALRAGREVVRVAE-------RPELGLRPRLAIGIHQPG
Rv1186c|M.tuberculosis_H37Rv HLQWIGQWGIFDALRPGREVVRVAE-------RPELGLRPRLAIGIHQPG
MMAR_4254|M.marinum_M HLKWIGQWGIFDALRSGSEVVRVAE-------RPELGLRPRLAIGIHQPP
MUL_0931|M.ulcerans_Agy99 HLKWIGQWGIFDALRSGSEVVRVAE-------RPELGLRPRLAIGIHQPP
MAV_1987|M.avium_104 LRALLEARGVFAHLQVADEPLFVAE-------DAERGLSGRMVVAVRAG-
TH_2137|M.thermoresistible__bu LRRLFEQLGVSEHLAAGDDPLFIAA-------RPGHDLTGRTVIAVRAG-
MSMEG_6290|M.smegmatis_MC2_155 LRTLFAERGVFRHLAESDEPLFVAG-------DPEQGLTGRMVVAARAG-
Mflv_1946|M.gilvum_PYR-GCK LRAVFDAHGVFAHLAVSDEPLFVPG-------DDAVGLTGRMVVAARAG-
Mvan_4779|M.vanbaalenii_PYR-1 LRAVYEAHGVFAHLAVSDDPVFVPGDAPDGMLDDAAGRTGRMVVAARAG-
MAB_1391|M.abscessus_ATCC_1997 -----ERQGVYGAAADARRDLFEAL-------------------------
MLBr_01652|M.leprae_Br4923 FTAATAYADAAEARGTWDSRMEASVVD-----------------------
. : .
Mb1218c|M.bovis_AF2122/97 VGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNT
Rv1186c|M.tuberculosis_H37Rv VGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNT
MMAR_4254|M.marinum_M VAARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPST
MUL_0931|M.ulcerans_Agy99 VAARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPST
MAV_1987|M.avium_104 ------AELIGSVWVACEAPLQPAALRALADGARTVALHLLRSRASADLE
TH_2137|M.thermoresistible__bu ------RELLGSVWVVTPEPLDDGRRRALADGARTVALHLLRSRASADLE
MSMEG_6290|M.smegmatis_MC2_155 ------RELLGSVWVTCAQPLPEANRAALADGARMVAVHLLRSRASADLE
Mflv_1946|M.gilvum_PYR-GCK ------RELLGSVWVAVPKPLAGQQRQALADGARTVALHLLRSRASADLE
Mvan_4779|M.vanbaalenii_PYR-1 ------RELLGSVWVACASPLVGDRRRALADGAHTVALHLLRSRASADLE
MAB_1391|M.abscessus_ATCC_1997 --------VKGMPWEEAAER-----ASVTLALSYHVLFLYMPEPATNTVV
MLBr_01652|M.leprae_Br4923 ------AVVRGDTGPELLSRAAALNWDTTAPATVVVGTPTPNHDGPNGQV
. * : : ..
Mb1218c|M.bovis_AF2122/97 HALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRD
Rv1186c|M.tuberculosis_H37Rv HALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRD
MMAR_4254|M.marinum_M HARRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD
MUL_0931|M.ulcerans_Agy99 HARRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD
MAV_1987|M.avium_104 RQVESELVIRLLEG-----TADAATVASRLDLAHNG-LRVVAVQAFVGAD
TH_2137|M.thermoresistible__bu RQVESDLVLRLLEG-----TSDAAGAAARLGLPQEA-LRIIAVRARSGVD
MSMEG_6290|M.smegmatis_MC2_155 RQVESDLVIRLLEG-----AADAATVASRLALPQTP-LRVIALRAHTADE
Mflv_1946|M.gilvum_PYR-GCK RQVESEMVIRLLES-----PADAETVASRLGLPPSA-LRVIALRALDTTG
Mvan_4779|M.vanbaalenii_PYR-1 RQVESELVIRLLES-----PADAATVASRLGLPPAT-LRVIALRASDEGG
MAB_1391|M.abscessus_ATCC_1997 ARRRAHRVQDIVDEY-----------------------------------
MLBr_01652|M.leprae_Br4923 SSERASQEVREIAAR-----------------------------------
.
Mb1218c|M.bovis_AF2122/97 TAVRHVRLVDVMALSAS--AFRHDAQVAANGSRIYVLLPQTTTGRAVTSW
Rv1186c|M.tuberculosis_H37Rv TAVRHVRLVDVMALSAS--AFRHDAQVAANGSRIYVLLPQTTTGRAVTSW
MMAR_4254|M.marinum_M ---KQSRLADVLALSAS--AFRRDAQVGTNGSRIYVVLPQTATARSLTSW
MUL_0931|M.ulcerans_Agy99 ---KQSRLADVLALSAS--AFRRDAQVGTNGSRIYVVLPQTATARSLTSW
MAV_1987|M.avium_104 ---RDAPLLLAFERATTGFGWSRPGRSALAGNSVYAVLPADEAS-TARRW
TH_2137|M.thermoresistible__bu ---RQGPLLLAFEHATTGFGWSRAGRSALAGDTVYTVLPADHAA-TARRW
MSMEG_6290|M.smegmatis_MC2_155 ---GHSALLLAFERATAGFGWSRPGRSALADNTVYTVLPSPDPD-TATTW
Mflv_1946|M.gilvum_PYR-GCK ---RHSALLQMFERATAGFGWSRPSRSALADATVYTVLAAEPAA-VARDW
Mvan_4779|M.vanbaalenii_PYR-1 ---RHAALLQMFERATAGFGWSRPSRSALADTTVYTVLAAEAAA-VARDW
MAB_1391|M.abscessus_ATCC_1997 --------------------AREPVLAALDGRGGTILLPAVGKVESLLPL
MLBr_01652|M.leprae_Br4923 --------------------HGRAALTDVHGTWLVAIISGQLAP--TDKF
. . ::.
