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SDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPG MTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVT IEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRL PTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRM GYIDCNQFTLAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0643c | mmaA3 | - | 100% (293) | METHOXY MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL MYCOLIC ACID SYNTHASE 3) (MMA3) (HYDROXY MYCOLIC ACID SYNTHASE) |
| M. tuberculosis H37Rv | Rv0644c | mmaA2 | e-115 | 69.06% (278) | methoxy mycolic acid synthase |
| M. tuberculosis H37Rv | Rv3392c | cmaA1 | e-113 | 68.59% (277) | cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0662c | mmaA3 | 1e-172 | 100.00% (293) | methoxy mycolic acid synthase |
| M. gilvum PYR-GCK | Mflv_3304 | - | 1e-105 | 60.75% (293) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. leprae Br4923 | MLBr_02459 | umaA2 | 1e-105 | 66.06% (277) | Mycolic acid synthase |
| M. abscessus ATCC 19977 | MAB_3881 | - | 1e-101 | 61.40% (285) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. marinum M | MMAR_0978 | mmaA3 | 1e-141 | 80.55% (293) | methoxy mycolic acid synthase 3, MmaA3 |
| M. avium 104 | MAV_4541 | - | 1e-109 | 67.03% (279) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_1351 | - | 1e-117 | 68.66% (284) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. thermoresistible (build 8) | TH_3093 | - | 1e-120 | 71.74% (276) | PUTATIVE ABC transporter ATP-binding protein |
| M. ulcerans Agy99 | MUL_0730 | mmaA3 | 1e-141 | 80.55% (293) | methoxy mycolic acid synthase 3, MmaA3 |
| M. vanbaalenii PYR-1 | Mvan_3025 | - | 1e-102 | 58.36% (293) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3881|M.abscessus_ATCC_1997 ---MS----KLTPKFSDVQAHYDLSDDFFALFLDPSRTYSCAYFEPE-TL
MSMEG_1351|M.smegmatis_MC2_155 ---MTKQPGKLQPHFDEVQAHYDLSDDFFALFLDPSRTYSCAYFERD-DM
Mflv_3304|M.gilvum_PYR-GCK MSDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLDPTQTYSCAYFERD-DM
Mvan_3025|M.vanbaalenii_PYR-1 MPETTSGSADLQPHFEDVQSHYDLSDDFYRLFLDPTQTYSCAYFERD-DM
MLBr_02459|M.leprae_Br4923 ------MSVQLTPHFRNVQAHYDLSDDFFRLFLDPTLTYSCAYFERD-DM
MAV_4541|M.avium_104 ------MAENLTPHFEEVQAHYDLSDDFFRLFLDPTMTYSCAYWDRNRDI
Rv0643c|M.tuberculosis_H37Rv MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERD-DM
Mb0662c|M.bovis_AF2122/97 MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERD-DM
MMAR_0978|M.marinum_M MSGKAVAASRKRSNLDDVQAHYDLSNEFFALFVDPTRTYSCAYFPRE-DM
MUL_0730|M.ulcerans_Agy99 MSGKAVAASHKRSNLDDVQAHYDLSNEFFALFVDPTRTYSCAYFPRE-DM
