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AEYDAIVIGAGHNGLTAAVLLQRAGLRTLCLDAKLYAGGMASTVELFDGYRFEIAGSVQFPTAAAVISEL GLDTLPTVDLEVMSVALRGVGDDPLVQYTDPMKMFAHLNEVHGADAVTGMAGLLAWSQAPTRALGRFESD TLPKTFDQMYACATNEFERSAIDDMLFGSVTDVLDRYFPDREKHAALRGSMTVLAVNTIYRGPATPGSAA ALAFGLGIPDGDFVQMKKLSGGIGALTAHLCRLFERDGGELRLRTKVSEILVDSAEAGARISGVRTEAGD IVAAPIVVSAIAPDVTINDLIDPTVLPSDVRDRYAHIDHRGSYLQMHFALEEAPAFAAPYEALNDPAMQA SIGIFCTPEEVQQQWEDCRRGIVPADPTVVLQVPSVHDPDLAPPGKHAASAFAMWFPIEGEQDSHEYGQA KTEMGQRVIDKVTRLAPNFERSIIRHTTFTPKHMGVMFGAPGGDYCHGLLHPDQIGQNRPGPRGFIGQPI PIAGLYLGSAGCHGGPGITFIPGFNAGRAALADR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5383 | - | - | 100% (525) | dehydrogenase |
| M. marinum M | MMAR_2813 | - | 0.0 | 61.26% (524) | dehydrogenase |
| M. marinum M | MMAR_4806 | crtI | 2e-11 | 23.18% (466) | phytoene dehydrogenase CrtI |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 0.0 | 83.24% (525) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1677 | - | 0.0 | 70.42% (524) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3829c | - | 0.0 | 83.43% (525) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0948c | - | 2e-06 | 35.62% (73) | hypothetical protein MAB_0948c |
| M. avium 104 | MAV_0198 | - | 0.0 | 81.90% (525) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_0664 | - | 3e-48 | 29.12% (546) | FAD dependent oxidoreductase |
| M. thermoresistible (build 8) | TH_4571 | - | 8e-12 | 25.71% (529) | PUTATIVE dehydrogenase |
| M. ulcerans Agy99 | MUL_2934 | - | 0.0 | 61.26% (524) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5076 | - | 0.0 | 71.62% (525) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1677|M.gilvum_PYR-GCK ----------------------MTDFDAIVVGAGHNGLTAAALLQQAGLR
Mvan_5076|M.vanbaalenii_PYR-1 ----------------------MADFDAIVVGAGHNGLTAAALLQRAGLR
Mb3859c|M.bovis_AF2122/97 ----------------------MTGYDAIVIGAGHNGLTAAVLLQRAGLR
Rv3829c|M.tuberculosis_H37Rv ----------------------MTGYDAIVIGAGHNGLTAAVLLQRAGLR
MMAR_5383|M.marinum_M ----------------------MAEYDAIVIGAGHNGLTAAVLLQRAGLR
MAV_0198|M.avium_104 ----------------------MNDYDAIVIGAGHNGLTAAVLLQKAGLR
MUL_2934|M.ulcerans_Agy99 ----------------------MTDYDAIVVGAGHNGLTAAAVLQRAGLR
MSMEG_0664|M.smegmatis_MC2_155 ---------------------MSNNYDALVIGGGHNGLVSAAYLARAGAR
MAB_0948c|M.abscessus_ATCC_199 -----------------MGLSESDRYDTVIVGGGHNALTAAAYLARAGQR
TH_4571|M.thermoresistible__bu VAAERSGADHGHLVPVPRRAGGGGVTTATVVGSGPNGLAAAVTLAKAGVA
: ::*.* *.*.:*. * :**
