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MRLSVLDLVPVRSDQSTGDALAATTLLAQAADRLGYTRYWVAEHHNMPAVAATSPPVLIAHLAAHTAAIR LGSGGVMLPNHAPLAVAEQFALLEAAHPGRIDLGIGRAPGSDPVTSLALRGAAGRDDRDIEAFPEYLDDV MALMSSKGVRVPLPRDLMRDNYILKATPAAASTPRLWLLGSSMYSARLAAAKGLPYVFAHHFAGQGTAEA LALYRENFQPSEQTPEPVTFLTVNAVVAESHDEAMRLVLPNLHMMARLRTGQPLVPLDLVEDAEALDLGP RAQAVIDGGRNLAVAGAPAEAADQLLSLAEEFGVDEVMVNPVASAYRGVDPATAPAREATLELLAKELF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2237 | - | - | 100% (349) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_0215 | - | 5e-38 | 32.51% (363) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_4429 | - | 4e-11 | 42.50% (80) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 8e-10 | 35.90% (78) | monooxygenase |
| M. tuberculosis H37Rv | Rv3618 | - | 2e-12 | 45.24% (84) | monooxygenase |
| M. leprae Br4923 | MLBr_01106 | - | 8e-15 | 43.69% (103) | hypothetical protein MLBr_01106 |
| M. abscessus ATCC 19977 | MAB_3639 | - | 3e-55 | 40.31% (325) | putative luciferase-like protein |
| M. marinum M | MMAR_4179 | - | 1e-139 | 72.36% (351) | monooxygenase |
| M. avium 104 | MAV_1409 | - | 1e-144 | 75.07% (349) | alkanal monooxygenase alpha chain |
| M. smegmatis MC2 155 | MSMEG_5029 | - | 1e-161 | 81.38% (349) | alkanal monooxygenase alpha chain |
| M. thermoresistible (build 8) | TH_4625 | - | 1e-129 | 79.24% (289) | PUTATIVE alkanal monooxygenase alpha chain |
| M. ulcerans Agy99 | MUL_4481 | - | 1e-138 | 71.79% (351) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_4458 | - | 1e-174 | 86.82% (349) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2237|M.gilvum_PYR-GCK ---------------MRLSVLDLVPVRSDQSTGDALAATTLLAQAADRLG
Mvan_4458|M.vanbaalenii_PYR-1 --------------MMRLSVLDLVPVRSDQSTSDAIAASTLLAQTADRLG
MSMEG_5029|M.smegmatis_MC2_155 ---------------MRLSVLDLVPVRTDQTTADALAATTHLAQTADRLG
TH_4625|M.thermoresistible__bu -----VTVMPGVDPDMRLSVLDLVPVRTDQTTADALTASTQLAQTADRLG
MMAR_4179|M.marinum_M ---------------MRLSVLDLVPVRTDQSTRDALAATVSLAQTAERLG
MUL_4481|M.ulcerans_Agy99 ------------MGSVRLSVLDLVPVRTDQSTRDALAATVSLAQTAERLG
MAV_1409|M.avium_104 ---------------MRLSVLDLVPVRTDQTTGDALAATVALAQAADRLG
MLBr_01106|M.leprae_Br4923 MLAENILMAGGVDSIGRISVLDLVPVRTDQSSRHALVATVQLTQTANQRN
MAB_3639|M.abscessus_ATCC_1997 -------------MARPVSILDLARVAPHETVAESFAASVEIARHAETLG
Rv3618|M.tuberculosis_H37Rv -----------MKAPLRFGVFITPFHPTGQSPTVALQYDMERVVALDRLG
Mb1971|M.bovis_AF2122/97 ---------------MEIGIFLMPAHPPERTLYDATRWDLDVIELADQLG
..:: . .: : : .
