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TTIGTPLSPRATKVMLLGSGELGREVLIALQRLGVETIAVDRYDNAPGQQVAHHARTIAMTDPEQLRALI EAERPDLVVPEIEAIATPALEALEAEGVVTVIPTARAARLTMDREGIRRLAAETLGLPTSPYRFCDSLEE LRAAIDGTVGYPCVVKPVMSSSGKGQSKIDGPEDVAPAWEYAMSGSRVSNTRIIVEGFVDFDYEITLLTV RARGASGEVQTQFCEPIGHRQVSGDYVESWQPHPMPSTALDRSRQIAKAVTENLGGQGIFGVELFVKGDD VWFSEVSPRPHDTGMVTMVTQWQNEFELHARAILGLPVDTTLKSPGASAVIYGGVDAEGVVFDGVDRALA VPHTDIRLFGKPESFVNRRMGVALAFADDVDTARRNAAEAASRVTPRAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2039 | purT | - | 100% (400) | phosphoribosylglycinamide formyltransferase 2 |
| M. gilvum PYR-GCK | Mflv_0222 | - | 7e-72 | 41.60% (387) | ATP-dependent carboxylate-amine ligase domain-containing |
| M. gilvum PYR-GCK | Mflv_4747 | - | 5e-16 | 26.88% (398) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0395 | purT | 2e-79 | 43.07% (404) | phosphoribosylglycinamide formyltransferase 2 |
| M. tuberculosis H37Rv | Rv0389 | purT | 5e-80 | 43.32% (404) | phosphoribosylglycinamide formyltransferase 2 |
| M. leprae Br4923 | MLBr_00735 | purK | 9e-16 | 29.41% (323) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. abscessus ATCC 19977 | MAB_1191c | purT | 0.0 | 83.67% (398) | phosphoribosylglycinamide formyltransferase 2 |
| M. marinum M | MMAR_0686 | purT | 7e-81 | 43.35% (406) | formate-dependent phosphoribosylglycinamide |
| M. avium 104 | MAV_4775 | purT | 2e-83 | 45.19% (385) | phosphoribosylglycinamide formyltransferase 2 |
| M. smegmatis MC2 155 | MSMEG_5274 | purT | 0.0 | 89.50% (400) | phosphoribosylglycinamide formyltransferase 2 |
| M. thermoresistible (build 8) | TH_1415 | purT | 9e-96 | 47.73% (396) | PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT |
| M. ulcerans Agy99 | MUL_2628 | purK | 1e-16 | 28.38% (370) | phosphoribosylaminoimidazole carboxylase ATPase subunit |
| M. vanbaalenii PYR-1 | Mvan_4678 | purT | 0.0 | 94.50% (400) | phosphoribosylglycinamide formyltransferase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2039|M.gilvum_PYR-GCK ---------------MTTIGTPLSPRAT----------------------
Mvan_4678|M.vanbaalenii_PYR-1 ---------------MTTIGTPLSPRAT----------------------
MSMEG_5274|M.smegmatis_MC2_155 ---------------MTTIGTPLSPRAT----------------------
MAB_1191c|M.abscessus_ATCC_199 ---------------MTTIGTPLSPRAT----------------------
Mb0395|M.bovis_AF2122/97 ------MIDGWTEGQHEPTVRHERPAAP----------------------
Rv0389|M.tuberculosis_H37Rv ------MIDGWTEEQHEPTVRHERPAAP----------------------