Mflv_1677|M.gilvum_PYR-GCK TVCLDFKLYAGGMASTVELFDG---FRFEIAGSVQVPTSAVVSDALELGD
Mvan_5076|M.vanbaalenii_PYR-1 TLCLDAKLYAGGMASTVELFDG---FRFEIAGSVQVPTSAVVSDALGLAE
Mb3859c|M.bovis_AF2122/97 TACLDAKRYAGGMASTVELFDG---YRFDIAGSVQFPTSSAVSSELGLDS
Rv3829c|M.tuberculosis_H37Rv TACLDAKRYAGGMASTVELFDG---YRFEIAGSVQFPTSSAVSSELGLDS
MMAR_5383|M.marinum_M TLCLDAKLYAGGMASTVELFDG---YRFEIAGSVQFPTAAAVISELGLDT
MAV_0198|M.avium_104 TLCLDAKLYAGGMASTVELFDG---YRFEIAGSVQFPTSQAVVDELGLDT
MUL_2934|M.ulcerans_Agy99 TLCMEANTYAGGMAATVELIDG---FHFEIAGSVQFPTASQISKELGLDT
MSMEG_0664|M.smegmatis_MC2_155 TLVLESRSSLGGAATTEAPWDDAPHLRVTRLSYVMSLMPPTIVRDLALER
MAB_0948c|M.abscessus_ATCC_199 VMLLERLDVFGGAAISAPAFEG-VEARLSRYSYLVSLMPRQIIDDLGLDV
TH_4571|M.thermoresistible__bu VTVLEAADEIGGGTRSFEAIVPG-LLHDHCSAIHPMAVGSPFINEFGLDR
. :: ** : : : . . : *
Mflv_1677|M.gilvum_PYR-GCK LPTVDLDVMSVQLRGVGDDPLVYYTDPMKLLTHLNDVHGAEAVNGMAGLM
Mvan_5076|M.vanbaalenii_PYR-1 LPTVDLDVMSVQLRGIGDDPLVYYTDPMKLLTHLNEVHGAEAVNGMAGLM
Mb3859c|M.bovis_AF2122/97 LPTVDLEVMSVALRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLL
Rv3829c|M.tuberculosis_H37Rv LPTVDLEVMSVALRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLL
MMAR_5383|M.marinum_M LPTVDLEVMSVALRGVGDDPLVQYTDPMKMFAHLNEVHGADAVTGMAGLL
MAV_0198|M.avium_104 IPTIDLDVMSVAVRGVGDDPLVQYSDPVKLFTHLNEVHGADAVNGMAGLM
MUL_2934|M.ulcerans_Agy99 LPTVAPEVMSTNIGESDEEAMIFYRDPLQLISHLGEKHGSAAVTGMAELI
MSMEG_0664|M.smegmatis_MC2_155 HGYKVHPMGPYYQAFPEGGSLTIYEDDPARTYEQLSRFSKKDADAWPKWN
MAB_0948c|M.abscessus_ATCC_199 R-LARRKYASYTPDPMNGGQRGFLAGP----------------NDFAEFG
TH_4571|M.thermoresistible__bu HGLRWRWPDIDCVHPLDDGTAGVLRRSVDHTAAGLGPDGRVWRALFGRPV
Mflv_1677|M.gilvum_PYR-GCK AWCQAPTRALGRFEAAQPP----KTLDEMFACATNEFERQAISDILFGSV
Mvan_5076|M.vanbaalenii_PYR-1 AWCQAPTRAVGRFDAAQRP----KSLDEMFACATNEFERQAISDMLFGSV
Mb3859c|M.bovis_AF2122/97 AWSQAPTRALGRFEAGTLP----KSFDEMYACATNEFERSAIDDMLFGSV
Rv3829c|M.tuberculosis_H37Rv AWSQAPTRALGRFEAGTLP----KSFDEMYACATNEFERSAIDDMLFGSV
MMAR_5383|M.marinum_M AWSQAPTRALGRFESDTLP----KTFDQMYACATNEFERSAIDDMLFGSV
MAV_0198|M.avium_104 AWAQAPTRALDRFEAGTPP----KSLDEMYACATNEFERSAIDDMLFGSV
MUL_2934|M.ulcerans_Agy99 GWSQGPARALGRFEVRTPP----RTLDEMYACATNQAERRAIHEMLFGSA
MSMEG_0664|M.smegmatis_MC2_155 AWLEGIADVMGPLLTQVPPNIGSHRPADLLDLAKLAWGQRGITSRAVADI
MAB_0948c|M.abscessus_ATCC_199 ALCDSVTRPMWDSMLQPLR-----RRGAVRTGAWEQLIETPIGEVIRAAT
TH_4571|M.thermoresistible__bu DRFDAVNDAVMGPLLRVPK----HPLTLARFGAPTVLPASALARVFRTPA
:. : * :
Mflv_1677|M.gilvum_PYR-GCK TDVLDR----YLPDREKHGALRGMLAFLAVNTTYRGPATPGSAAALAFG-