Mflv_2237|M.gilvum_PYR-GCK YTRYWVAEHHNMPAVAATSPPVLIAHLAAHTAAIRLGSGGVMLPNHAPLA
Mvan_4458|M.vanbaalenii_PYR-1 YTRYWVAEHHNMPSVAATSPPVLIAHLAAHTASMRVGSGGVMLPNHAPLA
MSMEG_5029|M.smegmatis_MC2_155 YHRFWVAEHHNMPAVAATSPPVLIAHLAAHTSQLRLGSGGVMLPNHAPLA
TH_4625|M.thermoresistible__bu YTRYWVAEHHNMEAVAATSPPVLIAHLAAHTTRMRIGSGGVMLPNHAPLA
MMAR_4179|M.marinum_M FTRYWVAEHHNMASVGATSPPVLIAYLAAQTTHLRLGSGGVMLPNHAPLA
MUL_4481|M.ulcerans_Agy99 FTRYWVAEHHNMASVGATSPPVLIAYLAAQTTHLRLGSGGVMLPNHAPLA
MAV_1409|M.avium_104 FTRYWVAEHHNMPSVGATSPPVLLAYLAPQTTRLRLGSGGVMLPNHAPLA
MLBr_01106|M.leprae_Br4923 FSSRLVVEDYSMLSVGATSPPVLITYLAVQTTRIEL------LGNLGAVS
MAB_3639|M.abscessus_ATCC_1997 FHRVWYAEHHNMRSIASSATSVLIAHVATQTSTIRLGAGGIMLPNHSPLQ
Rv3618|M.tuberculosis_H37Rv YDEAWFGEHHSGGYELIACPEVFIAAAAERTTHIRLGTGVVSLPYHHPLM
Mb1971|M.bovis_AF2122/97 YVEAWVGEHFTVPWEPICAPDLLLAQALLRTQQIKLAPGAHLLPYHHPVE
: *... .. :::: :* :.: * .:
Mflv_2237|M.gilvum_PYR-GCK VAEQFALLEAAHPGRIDLGIGRAPGSDPVTSLALRG--AAG--RDDRDIE
Mvan_4458|M.vanbaalenii_PYR-1 VAEQFALLEAAHPGRIDLGIGRAPGSDPVTSLALRG--AAG--RDERDIE
MSMEG_5029|M.smegmatis_MC2_155 VAEQFALLEAAHPGRIDLGIGRAPGSDPVTSLALRG--AAG--RDDRDIE
TH_4625|M.thermoresistible__bu VAEQFALLEAAHPGRIDLGIGRAPGSDPVTSLALRG--AAG--RDDRDIE
MMAR_4179|M.marinum_M VAEQFALLEAAAPGRIDLGIGRAPGSDPVTSYALRG--GRSPAQQERDIE
MUL_4481|M.ulcerans_Agy99 VAEQFALLEAAAPGRIDLGIGRAPGSDPVTSYALRG--GRSPAQQERDIE
MAV_1409|M.avium_104 VAEQFALLEAAAPGRIDLGIGRAPGSDPVTSYALRG--GRG----DEDIQ
MLBr_01106|M.leprae_Br4923 ERASFNYTRSVSRARIDLG-------------------------------
MAB_3639|M.abscessus_ATCC_1997 IAEQFGTLETLHPGRIDLGLGRAPGTDQVTLRALRH--GPG------DAE
Rv3618|M.tuberculosis_H37Rv VADRWVLLDHLTRGRVMFGTGPGALPSDAYMMGIDP--VEQRRMMQESLE
Mb1971|M.bovis_AF2122/97 LAHRVAYFDHLAQGRFMLGVGASGIPGDWALYDVDGKNGEHREMTREALE
.*. :*
Mflv_2237|M.gilvum_PYR-GCK AFPEYLDDVMA-LMSSKGVRVPLPRDLMRDNYILKATPAAASTPRLWLLG
Mvan_4458|M.vanbaalenii_PYR-1 AFPQYLDDVVA-LMSSKGVRVPLPRDLMRDNYILKATPAAVTEPRLWLLG
MSMEG_5029|M.smegmatis_MC2_155 AFPQYLDDVVA-LMGARGVRVPLPRDLLRDNYILKATPNATSVPQLWLLG
TH_4625|M.thermoresistible__bu AFPDHLDDIVA-LMSPHGVRVPIP----QQRYILKATPKAVSVPQLWLLG
MMAR_4179|M.marinum_M SFPDYLDDVVA-LMSARGVRVPLQ----SGDYILKATPAALTQPRLWLLG