MMAR_0686|M.marinum_M ------MTDGLTEGHDEAIGKHQRPATEGANAPEGDKTTTIAVPPVGTPR
MAV_4775|M.avium_104 ------MTDGRDDETTALAVPRPAPAEGGPAPADG---------------
TH_1415|M.thermoresistible__bu ------VTDPATDPTAEQATDPVAEAAGPGGEPKLQAGAPVDDEP---AA
MLBr_00735|M.leprae_Br4923 --------------------MMAVPSRC----------------------
MUL_2628|M.ulcerans_Agy99 MIHNDLVLQPPNTPVMGHDTMMAVPS------------------------
Mflv_2039|M.gilvum_PYR-GCK ----------KVMLLGSGELGREVLIALQRLGVETIAVDRYDNAPGQQVA
Mvan_4678|M.vanbaalenii_PYR-1 ----------KVMLLGSGELGREVLIALQRLGVETIAVDRYDNAPGQQVA
MSMEG_5274|M.smegmatis_MC2_155 ----------KVMLLGSGELGREVLIALQRLGVETIAVDRYENAPGHQVA
MAB_1191c|M.abscessus_ATCC_199 ----------RVMLLGSGELGREVLIALQRLGVETIAVDRYENAPGHQIA
Mb0395|M.bovis_AF2122/97 -----QDVR-RVMLLGSAEPSRELAIALQGLGAEVIAVDGYVGAPAHRIA
Rv0389|M.tuberculosis_H37Rv -----QDVR-RVMLLGSAEPSRELAIALQGLGAEVIAVDGYVGAPAHRIA
MMAR_0686|M.marinum_M RAEADVHVRPRVVLLGGGEQGRELTIALQGLGAEVIAVDTDADAPAHRVA
MAV_4775|M.avium_104 -GPAPADGRPAVMLLGSGDISRELAIALGRLGARVIAVDAHPQAPAHAVA
TH_1415|M.thermoresistible__bu QAEPARPARPTVMLLGAGELSRELVLAFQRLGAEVVAVDRYADAPAYPVA
MLBr_00735|M.leprae_Br4923 ----SLGVAPLVAMVGGGQLARMTHQAAIALGQTLRVLATAADEPAAQVT
MUL_2628|M.ulcerans_Agy99 ------SRTPQVAMVGGGQLARMTHQAAIALGQNLRVLVNSADDPAAQVT
* ::*..: .* * ** .: *. ::
Mflv_2039|M.gilvum_PYR-GCK HHARTIAMTDPEQLRALIEAERPDLVVPEIEAIATPALEALEA-----EG
Mvan_4678|M.vanbaalenii_PYR-1 HHARTIAMTDPDQLRALIEAERPDLVVPEIEAIATPALEALEA-----EG
MSMEG_5274|M.smegmatis_MC2_155 HHARTIAMSDPDQLRALIEAERPDLVVPEIEAIATPVLEALEA-----EG
MAB_1191c|M.abscessus_ATCC_199 HHARVISMTDPEQLRALIEAEKPDLVVPEIEAIATATLEALET-----EG
Mb0395|M.bovis_AF2122/97 DQSVVVTMTDAEELTAVIRRLQPDFLVTVTAAVSVDALDAVEQ---ADGE
Rv0389|M.tuberculosis_H37Rv DQSVVVTMTDAEELTAVIRRLQPDFLVTVTAAVSVDALDAVEQ---ADGE
MMAR_0686|M.marinum_M DQALVVAMTDADELKVVFTRLRPDFVVPLTDAVSVAALDALADRAPSEGG
MAV_4775|M.avium_104 DQALVLPLTDAGELSAAIHRLRPDVVVSTTDAVAVPALEALDG------T
TH_1415|M.thermoresistible__bu DRSVVATMSDADALTAVIEREAPQYVVAESTAVAVDALIAVAE-----RG
MLBr_00735|M.leprae_Br4923 PDVVIGSHTDLEDLRRVALG--ADALTFDHEHVPTELLDKLVA------E
MUL_2628|M.ulcerans_Agy99 PNVVIGSHTDLDDLRRIAAG--ADVVTFDHEHVPAELLDKLVA------E
. :* * .: :. :.. * :
Mflv_2039|M.gilvum_PYR-GCK VVTVIPTARAARLTMDREGIR-RLAAETLGLP-TSPYRFCDSLEELRAAI
Mvan_4678|M.vanbaalenii_PYR-1 VTTVIPTARAARLTMDREGIR-RLAAETLGLP-TSPYRFCDSLEELTAAI
MSMEG_5274|M.smegmatis_MC2_155 VTTVIPTARATRLTMDREGIR-RLAAETLGVP-TSPYRFCDSLAELQAAI