Mb1218c|M.bovis_AF2122/97 VRGTISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-
Rv1186c|M.tuberculosis_H37Rv VRGTISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-
MMAR_4254|M.marinum_M VRGTISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPIS
MUL_0931|M.ulcerans_Agy99 VRGTISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPIS
MAV_1987|M.avium_104 VGALRAALPERLTMIAGISGVAEVG---DLAAARQEADECLALHEMSPAA
TH_2137|M.thermoresistible__bu VEGLQAALPSEVTVSAGISGIADHT---ELPDARREADECLALHDALHDA
MSMEG_6290|M.smegmatis_MC2_155 VAGLRAALPDPVSVVAGVSGPAVAA---ELVLARREADECLALHEVRHGG
Mflv_1946|M.gilvum_PYR-GCK VSALISTLPDQVTVKAGISAPAAAT---DLAVARTEADECLALQESTDAG
Mvan_4779|M.vanbaalenii_PYR-1 VSALVAALPEQLTVQAGISAPAAAT---ELAVARTEADECLALQEGTGAD
MAB_1391|M.abscessus_ATCC_1997 FSEVAGGP-----VTIGLSEAADPA---EIAAAADEARELALLALRLGRA
MLBr_01652|M.leprae_Br4923 FSDLLHAFSDGPVVIGPTAPMLTAA----YHSASEAVSGMNAVAGWSGAP
. : : * .
Mb1218c|M.bovis_AF2122/97 LGQVT------------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLG
Rv1186c|M.tuberculosis_H37Rv LGQVT------------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLG
MMAR_4254|M.marinum_M IGRVT------------SLAEARTTVLLDEIVTLVGNDARLIDPRIPDLR
MUL_0931|M.ulcerans_Agy99 IGRVT------------SLAEARTTVLLDEIVTLVGNDARLIDPRIPDLR
MAV_1987|M.avium_104 PPP--------------AYDESWDDILLQRLRAAARSGRAPTRGPVADLG
TH_2137|M.thermoresistible__bu RPDTGSPDSDSDALAAVVYDESWHDVLLQRLRTAARAGRIPSRGPIAALH
MSMEG_6290|M.smegmatis_MC2_155 AVP--------------VYDEAWDDILLQRLRVAAQSGRAPQRGPVAELR
Mflv_1946|M.gilvum_PYR-GCK EPP--------------AYDESWDDLLLRRLKTAARSGRTPTRGAVAELR
Mvan_4779|M.vanbaalenii_PYR-1 APP--------------AYDESWDDLLLRRLRAAARSGRTPPRGAVAELR
MAB_1391|M.abscessus_ATCC_1997 PGAYR-----------------LSDLLLEYQITRPGRARDLLAATVQPLA
MLBr_01652|M.leprae_Br4923 RPVQAR------------------ELLPERALMGDASAIVALHTDVMLPL
:* :
Mb1218c|M.bovis_AF2122/97 AQDP----VLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLS
Rv1186c|M.tuberculosis_H37Rv AQDP----VLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLS
MMAR_4254|M.marinum_M AKDP----VLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLS
MUL_0931|M.ulcerans_Agy99 AKDP----VLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLS
MAV_1987|M.avium_104 RHDRANGTDYLATLRAWLQAQGDPAEAGRQLGVHENTVRYRLRKMAEITN
TH_2137|M.thermoresistible__bu EHDLRHATQYVATLRSWLAAQGDPAAAGAVLGVHENTVRYRLRKMTAVTQ
MSMEG_6290|M.smegmatis_MC2_155 RHDQAHGTHYAPTLQAWLQAQGDLAEAGRMLGVHENTVRYRLRRMAEVTN
Mflv_1946|M.gilvum_PYR-GCK EHDSAHGTAYVPTLRAWLQERGDPVRTAAHLGVHENTVRYRMRRMAELTE
Mvan_4779|M.vanbaalenii_PYR-1 AHDSTHGTAYVPTLRAWLQERGDPGRTGTRLGVHENTVRYRMRRMAELTD
MAB_1391|M.abscessus_ATCC_1997 AHPH-----LQQALSAYLQHEHGRQLAAKSLHVHPNTLDYRLRRVAELTG
MLBr_01652|M.leprae_Br4923 ADAG---PTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTG
. :* :* . * ** **: **:::: .
Mb1218c|M.bovis_AF2122/97 TSLGDPDVRLLFSLGLRAMERTA----
Rv1186c|M.tuberculosis_H37Rv TSLGDPDVRLLFSLGLRAMERTA----
MMAR_4254|M.marinum_M TSFADPDVRLVFSLGLRATDRSS----
MUL_0931|M.ulcerans_Agy99 TSFADPDVRLVFSLGLRATDHSS----
MAV_1987|M.avium_104 LSLDDSKKRLAMMIELAAIHTD-----
TH_2137|M.thermoresistible__bu LDLQDPDKRLAMMIELAAIEGPPILSG
MSMEG_6290|M.smegmatis_MC2_155 LELTDPRKRLAMMIQLAASEHLS----
Mflv_1946|M.gilvum_PYR-GCK LHLDDARKRFAMTIELAVLD-------
Mvan_4779|M.vanbaalenii_PYR-1 LRLDDADKRFAMMIELAVLD-------
MAB_1391|M.abscessus_ATCC_1997 LDPAQPSAARTLAAALLAVKAR-----
MLBr_01652|M.leprae_Br4923 HDPTLPRDAYVLRVAATVGKLNYPTHH
. : . .