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PFLDHDRGPAYYRHWAAEDPRAAVVFLHGFGEHTGLYHRYAFALNAAGIDVWAVDQFGHGLSPGTRGDFG SIEDSSALADALTERASTRSVPLIAQGHSFGSIVTLFRLLDGPNRYRAAVISGSPLIPVPELVDADTSID LDPGWLSSDPFYLDALENDPLAFVESDSTALTRELDRGWDRFGSDLPALSVPTLAVHGVNDPIAPIGAVR AYAEQIDALELAAFDGARHDVLNESQHGDVAAAIIGFIESHLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1469 | - | - | 100% (254) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_0518 | - | 6e-19 | 29.23% (260) | acylglycerol lipase |
| M. gilvum PYR-GCK | Mflv_1415 | - | 2e-07 | 34.19% (117) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0189 | - | 2e-21 | 29.01% (262) | lysophospholipase |
| M. tuberculosis H37Rv | Rv0183 | - | 2e-21 | 29.01% (262) | lysophospholipase |
| M. leprae Br4923 | MLBr_02603 | - | 2e-18 | 26.48% (253) | hypothetical protein MLBr_02603 |
| M. abscessus ATCC 19977 | MAB_4551c | - | 1e-17 | 27.82% (266) | lysophospholipase |
| M. marinum M | MMAR_0427 | - | 6e-21 | 29.25% (253) | lysophospholipase |
| M. avium 104 | MAV_4997 | - | 2e-24 | 30.38% (260) | lysophospholipase |
| M. smegmatis MC2 155 | MSMEG_6029 | - | 1e-108 | 71.37% (255) | hypothetical protein MSMEG_6029 |
| M. thermoresistible (build 8) | TH_3727 | - | 4e-06 | 24.55% (277) | PUTATIVE Chloride peroxidase |
| M. ulcerans Agy99 | MUL_1077 | - | 1e-20 | 28.85% (253) | lysophospholipase |
| M. vanbaalenii PYR-1 | Mvan_5302 | - | 1e-120 | 81.67% (251) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1469|M.gilvum_PYR-GCK ---------------------------MPFLDHDRGPAYYRHWAAE-DPR
Mvan_5302|M.vanbaalenii_PYR-1 ---------------------------MPFLGHERGRAYYRHWAAA-EPA
MSMEG_6029|M.smegmatis_MC2_155 MPDEISYHTAGRLETLAVAARHCCSNDMPFVEHPRGRAYYRHWPAP-EPR
Mb0189|M.bovis_AF2122/97 --------------------MTTTRTERNFAGIGDVRIVYDVWTPDTAPQ
Rv0183|M.tuberculosis_H37Rv --------------------MTTTRTERNFAGIGDVRIVYDVWTPDTAPQ
MMAR_0427|M.marinum_M --------------------MNTTRTERTFDGVGGVHIVYDVWTPDAAPK
MUL_1077|M.ulcerans_Agy99 --------------------MNTTRTERTFDGVGGVHIVYDVWTPDAAPK
MAV_4997|M.avium_104 --------------------MN--RTERSFDGVGGVRIVYDVWTPEVAPR
MLBr_02603|M.leprae_Br4923 --------------------MTITRTERNFYGVGGVRIVYDVWMPDTRPR
MAB_4551c|M.abscessus_ATCC_199 -------------------------MQRTFDGADDVRIVYDTWTPAGTPR
TH_3727|M.thermoresistible__bu --------------------------MATITTSDGVEIFYRDWGSG----
: * * .