MAB_1191c|M.abscessus_ATCC_199 VVRVIPTARAARLTMDREGIR-RLAAETLGLP-TSPYQFCGSLDELQAAI
Mb0395|M.bovis_AF2122/97 CTELVPNARAVRCTADREGLR-RLAADQLGLP-TAPFWFVGSLGELQAVA
Rv0389|M.tuberculosis_H37Rv CTELVPNARAVRCTADREGLR-RLAADQLGLP-TAPFWFVGSLGELQAVA
MMAR_0686|M.marinum_M SIGLVPSARCVRLAGDREALR-KLAADQLGLP-TAPFWFVGSLGELEAVA
MAV_4775|M.avium_104 GAEPVPSARAVRLAADREGLR-RLAADELGLP-TAPFWFAGSLGELEAVG
TH_1415|M.thermoresistible__bu SVEVFPTPRAIRLSYDREGLR-RLAADELGLP-TAPFWFAGSVEELTAVA
MLBr_00735|M.leprae_Br4923 GINVAPSPQALVHAQDKLVMRRRLAALGAAMPRFMALDSVDDLAEIDAFA
MUL_2628|M.ulcerans_Agy99 GVVLAPPPQALVHAQDKLVMRRRLQALDVPVPRYLGIHQLEELGELDAFA
* .:. : *: :* :* * :* .: *: *
Mflv_2039|M.gilvum_PYR-GCK D---GTVGYPCVVKPVMS-SSGKGQSKIDGPEDVAPAWEYAMSGS-----
Mvan_4678|M.vanbaalenii_PYR-1 E---GGIGYPCVVKPVMS-SSGKGQSKIDGPEGVAAAWEYAMSGS-----
MSMEG_5274|M.smegmatis_MC2_155 D---DEIGYPCVVKPVMS-SSGKGQSKINGPDEVAAAWEYAMAGG-----
MAB_1191c|M.abscessus_ATCC_199 DPESGGVGYPCVVKPLMS-SSGKGQSKLDGPADVEKAWDYAMAGS-----
Mb0395|M.bovis_AF2122/97 V----HAGFPLLVSPVAG-VAGQGSSVVAGPNEVEPAWQRAAGHQVQPQT
Rv0389|M.tuberculosis_H37Rv V----HAGFPLLVSPVAG-VAGQGSSVVAGPNEVEPAWQRAAGHQVQPQT
MMAR_0686|M.marinum_M A----HVGYPLLVKPVAG-ADVPRRSLVRGPDEVEAAWARAVAG----GP
MAV_4775|M.avium_104 A----HAGYPLLVKPVVG-AVGPRQSVVAGREDIAAAWHRAVDG----QP
TH_1415|M.thermoresistible__bu Q----HAGFPLVVRPVTG-PAGSGQSVLLREDDVEPAWHRAIAAG-----
MLBr_00735|M.leprae_Br4923 QRLTGSKDAPMVVKAVRGGYDGRGVQMVRDSAHAREVASGYLVDG-----
MUL_2628|M.ulcerans_Agy99 RQL----DAPLVVKAVRGGYDGRGVQMARDLADARDIASGYLAGG-----
. * :* .: . .
Mflv_2039|M.gilvum_PYR-GCK RVSNTRIIVEGFVDFDYEITLLTVRARGASGEVQTQFCEPIGHRQVSGDY
Mvan_4678|M.vanbaalenii_PYR-1 RVSNTRIIVEGFVDFDYEITLLTVRARGADGEIETRFCEPIGHRQVSGDY
MSMEG_5274|M.smegmatis_MC2_155 RVSHTRIIVEGFVDFDYEITLLTVRARGADGEIATQFCEPIGHRQVGGDY
MAB_1191c|M.abscessus_ATCC_199 RVTNNRVIVEGFVDFDYEITLLTVRALGDDGEVETSFCAPIGHRQANGDY
Mb0395|M.bovis_AF2122/97 GGVSPRVCAESVVEIEFLVTMIVVCSQGPNG-PLIEFCAPIGHRDADAGE
Rv0389|M.tuberculosis_H37Rv GGVSPRVCAESVVEIEFLVTMIVVCSQGPNG-PLIEFCAPIGHRDADAGE
MMAR_0686|M.marinum_M AGAPPRVWAETQVEVEFLVTLIAVCSQGPQG-PRIDFCAPIGH-GGDGGD
MAV_4775|M.avium_104 G---ARVLAETVVEVQFHVMLLAVRSEGAAG-PAIEFCSPIGHRGAGGRV
TH_1415|M.thermoresistible__bu HFAQNRVMAETVVEIDYEVTMLTVRTTGPAG-PTIRFCEPIGHHHRNGEV
MLBr_00735|M.leprae_Br4923 ----MPVLVEERVELRRELSALVARSPFGQG----AAWPVVETVQRDGIC
MUL_2628|M.ulcerans_Agy99 ----VPVLVEERVQLRRELSALVARSPFGQG----AAWPVVETVQQDGIC
: .* *:. : :.. : * : ..
