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TYRVVQWTTGNVGRKSVHAVVANSDLDLVGCYAWSPDKVGRDAGELCGLDPLGVMATDDVDALLALKPDC VVYNPMFADVDELVRILGAGVNVVTTSEFINGHNLGADRDRIAAACAHGDATIFGSGINPGFIQLFAVVT AGLSDRIDRISVVESFDTTIYNSPATEIPMGFGYPIDHPDLQSITEKGSGVFREAVQLIADALGTELDDI HCQATYAETTQDLPLPGDWNIAAGCVAGIDVRWTGRAGGRDVIDIRGIWTKGQSLAPQWSTSFGYTVTVE GRPTIKTTLSFEPPPDFVAETLDDFIMLGLTITAMPAITAIPAVVAAPAGIATYNDLPLLQPRGVLKTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1767 | - | - | 100% (350) | dihydrodipicolinate reductase |
| M. gilvum PYR-GCK | Mflv_1277 | - | e-117 | 60.00% (350) | dihydrodipicolinate reductase |
| M. gilvum PYR-GCK | Mflv_2658 | - | 1e-71 | 41.33% (346) | dihydrodipicolinate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1088 | - | 1e-41 | 34.28% (353) | hypothetical protein Mb1088 |
| M. tuberculosis H37Rv | Rv1059 | - | 1e-41 | 34.28% (353) | hypothetical protein Rv1059 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0727 | - | 1e-59 | 33.82% (346) | putative dihydrodipicolinate reductase |
| M. marinum M | MMAR_5250 | - | 1e-127 | 61.60% (349) | hypothetical protein MMAR_5250 |
| M. avium 104 | MAV_0371 | dapB | 1e-118 | 59.42% (345) | dihydrodipicolinate reductase |
| M. smegmatis MC2 155 | MSMEG_0560 | dapB | 1e-127 | 62.07% (348) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. thermoresistible (build 8) | TH_4249 | - | 1e-123 | 60.81% (347) | PUTATIVE dihydrodipicolinate reductase |
| M. ulcerans Agy99 | MUL_3685 | - | 9e-73 | 43.64% (346) | hypothetical protein MUL_3685 |
| M. vanbaalenii PYR-1 | Mvan_4980 | - | 1e-176 | 84.73% (347) | dihydrodipicolinate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1767|M.gilvum_PYR-GCK MT----YRVVQWTTGNVGRKSVHAVVANSDLDLVGCYAWSPDKVGRDAGE
Mvan_4980|M.vanbaalenii_PYR-1 MT----YRVVQWTTGNVGRKSVHAVIANTGLELVGCYAWSPDKVGRDAGE
MMAR_5250|M.marinum_M MPNS--YRVVQWTTGNVGKSSLQAIATHPALELVGCYAWSQEKAGRDAGE
MAV_0371|M.avium_104 MPNT--YRVVQWNTGNVGKSSLKSIVTNPTLELVGCYAWSAEKVGRDAGE
MSMEG_0560|M.smegmatis_MC2_155 MPDTTGYRVVQWTTGNVGKSSVAAIAKNPTLELVGCYAWSGDKVGKDVGE
TH_4249|M.thermoresistible__bu VPNTP-YRVVQWTTGNVGKSSVQALAANPLYELVGVYAWSPDKVGRDAGE
MAB_0727|M.abscessus_ATCC_1997 MS---VIRVFQVATGNVGTEMIRRIASHPDLELAGLHCYSPEKVGRDAGE
MUL_3685|M.ulcerans_Agy99 MSTARPLRVIQWTTGNIGRRSLHAIIGRPDLELVGVYAHGPDKVGVDAAE
Mb1088|M.bovis_AF2122/97 MTMS--LRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
Rv1059|M.tuberculosis_H37Rv MTMS--LRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
:. **.* **.:* : : .. :*.* . * * *..*
