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MRLGVMIGAERGDMARKVSKLVSDIEWAESAGLDTAWMPQVPNDFDCLTMVALMAAHTSRIELGTAVVPL QAQHPIALARQALSVHAMAAGRLALGVGPSHHWIVRDMLGLPYEKPAAYTRDYLEVLNTALAGPGDVDVE NDSFTVHNPTVLGAEQPLPVLVAALGPVMLQIAGERADGTVLWMADEKAIGEHIAPKITKAAADAGRPAP RIVAGIPVCLCANSEIDAAKDRANRILAEAETSPNYQRLLDRGDARNVGDLCAAGDEESILARFKQFADA GVTDLSVRLLPIGETRDELVASKYRTREVIGELAKAVQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2389 | - | - | 100% (318) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_2453 | - | 7e-93 | 52.85% (316) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_1261 | - | 2e-42 | 34.38% (317) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3550c | - | 4e-15 | 30.21% (192) | coenzyme F420-dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3520c | - | 4e-15 | 30.21% (192) | coenzyme F420-dependent oxidoreductase |
| M. leprae Br4923 | MLBr_00348 | - | 1e-15 | 30.21% (192) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1339 | - | 4e-38 | 30.82% (318) | putative monooxygenase (luciferase-like) |
| M. marinum M | MMAR_4796 | - | 1e-139 | 74.53% (318) | oxidoreductase |
| M. avium 104 | MAV_0923 | - | 3e-99 | 53.77% (318) | hypothetical protein MAV_0923 |
| M. smegmatis MC2 155 | MSMEG_4879 | - | 1e-163 | 87.74% (318) | hypothetical protein MSMEG_4879 |
| M. thermoresistible (build 8) | TH_4355 | - | 1e-157 | 86.35% (315) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_0365 | - | 1e-139 | 74.21% (318) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4259 | - | 1e-174 | 95.60% (318) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2389|M.gilvum_PYR-GCK -MRLG--VMIGAERGDM--ARKVSKLVSDIEWAESAGLDTAWMPQVPNDF
Mvan_4259|M.vanbaalenii_PYR-1 -MKLG--VMIGAERGDM--ARKVGKLVSDIEWAESAGLDTAWMPQVPNDF
MSMEG_4879|M.smegmatis_MC2_155 -MRLG--VMIGAERGDM--TRKVNKLAADIQWAEAAGLDSAWMPQVPDDF
TH_4355|M.thermoresistible__bu -MRVG--VMIGAERGDM--ARKVRKFLEDIEWAESAGFDTAWMPQVPNDF
MMAR_4796|M.marinum_M -MRVG--VMIGPERGDS--GRKVGRMLADIDWAETAGLDSAWIPQIPNDF
MUL_0365|M.ulcerans_Agy99 -MRVG--VMIGPERGDS--GRKVGRMLADIDWAETAGLDSAWIPQIPNDF
MAV_0923|M.avium_104 -MRIG--LMVGSDKERSR-AERLAGLVDDAAAAERGGFTAFWMPQVPGYL
MAB_1339|M.abscessus_ATCC_1997 -MKLG--VAIGRPLSVQNSTNLVDTFIAHARRVAEAGVRTLWLGQMY-HY
Mb3550c|M.bovis_AF2122/97 -MEAG--MKLGLQLGYWG-AQPPQNHAELVAAAEDAGFDTVFT-AEAWGS
Rv3520c|M.tuberculosis_H37Rv -MEAG--MKLGLQLGYWG-AQPPQNHAELVAAAEDAGFDTVFT-AEAWGS
MLBr_00348|M.leprae_Br4923 MVERANAMKLGLQLGYWA-AQPPGNAAELVAAAEGAGFDAVFT-GEAWGS
:. . : :* . . .*. : :
Mflv_2389|M.gilvum_PYR-GCK DCLTMVALMAAHTSRIELGTAVVPLQAQHPIALARQALSVHAMAAGRLAL
Mvan_4259|M.vanbaalenii_PYR-1 DCLTMVALMAAHTSRIELGTAVVPLQAQHPIALARQALSVHAMAQGRLAL
MSMEG_4879|M.smegmatis_MC2_155 DCLSMVALMAAHTSTIELGTAVVPLQAQHPVALARQALSVHAIAEGRLAL
TH_4355|M.thermoresistible__bu DALTMVALMATRTDRIELGTAVVPLQAQHPIALARQALSVHAGSGGRLAL
MMAR_4796|M.marinum_M DALVAVTLMGTRSSRIELGTAVVPLQTQHPIALARQALSVHAATGGRLVL
MUL_0365|M.ulcerans_Agy99 DALVAVTLMGTRSSRIELGTAVVPLQTQHPIALARQALSVHAATGGRLVL
MAV_0923|M.avium_104 DALTAVALIGQATERIEIGTAVVPIQTRHPMALAQQALTTQVACGGRFTL
