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MALEQFQLDGQVAIVTGAGKGVGQGIARVLAEAGATVIGTARTESDIVSTIDGIEAAGGRGVAVVADAMS RPDGERVVGTAMDRFGRIDILINNVGGSTYARFLDITDEDFRHTFDWCVTSAFIMSQLAAPHMIDAGRGS IVNISSGSARFGIRALTAYCVAKGGLEALTRAMAQELAPKIRVNAIALGSFATEGLQGSLDLLPGSLEKM KEATPLHRLGDVEDLGRLCVYLSTRDCYATNAIFHVDGGIDSNNSPLPIPDY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1776 | - | - | 100% (262) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1825 | - | 3e-47 | 43.35% (263) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1263 | - | 3e-35 | 33.06% (248) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0950c | - | 2e-44 | 39.62% (265) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0927c | - | 2e-44 | 39.62% (265) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 5e-16 | 26.78% (239) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4632 | - | 4e-52 | 40.75% (265) | short chain dehydrogenase |
| M. marinum M | MMAR_4581 | - | 1e-44 | 39.54% (263) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2460 | - | 1e-133 | 89.31% (262) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5584 | - | 4e-47 | 42.11% (266) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3898 | - | 5e-45 | 40.15% (264) | PUTATIVE short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4442 | - | 1e-43 | 39.16% (263) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4971 | - | 1e-138 | 91.98% (262) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1776|M.gilvum_PYR-GCK -MALEQFQLDGQVAIVTGAGKGVGQGIARVLAEAGATVIGTARTESDIVS
Mvan_4971|M.vanbaalenii_PYR-1 -MALEQFNLDGQVAVVTGAGKGVGQGIARVLAEAGATVVGTARTESDIVA
MAV_2460|M.avium_104 -MALEQFRLDGQVAIVTGAGKGVGAGIARVLAEAGATVVGTARTEADIVG
MSMEG_5584|M.smegmatis_MC2_155 MLILDRFRLDDKVAVVTGAGRGLGAAIALAFAEAGADVVIAARTQSQLDE
TH_3898|M.thermoresistible__bu -VILDRFRLDDRVAVVTGAGRGLGAAMAVAFAEAGADVLISARTQAQLEE
Mb0950c|M.bovis_AF2122/97 -MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDA
Rv0927c|M.tuberculosis_H37Rv -MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDA
MMAR_4581|M.marinum_M -MILDRFRLDDQVAVITGGGRGLGAAIALAFAEAGADVVIASRTQSQLDE
MUL_4442|M.ulcerans_Agy99 -MILDRFRLDDQVAVITGGGRGFGAAIALAFAEAGADVVIASRTQSQLDE
MAB_4632|M.abscessus_ATCC_1997 -MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTESQLRE
MLBr_01807|M.leprae_Br4923 -------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVA
* . : :. *:* :: : :*. . :
Mflv_1776|M.gilvum_PYR-GCK TIDGIEAAGGRGVA------VVADAMSRPDGERVVGTAMDRFGRIDILIN
Mvan_4971|M.vanbaalenii_PYR-1 TIAAIERAGGKGLA------LVADAMSRADGERVVATAVERFGRIDILVN
MAV_2460|M.avium_104 TMEGIEAAGGKGLA------LVADAMSRPDGERVVNTAMERLGRIDILVN
MSMEG_5584|M.smegmatis_MC2_155 VAGQVAGAGRKAHV------VVADLAHPDATAELVQAAIEAFGKLDVVVN
TH_3898|M.thermoresistible__bu VAAQIAATGRRAHV------VAADLAHPEATAELAGAAVEAFGKLDIVVN
Mb0950c|M.bovis_AF2122/97 VAEQIRAAGRRAHT------VAADLAHPEVTAQLAGQAVGAFGKLDIVVN
Rv0927c|M.tuberculosis_H37Rv VAEQIRAAGRRAHT------VAADLAHPEVTAQLAGQAVGAFGKLDIVVN
MMAR_4581|M.marinum_M VADTVRSIGRRAHV------VAADLAHPEATAELAGQAVEAFGRLDIVVN
MUL_4442|M.ulcerans_Agy99 VADTVRSIGRRAHV------VAADLAHPEATAELAGQAVEAFGRLDIVVN
MAB_4632|M.abscessus_ATCC_1997 VAAKVQAAGRQAEV------VVADLSDTEASAALAQKAVDRFGRLDVVVN
MLBr_01807|M.leprae_Br4923 DGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVEVLVA
: . . : .* . * :::::
Mflv_1776|M.gilvum_PYR-GCK NVGGSTYARFLDITDEDFRHTFDWCVTSAFIMSQLAAPHMID-AGRGSIV
