For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ADKKPSPIVIFAPLPVLTVTVEDRSGEADIHVHAGGQGVWQSRMVSSLGVPVVLCSALGGETGDVLGHLL PADGVTVQTVPVSARNGSYVHDRRSGSREIIAEADGSPLDRHELDSLYELTLTEGLTHGRVLLSGPQEDD VIPADLYRRLSTDLSANGCKVAADLSGERLKAVLEGKPDLIKVSHEELLDDGRAKSEDAADLVKAMHSMR DDGAGTIVVSRSGSAPALALLDDGDVLEVCMPTLEPADPAGAGDSMTAGMVSALALGRSLREALQIGAAC GALNVVRHGLGTGGARAVETLAERVELKEWKK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0949 | - | - | 100% (313) | ribokinase-like domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0751 | - | 2e-15 | 29.53% (298) | ribokinase-like domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4987 | - | 3e-14 | 30.00% (260) | ribokinase-like domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2054c | pfkB | 7e-12 | 26.20% (271) | phosphofructokinase pfkB (phosphohexokinase) |
| M. tuberculosis H37Rv | Rv2029c | pfkB | 8e-12 | 26.20% (271) | phosphofructokinase PfkB (phosphohexokinase) |
| M. leprae Br4923 | MLBr_00873 | - | 2e-05 | 23.33% (270) | putative carbohydrate kinase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3482 | pfkB_1 | 1e-10 | 26.64% (274) | phosphofructokinase, PfkB_1 |
| M. avium 104 | MAV_0347 | - | 1e-07 | 25.84% (267) | kinase, PfkB family protein |
| M. smegmatis MC2 155 | MSMEG_1378 | - | 2e-12 | 29.67% (246) | 1-phosphofructokinase |
| M. thermoresistible (build 8) | TH_4035 | - | 1e-140 | 77.57% (321) | PUTATIVE PfkB domain protein |
| M. ulcerans Agy99 | MUL_3559 | cbhK | 3e-06 | 24.32% (259) | carbohydrate kinase CbhK |
| M. vanbaalenii PYR-1 | Mvan_4105 | - | 3e-16 | 27.01% (274) | ribokinase-like domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00873|M.leprae_Br4923 -MTIAVTG--SIATDHLMRFPGRFSEQLLVDNLHKVSLSFLVDDLVIHRG
MUL_3559|M.ulcerans_Agy99 -MTIAVTG--SIATDHLMRFPGHFSEQLLPEHLHKVSLSFLVDDLVVHRG
Mflv_0949|M.gilvum_PYR-GCK -MADKKP------SPIVIFAPLPVLTVTVE-------DRSGEADIHVHAG
TH_4035|M.thermoresistible__bu -MTDAPPPDERPENAVVIFAPLPVLTVTIE-------DRSGEADIHVHAG
Mb2054c|M.bovis_AF2122/97 MTEPAAWD--EGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPRYDPG
Rv2029c|M.tuberculosis_H37Rv MTEPAAWD--EGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPRYDPG
MMAR_3482|M.marinum_M MTSPADPA--VRGPQIVTLTMNPALDITTCVGVVRPTEKLRCSETRYDPG
Mvan_4105|M.vanbaalenii_PYR-1 MTDITNVRSPVSGSRIVTLTMNPALDIATSTEIVMPTEKMRCSAARYDPG
MSMEG_1378|M.smegmatis_MC2_155 --------------MIVTVTPNPSLDRTLHLPALRPGEVNRATSTMTEPS
MAV_0347|M.avium_104 ---------------MVVIGQIGRDLVLRTDRPPTAGESATVLRREELLG
: .