MAB_1339|M.abscessus_ATCC_1997 DSITMAAVVGQTVPDVTVGVSVIPINPRHPIEVSAAAQTAQAATHGRFQL
Mb3550c|M.bovis_AF2122/97 DAYTPLAWWGSSTQRVRLGTSVIQLSARTPTACAMAALTLDHLSGGRHIL
Rv3520c|M.tuberculosis_H37Rv DAYTPLAWWGSSTQRVRLGTSVIQLSARTPTACAMAALTLDHLSGGRHIL
MLBr_00348|M.leprae_Br4923 DAYTPLAWWGSSTQRVRLGTSVVQLSARTPTACAMAALTLDHLSGGRHIL
*. : . : :*.:*: :..: * : * : . ** *
Mflv_2389|M.gilvum_PYR-GCK GVGPSHHWIVRDMLGLPYEKPAAYTRDYLEVLNTALAGPGDVDVENDSFT
Mvan_4259|M.vanbaalenii_PYR-1 GVGPSHHWIVRDMLGLPYEKPAAYTRDYLEVLNAALAGPGDVDVENDTFT
MSMEG_4879|M.smegmatis_MC2_155 GVGPSHHWIIRDMLGLPYDKPAAYTRDYLEVLNASLAGPGPVDVENDTFT
TH_4355|M.thermoresistible__bu GVGPSHHWIIRDMLGIPYERPAAYTRDYLEVLNAAIAGPGPVDVENDSFT
MMAR_4796|M.marinum_M GVGPSHHWIVDDMLGLPYQRPAAYTRDYLEVLAAALANPGPVDVENDSFR
MUL_0365|M.ulcerans_Agy99 GVGPSHHWIVDDMLGLPYQRPAAYTRDYLEVLAAALANPGPVDVENDSFR
MAV_0923|M.avium_104 GIGPSHHWIVNGQLGLPYERPARLTRNYLQVLGAAFAGPGSVDVDNESYC
MAB_1339|M.abscessus_ATCC_1997 GLGLGAPVIEGPSYGLHVDKPIRRLREYLITLRQLLD-AGTADFHGQTLT
Mb3550c|M.bovis_AF2122/97 GLGVSGPQVVEGWYGQRFPKPLARTREYIDIVRQVWARESPVTSAGPHYR
Rv3520c|M.tuberculosis_H37Rv GLGVSGPQVVEGWYGQRFPKPLARTREYIDIVRQVWARESPVTSAGPHYR
MLBr_00348|M.leprae_Br4923 GLGVSGPQVVEGWYGQPFPKPLSRTREYIDIVRQVWAREAPVVSDGQHYP
*:* . : * :* *:*: : . . .
Mflv_2389|M.gilvum_PYR-GCK VHNP-----------TVLG--AEQPLPVLVAALGPVMLQIAGERADGTVL
Mvan_4259|M.vanbaalenii_PYR-1 VHNP-----------TVLG--AEQPLPVLVAALGPVMLQIAGERADGTVL
MSMEG_4879|M.smegmatis_MC2_155 VHNP-----------TALA--AETPLPVLVAALGPVMLQIAGELADGTVL
TH_4355|M.thermoresistible__bu VHNP-----------TVLGT-DDTPMPVLVAALGPVMLQIAGELADGTVL
MMAR_4796|M.marinum_M VHNP-----------LDLA--AVAPLPVLVAALGPVMLTLAGERADGTVL
MUL_0365|M.ulcerans_Agy99 VHNP-----------LDLA--AVAPLPVLVAALGPVMLTLAGERADGTVL
MAV_0923|M.avium_104 VHSP-----------VDVT--DSFGVSILLSALGPTMLQLAGERADGTIL
MAB_1339|M.abscessus_ATCC_1997 VAPQ-----------FTTSQPGGENIPVLVAAMAPQALRATGELADGTIP
Mb3550c|M.bovis_AF2122/97 LPLTGEGTTGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEICDGWLP
Rv3520c|M.tuberculosis_H37Rv LPLTGEGTTGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEICDGWLP
MLBr_00348|M.leprae_Br4923 LPLTGAGATGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEICDGWLP
: :.:::.* .* : :.* .** :
Mflv_2389|M.gilvum_PYR-GCK WMADEKAIGEHIAPKITKAAADAGRPAPRIVAGIPVCLCANSEIDAAKDR
Mvan_4259|M.vanbaalenii_PYR-1 WMADEKAIGGHIAPKINKAAAEAGRPAPRIVAGIPVCLCANSEIDAAKDR
MSMEG_4879|M.smegmatis_MC2_155 WMADERAIGDHIAPRINKAADNAGRPAPRIVAGIPVCLCANSEIDTAKER
TH_4355|M.thermoresistible__bu WMADERAIGEHIAPRITKAADNAGRPAPRIIAGIPVCLCANSEIEVAKER
MMAR_4796|M.marinum_M WMADERAVAEHVVPRISKAADNAGRPAPRIVAGIPVCLCGSSEVEVARDR
MUL_0365|M.ulcerans_Agy99 WMADERAVAEHVVPRISKAADNAGRPVPRIVAGIPVCLCGSSEVEVARDR
MAV_0923|M.avium_104 WMADERAIGEHVVPRITAAAGGAGRPAPRVVAGVPVAVCSNSEIDDARAY
MAB_1339|M.abscessus_ATCC_1997 LHAGPRALGQEVVPVISAAAERAGRPRPRVIAGVAVVVTS--EPERVRAL
Mb3550c|M.bovis_AF2122/97 IFYSPRMAGMYNEWLDEGFARPGARR-----SREDFEICATAQVVITDDR
Rv3520c|M.tuberculosis_H37Rv IFYSPRMAGMYNEWLDEGFARPGARR-----SREDFEICATAQVVITDDR
MLBr_00348|M.leprae_Br4923 IFFSPRMADMYNEWLDEGFARTGARR-----SREDFEICASAQIVVTEDR
. : * ..* : . : . : .
