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QISMFGQISAFGGNAIDATIGYLSQLRDEGFGRVWISQLPYEPDLLTVLAVALHEVDTIEVASGVVPIQN QHPMQMAQRALTVSLASNGRFILGLGMTHAAVTEGMWGIPWDKPVRRLNEYLDGLLPLLAGEPANATGET VTTRGALMIPGAPRPDVYIAALGPQLLRLAGRRTQGTCTWMTGPATLRDHVSPTLRQAAADAGRPDGSVR VVASLPVAVTDDVDELRKQAADQFAMYGTLPSYRAMLDREGYAGPEDAAIIGDEATVRDQIAELGAAGVD EYVGAVFDSSVEGRDRTRALLRELG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0410 | - | - | 100% (306) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_2389 | - | 3e-40 | 33.33% (285) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_2453 | - | 7e-39 | 34.62% (260) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1395 | - | 2e-15 | 25.65% (308) | oxidoreductase |
| M. tuberculosis H37Rv | Rv1360 | - | 2e-15 | 25.65% (308) | oxidoreductase |
| M. leprae Br4923 | MLBr_00348 | - | 3e-11 | 28.23% (209) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1339 | - | 1e-40 | 35.91% (298) | putative monooxygenase (luciferase-like) |
| M. marinum M | MMAR_4796 | - | 1e-34 | 29.39% (313) | oxidoreductase |
| M. avium 104 | MAV_3337 | - | 4e-40 | 32.97% (279) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4879 | - | 1e-39 | 32.39% (284) | hypothetical protein MSMEG_4879 |
| M. thermoresistible (build 8) | TH_3430 | - | 1e-111 | 67.35% (294) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_0365 | - | 2e-34 | 28.71% (310) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0261 | - | 1e-160 | 91.48% (305) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1395|M.bovis_AF2122/97 -------MGGARRLK----------LDGSIPNQLARAADAAVALERNGFD
Rv1360|M.tuberculosis_H37Rv -------MGGARRLK----------LDGSIPNQLARAADAAVALERNGFD
Mflv_0410|M.gilvum_PYR-GCK ---------MQISMFGQ--------ISAFGGNAIDATIGYLSQLRDEGFG
Mvan_0261|M.vanbaalenii_PYR-1 ---------MQISMFGQ--------ISGLGGNPIDATIAYLSQLRDEGFA
TH_3430|M.thermoresistible__bu -VNRPTTHRMGVLMAGMRISLSIVGLTPDGPDPIDSLVRDLTALRDAGFG
MMAR_4796|M.marinum_M -------MRVGVMIG---------PERGDSGRKVGRMLADIDWAETAGLD
MUL_0365|M.ulcerans_Agy99 -------MRVGVMIG---------PERGDSGRKVGRMLADIDWAETAGLD
MSMEG_4879|M.smegmatis_MC2_155 -------MRLGVMIG---------AERGDMTRKVNKLAADIQWAEAAGLD
MAB_1339|M.abscessus_ATCC_1997 -------MKLGVAIGRP-------LSVQNSTNLVDTFIAHARRVAEAGVR
MAV_3337|M.avium_104 -------MSAGIIL----------MAHPDAANLVDDVIAQARRAHELGVG
MLBr_00348|M.leprae_Br4923 MVERANAMKLGLQLG------------YWAAQPPGNAAELVAAAEGAGFD
: *.
Mb1395|M.bovis_AF2122/97 GGWTAEA--SHDPFLPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWD
Rv1360|M.tuberculosis_H37Rv GGWTAEA--SHDPFLPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWD
Mflv_0410|M.gilvum_PYR-GCK RVWISQLPYEPDLLTVLAVALHEVDTIEVASGVVPIQNQHPMQMAQRALT
Mvan_0261|M.vanbaalenii_PYR-1 RVWISQLPYEPDLLTILAVALREVDTIEVASGVVPIQNQHPMQMAQRALT
TH_3430|M.thermoresistible__bu RVWLAQLPFDIDLPTVLGIALRAVDGIEVGSGVIPIQPQHPMQLAQRALT
MMAR_4796|M.marinum_M SAWIPQIPNDFDALVAVTLMGTRSSRIELGTAVVPLQTQHPIALARQALS
MUL_0365|M.ulcerans_Agy99 SAWIPQIPNDFDALVAVTLMGTRSSRIELGTAVVPLQTQHPIALARQALS
MSMEG_4879|M.smegmatis_MC2_155 SAWMPQVPDDFDCLSMVALMAAHTSTIELGTAVVPLQAQHPVALARQALS
MAB_1339|M.abscessus_ATCC_1997 TLWLGQM-YHYDSITMAAVVGQTVPDVTVGVSVIPINPRHPIEVSAAAQT
MAV_3337|M.avium_104 QVWLAQQ-QSYDAIALAALVGAAVPGLGVGTSVVPINPRHPLIVASLAQT
MLBr_00348|M.leprae_Br4923 AVFTGEA-WGSDAYTPLAWWGSSTQRVRLGTSVVQLSARTPTACAMAALT
: : * : :. : : * : .
