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VTDLDAVLFDFSGTLFRLEEDESWFDGMTLDSAGNRDVDEHVQAELMRRLTAPTGRSVSMTPEALEAWMK RDLAPHLHREAYLHVLRESGLACEHAESLYSRVIDPACWTPYPDTATVLTGLRRRGIRTAVVSNIAFDLR PAFDGVGTVDEFVLSFEVGAVKPDPSIFQTALDRLGVPAERALMVGDSDEADGGARALGCAFALVDPLPT RERSDGLLGALRAHGIRL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0023 | - | - | 100% (228) | HAD family hydrolase |
| M. gilvum PYR-GCK | Mflv_4417 | - | 3e-05 | 32.93% (82) | HAD family hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3410 | - | 6e-07 | 31.93% (119) | hypothetical protein Mb3410 |
| M. tuberculosis H37Rv | Rv3376 | - | 6e-07 | 31.93% (119) | hypothetical protein Rv3376 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2863 | - | 2e-06 | 27.54% (207) | HAD-superfamily hydrolase YfnB |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_4086 | - | 1e-08 | 35.51% (138) | transferase |
| M. smegmatis MC2 155 | MSMEG_1078 | - | 9e-90 | 72.93% (229) | hydrolase |
| M. thermoresistible (build 8) | TH_4652 | - | 6e-12 | 76.19% (42) | PUTATIVE - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0949 | - | 1e-105 | 81.28% (235) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3410|M.bovis_AF2122/97 --------------------------------------------------
Rv3376|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0023|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0949|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1078|M.smegmatis_MC2_155 --------------------------------------------------
TH_4652|M.thermoresistible__bu --------------------------------------------------
MAB_2863|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4086|M.avium_104 MRHDDYTLVIPTVGRESLRRLLIALRESMGPQPPEVVVVDDRPRPGDGLP
Mb3410|M.bovis_AF2122/97 --------------------------------------------------
Rv3376|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0023|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0949|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1078|M.smegmatis_MC2_155 --------------------------------------------------
TH_4652|M.thermoresistible__bu --------------------------------------------------
MAB_2863|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4086|M.avium_104 LPDDPPVRVLRSGGRGPAAARNVGWRASRSRWVCFLDDDVLPDRDWISAL
Mb3410|M.bovis_AF2122/97 --------------------------------------------------
Rv3376|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0023|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0949|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1078|M.smegmatis_MC2_155 --------------------------------------------------
TH_4652|M.thermoresistible__bu --------------------------------------------------
MAB_2863|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4086|M.avium_104 CLDLKAADACGAAGSQAVLEVPTPRRPSDDQRRTARLATAQWITADMAYR
Mb3410|M.bovis_AF2122/97 ---------------------MSISAVVFDRDGVLTSFD-----------
Rv3376|M.tuberculosis_H37Rv ---------------------MSISAVVFDRDGVLTSFD-----------
Mflv_0023|M.gilvum_PYR-GCK --------------------MTDLDAVLFDFSGTLF--------------
Mvan_0949|M.vanbaalenii_PYR-1 --------------------MSDLQAVLFDYSGTLF--------------
MSMEG_1078|M.smegmatis_MC2_155 -------------------MVVMVKAVLFDFSGTLF--------------
TH_4652|M.thermoresistible__bu --------------------------VLFDFSGTLF--------------
MAB_2863|M.abscessus_ATCC_1997 ---------------------MRYKAYLFDVQGTLLD-------------
MAV_4086|M.avium_104 RDILVAAGGFDERFPRAYREDSDLALRIVSAGGTILRGERRCTHPVAPAT
:.. *.:
Mb3410|M.bovis_AF2122/97 ---------------WTRAEEDVRRITGLPLEE--------IERRWGGWL
Rv3376|M.tuberculosis_H37Rv ---------------WTRAEEDVRRITGLPLEE--------IERRWGGWL
Mflv_0023|M.gilvum_PYR-GCK -----------------RLEEDESWFDGMTLDS-------AGNRDVDEHV
