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SDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLDPTQTYSCAYFERDDMTLEEAQRAKIDLALGKLGLEPG MTLLDIGCGWGGTLLRALEKYDVNVIGLTLSRNQQAHVQKVLDEHDSPRSKTVLLQGWEQFDQPVDRIVS IGAFEHFGSDRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEFAERKLPLTMTKLKFFKFIMDEIFPGGML PKVDDVEKHATKASFKVNRIQPLRLHYARTLQIWAASLESRRDDAIAIQSEEVYDRYMKYLTGCAELFTE GYTDVCQFTLAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3304 | - | - | 100% (293) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. gilvum PYR-GCK | Mflv_1801 | - | e-104 | 62.95% (278) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. gilvum PYR-GCK | Mflv_1800 | - | 3e-95 | 57.24% (290) | cyclopropane-fatty-acyl-phospholipid synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0479c | pcaA | 1e-116 | 68.88% (286) | mycolic acid synthase pcaA (cyclopropane synthase) |
| M. tuberculosis H37Rv | Rv0470c | pcaA | 1e-116 | 68.88% (286) | mycolic acid synthase pcaA (cyclopropane synthase) |
| M. leprae Br4923 | MLBr_02459 | umaA2 | 1e-117 | 70.63% (286) | Mycolic acid synthase |
| M. abscessus ATCC 19977 | MAB_3881 | - | 1e-103 | 63.25% (283) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. marinum M | MMAR_0979 | mmaA5_1 | 1e-119 | 69.72% (284) | methoxy mycolic acid synthase 5 MmaA5_1 |
| M. avium 104 | MAV_0130 | - | 1e-136 | 77.47% (293) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_3538 | - | 1e-131 | 76.33% (283) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. thermoresistible (build 8) | TH_3139 | - | 1e-133 | 78.09% (283) | PUTATIVE Cyclopropane-fatty-acyl-phospholipid synthase |
| M. ulcerans Agy99 | MUL_4539 | pcaA | 1e-118 | 69.58% (286) | mycolic acid synthase PcaA |
| M. vanbaalenii PYR-1 | Mvan_3025 | - | 1e-137 | 79.18% (293) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0479c|M.bovis_AF2122/97 ------MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
Rv0470c|M.tuberculosis_H37Rv ------MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
MUL_4539|M.ulcerans_Agy99 ------MSVQLTPHFGNVQAHYDLSDDFFRLFLDPSQTYSCAYFERDDMT
MLBr_02459|M.leprae_Br4923 ------MSVQLTPHFRNVQAHYDLSDDFFRLFLDPTLTYSCAYFERDDMT
Mflv_3304|M.gilvum_PYR-GCK MSDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLDPTQTYSCAYFERDDMT
Mvan_3025|M.vanbaalenii_PYR-1 MPETTSGSADLQPHFEDVQSHYDLSDDFYRLFLDPTQTYSCAYFERDDMT
MAV_0130|M.avium_104 MSENTGDAVNLQPHFDDVQAHYDLSDEFFALFLDPTRTYSCAYFERDDMT
TH_3139|M.thermoresistible__bu ----------LTPHFEEVQAHYDLSDDFFRLFLDPSQTYSCAYFERDDMT
MSMEG_3538|M.smegmatis_MC2_155 --------MALQPHFEDVQSHYDLSDEFFRLFLDPTQTYSCAYFERDDMT
