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NVPLSVLDLAPICDGSDAATALRNTVDLARHAERWGYRRFWVAEHHFVAVASTAPAVLIGQIAAATRTIR VGAAAVQLGQTTAVAVVETFGMLDAFHPGRIDLGIGRSGRRARPPRPDGQKRTPRPVPPWREIDGVVIPS PFDLSTLMRNPRLKARMSVLQQPGAVSPEFADQVDDILALIAGRYEIDGFAAHVVPGEGSALTPWVFGSS KGESARVAGARGLPFVASYHLTPATALDAVDVYRAHFRPSATLTEPYVVVSADVVVAEDTATARHLASSY GHWVHAIRTGDGAVPYPDPDRVAPLPDEQAATVKDRTATQFVGDPDEVAHRLEALRRVADADELVITSVT HGHEDRLRSHRLLAERWGITGEG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0215 | - | - | 100% (374) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_2237 | - | 6e-38 | 32.51% (363) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_4429 | - | 9e-07 | 32.63% (95) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv3618 | - | 9e-05 | 30.11% (93) | monooxygenase |
| M. leprae Br4923 | MLBr_01106 | - | 1e-05 | 32.35% (102) | hypothetical protein MLBr_01106 |
| M. abscessus ATCC 19977 | MAB_4233c | - | 1e-124 | 59.03% (371) | putative monooxygenase (luciferase-like) |
| M. marinum M | MMAR_0702 | - | 1e-153 | 71.54% (369) | monooxygenase-like hypothetical protein |
| M. avium 104 | MAV_2049 | - | 1e-147 | 68.02% (369) | hypothetical protein MAV_2049 |
| M. smegmatis MC2 155 | MSMEG_5029 | - | 5e-41 | 33.43% (362) | alkanal monooxygenase alpha chain |
| M. thermoresistible (build 8) | TH_4625 | - | 2e-34 | 33.86% (319) | PUTATIVE alkanal monooxygenase alpha chain |
| M. ulcerans Agy99 | MUL_4481 | - | 1e-40 | 33.52% (361) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_4458 | - | 3e-35 | 31.84% (358) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0215|M.gilvum_PYR-GCK -------------MNVPLSVLDLAPICDGSDAATALRNTVDLARHAERWG
MMAR_0702|M.marinum_M --------------MIPLSILDLSPISAGSTAATALRNTIELAQHAERWG
MAV_2049|M.avium_104 ------------MTVTPLSILDLAPISAGCDAATALRNTIDLARHAERWG
MAB_4233c|M.abscessus_ATCC_199 -------------MNVPLSVLDLSPVSEGADATTALRNSIDLAQHAEQWG
MSMEG_5029|M.smegmatis_MC2_155 ---------------MRLSVLDLVPVRTDQTTADALAATTHLAQTADRLG
TH_4625|M.thermoresistible__bu -----VTVMPGVDPDMRLSVLDLVPVRTDQTTADALTASTQLAQTADRLG
Mvan_4458|M.vanbaalenii_PYR-1 --------------MMRLSVLDLVPVRSDQSTSDAIAASTLLAQTADRLG
MUL_4481|M.ulcerans_Agy99 ------------MGSVRLSVLDLVPVRTDQSTRDALAATVSLAQTAERLG
MLBr_01106|M.leprae_Br4923 MLAENILMAGGVDSIGRISVLDLVPVRTDQSSRHALVATVQLTQTANQRN
Rv3618|M.tuberculosis_H37Rv -----------MKAPLRFGVFITPFHPTGQSPTVALQYDMERVVALDRLG
:.:: . . *: . :: .
Mflv_0215|M.gilvum_PYR-GCK YRRFWVAEHH-FVAVASTAPAVLIGQIAAATRTIRVGAAAVQLGQTTAVA
MMAR_0702|M.marinum_M YRRFWVAEHH-FVAVASASPAVLIGQIAAATDRIRVGSAAVQLSHTTAAA
MAV_2049|M.avium_104 YHRYWLAEHH-FVAVASSAPVTLIGQIAAATSRIRVGTAAVQIGHTTAVA
MAB_4233c|M.abscessus_ATCC_199 YRRYWLAEHH-FVAVASTVPALVIAHIAAATHRIRVGAGAVQIASTTPAA
MSMEG_5029|M.smegmatis_MC2_155 YHRFWVAEHHNMPAVAATSPPVLIAHLAAHTSQLRLGSGGVMLPNHAPLA
TH_4625|M.thermoresistible__bu YTRYWVAEHHNMEAVAATSPPVLIAHLAAHTTRMRIGSGGVMLPNHAPLA
Mvan_4458|M.vanbaalenii_PYR-1 YTRYWVAEHHNMPSVAATSPPVLIAHLAAHTASMRVGSGGVMLPNHAPLA
MUL_4481|M.ulcerans_Agy99 FTRYWVAEHHNMASVGATSPPVLIAYLAAQTTHLRLGSGGVMLPNHAPLA
MLBr_01106|M.leprae_Br4923 FSSRLVVEDYSMLSVGATSPPVLITYLAVQTTRIEL------LGNLGAVS
Rv3618|M.tuberculosis_H37Rv YDEAWFGEHHSGGYELIACPEVFIAAAAERTTHIRLGTGVVSLPYHHPLM
: . *.: : * .* * * :.: : .