TH_3093|M.thermoresistible__bu -----------------VQSHYDVSNEFFALFLDPSMTYSSAYFERD-DM
**:***:*: *: ** **: ***.**: : :
MAB_3881|M.abscessus_ATCC_1997 TLEQAQQAKIDLALGKLNLEPGMTLLDVGCGWGSTMKRALEHYDVNVIGL
MSMEG_1351|M.smegmatis_MC2_155 TLEEAQLAKIDLSLGKLGLQPGMTLLDVGCGWGATMLRALERYDVNVVGL
Mflv_3304|M.gilvum_PYR-GCK TLEEAQRAKIDLALGKLGLEPGMTLLDIGCGWGGTLLRALEKYDVNVIGL
Mvan_3025|M.vanbaalenii_PYR-1 TLEEAQIAKIDLSLGKLGLQPGMTLLDIGCGWGATLLRALDKYDVNVIGL
MLBr_02459|M.leprae_Br4923 TLEEAQLAKVDLALGKLKLEPGMTLLDIGCGWGATMKRAIEIYDVNVIGL
MAV_4541|M.avium_104 SLEEAQLRKIDLSLGKLGLRPGMTLLDVGCGWGATMRRAVENYDVNVIGL
Rv0643c|M.tuberculosis_H37Rv TLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGL
Mb0662c|M.bovis_AF2122/97 TLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGL
MMAR_0978|M.marinum_M TLQEAQIAKIDLTLDKLGLTPGMTLLDIGCGWGSVLKRAVEKYDVNVVGL
MUL_0730|M.ulcerans_Agy99 TLQEAQIAKIDLTLDKLGLTPGMTLLDIGCGWGSVLKRAVEKYDVNVVGL
TH_3093|M.thermoresistible__bu TLEEAQLAKLDLSLDKLRLEPGMTLLDIGCGWGATMKRALERYDVNVIGL
:*.:** *:**:*.** * *******:*****..: **:: *****:**
MAB_3881|M.abscessus_ATCC_1997 TLSKNQFAYVNTLLDSAGSSRNYEVRLAGWEEFEGTVDRIVSIGAFEHFG
MSMEG_1351|M.smegmatis_MC2_155 TLSRNQQAHVERRFSESSSPRTKRVLLAGWEEFDEPVDRIVSIGAFEHFG
Mflv_3304|M.gilvum_PYR-GCK TLSRNQQAHVQKVLDEHDSPRSKTVLLQGWEQFDQPVDRIVSIGAFEHFG
Mvan_3025|M.vanbaalenii_PYR-1 TLSRNQQAHVQKRLDAHGSGRSKRVLLAGWEQFDEPVDRIVSIGAFEHFG
MLBr_02459|M.leprae_Br4923 TLSENQAAHVQKTFDELDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFG
MAV_4541|M.avium_104 TLSRHQAAHVQQLLDAMDTPRSRRVLLHGWEEFDEPVDRIVSIGAFEHFG
Rv0643c|M.tuberculosis_H37Rv TLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFG
Mb0662c|M.bovis_AF2122/97 TLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFG
MMAR_0978|M.marinum_M TLSKNQHAYCQQVLDEVDTNRSHRVLLRDWAEFDEPVDRIVTIEALEHFG
MUL_0730|M.ulcerans_Agy99 TLSKNQHAYCQQVLDEVDTNRSHRVLLRDWAEFDEPVDRIVTIEALEHFG
TH_3093|M.thermoresistible__bu TLSENQVEYCTALLDTVDTDRSHRVLLSDWADFDEPVDRIITIEALEHFG
***.:* : :. .: *. * * .* .* .****::* *:****
MAB_3881|M.abscessus_ATCC_1997 HERYDSFFAMAHRVLPSDGKMLLHTIVSHHPDEWKRMGIPLLMSRVRFIY
MSMEG_1351|M.smegmatis_MC2_155 HERYDDFFRFAHRVLPDDGVMLLHTITGIHPKHAQELGVPLTFEMARFIR
Mflv_3304|M.gilvum_PYR-GCK SDRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEFAERKLPLTMTKLKFFK
Mvan_3025|M.vanbaalenii_PYR-1 RDRYDEFFKKAYQVLPDGGVMMLHTIIKPTDEEFADRGLKLTMSIVRFSK
MLBr_02459|M.leprae_Br4923 RQRYARFFKMAHEVLPADSVMLLHTIVRPTFKDARARGMTLTHEIVHFTQ
MAV_4541|M.avium_104 YDRYDDFFATAYRVLPDDGVMLLHTITMLTPEQIVERGLPLTEEQTSFNE
Rv0643c|M.tuberculosis_H37Rv FERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIR
Mb0662c|M.bovis_AF2122/97 FERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIR
MMAR_0978|M.marinum_M FHRYDDFFKFTYEALPADGVMLLHAITGLHPKQVMERGIPLTMEMAKFIR
MUL_0730|M.ulcerans_Agy99 FHRYDDFFKFTYEALPADGVMLLHAITGLHPKQVMERGIPLTMEMAKFIR
TH_3093|M.thermoresistible__bu FHRYDDFFSYAFNALPDDGVMLLHAITALTGKQIVERGLPVTFELARFIK
.** ** :. .:* .. *:**:* .. : : *
MAB_3881|M.abscessus_ATCC_1997 FIGTEIFPGGRLPSVPMVDKHAALAGFHITRHHSLQPHYARTLDCWATNL
MSMEG_1351|M.smegmatis_MC2_155 FIVTEIFPGGRLPTVDMVIDHATRASFTLERRQSLQLHYARTLDMWAAAL
Mflv_3304|M.gilvum_PYR-GCK FIMDEIFPGGMLPKVDDVEKHATKASFKVNRIQPLRLHYARTLQIWAASL
Mvan_3025|M.vanbaalenii_PYR-1 FIMDEIFPGGDLPKPTTVAEHATKAGFRLTREQRLREHYAKTLDIWADAL
MLBr_02459|M.leprae_Br4923 FILAEIFPGGWLPTVPTVEEHATAAGFKFTRIQSLQLHYAKTLDLWAARL
MAV_4541|M.avium_104 FIATEIFPGGQLPAIEVVEFHSSKMGFTLKRRQSLQLHYARTLDHWADAL
Rv0643c|M.tuberculosis_H37Rv FIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEAL
Mb0662c|M.bovis_AF2122/97 FIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEAL
MMAR_0978|M.marinum_M FIVTDIFPGGRLPMIETVEEHADKVGFKVARRQSLQLDFAKTLDFWAEAL
MUL_0730|M.ulcerans_Agy99 FIVTDIFPGGRLPMIETVEEHADKVGFKVARRQSLQLDFAKTLDFWAEAL
TH_3093|M.thermoresistible__bu FVVTEIFPGGRLPTIEKVEEHTARAGFTVTRNQSLRSSFQRTVELWAEAL
*: :***** ** : * .* . : *: : :*:: ** *
MAB_3881|M.abscessus_ATCC_1997 AAHEDEAISVQSQEVYDRYIKYLTGCAEGFREGWIDVVQFTCEK------
MSMEG_1351|M.smegmatis_MC2_155 ESHHDDAVRIQSQEVYDRYMHYLTGCANAFRVGYIDVNQFTLAK------
Mflv_3304|M.gilvum_PYR-GCK ESRRDDAIAIQSEEVYDRYMKYLTGCAELFTEGYTDVCQFTLAK------
Mvan_3025|M.vanbaalenii_PYR-1 RKREDDAVAIQSREDYDRYMKYLTGCADLFRDGYTDICQFTLEK------
MLBr_02459|M.leprae_Br4923 EANKNKAIAIQSEEVYDRYMKYLTGCAKLFRDGYTDVDQFTLEKQPATAR
MAV_4541|M.avium_104 RAHHSEAVAIQSEEVYQRYMRYLTGCADAFRAGYIDVNQFTLAK------
Rv0643c|M.tuberculosis_H37Rv QAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK------
Mb0662c|M.bovis_AF2122/97 QAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK------
MMAR_0978|M.marinum_M EERRDEAIKIQSEEVYERYMKYLTGCARAFRIGYIDCNQFTLAK------
MUL_0730|M.ulcerans_Agy99 EERRDEAIKIQSEEVYERYMKYLTGCARAFRIGYIDCNQFTLAK------
TH_3093|M.thermoresistible__bu EARRDEAVAIQSEEAYDRYMHFLTGTAKGFRMGYIDVNQFTLEKAAT---
....*: :** * *:**:::*** * * *: * *** *
MAB_3881|M.abscessus_ATCC_1997 --
MSMEG_1351|M.smegmatis_MC2_155 --
Mflv_3304|M.gilvum_PYR-GCK --
Mvan_3025|M.vanbaalenii_PYR-1 --
MLBr_02459|M.leprae_Br4923 RH
MAV_4541|M.avium_104 --
Rv0643c|M.tuberculosis_H37Rv --
Mb0662c|M.bovis_AF2122/97 --
MMAR_0978|M.marinum_M --
MUL_0730|M.ulcerans_Agy99 --
TH_3093|M.thermoresistible__bu --