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ALEQFNLDGQVAVVTGAGKGVGQGIARVLAEAGATVVGTARTESDIVATIAAIERAGGKGLALVADAMSR ADGERVVATAVERFGRIDILVNNVGGSTYARFLDITDDDFRHTFDWCVTSAFIMSQLAAPHMLEAGRGSI INISSGSARFGIRALTAYCVAKGGLEALTRAMAQELAPKIRVNAIALGSFATEGLQGSLDLLPGSLEKMK EATPLHRLGDVEDLGRLCVYLATRDCYATNSIFHVDGGIDSNNSPLPIPDY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4971 | - | - | 100% (262) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4921 | - | 5e-49 | 46.39% (263) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5573 | - | 1e-31 | 34.88% (258) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0950c | - | 1e-43 | 40.75% (265) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1776 | - | 1e-138 | 91.98% (262) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0927c | - | 1e-43 | 40.75% (265) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 1e-16 | 35.35% (198) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4632 | - | 4e-53 | 42.26% (265) | short chain dehydrogenase |
| M. marinum M | MMAR_4581 | - | 7e-44 | 41.06% (263) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2460 | - | 1e-131 | 88.93% (262) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5584 | - | 2e-48 | 44.15% (265) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3898 | - | 4e-45 | 41.29% (264) | PUTATIVE short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4442 | - | 5e-43 | 40.68% (263) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4971|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1776|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2460|M.avium_104 --------------------------------------------------
MSMEG_5584|M.smegmatis_MC2_155 --------------------------------------------------
TH_3898|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4581|M.marinum_M --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mvan_4971|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1776|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2460|M.avium_104 --------------------------------------------------
MSMEG_5584|M.smegmatis_MC2_155 --------------------------------------------------
TH_3898|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4581|M.marinum_M --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mvan_4971|M.vanbaalenii_PYR-1 --------------------------------------MALEQFN-----
Mflv_1776|M.gilvum_PYR-GCK --------------------------------------MALEQFQ-----
MAV_2460|M.avium_104 --------------------------------------MALEQFR-----
MSMEG_5584|M.smegmatis_MC2_155 -------------------------------------MLILDRFR-----
TH_3898|M.thermoresistible__bu --------------------------------------VILDRFR-----
Mb0950c|M.bovis_AF2122/97 --------------------------------------MILDMFR-----
Rv0927c|M.tuberculosis_H37Rv --------------------------------------MILDMFR-----
MMAR_4581|M.marinum_M --------------------------------------MILDRFR-----
MUL_4442|M.ulcerans_Agy99 --------------------------------------MILDRFR-----