Mflv_0215|M.gilvum_PYR-GCK VVETFGMLDAFHPGRIDLGIGRSG-RRARPPRPDGQKRTPRPVPPWREID
MMAR_0702|M.marinum_M VVESFGMLDAFHPGRIDLGVGRSAQRRGVKPRGPAKSLAPQPAREWREID
MAV_2049|M.avium_104 VVENFGILDALYPGRIDMGLGRSGQRRAEAAASSAAASPPE-ARPWRETD
MAB_4233c|M.abscessus_ATCC_199 VVESFGILDALYPGRIDLGLGRTGHRIRDRLAGNEQK--PEPAPAH-EVD
MSMEG_5029|M.smegmatis_MC2_155 VAEQFALLEAAHPGRIDLGIGRAPGSDPVTS-------------------
TH_4625|M.thermoresistible__bu VAEQFALLEAAHPGRIDLGIGRAPGSDPVTS-------------------
Mvan_4458|M.vanbaalenii_PYR-1 VAEQFALLEAAHPGRIDLGIGRAPGSDPVTS-------------------
MUL_4481|M.ulcerans_Agy99 VAEQFALLEAAAPGRIDLGIGRAPGSDPVTS-------------------
MLBr_01106|M.leprae_Br4923 ERASFNYTRSVSRARIDLG-------------------------------
Rv3618|M.tuberculosis_H37Rv VADRWVLLDHLTRGRVMFGTGPGALPSDAYMMGIDPVEQRRMMQESLEAI
: .*: :*
Mflv_0215|M.gilvum_PYR-GCK GVVIPSPFDLSTLMRNPRLKARMSVLQQ-----PGAVSPEFADQVDDILA
MMAR_0702|M.marinum_M GVVIPPPFDLRTLLSGGRVQATMAILQQ-----PEAVAPDFAEQVGDILA
MAV_2049|M.avium_104 GLVIPTPFDQTALMKSERIRAQSSVLAP-----PCAQPADFGEQIADIEA
MAB_4233c|M.abscessus_ATCC_199 GLFIPRAPTEFGIKDNPKLRATAAALQQ-----PGAHVADFDQQVADIQA
MSMEG_5029|M.smegmatis_MC2_155 ---LALRG--AAGRDDRDIEAFPQYLDD-----VVALMGARGVRVPLPRD
TH_4625|M.thermoresistible__bu ---LALRG--AAGRDDRDIEAFPDHLDD-----IVALMSPHGVRVPIP--
Mvan_4458|M.vanbaalenii_PYR-1 ---LALRG--AAGRDERDIEAFPQYLDD-----VVALMSSKGVRVPLPRD
MUL_4481|M.ulcerans_Agy99 ---YALRGGRSPAQQERDIESFPDYLDD-----VVALMSARGARVPLQ--
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv LALFRAAPDERIDRHSDWFTLREAQLHIRPYTWPYPEIATAAMISPSGPR
Mflv_0215|M.gilvum_PYR-GCK LIAGRYE-IDGFAAHVVPGEGSALTPW-VFGSSKGESARVAGARGLPFVA
MMAR_0702|M.marinum_M LLAGTYR-AEGFDVHAVPGENAALTPW-IFGSSKGRSAQVAGALGLPFVA
MAV_2049|M.avium_104 MLDGSYA-VNGHRLQVVPGEHAELTPW-IFGSTRGQSAEVAGARGLPFVA
MAB_4233c|M.abscessus_ATCC_199 FLDGSYVSPEGVALHIRPGEGADLPLW-LFGSSKGESAQVAARRGLPFVA
MSMEG_5029|M.smegmatis_MC2_155 LLRDNYI------LKATPNATSVPQLW-LLGSS-MYSAHLAAAKGLPYVF
TH_4625|M.thermoresistible__bu --QQRYI------LKATPKAVSVPQLW-LLGSS-TYSAHLAAAKGLPYVF
Mvan_4458|M.vanbaalenii_PYR-1 LMRDNYI------LKATPAAVTEPRLW-LLGSS-MYSAQLAAAKGLPYVF
MUL_4481|M.ulcerans_Agy99 --SGDYI------LKATSAALTQPRLW-LLGSS-MYSARLAAAKGLPYVF
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv LAGALGTSLLSLSMSVPGGYAALETAWGVVREQAAKAGRGEPDRADWRVL
Mflv_0215|M.gilvum_PYR-GCK SYHLTPATALDAVDVYRAHFRPSATLTEPYVVVSADVVVAEDTATARHLA
MMAR_0702|M.marinum_M SYHLTPATALEAIETYRDAFVPSAALQRPYVVVSADIVVAQDSATARRLA