Mflv_1767|M.gilvum_PYR-GCK LCGLD-PLGVMATDDVDALLALKPDCVVYNPMFADVDELVRILGAGVNVV
Mvan_4980|M.vanbaalenii_PYR-1 LCGVG-PIGITATDDVDALLALRPDCVVYNPMFADVDELIRILGAGVNVV
MMAR_5250|M.marinum_M LCGMA-PLGITASNDVEALLALKPDCVVYNPMWIDVDELVRILSAGVNVV
MAV_0371|M.avium_104 LVGIP-PLGVAATNDVDELLALKPDCVVYNPMWIDVDELVRILSAGVNVV
MSMEG_0560|M.smegmatis_MC2_155 LCGIE-PLGVSATDDVDALLALKPDVVVYNPMWIDVDELVRILESGVNVV
TH_4249|M.thermoresistible__bu LAGIE-PLGVKATNDVDELLALKPDVVVYNPMWIDVDELVRILSAGINVV
MAB_0727|M.abscessus_ATCC_1997 LVGLE-PNGVIATGTVEEIVAAKPDVLTFHGVFPDEDLYVKVLEAGIDIV
MUL_3685|M.ulcerans_Agy99 LAGWPDPTGVRATSDIGALLALGADACCYNPLWPNIDELVGLLESGVNVC
Mb1088|M.bovis_AF2122/97 IIGSP-PLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVV
Rv1059|M.tuberculosis_H37Rv IIGSP-PLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVV
: * * *: *:. : ::* .* : : . * :* :* ::
Mflv_1767|M.gilvum_PYR-GCK TTSEFINGHNLG------ADR---DRIAAACAHGDATIFGSGINPG-FIQ
Mvan_4980|M.vanbaalenii_PYR-1 TTSEFINGHRLG------ADR---DRIVDACLRGNATLFGSGINPG-FIQ
MMAR_5250|M.marinum_M TTAAFITGHNLG------AGR---DRILAACRHGGSTIFGSGVSPG-FAE
MAV_0371|M.avium_104 TTASFITGGNLG------DGR---DRILQACQQGGSTIFGSGVSPG-FAE
MSMEG_0560|M.smegmatis_MC2_155 STASFITGHNQG------TGR---DRIAEACTRGGSSMFGSGISPG-YVN
TH_4249|M.thermoresistible__bu SSASFITGHNLR------DGR---DRIEEACRQGGSTMFGSGISPG-FAE
MAB_0727|M.abscessus_ATCC_1997 TTADWITGHHRDQNHPHPSGRPTTEVLQQACERGGSTFYGTGMNPG-LTQ
MUL_3685|M.ulcerans_Agy99 TSAAWITGGKQTP-----RDR---ERILAACERGGATIFGSDAHPG-MTN
Mb1088|M.bovis_AF2122/97 TPLGWFYPSEKE-----------AAPLEVAAQAGNATLHGAGIGPGAVTE
Rv1059|M.tuberculosis_H37Rv TPLGWFYPSEKE-----------AAPLEVAAQAGNATLHGAGIGPGAVTE
:. :: . : *. *.:::.*:. ** :
Mflv_1767|M.gilvum_PYR-GCK LFAVVTAGLSDRIDRISVVESFDTTIYNSP-ATEIPMGFGYPIDHPDLQS
Mvan_4980|M.vanbaalenii_PYR-1 LFAVVTAGISDRVDRISIVESFDTTIYNSP-ATEIPMGFGYPIDHPDLPA
MMAR_5250|M.marinum_M LLAIVSAMVCNRIDKVTVNEAADTTFYDSP-ATERPVGFGQPIDHPQLQA
MAV_0371|M.avium_104 LLAIVSAMVCNRIDKVTVNEAADTTFYDSP-ETEKPVGFGQPIDHPDLPA
MSMEG_0560|M.smegmatis_MC2_155 QLSVVAAGICDRVDKITVNEAADTTFYDSP-ATEKPVGFGQPIDHPDLQA
TH_4249|M.thermoresistible__bu LLAIIGTQMCDRVDKVTICEQSDTTFYDSP-ATEKPVGFGTPIDDPNLPQ
MAB_0727|M.abscessus_ATCC_1997 ILGVIHSCDVAEIENVTVIESVDVSCHHSV-DSWEMVGYGLPVGDPSIPA
MUL_3685|M.ulcerans_Agy99 MVGMVLSGSCERVDEIRITESVDCSTYESA-ATQTAMGFSQHPDTPGLAE
Mb1088|M.bovis_AF2122/97 LFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP
Rv1059|M.tuberculosis_H37Rv LFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP
. :: : : : * * : : :*:. . .