MUL_4481|M.ulcerans_Agy99 SFPDYLDDVVA-LMSARGARVPLQ----SGDYILKATSAALTQPRLWLLG
MAV_1409|M.avium_104 RFPDYLDDVAA-LMSARGVVVPLR----SGDYRLRATPAAAGEPRLWLLG
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
MAB_3639|M.abscessus_ATCC_1997 HFP---QDVLE-LQAFLGDQSRVPG--------VTATPGHGTQVPLYILG
Rv3618|M.tuberculosis_H37Rv AILALFRAAPDERIDRHSDWFTLREAQLHIRPYTWPYPEIATAAMISPSG
Mb1971|M.bovis_AF2122/97 IMLRIWTEDEPWEHRGKYWNANGIAPMFEGLMRRHIKPYQKPHPPIGVTG
Mflv_2237|M.gilvum_PYR-GCK SSMYSARLAAAKG---LPYVFAHHFAGQGTAEALALYRENFQPSEQTPEP
Mvan_4458|M.vanbaalenii_PYR-1 SSMYSAQLAAAKG---LPYVFAHHFAGQGTEEALQYYRDNFRPSDLTPEP
MSMEG_5029|M.smegmatis_MC2_155 SSMYSAHLAAAKG---LPYVFAHHFSGHGTAEALAIYREEFQPSEAAPEP
TH_4625|M.thermoresistible__bu SSTYSAHLAAAKG---LPYVFAHHFSGQGTAEALRIYRENFRPGKHTPEP
MMAR_4179|M.marinum_M SSMYSARLAAAKG---LPYVFAHHFSGKGTEEALELYRSRFVPSALAARP
MUL_4481|M.ulcerans_Agy99 SSMYSARLAAAKG---LPYVFAHHFSGKGTEEALELYRSRFVPSALAARP
MAV_1409|M.avium_104 SSMYSAHLAAAKG---LPYVFAHHFSGKGTEEALEVYRSRFRPSALTPEP
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
MAB_3639|M.abscessus_ATCC_1997 SSLFGAKLAAVLG---LPYGFASHFAPPALQDAVALYRREFQPSQQLDAP
Rv3618|M.tuberculosis_H37Rv PRLAGALGTSLLS---LSMSVPGGYAALETAWGVVREQAAKAGRGEPDRA
Mb1971|M.bovis_AF2122/97 FSAGSETLKLAGERGYIPMSLDLNTEYVATHWDAVEEGALRSGR-TPDRR
Mflv_2237|M.gilvum_PYR-GCK VTFLTVNAVVAESHDEAMRLVLP-NLHMMARLRTGQPLVPLDLVEDAEAL
Mvan_4458|M.vanbaalenii_PYR-1 VTFLTVNAAVAETHDDAMRLILP-NLQMMARLRTGQPMVPIDLVEDAEAQ
MSMEG_5029|M.smegmatis_MC2_155 VTFLTVNAVVAETTEEAEALLLP-QLQMMARLRTGQPLNALDLVEDAQTT
TH_4625|M.thermoresistible__bu LTFLTVNAVVADTRDEAMALLLP-QLQMMARLRTGEPLGALDLVEDAEQR
MMAR_4179|M.marinum_M VTFLTVNAAVADTREEATALMMP-NLHMMARLRTGQPLGAVQLVEEAQDA
MUL_4481|M.ulcerans_Agy99 VTFLTVNAAVADTREEATALMMP-NLHMMARLRTGQPLGPVQLVEEAQDA
MAV_1409|M.avium_104 LTFLTVNAVVAETRDEATALMLP-NLQMMAKLRTGQPLGPVPLVEDAEHA
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
MAB_3639|M.abscessus_ATCC_1997 YVLAGVNVIAADDEATARDQHQA-ALIERAKLFLHRSGGPR-LTDEEALA
Rv3618|M.tuberculosis_H37Rv DWRVLSIMHLSDSRDQAIDDCTY-GLPDFSRYFGAAGFVPLANTVEGTQS
Mb1971|M.bovis_AF2122/97 DWRLVREVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKFYKHN
Mflv_2237|M.gilvum_PYR-GCK DLGPRAQAVIDGGRN-LAVAGAPAEAADQLLSLAEEFG------------
Mvan_4458|M.vanbaalenii_PYR-1 VVSPRAQAVIDAGLR-QAVVGSPAEAGDQLRALAEKFG------------
MSMEG_5029|M.smegmatis_MC2_155 VLTPQGDAVVADGRR-RAVVGSPTEAAEQVRALAEEFD------------
TH_4625|M.thermoresistible__bu PLTPQQRAVVEAGAR-XXXX--RTRRAGSVRPRPR---------------
MMAR_4179|M.marinum_M RLTPEQQRIVDSGLE-RAVVGSPEEAAEQVRALGQRFG------------
MUL_4481|M.ulcerans_Agy99 RLTPEQQRIVDSGLE-RAVVGSPEEAAEQVRALGQRFG------------
MAV_1409|M.avium_104 ELTAEQRRIVDSGLR-RAVLGGPAEAAEQVRALAERFG------------
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
MAB_3639|M.abscessus_ATCC_1997 ALESPAGRQIQSMTK-YFAVGTADQVGAYLEDFAQLAD------------
Rv3618|M.tuberculosis_H37Rv SREFVEQYAAKG----NCCIGTPDDAIAHIEDLLHRSGGFGTLLLLGHDW
Mb1971|M.bovis_AF2122/97 PSVPDDEVTPEYLAENTFVVGSVQTVVDKLEATYDQVG------------
Mflv_2237|M.gilvum_PYR-GCK --------VDEVMVNPVASAYRGVDPATAPAREATLELLAKELF------
Mvan_4458|M.vanbaalenii_PYR-1 --------VDEVMVHPVASAFRGVDPATAPAREATLELLAKEIF------
MSMEG_5029|M.smegmatis_MC2_155 --------VDEVMINPVASAHRGADPRTATARDTTLELLAKELF------
TH_4625|M.thermoresistible__bu --------------------------------------------------
MMAR_4179|M.marinum_M --------VDEVMVHPVASAHRGTDPATAPARVATCELLAKELF------
MUL_4481|M.ulcerans_Agy99 --------VDEVMVHPVASAHRGTGPATAPARVATCELLAKELF------
MAV_1409|M.avium_104 --------VDEVMVNPVASARRGTDPATAPARVATLELLAKELF------
MLBr_01106|M.leprae_Br4923 --------------------------------------------------
MAB_3639|M.abscessus_ATCC_1997 --------ADELIVVPNAPDRKLQLRSLEIVAEVSGLTLRG---------
Rv3618|M.tuberculosis_H37Rv APPPATFHSYELFARAVIPYFKGQLAAPRASHEWARGKRDQLIGRAGEAV
Mb1971|M.bovis_AF2122/97 --------GFGHLLILGFDYSDNPGPWKESLRLLAHEVMPRLNARLATKP
Mflv_2237|M.gilvum_PYR-GCK ----------------
Mvan_4458|M.vanbaalenii_PYR-1 ----------------
MSMEG_5029|M.smegmatis_MC2_155 ----------------
TH_4625|M.thermoresistible__bu ----------------
MMAR_4179|M.marinum_M ----------------
MUL_4481|M.ulcerans_Agy99 ----------------
MAV_1409|M.avium_104 ----------------
MLBr_01106|M.leprae_Br4923 ----------------
MAB_3639|M.abscessus_ATCC_1997 ----------------
Rv3618|M.tuberculosis_H37Rv VKAITEHVAEQGEAGS
Mb1971|M.bovis_AF2122/97 ATAVV-----------