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VHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQPSSSAVLLVAAFGAFLAFLDSTIVNVAFPDIQRH FHSDISDLSWMLNAYNIVFAAFLVAAGRLADLMGRKRVFILGVALFTVASGLCAIAESVGELVAFRVLQG IGAAVLVPASLGLVVEAFPAERRAHGVNLWGAAGAIAAGLGPPIGGALIEADGWRWVFLVNLPLGVFAVL AARRALVENRAAGRRRVPDVRGAVLLAFALGLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVMSSRH HPAPMVEPTLLRIQSFVAGTGLTAVASAGFYAYLLTHVLFLNYVWGYTLLEAGMAVAPAALVAAVVAAVL GRVADRHGYRFIVGIGALIWAASLLWYLKVVGSQPDFLGEWLPGQILQGIGVGATFPLLGSAALARLAKG GSYATASAVTGTIRQVGAVIGVAVLVILVGTPAPGAAEEALRHRWALAAICFVAVGIGALSLGRIRPVPA AVEPPPGPPVAPLGARRPPRPAPVASPAAAVAPTPKTSREVNLLEALRFARPDTQQIELQAGSYLFHAGD VSDALYVVRSGRLQVLAGDGAKDEVVAELGRGQVVGELGVLLDAPRSASVRAVRDSSLMRVTKAEFAKIA DAGVLGALAGVLAKRQHQTRVASQRTTPEVVVAVVGVDANAPVAMVATELCRALSTRLRAVAPGRVDCDG LERAEQTADRVVLHAAVGDARWREFCLRVADRVVLVASNPAVPVAPLPTRATGADLVLAGRPAGREHRRA WEQLITPRSMHVVRREFVADDLRVLATRIAGRSVGLVLSGGAARACAHLGVLEELEAAGVTVDRFAGTSM GAIIAALAASGLDAAGVDAQIYEHFVRKSHGDYTLPSKGLIRGKRTQSTLRTIFGDHLVEELPKHFRCVS VDLLARRPVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVPVTTLVGKDGPLIAVNVASGG NPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEKVLAQADLVIKPNPIGVGLMEYHQIDRAREAGRI AAREALPQIMELVHG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3755 | - | - | 100% (1065) | hypothetical protein Mb3755 |
M. bovis AF2122 / 97 | Mb3267c | - | 0.0 | 63.96% (1046) | transmembrane transport protein |
M. bovis AF2122 / 97 | Mb2594 | - | 6e-68 | 33.22% (569) | hypothetical protein Mb2594 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0301 | - | 1e-56 | 32.84% (469) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv3728 | - | 0.0 | 99.91% (1065) | hypothetical protein Rv3728 |
M. leprae Br4923 | MLBr_01562 | - | 6e-49 | 31.48% (486) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_1396 | - | 4e-56 | 31.58% (475) | EmrB/QacA family drug resistance transporter |
M. marinum M | MMAR_2964 | - | 0.0 | 72.43% (1059) | transmembrane transport protein |
M. avium 104 | MAV_1387 | - | 6e-49 | 31.75% (422) | drug transporter |
M. smegmatis MC2 155 | MSMEG_5670 | - | 2e-57 | 31.63% (490) | efflux membrane protein |
M. thermoresistible (build 8) | TH_3965 | - | 2e-51 | 32.66% (398) | PUTATIVE drug transporter |
M. ulcerans Agy99 | MUL_3590 | - | 0.0 | 63.27% (1051) | transmembrane transport protein |
M. vanbaalenii PYR-1 | Mvan_4014 | - | 8e-56 | 33.64% (428) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0301|M.gilvum_PYR-GCK ------------------------------------------MTGLRMGT MSMEG_5670|M.smegmatis_MC2_155 ----------------------------------------MNETVGALSA MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu --------------------------VTSVDAGRSTMSEVFTAYAPRSAA Mvan_4014|M.vanbaalenii_PYR-1 ----------------------------------MSQHRPHDAIAAEPTD MAB_1396|M.abscessus_ATCC_1997 ---------------------------------------------MRPEY Mb3755|M.bovis_AF2122/97 --------------MHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQ Rv3728|M.tuberculosis_H37Rv --------------MHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQ MMAR_2964|M.marinum_M ------------MAVQPLSPTRKAPPVGDAEPDRPGRLGGPHFRLGRRRQ MUL_3590|M.ulcerans_Agy99 --------------MHLSAPAERS-------------------ALTSRRQ MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF Mflv_0301|M.gilvum_PYR-GCK AAGRWVLLATVLG--SGIVMVDATVVNVALPHIAADLGG-GFGDLQWVVN MSMEG_5670|M.smegmatis_MC2_155 RRKAIILVSCCLS--LLIVSMDATIVNVAIPSIRSDLGA-SPSQLQWVID MAV_1387|M.avium_104 ---------MMIG--FFMIMVDSTIVAIANPTIMADLHI-GYDTVVWVTS TH_3965|M.thermoresistible__bu ANPWHALWAMLIG--FFMILVDATIVPVANLEIMADLGA-DYTAVIWVTS Mvan_4014|M.vanbaalenii_PYR-1 DHPFRALWVMMVG--FFLIVVDSTVIAVANPVLKNDFDV-EYHSVIWVTS MAB_1396|M.abscessus_ATCC_1997 PRPWITLWVVLFG--LFMILLDSTIVSVANPAIKAGFGA-DYSSTVWVTS Mb3755|M.bovis_AF2122/97 PSSSAVLLVAAFG--AFLAFLDSTIVNVAFPDIQRHFHS-DISDLSWMLN Rv3728|M.tuberculosis_H37Rv PSSSAVLLVAAFG--AFLAFLDSTIVNVAFPDIQRHFHS-DISDLSWMLN MMAR_2964|M.marinum_M PSPATVLLVAAFG--AFLAFLDSTIVNVAFPDIQRYFHS-GISDLSWVLN MUL_3590|M.ulcerans_Agy99 PSATAVLLVASFG--AFLAFLDSTIVNIAFPHIQRSFPSYDISSLSWILN MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSL-SDAGRSWGIT .. : :*:*: :* : : * Mflv_0301|M.gilvum_PYR-GCK AYTLTLASLILLGGSLGDHFGRRKVFVLGVVWFALASIACGLAPSIEVLI MSMEG_5670|M.smegmatis_MC2_155 VYTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLI MAV_1387|M.avium_104 AYLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLI TH_3965|M.thermoresistible__bu AYLLAYAVPLLIAGRLGDRFGPRTMYLIGLAIFTAASLWCGLAGTIGMLI Mvan_4014|M.vanbaalenii_PYR-1 GYLLAFAAFLLIGGRLGDRFGSKPVYLVGLTLFAAASVWCGLSTSVGMLI MAB_1396|M.abscessus_ATCC_1997 AYLLGYAVPLLITGRLGDQFGPRSMYLSGLAVFTAASLWCGLAGSIGWLI Mb3755|M.bovis_AF2122/97 AYNIVFAAFLVAAGRLADLMGRKRVFILGVALFTVASGLCAIAESVGELV Rv3728|M.tuberculosis_H37Rv AYNIVFAAFLVAAGRLADLMGRKRVFILGVALFTVASGLCAIAESVGELV MMAR_2964|M.marinum_M AYNIVFAAFLVAAGKLADLLGRKRLFVYGVVLFTIASGLCAAADSVEQLV MUL_3590|M.ulcerans_Agy99 GYNIVFAAFLVASGRLADVLGRKRMFVFGVVLFTIASGLCAVAGDVEQLV MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLV * : . :: * .* :* : : *:. *: :* *. : *: Mflv_0301|M.gilvum_PYR-GCK VARALQGVGGALLTPGSLALISAAFAS-GDRGAAVGAWSGLGGIAGAIGP MSMEG_5670|M.smegmatis_MC2_155 AARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGP MAV_1387|M.avium_104 AARVVQGVGAGVMTPQTLSTITRIFPA-ERRGVAVSVWSATAGAASLAGP TH_3965|M.thermoresistible__bu AARVLQGLGAALLTPQTLSMITRIFPA-DRRGVPMGVWGATAGVATLIGP Mvan_4014|M.vanbaalenii_PYR-1 AARVAQGVGAALLTPQIMSTITRTFPP-QRHGMAMSVWGATAGVGMLAGP MAB_1396|M.abscessus_ATCC_1997 