Mflv_2389|M.gilvum_PYR-GCK ANRILAEAETSPNYQRLLDRGDARNVGDLCAAGDEESILARFKQFADAGV
Mvan_4259|M.vanbaalenii_PYR-1 ANRILAEAETSPNYQKLLDRGDARSVGDLCAAGDEDAILARFKQFADAGV
MSMEG_4879|M.smegmatis_MC2_155 ANRILAEAETSPNYQRLLDRGDARNVGDLCAAGDEDAILARFKRFADAGV
TH_4355|M.thermoresistible__bu ANRILGEAEVSPNYQRLLERGDARDVGDLCAAGDEEAIMARFRRFADAGV
MMAR_4796|M.marinum_M ANRILGEAEVSPNYQRLLGYGDAKDVGDICAAGDEDAILARFRRFAEAGV
MUL_0365|M.ulcerans_Agy99 ANRILGEAEVSPNYQRLLGHGDAKDVGDICAAGDEDAILARFRRFAEAGV
MAV_0923|M.avium_104 AGEMLGHAEFSPNYVRLLQHGDAEDVGDTMAAGDESAVLRRLRRYRDAGA
MAB_1339|M.abscessus_ATCC_1997 AIEDMAFYENIPSYRKVLDAEGVQHTGELAIIGDEQHVATELQRYFDAGA
Mb3550c|M.bovis_AF2122/97 AAAFAGIKPFLALYMGGMGAEETNFHADVYRRMGYTQVVDEVTKLFRSGR
Rv3520c|M.tuberculosis_H37Rv AAAFAGIKPFLALYMGGMGAEETNFHADVYRRMGYTQVVDEVTKLFRSGR
MLBr_00348|M.leprae_Br4923 AAAFAGIKPFLALYMGGMGAEGTNFHADVYRRMGYAEVVDEVTALFRSNQ
* . . * : .. .: . : .. :.
Mflv_2389|M.gilvum_PYR-GCK TDLSVRLLP------------IGETRDELVASKYRTREVIGELAKAVQ--
Mvan_4259|M.vanbaalenii_PYR-1 TDLSVRLLP------------IGETRDELVASKYRTREVIGELAKAVR--
MSMEG_4879|M.smegmatis_MC2_155 TDLSVRLLP------------IGDNRDELIASKYRTREVIAELAKAVR--
TH_4355|M.thermoresistible__bu TDLSVRLLP------------IGETRDELVASKYRTREVIAQLAADLR--
MMAR_4796|M.marinum_M TDLSVRLLP------------IGDNREELVASKRRTRDMIATLATEVR--
MUL_0365|M.ulcerans_Agy99 TDLSVRLLP------------IGDNREELVASKRRTRDMIATLATEVR--
MAV_0923|M.avium_104 TDLAARIVP------------LGNDARERAESRRRTHEFLSAVCPAL---
MAB_1339|M.abscessus_ATCC_1997 TEVFASHTE------------LGGPQD-----EARTLALLGELSRGN---
Mb3550c|M.bovis_AF2122/97 KDEAAEIIPDELVDDAVIVGDIDHVRKQMAVWEAAGVTMMVVTAGSAEQV
Rv3520c|M.tuberculosis_H37Rv KDEAAEIIPDELVDDAVIVGDIDHVRKQMAVWEAAGVTMMVVTAGSAEQV
MLBr_00348|M.leprae_Br4923 KDKAAEIIPNELVDSTMIVGDVDYVCKQIAAWSAAGVTMMMVSASSVEQV
.: . :. .: .
Mflv_2389|M.gilvum_PYR-GCK -------
Mvan_4259|M.vanbaalenii_PYR-1 -------
MSMEG_4879|M.smegmatis_MC2_155 -------
TH_4355|M.thermoresistible__bu -------
MMAR_4796|M.marinum_M -------
MUL_0365|M.ulcerans_Agy99 -------
MAV_0923|M.avium_104 -------
MAB_1339|M.abscessus_ATCC_1997 -------
Mb3550c|M.bovis_AF2122/97 RDLAALV
Rv3520c|M.tuberculosis_H37Rv RDLAALV
MLBr_00348|M.leprae_Br4923 RDLAGLF