Mb1395|M.bovis_AF2122/97 LQTYSKGRLILGLGTQIRPHIEKRFSMPWGHPARRMREFVAALRAIWLAW
Rv1360|M.tuberculosis_H37Rv LQTYSKGRLILGLGTQIRPHIEKRFSMPWGHPARRMREFVAALRAIWLAW
Mflv_0410|M.gilvum_PYR-GCK VSLASNGRFILGLGMTHAAVTEGMWGIPWDKPVRRLNEYLDGLLPLLAG-
Mvan_0261|M.vanbaalenii_PYR-1 VSLASGGRFILGLGMTHAAVTEGMWGIPWDRPVRRLNEYLDGLLPLLAG-
TH_3430|M.thermoresistible__bu LSLISGGRFLLGIGMSHRMVAEGMWGVSWDRPVRQMREYLDGLQPLLAG-
MMAR_4796|M.marinum_M VHAATGGRLVLGVGPSHHWIVDDMLGLPYQRPAAYTRDYLEVLAAALANP
MUL_0365|M.ulcerans_Agy99 VHAATGGRLVLGVGPSHHWIVDDMLGLPYQRPAAYTRDYLEVLAAALANP
MSMEG_4879|M.smegmatis_MC2_155 VHAIAEGRLALGVGPSHHWIIRDMLGLPYDKPAAYTRDYLEVLNASLAGP
MAB_1339|M.abscessus_ATCC_1997 AQAATHGRFQLGLGLGAPVIEGPSYGLHVDKPIRRLREYLITLRQLLDA-
MAV_3337|M.avium_104 AQAAAHGRFSLGLGLGAADLERRTFGTEWPNTITRLREHLTILGSVFHS-
MLBr_00348|M.leprae_Br4923 LDHLSGGRHILGLGVSGPQVVEGWYGQPFPKPLSRTREYIDIVRQVWAR-
: ** **:* . .. .:.: :
Mb1395|M.bovis_AF2122/97 QDGTKLCFEGEFYTHKIM-------TPMFTPEP-QPYPVPRVFIAAVGEA
Rv1360|M.tuberculosis_H37Rv QDGTKLCFEGEFYTHKIM-------TPMFTPEP-QPYPVPRVFIAAVGEA
Mflv_0410|M.gilvum_PYR-GCK ---EPANATGETVTTRG---------ALMIPG----APRPDVYIAALGPQ
Mvan_0261|M.vanbaalenii_PYR-1 ---EPANATGETVTTRG---------ALVIPG----APRPDVYIAALGPQ
TH_3430|M.thermoresistible__bu ---RPADVTGEFWSTRG---------ALRLAGGGTSPPEPPVYLAALGPQ
MMAR_4796|M.marinum_M ---GPVDVENDSFRVHN---------PLDLAA----VAPLPVLVAALGPV
MUL_0365|M.ulcerans_Agy99 ---GPVDVENDSFRVHN---------PLDLAA----VAPLPVLVAALGPV
MSMEG_4879|M.smegmatis_MC2_155 ---GPVDVENDTFTVHN---------PTALAA----ETPLPVLVAALGPV
MAB_1339|M.abscessus_ATCC_1997 ---GTADFHGQTLTVAPQ-------FTTSQPG----GENIPVLVAAMAPQ
MAV_3337|M.avium_104 ---GAVDFHGSELSAAPS-------FPVRVPG----GTPIPVYVAAMGPK
MLBr_00348|M.leprae_Br4923 --EAPVVSDGQHYPLPLTGAGATGLGKALKPITHPLRADIPIMLGAEGPK
.. . : :.* .
Mb1395|M.bovis_AF2122/97 MTEMCGEVADGHLGHPMVSKRY--LTEVSVPALLRGLARSGRDRSAFEVS
Rv1360|M.tuberculosis_H37Rv MTEMCGEVADGHLGHPMVSKRY--LTEVSVPALLRGLARSGRDRSAFEVS
Mflv_0410|M.gilvum_PYR-GCK LLRLAGRRTQGTCTW-MTGPAT--LRDHVSPTLRQAAADAGRPDGSVRVV
Mvan_0261|M.vanbaalenii_PYR-1 LLRVAGRRTAGTCTW-MTGPAT--LRDHVSPALRQAAADAGRPPGSVRVV
TH_3430|M.thermoresistible__bu MLRLAGRRTAGTLTW-MTGPKT--LAGHIVPTLRQAAADAGRSGSDVRVV
MMAR_4796|M.marinum_M MLTLAGERADGTVLW-MADERA--VAEHVVPRISKAADNAGRPAPRIVAG
MUL_0365|M.ulcerans_Agy99 MLTLAGERADGTVLW-MADERA--VAEHVVPRISKAADNAGRPVPRIVAG
MSMEG_4879|M.smegmatis_MC2_155 MLQIAGELADGTVLW-MADERA--IGDHIAPRINKAADNAGRPAPRIVAG
MAB_1339|M.abscessus_ATCC_1997 ALRATGELADGTIPL-HAGPRA--LGQEVVPVISAAAERAGRPRPRVIAG
MAV_3337|M.avium_104 ALQVTGELADGTLPY-LAGPRT--IEEFIVPRITKAAAEAGRPAPRIIAA
MLBr_00348|M.leprae_Br4923 NVALAAEICDGWLPIFFSPRMADMYNEWLDEGFARTGARRSREDFEICAS
.. * : .* . .