Mflv_1469|M.gilvum_PYR-GCK AAVVFLHGFGEHTGLYHRYAFALNAAGIDVWAVDQFGHGLSPGTRGDFGS
Mvan_5302|M.vanbaalenii_PYR-1 AAVVFLHGFGEHTGLYHRYGFALNAAGIDLWAVDQFGHGLSPGDRGDFGT
MSMEG_6029|M.smegmatis_MC2_155 AAVIFLHGFGEHTGLYHRYGFTLNAAGIDLWVVDQFGHGLTPGTRGDFGK
Mb0189|M.bovis_AF2122/97 AVVVLAHGLGEHARRYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRD
Rv0183|M.tuberculosis_H37Rv AVVVLAHGLGEHARRYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRD
MMAR_0427|M.marinum_M AVVVLAHGLGEHARRYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRD
MUL_1077|M.ulcerans_Agy99 AVVVLAHGLGEHARRYDHVAQRLGAAGLVTYTLDHRGHGRSGGKRVLVRD
MAV_4997|M.avium_104 AVLVLAHGFGEHARRYDHVARRFGAAGLVTYALDHRGHGRSGGKRVLVRD
MLBr_02603|M.leprae_Br4923 AVIILAHGFGEHARRYDHVAHYFAAAGLATYALDLRGHGRSAGKRVLVRD
MAB_4551c|M.abscessus_ATCC_199 AVVVLSHGFGEHARRYDHVARRFNEAGYLVYALDHRGHGRSGGKRVYLRD
TH_3727|M.thermoresistible__bu QPIVFSHGWPLTADDWDPQMLFFLNAGYRVIAHDRRGHGRSS-PVPDGHD
::: ** : :. : ** . * *** :
Mflv_1469|M.gilvum_PYR-GCK IEDSSALADALTERASTRS--VPLIAQGHSFGSIVTLFRLLDGPNRYRAA
Mvan_5302|M.vanbaalenii_PYR-1 IEDSSALAEQLTDLVAQQHPGLPLIAQGHSFGAIVTLFRLLDGAARYRAA
MSMEG_6029|M.smegmatis_MC2_155 IEDSSALAEALTVLAEKQNPGLPLIAQGHSFGSVVTLFRLLAEPDRYRAG
Mb0189|M.bovis_AF2122/97 ISEYTADFDTLVGIATREYPGCKRIVLGHSMGGGIVFAYGVERPDNYDLM
Rv0183|M.tuberculosis_H37Rv ISEYTADFDTLVGIATREYPGCKRIVLGHSMGGGIVFAYGVERPDNYDLM
MMAR_0427|M.marinum_M ISEYTADFDTLVGIATRDNPGLKCIVLGHSMGGGIVFAYGVERPDNYDLM
MUL_1077|M.ulcerans_Agy99 ISEYTADFDTLVGIATRDNPGLKCIVLGHSMGGGIVFAYGVERPDNYDLM
MAV_4997|M.avium_104 IHEYTTDFDTLVGIATREHHGLKCIVVGHSMGGGIVFAYGVERPDNYDLM
MLBr_02603|M.leprae_Br4923 LSEYNADFDILVGIATRDHPGLKRIVAGHSMGGAIVFAYGVERPDNYDLM
MAB_4551c|M.abscessus_ATCC_199 ISEYTDDFGTLVDIAAREHPDLKRIVLGHSMGGGIVFAYGVDHQDRYDLM
TH_3727|M.thermoresistible__bu MDHYADDLAALVEHLGLRD----AVHVGHSTGGGVVVRYLARHGEERTAK
: . *. : *** *. :.. .
Mflv_1469|M.gilvum_PYR-GCK VISGSPLIP--------------VPELVDADTSIDLDPGWLSSDPFYLDA
Mvan_5302|M.vanbaalenii_PYR-1 VVSGAPLIP--------------IPDLLDADTSFDLDPAWLSADPFYVDS
MSMEG_6029|M.smegmatis_MC2_155 IISGAPLVP--------------IPDMLDADTSLDLDLNWLSSDPFYRDS
Mb0189|M.bovis_AF2122/97 VLSAPAVAAQDLVSPVVAVAAKLLGVVVPGLPVQELDFTAISRDPEVVQA
Rv0183|M.tuberculosis_H37Rv VLSAPAVAAQDLVSPVVAVAAKLLGVVVPGLPVQELDFTAISRDPEVVQA
MMAR_0427|M.marinum_M VLSAPAVAAQDLVSPVIAAAAKVLGVVVPGLPVQELDFTAISRDPEVVAA
MUL_1077|M.ulcerans_Agy99 VLSAPAVAAQDLVSPVIAAAAKVLGVVVPGLPVQELDFTAISRDPEVVAA
MAV_4997|M.avium_104 VLSGPAVAAQDQVSPLLALAAKVLGVIVPGLPAQELDADAVSRDPEVVAA
MLBr_02603|M.leprae_Br4923 VLSGPAVAAQDMVSPLRAVVGKGLGLVAPGLPVHQLEVDAISRNRAVVAA