Mvan_5076|M.vanbaalenii_PYR-1 TDVLDR----YLPDREKHGALRGMLAFLAVNTTYRGPATPGSAAALAFG-
Mb3859c|M.bovis_AF2122/97 TDVLDR----HFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFG-
Rv3829c|M.tuberculosis_H37Rv TDVLDR----HFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFG-
MMAR_5383|M.marinum_M TDVLDR----YFPDREKHAALRGSMTVLAVNTIYRGPATPGSAAALAFG-
MAV_0198|M.avium_104 TDILDR----YLPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFG-
MUL_2934|M.ulcerans_Agy99 MDVIDR----FLPDKEKHAVMRGILAFLAVNSTYRGPFTPGSAACLAFA-
MSMEG_0664|M.smegmatis_MC2_155 TRLLTMSIADLLDDWFESPQIKGALAVNGVIGTWAGPYEPGTAYVMAHHS
MAB_0948c|M.abscessus_ATCC_199 PDDVRR----------------GVLLTDALIGTFASADDLSLQQNICFLY
TH_4571|M.thermoresistible__bu ARALWG----------------------GVAAHAFRPLHLPMTSAIGVG-
: .: . :
Mflv_1677|M.gilvum_PYR-GCK -LAVPDENATLIKKFRGGMGAVTEHLLQMFTAAGGELRLRTKVDEILVD-
Mvan_5076|M.vanbaalenii_PYR-1 -LAVPDENATLIKKFRGGMGAVTEHLLQMFSAAGGELRLRSKVDEIIVE-
Mb3859c|M.bovis_AF2122/97 -LGVPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDN
Rv3829c|M.tuberculosis_H37Rv -LGVPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDN
MMAR_5383|M.marinum_M -LGIPDGDFVQMKKLSGGIGALTAHLCRLFERDGGELRLRTKVSEILVDS
MAV_0198|M.avium_104 -LGVPDGDTMQMKKLRGGIGALTSHLCDVLERHGGELRLRTKVTEILVEH
MUL_2934|M.ulcerans_Agy99 -LAVPDDSTAMMTKLRGGIGALTDHLRERFASAGGEIRFRSKVVEIVVD-
MSMEG_0664|M.smegmatis_MC2_155 IGDVGDGQLGSWGFPEGGMGAVSAAIACSARSFGAEIRTNARVSRLLVR-
MAB_0948c|M.abscessus_ATCC_199 ------HQMNPWDVPIGGMGAVTGSLEASARRHGAELLSGAEVLSISPD-
TH_4571|M.thermoresistible__bu --IITAGHRHGWAVAEGGSRAITDAMAARLRELGGTIETGVRVRDIADLP
** *:: : *. : .* :
Mflv_1677|M.gilvum_PYR-GCK ---GGRVTGVRLEDGATLSAPVVVSNLAPDLTVNQLVDGSAIPADIRERF
Mvan_5076|M.vanbaalenii_PYR-1 ---DGRVAGVRLEDGSTLAAPMVVSAVAPDLTVNTLVDGGAVPPDVRERF
Mb3859c|M.bovis_AF2122/97 SRSSARVRGVRTAAGDTLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRY
Rv3829c|M.tuberculosis_H37Rv SRSSARVRGVRTAAGDTLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRY
MMAR_5383|M.marinum_M AEAGARISGVRTEAGDIVAAPIVVSAIAPDVTINDLIDPTVLPSDVRDRY
MAV_0198|M.avium_104 AGSGGRVTGVRTESGETLSAPIVVSGIAPDVTLNELLDPAALPADLRARY
MUL_2934|M.ulcerans_Agy99 ---RGAVSGVRLPDGSVIGTPVVVSNLAPDVTLAKLVGPEHVPADLLARL
MSMEG_0664|M.smegmatis_MC2_155 ---NGRVEGAVLDNGDEIHAPVVVTTLHPKTAFLDHIPRTELPQDFVGDI
MAB_0948c|M.abscessus_ATCC_199 ----AEVRYRSDGGEHTVAGDRVLSGVSP-----------TVLAGLLGET
TH_4571|M.thermoresistible__bu --------------------PTTITVFDLAPEAVAEILGDRLPPRVARAY
.:: . : .