MMAR_0979|M.marinum_M ------MAKELKPHFDDVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
MAB_3881|M.abscessus_ATCC_1997 -------MSKLTPKFSDVQAHYDLSDDFFALFLDPSRTYSCAYFEPETLT
* *:* :**:******:*: *****: ******** : :*
Mb0479c|M.bovis_AF2122/97 LQEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
Rv0470c|M.tuberculosis_H37Rv LQEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
MUL_4539|M.ulcerans_Agy99 LEQAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
MLBr_02459|M.leprae_Br4923 LEEAQLAKVDLALGKLKLEPGMTLLDIGCGWGATMKRAIEIYDVNVIGLT
Mflv_3304|M.gilvum_PYR-GCK LEEAQRAKIDLALGKLGLEPGMTLLDIGCGWGGTLLRALEKYDVNVIGLT
Mvan_3025|M.vanbaalenii_PYR-1 LEEAQIAKIDLSLGKLGLQPGMTLLDIGCGWGATLLRALDKYDVNVIGLT
MAV_0130|M.avium_104 LEEAQIAKVDLSLGKLGLQPGMTLLDIGCGWGTTIVRALERYDVNVVGLT
TH_3139|M.thermoresistible__bu LEEAQLAKIDLSLGKLDLKPGMTLLDIGCGWGATIKRAVEKYDVNVVGLT
MSMEG_3538|M.smegmatis_MC2_155 LEEAQLAKIDLSLGKLGLQPGMKLLDIGCGWGATLRRALSRYDVDVVGLT
MMAR_0979|M.marinum_M LEEAQIAKIDLALGKLGLEPGMTLLDVGCGWGATMRRAIEKYDVNVVGLT
MAB_3881|M.abscessus_ATCC_1997 LEQAQQAKIDLALGKLNLEPGMTLLDVGCGWGSTMKRALEHYDVNVIGLT
*::** **:**:**** *:***.***:***** *: **:. ***:*:***
Mb0479c|M.bovis_AF2122/97 LSENQAGHVQKMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGH
Rv0470c|M.tuberculosis_H37Rv LSENQAGHVQKMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGH
MUL_4539|M.ulcerans_Agy99 LSENQAAHVQQMFDQIDTSRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGR
MLBr_02459|M.leprae_Br4923 LSENQAAHVQKTFDELDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFGR
Mflv_3304|M.gilvum_PYR-GCK LSRNQQAHVQKVLDEHDSPRSKTVLLQGWEQFDQPVDRIVSIGAFEHFGS
Mvan_3025|M.vanbaalenii_PYR-1 LSRNQQAHVQKRLDAHGSGRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGR
MAV_0130|M.avium_104 LSRNQQAHVQRPLDNHPSPRSKRVLLQGWEQFDEKVDRIVSIGAFEHFGR
TH_3139|M.thermoresistible__bu LSRNQQAHVQQVLDEMDSTRSRRVLLQGWEQFREPVDRIVSIGAFEHFGR
MSMEG_3538|M.smegmatis_MC2_155 LSKNQQAHVERSFAETDTERSRRVLLQGWEQFDEPVDRIVSIGAFEHFGA
MMAR_0979|M.marinum_M LSKNQAAHVQKSFDQLDTARTRRVLLEGWEQFDEPVDRIVSIGAFEHFGH
MAB_3881|M.abscessus_ATCC_1997 LSKNQFAYVNTLLDSAGSSRNYEVRLAGWEEFEGTVDRIVSIGAFEHFGH
**.** .:*: : : *. * * ***:* **************
Mb0479c|M.bovis_AF2122/97 QRYHHFFEVTHRTLPADGKMLLHTIVRPTFKEGREKGLTLTHELVHFTKF
Rv0470c|M.tuberculosis_H37Rv QRYHHFFEVTHRTLPADGKMLLHTIVRPTFKEGREKGLTLTHELVHFTKF
MUL_4539|M.ulcerans_Agy99 LRYAHFFKMAYQALPADGIMLLHTIARPTFKEARAKGLTLTHEIVHFSQF
MLBr_02459|M.leprae_Br4923 QRYARFFKMAHEVLPADSVMLLHTIVRPTFKDARARGMTLTHEIVHFTQF
Mflv_3304|M.gilvum_PYR-GCK DRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEFAERKLPLTMTKLKFFKF
Mvan_3025|M.vanbaalenii_PYR-1 DRYDEFFKKAYQVLPDGGVMMLHTIIKPTDEEFADRGLKLTMSIVRFSKF