Mvan_0949|M.vanbaalenii_PYR-1 -----------------RLEEDESWFAGMELDTPLS---PDANREIDGHV
MSMEG_1078|M.smegmatis_MC2_155 -----------------RLEEDESWFEGMTVDE----------REVDGHV
TH_4652|M.thermoresistible__bu -----------------RLEEDASWFGGMTIAE---------QREVDRHV
MAB_2863|M.abscessus_ATCC_1997 -----------------FFEPVSRAVAEYSPDVD--------AAAFTRAW
MAV_4086|M.avium_104 WRSSVRAQIGNRDNALMRRKHGRRWRTRIGEGPGRMPAHAATTAAGTAAL
:
Mb3410|M.bovis_AF2122/97 NGLTIDDAFVETQP----------------------ISEFLSSLARELEL
Rv3376|M.tuberculosis_H37Rv NGLTIDDAFVETQP----------------------ISEFLSSLARELEL
Mflv_0023|M.gilvum_PYR-GCK QAELMRRLTAPTGRSVSMTPEALEAWMKRDLAPHLHREAYLHVLRESGLA
Mvan_0949|M.vanbaalenii_PYR-1 QAELMRRLTAPTGHSVSMTPDALDAWLNRDLAPHLHREAYLHVLRESGLA
MSMEG_1078|M.smegmatis_MC2_155 QAELMRRLTAPTGRSVQMSDEQYHAWVNRDLAPHLHREAYLHVLRESGLA
TH_4652|M.thermoresistible__bu QVELMR--------------------------------------------
MAB_2863|M.abscessus_ATCC_1997 RADYFERVSSLTQSADHWTR-----------VQDLYAAGFADVCQTFGLP
MAV_4086|M.avium_104 LAGLLGRRATARRAAALWLLCTIEFAARRWLSGPRNVREALGLSATSVLI
:
Mb3410|M.bovis_AF2122/97 GSKARDELVR------------------------------LDYMAFAQGY
Rv3376|M.tuberculosis_H37Rv GSKARDELVR------------------------------LDYMAFAQGY
Mflv_0023|M.gilvum_PYR-GCK CEHAESLYSR------------------------------VIDPACWTPY
Mvan_0949|M.vanbaalenii_PYR-1 HHHAESLYSR------------------------------VIDPACWTPY
MSMEG_1078|M.smegmatis_MC2_155 DPHAESLYGR------------------------------VIDPDSWTAY
TH_4652|M.thermoresistible__bu --------------------------------------------------
MAB_2863|M.abscessus_ATCC_1997 CPDTATAEDV------------------------------ASSWQRLVPW
MAV_4086|M.avium_104 PPVAVAHRLAGEWTFRRARPEPPLAVLLDRDDTLIVDRPYLNDPAGVRPT
Mb3410|M.bovis_AF2122/97 PDARPALEEARRRGLKVGVLTNNS-LLVSARSLLQCAALHDLVDVVL---
Rv3376|M.tuberculosis_H37Rv PDARPALEEARRRGLKVGVLTNNS-LLVSARSLLQCAALHDLVDVVL---
Mflv_0023|M.gilvum_PYR-GCK PDTATVLTGLRRRGIRTAVVSN---IAFDLRPAFDGVG---TVDEFV---
Mvan_0949|M.vanbaalenii_PYR-1 PDTATVLDGLHRRGISTAVVSN---IAFDVRPAFEVLGAAGHVDEFV---
MSMEG_1078|M.smegmatis_MC2_155 PDTATVLKSLKQQDIKTAVVSN---IAFDVRPAFTALGIDADVDEFV---
TH_4652|M.thermoresistible__bu --------------------------------------------------
MAB_2863|M.abscessus_ATCC_1997 PDVPAGLAALRMRAVVATLSNT---DMATMVNLFKRLDIS--WDAIF---
MAV_4086|M.avium_104 YDAAKALTRLRRRGLLLAVVTNQSGVARGLISAGQLAAVNDRVDEVLGPF
Mb3410|M.bovis_AF2122/97 ---------SSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEG
Rv3376|M.tuberculosis_H37Rv ---------SSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEG
Mflv_0023|M.gilvum_PYR-GCK ---------LSFEVGAVKPDPSIFQTALDRLGVPAERALMVGDSDEADGG
Mvan_0949|M.vanbaalenii_PYR-1 ---------LSFEVGAVKPDPAIFQTALDRLGVAADRALMVGDSDEADGG
MSMEG_1078|M.smegmatis_MC2_155 ---------LSYEVGAVKPDAAIFTTTLQRLGVAPQDALMVGDSEEADGG
TH_4652|M.thermoresistible__bu --------------------------------------------------
MAB_2863|M.abscessus_ATCC_1997 ---------TAEVFGRFKPDPSVYRGALRYLGVEPYEAAMVAAHPYDLRA
MAV_4086|M.avium_104 DSWQVCVHGAADGCGCRKPRPGLILAAAEALGVPARRCVMIGDTGADVRA
Mb3410|M.bovis_AF2122/97 ARCAGMRAYLVD----------RSGQTRDGVVRDLSSLGAILDGAGP
Rv3376|M.tuberculosis_H37Rv ARCAGMRAYLVD----------RSGQTRDGVVRDLSSLGAILDGAGP
Mflv_0023|M.gilvum_PYR-GCK ARALGCAFALVDP--------LPTRERSDGLLGALRAHGIRL-----
Mvan_0949|M.vanbaalenii_PYR-1 ARTLGCAFALVDP--------LPTAERKDGLVAALWANGIQL-----
MSMEG_1078|M.smegmatis_MC2_155 ATAVGCAFALVDP--------LPTTERPDGLIAAVSSVGIAT-----
TH_4652|M.thermoresistible__bu -------LVLVDP--------LPSGQRPDGLRTALRDHGLRV-----
MAB_2863|M.abscessus_ATCC_1997 ARQLGMGTIFVSRPHEYGDPVLAHTDPDEEFDQRVTAIGELS-----
MAV_4086|M.avium_104 ALAAGAAAVLVPTDR-TLPAEVEHARAHARVAATLNDAVSLVLSECR
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