AARVVQGIGAAMLTPQTLTVVQRVFPP-ERRGTAMGVWGAVAGIATLVGP Mb3755|M.bovis_AF2122/97 AFRVLQGIGAAVLVPASLGLVVEAFPA-ERRAHGVNLWGAAGAIAAGLGP Rv3728|M.tuberculosis_H37Rv AFRVLQGIGAAVLVPASLGLVVEAFPA-ERRAHGVNLWGAAGAIAAGLGP MMAR_2964|M.marinum_M AFRVLQGIGAAVLVPASLGLVVESFPA-ERRAHGVNLWGAAGAIAAGLGP MUL_3590|M.ulcerans_Agy99 GFRVLQGIGAAVLVPASLALVVEGFDA-SHRAHAVGLWGAAAAVASGLGP MLBr_01562|M.leprae_Br4923 IARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGL * *.:*..: * : : * : :.. . . * Mflv_0301|M.gilvum_PYR-GCK FLGGALVEWN-WRAAFLINVPLAAFVIAVTLLRVPESRDPSASRRLDVGG MSMEG_5670|M.smegmatis_MC2_155 LVGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQ MAV_1387|M.avium_104 LAGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVP--VLPTQSHRFDLVG TH_3965|M.thermoresistible__bu LAGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMP--RLPRQDQGFDVLG Mvan_4014|M.vanbaalenii_PYR-1 LIGGVLLAGLGWQWIFFVNAPIGAIGIALAVRLVP--NLPGRPVRIDVVG MAB_1396|M.abscessus_ATCC_1997 VAGGLLVDGWGWQWIFYVNVPVGVLGIILGAIYIP--RMPTHRHRLDLLG Mb3755|M.bovis_AF2122/97 PIGGALIEADGWRWVFLVNLPLGVFAVLAARRALVENRAAGRRRVPDVRG Rv3728|M.tuberculosis_H37Rv PIGGALIEADGWRWVFLVNLPLGVFAVLAARRALVENRAAGRRRVPDVRG MMAR_2964|M.marinum_M PIGGALVEALNWRWVFLVNLPLGIVAVLAARRALVESRACGRRRVPDVRG MUL_3590|M.ulcerans_Agy99 PVGGMLVEASSWRLVFLVNIPLGIVAVLVAGRVLTESRASGRRRVPDLRG MLBr_01562|M.leprae_Br4923 VVGGALTEVS-WRLAFLVNVPIGLVMIYLARTALH--ETHKERMKLDAAG ** * *: * :* *: : : Mflv_0301|M.gilvum_PYR-GCK AVLTVVGLGALTFGLTELGNRGASPAAVVSVGGGLVALVVFVLVEQR-SS MSMEG_5670|M.smegmatis_MC2_155 GLGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESR-RH MAV_1387|M.avium_104 VGLSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVR TH_3965|M.thermoresistible__bu MVLSAVGLFLIVFALQEAQTHRWAPWIWGTLAGGAGVMAMFVIWQSANRR Mvan_4014|M.vanbaalenii_PYR-1 ALLSGAGICLIVLGLQEGQHERWSWWIWVAIAGGLVSITAFLRWQTVHAD MAB_1396|M.abscessus_ATCC_1997 MALSAVGMFAFVFALQEGESFQWAPGVWAMMAAGLVVLGVFVWWQSANRG Mb3755|M.bovis_AF2122/97 AVLLAFALGLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVMSSRHHP Rv3728|M.tuberculosis_H37Rv AVLLAFALGLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVMSSRHHP MMAR_2964|M.marinum_M AAMLATALGLLTLGLIKGPDWGWSSLPAIGSLVAAALAMIGFVMSSRNHP MUL_3590|M.ulcerans_Agy99 AMLLGVALGLMTLGLVKGPEWGWISTATIGSFVASSVALVAFVASSRSHP MLBr_01562|M.leprae_Br4923 AILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAE . : . Mflv_0301|M.gilvum_PYR-GCK HPLMSPKLFADRNFGVANAVTLLIYGALGAVFLLLVLQLQTVSGFSPVAA MSMEG_5670|M.smegmatis_MC2_155 DPFIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFT MAV_1387|M.avium_104 EPLIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRS TH_3965|M.thermoresistible__bu HPLVPLQIFADRNFMLANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGS Mvan_4014|M.vanbaalenii_PYR-1 EPLIPMSLMSHRNFVLSTAGIALVSFVFVSFGVPLMIYLQEVCGLSPVHA