Mflv_2039|M.gilvum_PYR-GCK VESWQPH-PMPSTALDRSRQIAKAVTENLGGQGIFGVELFVKGD-DVWFS
Mvan_4678|M.vanbaalenii_PYR-1 VESWQPH-PMPGTALERARQIAGAVTRDLGGQGIFGVELFVKGD-QVWFS
MSMEG_5274|M.smegmatis_MC2_155 VESWQPH-PMPATALERAQEIAGAVTGNLGGQGIFGVELFVKGD-QVWFS
MAB_1191c|M.abscessus_ATCC_199 VESWQPH-PMTEAALRSAQHIARSVTENLGGQGIFGVELFIKGD-QVYFS
Mb0395|M.bovis_AF2122/97 LESWQPQ-KLSTAALDAAKSIAARIVKALGGRGVFGVELMINGD-EVYFA
Rv0389|M.tuberculosis_H37Rv LESWQPQ-KLSTAALDAAKSIAARIVKALGGRGVFGVELMINGD-EVYFA
MMAR_0686|M.marinum_M QESWQPQ-KVSVAALDAAKSIAARIVKALGGCGVFGVELMVNGD-EVYFA
MAV_4775|M.avium_104 LESWQPQ-KMSPAAMDAAKSIAARIVKALGGRGVFGVELMVNDD-EVYFA
TH_1415|M.thermoresistible__bu LELWQPQ-QMSPVALDAAKSIAARIVNSLGGRGVYGVELLVRDD-EVYFS
MLBr_00735|M.leprae_Br4923 VLVVAPALALADDLASAAQQLALRLAAELGVVGVFAVELFETADGALLVN
MUL_2628|M.ulcerans_Agy99 VAVIAPAPALSAQAGADAQQLALRLAAELGVVGVLAVELFETTDGALVVN
* :. :: :* :. ** *: .***: * : .
Mflv_2039|M.gilvum_PYR-GCK EVSPRPHDTGMVTMVTQWQNEFELHARAILGLPVDTTLKSPGASAVIYG-
Mvan_4678|M.vanbaalenii_PYR-1 EVSPRPHDTGMVTMVTQWQNEFELHARAILGLPVDTTLKSPGASAVIYG-
MSMEG_5274|M.smegmatis_MC2_155 EVSPRPHDTGMVTMVTQWQNEFELHARAILGLPVDTTLRAPGASAVIYG-
MAB_1191c|M.abscessus_ATCC_199 EVSPRPHDTGMVTMITQWQNEFELHARAILGLPVDTTLKSAGASAVIYG-
Mb0395|M.bovis_AF2122/97 DVTVCPAGSAWVTVRSQRLSVFELQARATLGLAVDTLMISPGAARVINP-
Rv0389|M.tuberculosis_H37Rv DVTVCPAGSAWVTVRSQRLSVFELQARAILGLAVDTLMISPGAARVINP-
MMAR_0686|M.marinum_M DVQPFPRDTAWVTLRSQRLSVFELQARAILGFAVDTLMVSPGAARLI---
MAV_4775|M.avium_104 DVTAHPGDSAWVTVRSQRLSAFELQARTILGLPVDTMMVSPAAARVVD--
TH_1415|M.thermoresistible__bu DVRVRPQDTGLVTLRSQRLSHFELHARAILGLAVDTIMISPAAAEVHYGG
MLBr_00735|M.leprae_Br4923 ELAMRPHNSGHWTMDGARTSQFEQHLRAVLDYPLGETDAVAPVTVMVNVL
MUL_2628|M.ulcerans_Agy99 ELAMRPHNSGHWTMDGSRTSQFEQHLRAVLDYPLGDTEAIAPVTVMTNVL
:: * .:. *: . ** : *: *. .:. . .: :
Mflv_2039|M.gilvum_PYR-GCK ------GVDAEGVVFDGVDRALAVPHTDIRLFGKPES--FVNRRMGVALA
Mvan_4678|M.vanbaalenii_PYR-1 ------GVDAEGVVFDGVDLALRVPHTDIRLFGKPES--FVNRRMGVALA