MLBr_00873|M.leprae_Br4923 GVAGNMAYAIGVLGGDVALIGAVG--DDFADYRDWLQNHGVNCDSVLISK
MUL_3559|M.ulcerans_Agy99 GVAGNMAFAIGVLGGDVALVGAAG--ADFADYRDWLKAHGVNCDHVLISQ
Mflv_0949|M.gilvum_PYR-GCK GQGVWQSRMVSSLGVPVVLCSALGG-ETGDVLGHLLPADGVTVQTVPVSA
TH_4035|M.thermoresistible__bu GQGVWQSRMLSSLGVPVVLCAAVGG-ETGDVLGHLLPIPDVTVRTVPVSS
Mb2054c|M.bovis_AF2122/97 GGGINVARIVHVLGGCSTALFPAGG-STGSLLMALLGDAGVPFRVIPIAA
Rv2029c|M.tuberculosis_H37Rv GGGINVARIVHVLGGCSTALFPAGG-STGSLLMALLGDAGVPFRVIPIAA
MMAR_3482|M.marinum_M GGGINVARIAHVLGGSVFAVFPVGG-SHGAHVSKLLSEAGVAFGEIPIAA
Mvan_4105|M.vanbaalenii_PYR-1 GGGINVARVARTLGASVVALFPAGG-ASGDLFADMLEAIGISAHMIPIAG
MSMEG_1378|M.smegmatis_MC2_155 GKGVNVALALHGAGHATRAVLPVGG-SVGAEIASALEGFGLDTIGVPVAG
MAV_0347|M.avium_104 GKGANQAVGLAQLGVPVTLIGVVGDDQAGTSILQQAQRDGIDVSKVARRG
* . : * * .: :
MLBr_00873|M.leprae_Br4923 TAHTARFVCTTDLDMAQIGSFYTGAMSEARNIKLVDAIATIGTPELVIIG
MUL_3559|M.ulcerans_Agy99 TAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAVGTPELVIVA
Mflv_0949|M.gilvum_PYR-GCK RN-GSYVHDRRSGSREIIAEADGSPLDRHELDSLYELTLTEGLTHGRVLL
TH_4035|M.thermoresistible__bu RN-GAYVHDRRTGERQVIAESPGSPLDRHELDSLYELTLTEGLKHGRVLL
Mb2054c|M.bovis_AF2122/97 STRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVA
Rv2029c|M.tuberculosis_H37Rv STRESFTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVA
MMAR_3482|M.marinum_M STRESFTVNESSTGEQYRFVLPGPVLAPEEQAQCLQELGFAARSAQFVVA
Mvan_4105|M.vanbaalenii_PYR-1 STRESITVNELRTQRQYRFVLPGPTLTAAEQTECLNQLREVAASADFVVA
MSMEG_1378|M.smegmatis_MC2_155 SVRSNVTLVEAD-GRSTKVNEPGPFLSEDEVDALCAAA--LADAADWVVW
MAV_0347|M.avium_104 TTALLVDVVAAPPERMLLEDVPDSSLVRVADLDRSSSLFDTADTVSIQLQ
: . :
MLBr_00873|M.leprae_Br4923 ANDPAAMLGYTQECRKLGLAFAADPSQQLARLSGEEIRNLIDG--ATYLF
MUL_3559|M.ulcerans_Agy99 ANDPEAMFLHTEECRQLGLAFAADPSQQLARLSGDEIKRLING--ATYLF
Mflv_0949|M.gilvum_PYR-GCK SGPQEDDVIPADLYRRLSTDLSANGCKVAADLSGERLKAVLEGK-PDLIK
TH_4035|M.thermoresistible__bu SGPQEFGTLPAQLYRRLAGDLGGNGCQVAADLSGDRLEAVLAGG-PELIK
Mb2054c|M.bovis_AF2122/97 SGSLPPG-VAADYYQRVADICRRSSTPLILDTSGGGLQHISSG--VFLLK
Rv2029c|M.tuberculosis_H37Rv SGSLPPG-VAADYYQRVADICRRSSTPLILDTSGGGLQHISSG--VFLLK
MMAR_3482|M.marinum_M SGSLPPG-VPADFYQRVAEACRGLGARLILDTSGGGLSHISAG--VYLLK
Mvan_4105|M.vanbaalenii_PYR-1 SGSLPPG-VSPEFYNRIADVCAQLDAPLVLDASGGGLQHLTGGN-VYLLK
MSMEG_1378|M.smegmatis_MC2_155 AGSLPAG-FAPARLAAAVDEARAAGRRVAVDASGAAMTAVLAGGSPHLIK
MAV_0347|M.avium_104 Q--------PAATALEAAQRARQRGLRVVADGVPAPQVRADLLATLDVLR
. :
MLBr_00873|M.leprae_Br4923 TNDYEWDLLLSKTGWSEADVMAQI---------QLRVTTLGAKGVDLVEP
MUL_3559|M.ulcerans_Agy99 TNDYEWDLLLSKTGWSEADVMAQI---------GLRVTTLGPKGVDLVEP
Mflv_0949|M.gilvum_PYR-GCK VSHEELLDDGRAKSEDAADLVKAMHSMRDDGAGTIVVSRSGSAPALALLD
TH_4035|M.thermoresistible__bu VSHEELLADGRAKSDDAADLVDAMRTLRDDGAGTVVVSRAGSAPALALLD
Mb2054c|M.bovis_AF2122/97 ASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGALLATR
Rv2029c|M.tuberculosis_H37Rv ASVRELRECVGSELLTEPEQLAAAHELIDRGRAEVVVVSLGSQGALLATR
MMAR_3482|M.marinum_M ASVRELRECVGRPLVTEAEQLAAASELVETGRAEVVVVSLGSDGALLATR
Mvan_4105|M.vanbaalenii_PYR-1 PSIRELRECVRRELGSEAEQVAAARELIERGGARNVLVSLGAQGALLVTA
MSMEG_1378|M.smegmatis_MC2_155 PNLDELADATGATPATLADVVDAARSLR----VDTVLVSLGGDGAVLVTS
MAV_0347|M.avium_104 ADATEASIIAGTEITTVEQAFELADHLLS-GGPELVALAVPDVGDLLTWR
. * : .