Mflv_1767|M.gilvum_PYR-GCK ITEKGSGVFREAVQLIADALGTELD-DIHCQATYAETTQDLPLPGDWNIA
Mvan_4980|M.vanbaalenii_PYR-1 ITEAGSGIFGEAVQLVADALGAELD-DIRCETEYAQTTDTLHLPGDWTIG
MMAR_5250|M.marinum_M MTAQGTAIFGEAVRLVADALGVELD-EVRCVAEHAQTTADLDL-GSWTIA
MAV_0371|M.avium_104 MAAKGTAIFGEAVRLVGDALGVELD-DVRCVAEFAQTTEDLVM-ASWTIP
MSMEG_0560|M.smegmatis_MC2_155 MTAQGTGVFGEAVRMIADALGIELD-EVRCDAEYAQTTEDLDL-GSWTIP
TH_4249|M.thermoresistible__bu MASQGTAIFAEAVQLIADSLGVELD-EIVCEAEYAQTTEDLDL-GSWKIG
MAB_0727|M.abscessus_ATCC_1997 LLEKGTRVFADGVYLMADCFGLELD-DVTFSYELGACTEDIDL-GWYRLP
MUL_3685|M.ulcerans_Agy99 SVRVESEVFAESAAMMADAIGATLD-KMTFDVTFTAATADTDL-GFMKIP
Mb1088|M.bovis_AF2122/97 MQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAPIDS-PIGVIE
Rv1059|M.tuberculosis_H37Rv MQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAPIDS-PIGVIE
* :.. : * :* * .: * :
Mflv_1767|M.gilvum_PYR-GCK AGCVAGIDVRWTGRAGGRDVIDIRGIWTKG-QSLAPQWST---SFGYTVT
Mvan_4980|M.vanbaalenii_PYR-1 PGCVAGIDVRWIGSIDGRDVIDIRGIWTKG-QVLEPVWST---AFGYTVT
MMAR_5250|M.marinum_M AGCVAGVHASWQGVAGGRTIVELNVRWRKG-QTLEPDWQID--QDGWVIQ
MAV_0371|M.avium_104 AGHVAGTYISWQGIVGDQVLIDLNVRWRKG-QTLDPDWKIE--QDGWVIQ
MSMEG_0560|M.smegmatis_MC2_155 AGCVAGVYASWKGIVAGHTRVEINVRWRKG-QTLQPDWKID--QDGWVIE
TH_4249|M.thermoresistible__bu AGCVAGVYASWQGRIGGRTLIDLNVRWKKG-QTLEPNWQLE--REGWKIT
MAB_0727|M.abscessus_ATCC_1997 KGSLGANYLKYQGIVGGVPKVEVHVEWQMT-PKTEPHWNV---KGCYITK
MUL_3685|M.ulcerans_Agy99 AGTVGSVYGYHRGWVGDRNVVSVGFNWTMG-NHVVPPKPL---KHGHVIQ
Mb1088|M.bovis_AF2122/97 PGQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGERYEIE
Rv1059|M.tuberculosis_H37Rv PGQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGERYEIE
* :.. . . :.: * *
Mflv_1767|M.gilvum_PYR-GCK VEGRPTIKTTLSFEPPPDFVAETLDDFIMLGLTITAMPAITAIPAVVAAP
Mvan_4980|M.vanbaalenii_PYR-1 VEGRPSIKSTLSFEPPPDFVAETLDDFVMLGLTITAMPAITAIPAVVAAP
MMAR_5250|M.marinum_M VDGTPTVTTKVSFLPPPYFQAETIADFMVLGHIMTAMPTINAIPAVVAAA
MAV_0371|M.avium_104 IDGQPTVTTKVGFLPPPYFEATTIEEFMDLGHIMTAMPAINAIPAVVAAA
MSMEG_0560|M.smegmatis_MC2_155 VAGRPTVTMKVGFLPPPDFEATTLEEFMVLGHIMTATPPLNAIPAVVAAP
TH_4249|M.thermoresistible__bu VDGRPTVNMEIGFLPPPDFGATTMEEFMVLGHIMTAMPPIHMIPAVVAAE
MAB_0727|M.abscessus_ATCC_1997 IQGDPCVYSKHMVIPKPGTDFTDPAAFASVGMTVTGLPALNAIRSVIDAP
MUL_3685|M.ulcerans_Agy99 VFGLPNMRTVLHCLPPKDWTES---GFMGLGMIYTAMPVTNAVPAVVAAK
Mb1088|M.bovis_AF2122/97 VRGSPDTCVTIKGWQPQTVAAG---LKSNPGIVATAAHCVNAIPATCAAP
Rv1059|M.tuberculosis_H37Rv VRGSPDTCVTIKGWQPQTVAAG---LKSNPGIVATAAHCVNAIPATCAAP
: * * * *. : :. *
Mflv_1767|M.gilvum_PYR-GCK AGIATYNDLPLLQPRGVLKTS-------------
Mvan_4980|M.vanbaalenii_PYR-1 AGIATYTDLPLLLPRGVLAPR-------------
MMAR_5250|M.marinum_M PGIVTYSDLALTLPRGMVPTDRNSDPKLGASRTP
MAV_0371|M.avium_104 PGIASYADLPLTLPRGNAHVAGQP----------
MSMEG_0560|M.smegmatis_MC2_155 PGIVTYNDLPLILPRGVVPTP-------------
TH_4249|M.thermoresistible__bu PGIATYNDLPLPQARGVVRV--------------
MAB_0727|M.abscessus_ATCC_1997 PGILTSADLPLRGFAGRFK---------------
MUL_3685|M.ulcerans_Agy99 PGIVTLADLPPITGRAAL----------------
Mb1088|M.bovis_AF2122/97 AGIQSFFDLPLITGRAAPGLAR------------
Rv1059|M.tuberculosis_H37Rv AGIQSFFDLPLITGRAAPGLAR------------
.** : **. .