MSMEG_5274|M.smegmatis_MC2_155 ------GVDATGVVFDGVDAALQVPHTDIRLFGKPES--FVKRRMGVALA
MAB_1191c|M.abscessus_ATCC_199 ------GVEAQGVVFDGVDEALRVPRTELRLFGKPES--FITRRMGVALA
Mb0395|M.bovis_AF2122/97 DHTAGRAAVGAAPPADALTGALGVPESDVVIFGRG---------LGVALA
Rv0389|M.tuberculosis_H37Rv DHTAGRAAVGAAPPADALTGALGVPESDVVIFGRG---------LGVALA
MMAR_0686|M.marinum_M ----GAATVGPVPGADALAAALAVPESDVRVFGRPRA---GSSVLGVALA
MAV_4775|M.avium_104 -----SADPGDR---AALSGALGVPESDLRVCGRG----------FRALA
TH_1415|M.thermoresistible__bu SEAAWPGGTGGAELTAVLREALSVPESDVRLFGGPDDETDAPHRLGVALA
MLBr_00735|M.leprae_Br4923 GAPQPPTLSVVTMDERLHHLFARMPDARVHLYDKVERPGRKVGHINFRGT
MUL_2628|M.ulcerans_Agy99 GAAAQPAMS---LDERLHHLFARMPDARVHLYGKDERPGRKVGHINFLGF
:* : : : .
Mflv_2039|M.gilvum_PYR-GCK FA--DDVDTARRNAAEAASRVTPRAV------------------------
Mvan_4678|M.vanbaalenii_PYR-1 FA--DDVDTARRNAAEAAGRVTPRAV------------------------
MSMEG_5274|M.smegmatis_MC2_155 FD--DDVQTARRNAAEAASRMKPRAV------------------------
MAB_1191c|M.abscessus_ATCC_199 RD--EDVDTARRNAAEAAGRVRVSG-------------------------
Mb0395|M.bovis_AF2122/97 TA--PEVAIARERAREVASRLNVPDSRE----------------------
Rv0389|M.tuberculosis_H37Rv TA--PEVAIARERAREVASRLNVPDSRE----------------------
MMAR_0686|M.marinum_M TA--PDVAVARDRAREVVDRLNVRDSRG----------------------
MAV_4775|M.avium_104 TA--PEVAAARERAGQVAARLTAGAGGVGGAGG-----------------
TH_1415|M.thermoresistible__bu TA--PDATAARRQVRQVSTALRRLW-------------------------
MLBr_00735|M.leprae_Br4923 DKDRKNPTKLRERAELAAHWLSHGQWTDGWDPHRAGDDVVEISLACGGRN
MUL_2628|M.ulcerans_Agy99 DP--AAVAGLRERAELAAHWLSHGQWTDGWDPHG----------------
* .. . :
Mflv_2039|M.gilvum_PYR-GCK ------
Mvan_4678|M.vanbaalenii_PYR-1 ------
MSMEG_5274|M.smegmatis_MC2_155 ------
MAB_1191c|M.abscessus_ATCC_199 ------
Mb0395|M.bovis_AF2122/97 ------
Rv0389|M.tuberculosis_H37Rv ------
MMAR_0686|M.marinum_M ------
MAV_4775|M.avium_104 ------
TH_1415|M.thermoresistible__bu ------
MLBr_00735|M.leprae_Br4923 DAQRQR
MUL_2628|M.ulcerans_Agy99 ------