Mb1395|M.bovis_AF2122/97 CEVMVATGADDAELAAACTATRKQIAFYGSTPA--YRKVLEQHGWGDLHP
Rv1360|M.tuberculosis_H37Rv CEVMVATGADDAELAAACTATRKQIAFYGSTPA--YRKVLEQHGWGDLHP
Mflv_0410|M.gilvum_PYR-GCK ASLPVAV---TDDVDELRKQAADQFAMYGTLPS--YRAMLDREGYAGPE-
Mvan_0261|M.vanbaalenii_PYR-1 ASLPVAV---TDDVEAARKQAAEQFAVYGTLPS--YRAMLDREGYAGPE-
TH_3430|M.thermoresistible__bu ASLPVSV---TDDVEGARAQAVEQFAVYGTLPS--YRAMLDREGYVNPE-
MMAR_4796|M.marinum_M IPVCLCG---SSEVEVARDRANRILGEAEVSPN--YQRLLGYGDAKDVG-
MUL_0365|M.ulcerans_Agy99 IPVCLCG---SSEVEVARDRANRILGEAEVSPN--YQRLLGHGDAKDVG-
MSMEG_4879|M.smegmatis_MC2_155 IPVCLCA---NSEIDTAKERANRILAEAETSPN--YQRLLDRGDARNVG-
MAB_1339|M.abscessus_ATCC_1997 VAVVVT-----SEPERVRALAIEDMAFYENIPS--YRKVLDAEGVQHTG-
MAV_3337|M.avium_104 VPVLLS-----DDVEGARAAAAQQLSFYETIPS--YRNVIAREGLSNAV-
MLBr_00348|M.leprae_Br4923 AQIVVTEDR-AAAFAGIKPFLALYMGGMGAEGTNFHADVYRRMGYAEVVD
: : :. : : .
Mb1395|M.bovis_AF2122/97 ELHRLSKLGEWEAMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRV
Rv1360|M.tuberculosis_H37Rv ELHRLSKLGEWEAMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRV
Mflv_0410|M.gilvum_PYR-GCK ---DAAIIGDEATVRDQIAELGAAGVDEYVGAVFDSSVEGR------DRT
Mvan_0261|M.vanbaalenii_PYR-1 ---DAAIIGDEATVRDRLAELAEAGVDEYVGAVFDSSAEGR------DRT
TH_3430|M.thermoresistible__bu ---DAAIIGDEQTVSQRLDELAAAGVDEFTAAVFDADPEIR------ART
MMAR_4796|M.marinum_M ---DICAAGDEDAILARFRRFAEAGVTDLSVRLLPIGDNREELVASKRRT
MUL_0365|M.ulcerans_Agy99 ---DICAAGDEDAILARFRRFAEAGVTDLSVRLLPIGDNREELVASKRRT
MSMEG_4879|M.smegmatis_MC2_155 ---DLCAAGDEDAILARFKRFADAGVTDLSVRLLPIGDNRDELIASKYRT
MAB_1339|M.abscessus_ATCC_1997 ---ELAIIGDEQHVATELQRYFDAGATEVFASHTELGGPQD-----EART
MAV_3337|M.avium_104 ---ELAAIGPEESVLRQVRRYFDAGATDVVLSPLDRSASVD-----REAL
MLBr_00348|M.leprae_Br4923 EVTALFRSNQKDKAAEIIPNELVDSTMIVGDVDYVCKQIAAWSAAGVTMM
. . .
Mb1395|M.bovis_AF2122/97 LPIFMAASQECINAALQDFRR
Rv1360|M.tuberculosis_H37Rv LPIFMAASQECINAALQDFRR
Mflv_0410|M.gilvum_PYR-GCK RALLRELG-------------
Mvan_0261|M.vanbaalenii_PYR-1 RALLRDMRSGG----------
TH_3430|M.thermoresistible__bu RALLVSRQTG-----------
MMAR_4796|M.marinum_M RDMIATLATEVR---------
MUL_0365|M.ulcerans_Agy99 RDMIATLATEVR---------
MSMEG_4879|M.smegmatis_MC2_155 REVIAELAKAVR---------
MAB_1339|M.abscessus_ATCC_1997 LALLGELSRGN----------
MAV_3337|M.avium_104 WRLTAAL--------------
MLBr_00348|M.leprae_Br4923 MVSASSVEQVRDLAGLF----