MAB_1396|M.abscessus_ATCC_1997 EPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFYTQLALGFSPTKA Mb3755|M.bovis_AF2122/97 APMVEPTLLRIQSFVAGTGLTAVASAGFYAYLLTHVLFLNYVWGYTLLEA Rv3728|M.tuberculosis_H37Rv APMVEPTLLRIQSFVAGTGLTAVASAGFYAYLLTHVLFLNYVWGYTLLEA MMAR_2964|M.marinum_M TPLVEPALLRIRSFVAGSALTAIASAGFYAYLLTHVLFLNYVWGYTLLQA MUL_3590|M.ulcerans_Agy99 TPLIDPAFLRVRSFVAGNLLTLVAAAGFYCYVLTHVLYLNYVWHYSLLKA MLBr_01562|M.leprae_Br4923 NPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRA *.: :: . . : : : : Mflv_0301|M.gilvum_PYR-GCK GTALLPFTIVMLLFSSRAGALSGRIGPRLPMTVGPVLAGLGLLLMLRIGE MSMEG_5670|M.smegmatis_MC2_155 GLIYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVMLAQMTA MAV_1387|M.avium_104 ALLIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMS TH_3965|M.thermoresistible__bu ALLIAPMAVASGVLAPMAGRIVDRSHPTPVVGFGFSVVAVGLTWLAVEMA Mvan_4014|M.vanbaalenii_PYR-1 ALLTAPMAVATAVLAPVVGRIVDRAHPRPVVGFGFGLLTAGLIWLAVEMT MAB_1396|M.abscessus_ATCC_1997 ALTQAPTAIVSGILAPLAGWLVDRVRPSILIGGGIALMIASTLWWTLLMR Mb3755|M.bovis_AF2122/97 GMAVAPAALVAAVVAAVLGRVADRHGYRFIVGIGALIWAASLLWYLKVVG Rv3728|M.tuberculosis_H37Rv GMAVAPAALVAAVVAAVLGRVADRHGYRFIVGIGALIWAASLLWYLKVVG MMAR_2964|M.marinum_M GLAVCPAAIIAAVTAGLLGRVADRHGYRVIIGVGALIWAGSLLWYLTCVG MUL_3590|M.ulcerans_Agy99 GFAIAPAALIAAVVAAVLGRIADQRGHRLVVMAGAIIWAGSLVWYLQRVG MLBr_01562|M.leprae_Br4923 GIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMN . * .: : . : .: . : . Mflv_0301|M.gilvum_PYR-GCK DASWVFDVAPA-ALVFGAGMVLVVAPLTATVLDAAP-EHMAGSASGVNNA MSMEG_5670|M.smegmatis_MC2_155 TTP-VWLLLVI-FAVFGIGFALVNAPITTAAVSGMP-LDRAGAASAVAST MAV_1387|M.avium_104 PATPIWRLVLP-FFAMGVGMAFVWSPLTATATRNLS-AQLAGAGSAVYNS TH_3965|M.thermoresistible__bu PTTPIWRLVLP-FVAVGVGMAFIWSPLATTATRQLP-LHLSGAGSGVYNT Mvan_4014|M.vanbaalenii_PYR-1 PDTPAWRLALP-LTMVGAAGAFTWEPLSAIATRGLT-SELAGAGSAVCNT MAB_1396|M.abscessus_ATCC_1997 PETQMWQLMLP-AAGIGAAMACIWGPLATTATRNLP-PSVAGAGSGVYNT Mb3755|M.bovis_AF2122/97 SQPDFLGEWLPGQILQGIGVGATFPLLGSAALARLAKGGSYATASAVTGT Rv3728|M.tuberculosis_H37Rv SQPDFLGEWLPGQILQGIGVGATFPLLGSAALARLAKGGSYATASAVTGT MMAR_2964|M.marinum_M TTPNFLGEWLPGQILQGIGVGAAFPLLGSAALAGLASGSSYATASAVTGT MUL_3590|M.ulcerans_Agy99 TEPNFLREWLPGQLLQGIGVGATLPVLGSAALAGLTKGGSYATASAVVST MLBr_01562|M.leprae_Br4923 RGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVG-FDRIGPVSAIALM * . : . .. *.: Mflv_0301|M.gilvum_PYR-GCK VARAGGLLAVAVLPGVAGISGNDYAD--P--------------------- MSMEG_5670|M.smegmatis_MC2_155 SRQVGVSIGVALCGSVAGTALAGTG------------------------- MAV_1387|M.avium_104 VRQLGAVLGSAGMAAFMTWRIGAEMPGQP--------------------- TH_3965|M.thermoresistible__bu TRQIGSVLGSAGMAAFLTGRLSAELPFGA--------------------- Mvan_4014|M.vanbaalenii_PYR-1 ARHVGAALSSAGIAALMAVLLGDEHAEEA--------------------- MAB_1396|M.abscessus_ATCC_1997 