MAB_4551c|M.abscessus_ATCC_199 VLSGPAIAAQVGLPYVLTLVAPVVGRLAPGLPVQKLDVNAISHDPAIIAA
TH_3727|M.thermoresistible__bu AVLIAAVPP-------LMVRTDANPGGLPKSVFDDFQAQLAANRSEFYRA
: ..: . .:: : :
Mflv_1469|M.gilvum_PYR-GCK LENDPLAFVESDSTALTRELDR---------------------GWDRFGS
Mvan_5302|M.vanbaalenii_PYR-1 LENDPLAFVASDSTALTRELDR---------------------GWDRFGT
MSMEG_6029|M.smegmatis_MC2_155 LENDPLAFSDADAAPLTRELDR---------------------AWDRFGL
Mb0189|M.bovis_AF2122/97 YNTDPLVHHGRVPAGIGRALLQ---------------------VGETMPR
Rv0183|M.tuberculosis_H37Rv YNTDPLVHHGRVPAGIGRALLQ---------------------VGETMPR
MMAR_0427|M.marinum_M YQNDPQVYHGRVPAGIGRALLQ---------------------VGETMPR
MUL_1077|M.ulcerans_Agy99 YQNDPQVYHGRVPAGIGRALLQ---------------------VGETMPR
MAV_4997|M.avium_104 YRNDPLVYHGKVPAGVGRALLQ---------------------VGETMPQ
MLBr_02603|M.leprae_Br4923 YKDDPLVYHGKVPAGVGRVMLQ---------------------VGETMTR
MAB_4551c|M.abscessus_ATCC_199 YHADPLVHHGRVPAGIGRALLG---------------------VGKTMRQ
TH_3727|M.thermoresistible__bu LASGPFYGFNRDGVEPSEALIANWWRQGMMGDAKAHYDGIVAFSQTDFTE
.* . . : :
Mflv_1469|M.gilvum_PYR-GCK DLPALSVPTLAVHGVNDPIAPIGAVRAYAEQI--DALELAAFDGARHDVL
Mvan_5302|M.vanbaalenii_PYR-1 DLPSLSVPTLAVHGVNDPIAPIGAVRAYAEQI--EALQLVEFAGARHDVL
MSMEG_6029|M.smegmatis_MC2_155 ELPQLTVPTLAVHGSADVIAPVDAVRAYAEQI--EPLQLKEFHGARHDVL
Mb0189|M.bovis_AF2122/97 RAPALTAPLLVLHGTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVF
Rv0183|M.tuberculosis_H37Rv RAPALTAPLLVLHGTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVF
MMAR_0427|M.marinum_M RAPALTAPLLVIHGTDDRLIPIEGSRRLVGHVGSADVELKEYPGLYHEAF
MUL_1077|M.ulcerans_Agy99 RAPALTAPLLVIHGTDDRLIPIEGSRRLVGHVGSADVELKEYPGPYHEAF
MAV_4997|M.avium_104 RAPALTAPLLVVHGSDDRLIPVAGSRRLVECVGSADVELKVYPGLYHEVF
MLBr_02603|M.leprae_Br4923 RAPVLTTPLLVVHGSEDRLVLVDGSHRLVECVGSTDVELKVYPGLYHEVF
MAB_4551c|M.abscessus_ATCC_199 RAAGLKRPVLTMHGSDDRLTAPEGSRWLSESA--PDATLKIWNGLYHEIF
TH_3727|M.thermoresistible__bu DLTKITVPVLVMHGDDDQVVPYANSGPLTAEL-LRNAKLKTYQGFPHGMM
. :. * *.:** * : * : * * :
Mflv_1469|M.gilvum_PYR-GCK NESQHGDVAAAIIGFIESHLR
Mvan_5302|M.vanbaalenii_PYR-1 NEVQHRDVAAAIIDFIHRSY-
MSMEG_6029|M.smegmatis_MC2_155 NESVHREVAATVVKFISSQIG
Mb0189|M.bovis_AF2122/97 NEPERNQVLDDVVAWLTERL-
Rv0183|M.tuberculosis_H37Rv NEPERNQVLDDVVAWLTERL-
MMAR_0427|M.marinum_M NEPERDQVLDDVVSWITARL-
MUL_1077|M.ulcerans_Agy99 NEPERDQVLDDVVSWITARL-
MAV_4997|M.avium_104 NEPEREQVLDDVVGWITARL-
MLBr_02603|M.leprae_Br4923 NEPERDQVLEDVVCWILKRL-
MAB_4551c|M.abscessus_ATCC_199 NEFEKELVLDEVVGWIDARL-
TH_3727|M.thermoresistible__bu T-THAEVVNADILEFLRS---
. * :: ::