MAV_0130|M.avium_104 DRYDDFFKMAYAALPDDGVMMLHTIIKPSDEEFAERGLPITMTKLRFMKF
TH_3139|M.thermoresistible__bu DRYEEFFKMAYEVLPADGIMMLHTIIKPSDEEFAARELPITMRYLRFFKF
MSMEG_3538|M.smegmatis_MC2_155 DRYDDFFRMAHTALPDDGVMLLHTIVKPSGDEMSQRGLPLTMRKLRFFKF
MMAR_0979|M.marinum_M DRYDDFFTLAHNILPSDGVMLLHTITGLTFQQATDRGMPLTFEIARFIKF
MAB_3881|M.abscessus_ATCC_1997 ERYDSFFAMAHRVLPSDGKMLLHTIVSHHPDEWKRMGIPLLMSRVRFIYF
** ** :: ** .. *:**** .: : : :* *
Mb0479c|M.bovis_AF2122/97 ILAEIFPGGWLPSIPTVHEYAEKVGFRVTAVQSLQLHYARTLDMWATALE
Rv0470c|M.tuberculosis_H37Rv ILAEIFPGGWLPSIPTVHEYAEKVGFRVTAVQSLQLHYARTLDMWATALE
MUL_4539|M.ulcerans_Agy99 ILAEIFPGGWLPTIPTVEEHATAAGFKVTRVQSLQLHYARTLEIWAAALE
MLBr_02459|M.leprae_Br4923 ILAEIFPGGWLPTVPTVEEHATAAGFKFTRIQSLQLHYAKTLDLWAARLE
Mflv_3304|M.gilvum_PYR-GCK IMDEIFPGGMLPKVDDVEKHATKASFKVNRIQPLRLHYARTLQIWAASLE
Mvan_3025|M.vanbaalenii_PYR-1 IMDEIFPGGDLPKPTTVAEHATKAGFRLTREQRLREHYAKTLDIWADALR
MAV_0130|M.avium_104 IMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRPHYARTLDTWAAALR
TH_3139|M.thermoresistible__bu IMDEIFPGGDLPQAKVVEEHATRAGFTVAHTQPLRLHYARTLDHWSSALE
MSMEG_3538|M.smegmatis_MC2_155 IMDEIFPGGELPYVAQVSEHAQRAGFRVDRVQSLRPHYAKTLDIWAETLR
MMAR_0979|M.marinum_M IVTEIFPGGRLPSIEKVADHSSKAGFTLTRRQSLQPHYARTLDLWAQALQ
MAB_3881|M.abscessus_ATCC_1997 IGTEIFPGGRLPSVPMVDKHAALAGFHITRHHSLQPHYARTLDCWATNLA
* ****** ** * .:: ..* . : *: ***:**: *: *
Mb0479c|M.bovis_AF2122/97 ANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQGYTDVDQFTLEK-------
Rv0470c|M.tuberculosis_H37Rv ANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQGYTDVDQFTLEK-------
MUL_4539|M.ulcerans_Agy99 AKKEEAIAIQSQKVYDRYMKYLTGCAKLFRQGYTDIDQFTLEK-------
MLBr_02459|M.leprae_Br4923 ANKNKAIAIQSEEVYDRYMKYLTGCAKLFRDGYTDVDQFTLEKQPATARR
Mflv_3304|M.gilvum_PYR-GCK SRRDDAIAIQSEEVYDRYMKYLTGCAELFTEGYTDVCQFTLAK-------
Mvan_3025|M.vanbaalenii_PYR-1 KREDDAVAIQSREDYDRYMKYLTGCADLFRDGYTDICQFTLEK-------
MAV_0130|M.avium_104 ARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG------
TH_3139|M.thermoresistible__bu ARKDEAIAIQSEEVYERYMKYLTGCADLFRKGYTDVCQFTLKK-------
MSMEG_3538|M.smegmatis_MC2_155 GRKDEAIAVQSEEMYERYMKYLTGCADLFREGYTDVCQFTLVKA------
MMAR_0979|M.marinum_M ARRDEAIEVQSEEVYERYMKYLTGCADGFRVGYIDVNQFTLEKS------
MAB_3881|M.abscessus_ATCC_1997 AHEDEAISVQSQEVYDRYIKYLTGCAEGFREGWIDVVQFTCEK-------
..:.*: :**. *:**:*******. * *: *: *** *
Mb0479c|M.bovis_AF2122/97 -
Rv0470c|M.tuberculosis_H37Rv -
MUL_4539|M.ulcerans_Agy99 -
MLBr_02459|M.leprae_Br4923 H
Mflv_3304|M.gilvum_PYR-GCK -
Mvan_3025|M.vanbaalenii_PYR-1 -
MAV_0130|M.avium_104 -
TH_3139|M.thermoresistible__bu -
MSMEG_3538|M.smegmatis_MC2_155 -
MMAR_0979|M.marinum_M -
MAB_3881|M.abscessus_ATCC_1997 -