Mflv_1677|M.gilvum_PYR-GCK ARIDHRGSYVQMHFALDGPPTFAEPYEVLNDPEYQSAIGIFTTPEELQQQ
Mvan_5076|M.vanbaalenii_PYR-1 SRIDHRGSYLQMHFALDGAPTFAEPYEMLNDPGYQSAIGIFTTPEELQQQ
Mb3859c|M.bovis_AF2122/97 LRIDHRGSYLQMHFALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQ
Rv3829c|M.tuberculosis_H37Rv LRIDHRGSYLQMHFALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQ
MMAR_5383|M.marinum_M AHIDHRGSYLQMHFALEEAPAFAAPYEALNDPAMQASIGIFCTPEEVQQQ
MAV_0198|M.avium_104 ARIDHRGSYLQMHFALQEAPVFAAPYQVLNEPAMQASIGLFCTPEEVQQQ
MUL_2934|M.ulcerans_Agy99 AGRDHRASFVQIHFALDALPEFAPPYELLNEPGMQQSVGIFGTPEEQQQQ
MSMEG_0664|M.smegmatis_MC2_155 EHWKSRSGVVKINLALAELPNFTADPSSGIAEHHTGSVEMAPTMEFIEAA
MAB_0948c|M.abscessus_ATCC_199 PPAGQPGAQVKVNLLLRRLPRLRDE-NVTPEQAFGGTFHVNETYTQLEYA
TH_4571|M.thermoresistible__bu RAFRRGPGAFKVDFAVEGGVPWCNP-----DAHRAGTVHVGGTFEEIAAT
. .::.: : :. : *
Mflv_1677|M.gilvum_PYR-GCK WEDSRRGVVPADP-----AIALQIPSANDPTLAPPGKHAVSAFSLWFPLS
Mvan_5076|M.vanbaalenii_PYR-1 WEDSRRGVVPADP-----AIALQIPSANDPGLAPPGKHAVSAFALWFPLS
Mb3859c|M.bovis_AF2122/97 WEDCRRGIVPADP-----TVVLQIPSLHDPSLAPAGKQAASAFAMWFPIE
Rv3829c|M.tuberculosis_H37Rv WEDCRRGIVPADP-----TVVLQIPSLHDPSLAPAGKQAASAFAMWFPIE
MMAR_5383|M.marinum_M WEDCRRGIVPADP-----TVVLQVPSVHDPDLAPPGKHAASAFAMWFPIE
MAV_0198|M.avium_104 WEQARRGVVPADP-----TVVLQIPSQNDPGLAPEGKHAASAFALWFPIE
MUL_2934|M.ulcerans_Agy99 WETCRRGIVPENP-----SMGMQIPSVHDSGLAPPGKHAASAYAYAFPVE
MSMEG_0664|M.smegmatis_MC2_155 FQDARNGKPALLP-----FSDGVIPTTLDTTLNPDGTHIMSLFTQWVPAE
MAB_0948c|M.abscessus_ATCC_199 YQQASHGRIPDPLPCEIYCHSLADPSILSPELRASGAHTLTVFGLHTPHG
TH_4571|M.thermoresistible__bu ERDVNAGRMPERP-----FVLVAQQYVADPGRSVGDIHPVWSYAHVPHGY
. * . .. . : :
Mflv_1677|M.gilvum_PYR-GCK E-EISG--YGALKTEMGRRVIDKITRLATDFEKLILRHTTFTPKHMGTMF
Mvan_5076|M.vanbaalenii_PYR-1 E-ERAS--YGEMKAEMGQRVIDKITRLAPDFESLMLRHTTFTPKHMGTMF
Mb3859c|M.bovis_AF2122/97 G-GSKYGGYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMF
Rv3829c|M.tuberculosis_H37Rv G-GSKYGGYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMF
MMAR_5383|M.marinum_M G-EQDSHEYGQAKTEMGQRVIDKVTRLAPNFERSIIRHTTFTPKHMGVMF
MAV_0198|M.avium_104 G-EVD---YGQAKIEMGQRVIDKITRLAPNFEDSIIRHTTFTPRHMGVMF
MUL_2934|M.ulcerans_Agy99 V-DRDQ--HGHLKRIMARRVIDKITRFAPNFKDIVIRYITFAPYHMQTMF
MSMEG_0664|M.smegmatis_MC2_155 W-AAEP--HTEELDAYADRLIELYDQVAPGFKASITHRDIVGPYDMEHEY
MAB_0948c|M.abscessus_ATCC_199 LGASAEQLQQAVLASLSSVLAEPITDVVATDTHGRPCIETKTTIDLESAL
TH_4571|M.thermoresistible__bu P------------GDATEAVVAQIERFAPGFRDRIVGYRTESAEGMARFN
: ... . :
Mflv_1677|M.gilvum_PYR-GCK N-APGGDYCHGLIHPEQMGPNRPGPKGYVDQPIPIAG--LYLAGAGCHGG
Mvan_5076|M.vanbaalenii_PYR-1 G-APGGDYCHGLIHPEQMGPNRPGPKGYADQPIPVDG--LYLASAGCHGG
Mb3859c|M.bovis_AF2122/97 G-APGGDYCHALLHSDQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGG
Rv3829c|M.tuberculosis_H37Rv G-APGGDYCHALLHSDQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGG
MMAR_5383|M.marinum_M G-APGGDYCHGLLHPDQIGQNRPGPRGFIGQPIPIAG--LYLGSAGCHGG
MAV_0198|M.avium_104 G-APGGDYCHGLLNANQVGPNRPGPRGFLGQPIPIEG--LYLGSAGCHGG
MUL_2934|M.ulcerans_Agy99 G-APSGDFCHGLLHPDLMGPNRPGPGGFLDFPIPIDG--LYLGGAGCHGG
MSMEG_0664|M.smegmatis_MC2_155 G-LIGGNIFHGELSLEQLFHMRPAP-GYADYRTPIAG--LYNGSSATHAG
MAB_0948c|M.abscessus_ATCC_199 G-MTAGNIFHGGLQWPFAEDDDPLETAAQRWGVATNHDRILLCGSGSRRG
TH_4571|M.thermoresistible__bu ANFTGGDILTGAKDIRQLTFG--PRITLSPYATGAPG--YYICSAATPPG
.*: . .:. *
Mflv_1677|M.gilvum_PYR-GCK PGITFIPGYNAAQQVLAEH---------------------
Mvan_5076|M.vanbaalenii_PYR-1 PGITFIPGYNAAQQVLADRT--------------------
Mb3859c|M.bovis_AF2122/97 PGITFIPGYNAARQALADRRAANCCVLSGR----------
Rv3829c|M.tuberculosis_H37Rv PGITFIPGYNAARQALADRRAANCCVLSGR----------
MMAR_5383|M.marinum_M PGITFIPGFNAGRAALADR---------------------
MAV_0198|M.avium_104 PGITFIPGYNAARQALTDRSG-------------------
MUL_2934|M.ulcerans_Agy99 PGITFIPGYNAAYQVLEDVATRQTSG--------------
MSMEG_0664|M.smegmatis_MC2_155 GGVCGIPGWQAARAVLADKKRARRSEALRKRLPAALGGRS
MAB_0948c|M.abscessus_ATCC_199 GGVSGLGGYHAARAVLETH---------------------
TH_4571|M.thermoresistible__bu PGAHGMCGYHAAQTALRELAR-------------------
* : *::*. .*