LRQVGGVVGSSAMGALMTARLTATMPAMP--------------------- Mb3755|M.bovis_AF2122/97 IRQVGAVIGVAVLVILVGTPAPGAAEEALRHRWALAAICFVAVGIGALSL Rv3728|M.tuberculosis_H37Rv IRQVGAVIGVAVLVILVGTPAPGAAEEALRHGWALAAICFVAVGIGALSL MMAR_2964|M.marinum_M IRQVGAVIGVALLVILVGTPAPGAAEESLRRGWTMAAICFVAVALGAVWL MUL_3590|M.ulcerans_Agy99 TRQLGAVIGVALLVILIGKPAPGTGVEALRHGWVLAAVCFAAVAVLAGFL MLBr_01562|M.leprae_Br4923 LQSLGGPLVLAVIQAVITSRTLYLGGTTG--------------------- * : : . Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu -------------------------------------------------- Mvan_4014|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 -------------------------------------------------- Mb3755|M.bovis_AF2122/97 GRIRPVPAAVEPPPGPPVAPLGARRPPRPAPVAS-PAAAVAPTPKTSREV Rv3728|M.tuberculosis_H37Rv GRIRPVPAAVEPPPGPPVAPLGARRPPRPAPVAS-PAAAVAPTPKTSREV MMAR_2964|M.marinum_M GRIRPAPAEAVTPESAP-----------PAQAPL-PQPSVAPVVSTSPDI MUL_3590|M.ulcerans_Agy99 GRTQQGADVAGAPESGVAR-----APARPQPVTPRPAAAPARPPQTTADG MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu -------------------------------------------------- Mvan_4014|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 -------------------------------------------------- Mb3755|M.bovis_AF2122/97 NLLEALR-----------FARPDTQQIELQAGSYLFHAGDVSDALYVVRS Rv3728|M.tuberculosis_H37Rv NLLEALR-----------FARPDTQQIELQAGSYLFHAGDVSDALYVVRS MMAR_2964|M.marinum_M DVLQAVP-----------DLHRHAEHVELQAGSYLFRAGDVSDSLYVVRS MUL_3590|M.ulcerans_Agy99 DLLRQLPLFAGLPAATMAELRHHTDEIELQAGSYLFHEVDPSDALYVVRS MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------AAFSAGFHTAVVISAVLMVAAAVLAAIGIRR MSMEG_5670|M.smegmatis_MC2_155 -------------------VDFAAASRPLWLICTALGVVIVAIGIVSTSP MAV_1387|M.avium_104 -------------------GGGGEDSAGPVLPEFLRGPFAAAMSQSVLLP TH_3965|M.thermoresistible__bu -------------------TAVPAGEQTRVLPEFLHAPYAAAMAQSMLLP Mvan_4014|M.vanbaalenii_PYR-1 -------------------GARHETLAP--LVDSLKDPFAGAMAQSMLLP MAB_1396|M.abscessus_ATCC_1997 -------------------PGSG-STPEAALPPGLRAPFSAAMAQSMLLG Mb3755|M.bovis_AF2122/97 GRLQVLAGDGAKDEVVAELGRGQVVGELGVLLDAPRSASVRAVRDSSLMR Rv3728|M.tuberculosis_H37Rv GRLQVLAGDGAKDEVVAELGRGQVVGELGVLLDAPRSASVRAVRDSSLMR MMAR_2964|M.marinum_M GRLQVIDEHG----LVAELGRGQLVGEVGVLRDAPRSASVLAVRDSSLLR MUL_3590|M.ulcerans_Agy99 GRLRVVQRDL----VLRELGRGEVVGELGLLIDAPRSASVQAMRDFVLIR MLBr_01562|M.leprae_Br4923 ------------------PVKFMNDAQLRALDHGYTYGLLWVAGAVVIVG : . Mflv_0301|M.gilvum_PYR-GCK APARSDERMAVENCTHCA-------------------------------- MSMEG_5670|M.smegmatis_MC2_155 WALRSAERLAPLIGQHHR-------------------------------- MAV_1387|M.avium_104 AFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDDYDDDDAYV TH_3965|M.thermoresistible__bu AFVALFGVLAAIFLAGIVLSTPQP---------DADAQYLDEHDD---YL Mvan_4014|M.vanbaalenii_PYR-1 