MLBr_00873|M.leprae_Br4923 D---------GTRVHVSVVPEAGQVDPTGVGDAFRAGFLTGRSAGLSLER
MUL_3559|M.ulcerans_Agy99 D---------GTSIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLNLER
Mflv_0949|M.gilvum_PYR-GCK D----------GDVLEVCMPTLEPADPAGAGDSMTAGMVSALALGRSLRE
TH_4035|M.thermoresistible__bu GQRPGGDGSRGGSVVEIVMPTLEPADSAGAGDSMTAGIVAALAQGRPLRR
Mb2054c|M.bovis_AF2122/97 H-----------ASHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIK
Rv2029c|M.tuberculosis_H37Rv H-----------ASHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIK
MMAR_3482|M.marinum_M R-----------ARHRFRAVEMRGGSGVGAGDAMVAAITVGLARGWPLVK
Mvan_4105|M.vanbaalenii_PYR-1 D-----------GAQRYPAVEVPPGSGVGAGDAMVAGVTCGLGRGWGLPK
MSMEG_1378|M.smegmatis_MC2_155 D-----------LALHGTAPVDRVVNTVGAGDALLAGYLAACSDGP--AD
MAV_0347|M.avium_104 G-----------GSELFEFADVEVVDPTGAGDAFVAGLVAALREGAAPRE
. .*.**:: *. . *
MLBr_00873|M.leprae_Br4923 SAQLGSLVAVLVLESTGTQQWGWDRDVAVARLAGAYGEEAAAEITVVLS-
MUL_3559|M.ulcerans_Agy99 AAQLGSLVAVLVLESTGTQEWQWDRQVATARLAEAYGDDAANEITAVLA-
Mflv_0949|M.gilvum_PYR-GCK ALQIGAACGALNVVRHGLGTGGARAVETLAERVELKEWKK----------
TH_4035|M.thermoresistible__bu ALQVGAACGALNVVRHGLGTGGAEAVETLAERVELRAWEAAG--------
Mb2054c|M.bovis_AF2122/97 SVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIV
Rv2029c|M.tuberculosis_H37Rv SVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIV
MMAR_3482|M.marinum_M SVRLGIAAGAAMLLTPGTQACERADVERLFEHVAEPVEVA----------
Mvan_4105|M.vanbaalenii_PYR-1 SVRLGIAAGAAMLMTPGTASCTRADVERLFDRTPDPVDLTVPAADR----
MSMEG_1378|M.smegmatis_MC2_155 ALASALRFGATAVEHEGTLIG-VPDPQRPVRIGPARGDLRLG--------
MAV_0347|M.avium_104 AGRRAAAAAGATVQRLG----GRPDLTGLRA-------------------
: . . : *
MLBr_00873|M.leprae_Br4923 ------
MUL_3559|M.ulcerans_Agy99 ------
Mflv_0949|M.gilvum_PYR-GCK ------
TH_4035|M.thermoresistible__bu ------
Mb2054c|M.bovis_AF2122/97 NPEASP
Rv2029c|M.tuberculosis_H37Rv NPEASP
MMAR_3482|M.marinum_M ------
Mvan_4105|M.vanbaalenii_PYR-1 ------
MSMEG_1378|M.smegmatis_MC2_155 ------
MAV_0347|M.avium_104 ------