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------MILDRFK-----
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
*: *
Mvan_4971|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1776|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2460|M.avium_104 --------------------------------------------------
MSMEG_5584|M.smegmatis_MC2_155 --------------------------------------------------
TH_3898|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4581|M.marinum_M --------------------------------------------------
MUL_4442|M.ulcerans_Agy99 --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mvan_4971|M.vanbaalenii_PYR-1 ----------LDGQVAVVTGAGKGVGQGIARVLAEAGATVVGTARTESDI
Mflv_1776|M.gilvum_PYR-GCK ----------LDGQVAIVTGAGKGVGQGIARVLAEAGATVIGTARTESDI
MAV_2460|M.avium_104 ----------LDGQVAIVTGAGKGVGAGIARVLAEAGATVVGTARTEADI
MSMEG_5584|M.smegmatis_MC2_155 ----------LDDKVAVVTGAGRGLGAAIALAFAEAGADVVIAARTQSQL
TH_3898|M.thermoresistible__bu ----------LDDRVAVVTGAGRGLGAAMAVAFAEAGADVLISARTQAQL
Mb0950c|M.bovis_AF2122/97 ----------LDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSEL
Rv0927c|M.tuberculosis_H37Rv ----------LDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSEL
MMAR_4581|M.marinum_M ----------LDDQVAVITGGGRGLGAAIALAFAEAGADVVIASRTQSQL
MUL_4442|M.ulcerans_Agy99 ----------LDDQVAVITGGGRGFGAAIALAFAEAGADVVIASRTQSQL
MAB_4632|M.abscessus_ATCC_1997 ----------LDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTESQL
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAID-VESAA
*:..**::**..:*.* .:* ..*. ** *: ..:
Mvan_4971|M.vanbaalenii_PYR-1 VATIAAIERAGGKGLALVADAMSRADGERVVATAVERFG-RIDILVNNVG
Mflv_1776|M.gilvum_PYR-GCK VSTIDGIEAAGGRGVAVVADAMSRPDGERVVGTAMDRFG-RIDILINNVG
MAV_2460|M.avium_104 VGTMEGIEAAGGKGLALVADAMSRPDGERVVNTAMERLG-RIDILVNNVG
MSMEG_5584|M.smegmatis_MC2_155 DEVAGQVAGAGRKAHVVVADLAHPDATAELVQAAIEAFG-KLDVVVNNVG
TH_3898|M.thermoresistible__bu EEVAAQIAATGRRAHVVAADLAHPEATAELAGAAVEAFG-KLDIVVNNVG
Mb0950c|M.bovis_AF2122/97 DAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFG-KLDIVVNNVG
Rv0927c|M.tuberculosis_H37Rv DAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFG-KLDIVVNNVG
MMAR_4581|M.marinum_M DEVADTVRSIGRRAHVVAADLAHPEATAELAGQAVEAFG-RLDIVVNNVG
MUL_4442|M.ulcerans_Agy99 DEVADTVRSIGRRAHVVAADLAHPEATAELAGQAVEAFG-RLDIVVNNVG
MAB_4632|M.abscessus_ATCC_1997 REVAAKVQAAGRQAEVVVADLSDTEASAALAQKAVDRFG-RLDVVVNNVG
MLBr_02565|M.leprae_Br4923 EALDETANRVG--GTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAG
* . .: * :. * : *:::**.*
Mvan_4971|M.vanbaalenii_PYR-1 GSTYARFLDITDDDFRHTFDWCVTSAFIMSQLAAPHMLE-AGRGSIINIS
Mflv_1776|M.gilvum_PYR-GCK GSTYARFLDITDEDFRHTFDWCVTSAFIMSQLAAPHMID-AGRGSIVNIS
MAV_2460|M.avium_104 GSSYARFLDITDEDFRHTFDWCVTSAFIMSQLVAAHMLA-AGHGSIVNIS
MSMEG_5584|M.smegmatis_MC2_155 GTMPAPLLNTSTKDLRDAFTFNVSTAHALTSAAVPLMLEHSGGGSIINIT
TH_3898|M.thermoresistible__bu GTMPGPLLNTSAKEMRDAFTFNVGTAHALTTAAVPLMLKHSGGGSIINIT
Mb0950c|M.bovis_AF2122/97 GTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINIS
Rv0927c|M.tuberculosis_H37Rv GTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINIS
MMAR_4581|M.marinum_M GTMPNTLLTTSTKDLKDAFTFNVATAHALTVAAVPLMLEHSGGGSIINIT
MUL_4442|M.ulcerans_Agy99 GTMPNTLLTTSTKDLKDAFTFNVATAHALTVAAVPLMLEHSGGGGIINIT
MAB_4632|M.abscessus_ATCC_1997 GTMPKPFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLK-SDNASVINIT
MLBr_02565|M.leprae_Br4923 ITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGR-VIVLS
: : .: : : : . . :: ::
Mvan_4971|M.vanbaalenii_PYR-1 SGSARFGIRALTAYCVAKGGLEALTRAMAQELAPK-IRVNAIALGSFATE
Mflv_1776|M.gilvum_PYR-GCK SGSARFGIRALTAYCVAKGGLEALTRAMAQELAPK-IRVNAIALGSFATE
MAV_2460|M.avium_104 SGSARFGIRALTAYCVAKGGLEALTRAMAQELAPK-IRVNAIALGSFATD
MSMEG_5584|M.smegmatis_MC2_155 STMGRLAGRGFVAYGTAKAALAHYTRLAALDLCPR-IRVNAIAPGSILTS
TH_3898|M.thermoresistible__bu STMGRLAGRGFAAYGTAKAALAHYTRLAALDLAPR-IRVNAIAPGSILTS
Mb0950c|M.bovis_AF2122/97 STMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRVNAIAPGSILTS
Rv0927c|M.tuberculosis_H37Rv STMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRVNAIAPGSILTS
MMAR_4581|M.marinum_M STMGRVAGRGFAAYGTAKAALAHYTRLAALDLCPR-IRVNAIAPGSILTS
MUL_4442|M.ulcerans_Agy99 STMGRVAGRGFAAYGTAKVALAHYTRLAALDLCPR-IRVNAIAPGSILTS
MAB_4632|M.abscessus_ATCC_1997 STMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVNGIAPGSILTS
MLBr_02565|M.leprae_Br4923 SMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQ
* . *. * .** .: *: * *. : : :*.:* * : *.
Mvan_4971|M.vanbaalenii_PYR-1 GLQGSLDLLPGSLEKMKEATPLHRLGDVEDLGRLCVYLAT-RDCYATNSI
Mflv_1776|M.gilvum_PYR-GCK GLQGSLDLLPGSLEKMKEATPLHRLGDVEDLGRLCVYLST-RDCYATNAI
MAV_2460|M.avium_104 GLRGSLDLMPGSLEKMLAATPLHRLGDVEDLGRLTVYLCT-RDCYATNAI
MSMEG_5584|M.smegmatis_MC2_155 ALD-VVASNDALREPMEKVTPLRRLGDPADIAAAAVYLASPAGAYLTGKT
TH_3898|M.thermoresistible__bu ALD-VVASNDELRTPMEQATPLRRLGEPADIAAAAVYLASPAGSYLTGKV
Mb0950c|M.bovis_AF2122/97 ALE-VVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTGKT
Rv0927c|M.tuberculosis_H37Rv ALE-VVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTGKT
MMAR_4581|M.marinum_M ALE-VVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTGKT
MUL_4442|M.ulcerans_Agy99 ALE-VVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTGKT
MAB_4632|M.abscessus_ATCC_1997 ALE-VVAGNDEMRNTLEQNTPLHRLGDPADIAAAAVYLASPAGSFLTGKV
MLBr_02565|M.leprae_Br4923 MTA---AIPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNV
..* : * *:. .*:. . *.
Mvan_4971|M.vanbaalenii_PYR-1 FHVDGGIDSNNSPLPIPDY-
Mflv_1776|M.gilvum_PYR-GCK FHVDGGIDSNNSPLPIPDY-
MAV_2460|M.avium_104 FHVDGGLDSNNSPLPIPDY-
MSMEG_5584|M.smegmatis_MC2_155 LEVDGGLTMPNLDLPIPDL-
TH_3898|M.thermoresistible__bu LEVDGGLTRPNLDMPIPDL-
Mb0950c|M.bovis_AF2122/97 LEVDGGLTFPNLDLPIPDL-
Rv0927c|M.tuberculosis_H37Rv LEVDGGLTFPNLDLPIPDL-
MMAR_4581|M.marinum_M LEVDGGLTHPNLDIPVPDL-
MUL_4442|M.ulcerans_Agy99 LEVDGGLTHPNLDIPVPDL-
MAB_4632|M.abscessus_ATCC_1997 LEVDGGLIAPNLDIPLPDLA
MLBr_02565|M.leprae_Br4923 IRVCGQAMLGA---------
:.* *