MAV_2049|M.avium_104 SYHITPGTALDAIEAYRNAFRPSARLARPYVVVSADVVVAEDSATARHLA
MAB_4233c|M.abscessus_ATCC_199 NYHVTPWSTVEAVEAYRDAFQPSKALAEPYVIVSADAVAADDETTARHLT
MSMEG_5029|M.smegmatis_MC2_155 AHHFSGHGTAEALAIYREEFQPSEAAPEPVTFLTVNAVVAETTEEAEALL
TH_4625|M.thermoresistible__bu AHHFSGQGTAEALRIYRENFRPGKHTPEPLTFLTVNAVVADTRDEAMALL
Mvan_4458|M.vanbaalenii_PYR-1 AHHFAGQGTEEALQYYRDNFRPSDLTPEPVTFLTVNAAVAETHDDAMRLI
MUL_4481|M.ulcerans_Agy99 AHHFSGKGTEEALELYRSRFVPSALAARPVTFLTVNAAVADTREEATALM
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv SIMHLSDSRDQAIDDCTYGLPDFSRYFGAAGFVPLANTVEGTQSSREFVE
Mflv_0215|M.gilvum_PYR-GCK SSYGHWVHAIRTGD--GAVPYPDPDRVAPLPDEQAATVKDRTATQFVGDP
MMAR_0702|M.marinum_M SSYGHWVYSIRAGG--GAAPYPDPDDCAALTDDQLAVVSDRLATQFVGNP
MAV_2049|M.avium_104 SSYGHWVYSIRSGQ--GAIPYPDPDLCDPLTEEQRALVADRTATQFVGNP
MAB_4233c|M.abscessus_ATCC_199 STFGRWVHSIRSGH--GAIPYPDPDVAQPLTEEERQHSEDRVATQFVGDA
MSMEG_5029|M.smegmatis_MC2_155 LPQLQMMARLRTGQPLNALDLVEDAQTTVLTPQGDAVVADGRRRAVVGSP
TH_4625|M.thermoresistible__bu LPQLQMMARLRTGEPLGALDLVEDAEQRPLTPQQRAVVEAGARXXXX--R
Mvan_4458|M.vanbaalenii_PYR-1 LPNLQMMARLRTGQPMVPIDLVEDAEAQVVSPRAQAVIDAGLRQAVVGSP
MUL_4481|M.ulcerans_Agy99 MPNLHMMARLRTGQPLGPVQLVEEAQDARLTPEQQRIVDSGLERAVVGSP
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv QYAAKGNCCIGTPD--DAIAHIEDLLHRSGGFGTLLLLGHDWAPPPATFH
Mflv_0215|M.gilvum_PYR-GCK DEVAHRLEALRRVADADELVITSVTHGHE--------DRLRSHRLLAERW
MMAR_0702|M.marinum_M DEVAERMLALQRVAGADELVVTSVTHGHQ--------DRLRSHELIARRW
MAV_2049|M.avium_104 DEVADRLEVLRRVSGADELVITSVTHRHA--------DRLRSHELIAKRW
MAB_4233c|M.abscessus_ATCC_199 GQVAERLDTLARVTGADELVITSITHRHE--------DRRRSYELIAKEW
MSMEG_5029|M.smegmatis_MC2_155 TEAAEQVRALAEEFDVDEVMINPVASAHRGADPRTATARDTTLELLAKEL
TH_4625|M.thermoresistible__bu TRRAGSVRPRPR--------------------------------------
Mvan_4458|M.vanbaalenii_PYR-1 AEAGDQLRALAEKFGVDEVMVHPVASAFRGVDPATAPAREATLELLAKEI
MUL_4481|M.ulcerans_Agy99 EEAAEQVRALGQRFGVDEVMVHPVASAHRGTGPATAPARVATCELLAKEL
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv SYELFARAVIPYFKGQLAAPRASHEWARGKRDQLIGRAGEAVVKAITEHV
Mflv_0215|M.gilvum_PYR-GCK GITGEG--
MMAR_0702|M.marinum_M GLWS----
MAV_2049|M.avium_104 GLTG----
MAB_4233c|M.abscessus_ATCC_199 GLI-----
MSMEG_5029|M.smegmatis_MC2_155 F-------
TH_4625|M.thermoresistible__bu --------
Mvan_4458|M.vanbaalenii_PYR-1 F-------
MUL_4481|M.ulcerans_Agy99 F-------
MLBr_01106|M.leprae_Br4923 --------
Rv3618|M.tuberculosis_H37Rv AEQGEAGS