Mvan_4971|M.vanbaalenii_PYR-1 NVGGSTYARFLDITDDDFRHTFDWCVTSAFIMSQLAAPHMLE-AGRGSII
MAV_2460|M.avium_104 NVGGSSYARFLDITDEDFRHTFDWCVTSAFIMSQLVAAHMLA-AGHGSIV
MSMEG_5584|M.smegmatis_MC2_155 NVGGTMPAPLLNTSTKDLRDAFTFNVSTAHALTSAAVPLMLEHSGGGSII
TH_3898|M.thermoresistible__bu NVGGTMPGPLLNTSAKEMRDAFTFNVGTAHALTTAAVPLMLKHSGGGSII
Mb0950c|M.bovis_AF2122/97 NVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVI
Rv0927c|M.tuberculosis_H37Rv NVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVI
MMAR_4581|M.marinum_M NVGGTMPNTLLTTSTKDLKDAFTFNVATAHALTVAAVPLMLEHSGGGSII
MUL_4442|M.ulcerans_Agy99 NVGGTMPNTLLTTSTKDLKDAFTFNVATAHALTVAAVPLMLEHSGGGGII
MAB_4632|M.abscessus_ATCC_1997 NVGGTMPKPFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLK-SDNASVI
MLBr_01807|M.leprae_Br4923 NAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIK-QRFGRYI
*.* : :: : .:: ..: : . : . :: . :
Mflv_1776|M.gilvum_PYR-GCK NISSGSARFGIRALTAYCVAKGGLEALTRAMAQELAPK-IRVNAIALGSF
Mvan_4971|M.vanbaalenii_PYR-1 NISSGSARFGIRALTAYCVAKGGLEALTRAMAQELAPK-IRVNAIALGSF
MAV_2460|M.avium_104 NISSGSARFGIRALTAYCVAKGGLEALTRAMAQELAPK-IRVNAIALGSF
MSMEG_5584|M.smegmatis_MC2_155 NITSTMGRLAGRGFVAYGTAKAALAHYTRLAALDLCPR-IRVNAIAPGSI
TH_3898|M.thermoresistible__bu NITSTMGRLAGRGFAAYGTAKAALAHYTRLAALDLAPR-IRVNAIAPGSI
Mb0950c|M.bovis_AF2122/97 NISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRVNAIAPGSI
Rv0927c|M.tuberculosis_H37Rv NISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRVNAIAPGSI
MMAR_4581|M.marinum_M NITSTMGRVAGRGFAAYGTAKAALAHYTRLAALDLCPR-IRVNAIAPGSI
MUL_4442|M.ulcerans_Agy99 NITSTMGRVAGRGFAAYGTAKVALAHYTRLAALDLCPR-IRVNAIAPGSI
MAB_4632|M.abscessus_ATCC_1997 NITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVNGIAPGSI
MLBr_01807|M.leprae_Br4923 FMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVVAPGFI
: * . . * .:* .* :* * :* .: : .* :* * :
Mflv_1776|M.gilvum_PYR-GCK ATEGLQGSLDLLPGSLEKMKEATPLHRLGDVEDLGRLCVYLST-RDCYAT
Mvan_4971|M.vanbaalenii_PYR-1 ATEGLQGSLDLLPGSLEKMKEATPLHRLGDVEDLGRLCVYLAT-RDCYAT
MAV_2460|M.avium_104 ATDGLRGSLDLMPGSLEKMLAATPLHRLGDVEDLGRLTVYLCT-RDCYAT
MSMEG_5584|M.smegmatis_MC2_155 LTSALD-VVASNDALREPMEKVTPLRRLGDPADIAAAAVYLASPAGAYLT
TH_3898|M.thermoresistible__bu LTSALD-VVASNDELRTPMEQATPLRRLGEPADIAAAAVYLASPAGSYLT
Mb0950c|M.bovis_AF2122/97 LTSALE-VVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLT
Rv0927c|M.tuberculosis_H37Rv LTSALE-VVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLT
MMAR_4581|M.marinum_M LTSALE-VVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLT
MUL_4442|M.ulcerans_Agy99 LTSALE-VVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLT
MAB_4632|M.abscessus_ATCC_1997 LTSALE-VVAGNDEMRNTLEQNTPLHRLGDPADIAAAAVYLASPAGSFLT
MLBr_01807|M.leprae_Br4923 DTEMTR---AMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYIS
*. ** *:* ::. :*.: : :
Mflv_1776|M.gilvum_PYR-GCK NAIFHVDGGIDSNNSPLPIPDY-
Mvan_4971|M.vanbaalenii_PYR-1 NSIFHVDGGIDSNNSPLPIPDY-
MAV_2460|M.avium_104 NAIFHVDGGLDSNNSPLPIPDY-
MSMEG_5584|M.smegmatis_MC2_155 GKTLEVDGGLTMPNLDLPIPDL-
TH_3898|M.thermoresistible__bu GKVLEVDGGLTRPNLDMPIPDL-
Mb0950c|M.bovis_AF2122/97 GKTLEVDGGLTFPNLDLPIPDL-
Rv0927c|M.tuberculosis_H37Rv GKTLEVDGGLTFPNLDLPIPDL-
MMAR_4581|M.marinum_M GKTLEVDGGLTHPNLDIPVPDL-
MUL_4442|M.ulcerans_Agy99 GKTLEVDGGLTHPNLDIPVPDL-
MAB_4632|M.abscessus_ATCC_1997 GKVLEVDGGLIAPNLDIPLPDLA
MLBr_01807|M.leprae_Br4923 GAVIPVDGGLGMGH---------
. : ****: :