AAAAAMGVLTALFLVG---------------------------------- MAB_1396|M.abscessus_ATCC_1997 IAALALGLVAALFMRP---------------------------------- Mb3755|M.bovis_AF2122/97 VTKAEFAKIADAGVLGALAGVLAKRQHQT--RVASQRTTPEVVVAVVGVD Rv3728|M.tuberculosis_H37Rv VTKAEFAKIADAGVLGALAGVLAKRQHQT--RVASQRTTPEVVVAVVGVD MMAR_2964|M.marinum_M VPKSEFAKIADARLLGVLASVLANRQVPTS-RTASRPPTREVVVAVIGVD MUL_3590|M.ulcerans_Agy99 LSKAQFNRIADRGVLAALVGTLATRLHTAPPPTVDRPASPEAVIAVIGLG MLBr_01562|M.leprae_Br4923 VAALFIGYTPEQVAYA---------------------------------- . Mflv_0301|M.gilvum_PYR-GCK ----------------------------ITGLPAHPAAETR--------- MSMEG_5670|M.smegmatis_MC2_155 ----------------------------PAEVAHAR-------------- MAV_1387|M.avium_104 ELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRRSVLDERPA TH_3965|M.thermoresistible__bu VIELAR-----------------PDPNPRTDIAVTAVIPALRPTLRP--- Mvan_4014|M.vanbaalenii_PYR-1 -----------------------------GDATARAAPLSLR-------- MAB_1396|M.abscessus_ATCC_1997 -----------------------------GGSQVGAVP------------ Mb3755|M.bovis_AF2122/97 ANAPVAMVATELCRALSTRLRAVAPGRVDCDGLERAEQTADRVVLHAAVG Rv3728|M.tuberculosis_H37Rv ANAPVAMVATELCRALSTRLRAVAPGRVDCDGLERAEQTADRVVLHAAVG MMAR_2964|M.marinum_M AGAPATVVATELCAALSQRLRAVAPGRVNADGLERAERSADRVVLQATVG MUL_3590|M.ulcerans_Agy99 AAVPVRPVALALLNALSARVTAVDPGRVDRAGLERAEASADKVVLDASAN MLBr_01562|M.leprae_Br4923 -----------------------------QEVKEAVDAGEL--------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 QVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPRRHHPGPA TH_3965|M.thermoresistible__bu -----------------------TLR--PSLGPPGGPVVQP--------- Mvan_4014|M.vanbaalenii_PYR-1 --------------------------------PWGDASVSS--------- MAB_1396|M.abscessus_ATCC_1997 ----------------------------------LDDVVSVED------- Mb3755|M.bovis_AF2122/97 DARWREFCLRVADRVVLVASNPAVPVAPLPTRATGADLVLAGRPAGREHR Rv3728|M.tuberculosis_H37Rv DARWREFCLRVADRVVLVASNPAVPVAPLPTRATGADLVLAGRPAGREHR MMAR_2964|M.marinum_M DGPWLDFCVRVADRVVLVARDFLAPPRRLTAKAPGVDLVLTGPSAAPVYR MUL_3590|M.ulcerans_Agy99 DTGWRDFCLRAADRIVLVSEGPAPRDTQLPARAVGADLVLIGAPASQEDR MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 GHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN----------------- TH_3965|M.thermoresistible__bu ----NNTAALR--------------------------------------- Mvan_4014|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 -------------------------------------------------- Mb3755|M.bovis_AF2122/97 RAWEQLITPRSMHVVRREFVADDLRVLATRIAGRSVGLVLSGGAARACAH Rv3728|M.tuberculosis_H37Rv RAWEQLITPRSMHVVRREFVADDLRVLATRIAGRSVGLVLSGGAARACAH MMAR_2964|M.marinum_M REWEELITPRSVHTVHPATIADDLRPLAARIAGRSVGLVLGGGGALACAH MUL_3590|M.ulcerans_Agy99 SRWEELIPPRSVHSVSYRSLKDDVRPLAARITGGSIGLVLGGGGARAFAH MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu -------------------------------------------------- Mvan_4014|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 -------------------------------------------------- Mb3755|M.bovis_AF2122/97 LGVLEELEAAGVTVDRFAGTSMGAIIAALAASGLDAAGVDAQIYEHFVRK Rv3728|M.tuberculosis_H37Rv LGVLEELEAAGVTVDRFAGTSMGAIIAALAASGLDAAGVDAQIYEHFVRK MMAR_2964|M.marinum_M LGVLEELEAAGITVDRYAGTSMGALMAALAADGVDAAGVDAYIYEYFVRK MUL_3590|M.ulcerans_Agy99 LGVLDELEAAGIVVDRFAGTSMGAVIAALAASGLDAAGVDAHVFEYLVRH MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu -------------------------------------------------- Mvan_4014|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 -------------------------------------------------- Mb3755|M.bovis_AF2122/97 S-HGDYTLPSKGLIRGKRTQSTLRTIFGDHLVEELPKHFRCVSVDLLARR Rv3728|M.tuberculosis_H37Rv S-HGDYTLPSKGLIRGKRTQSTLRTIFGDHLVEELPKHFRCVSVDLLARR MMAR_2964|M.marinum_M N-HSDFTLPSKGFLRGKRTEVALRSAFGDRLVEELPKQFRCVSVDLLARQ MUL_3590|M.ulcerans_Agy99 NPLGDYTLPSKGLVRGRRTMGLLREAYSGRMVEELPKEFRCVSVDLLARQ MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu -------------------------------------------------- Mvan_4014|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 -------------------------------------------------- Mb3755|M.bovis_AF2122/97 PVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVPVTTLVGK Rv3728|M.tuberculosis_H37Rv PVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVPVTTLVGK MMAR_2964|M.marinum_M SVVHRSGLLTDVISCSMRLPVMYPPMAHAGSLHVDGGILDNVPVTALAGP MUL_3590|M.ulcerans_Agy99 AVVHRRGPVAEVVGCSLRVPGLYPPQIYNGQLHVDGGVLNNLPVTALTRA MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu -------------------------------------------------- Mvan_4014|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 -------------------------------------------------- Mb3755|M.bovis_AF2122/97 DGPLIAVNVASGGNPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEK Rv3728|M.tuberculosis_H37Rv DGPLIAVNVASGGNPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEK MMAR_2964|M.marinum_M EGPVIAVNVA-GGNRDSAPDSRHGKRLQVPGITDTLLRALTIGSAMTSSE MUL_3590|M.ulcerans_Agy99 EGPMIAVSVGFGGNPSGGQ-PRRSGPIQVPGIGDTLMRTMMMGSRTVADA MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu -------------------------------------------------- Mvan_4014|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1396|M.abscessus_ATCC_1997 -------------------------------------------------- Mb3755|M.bovis_AF2122/97 VLAQADLVIKPNPIGVGLMEYHQIDRAREAGRIAAREALPQIMELVHG-- Rv3728|M.tuberculosis_H37Rv VLAQADLVIKPNPIGVGLMEYHQIDRAREAGRIAAREALPQIMELVHG-- MMAR_2964|M.marinum_M VLAHADVVIQPNPSGIGFLEFHQIDRAREAGRMAARQALPQIMKLVFP-- MUL_3590|M.ulcerans_Agy99 AQAEALVVIRPDTRAVGLLEFHQIDAAREAGRAAARAALPQIIPLLRSGP MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK ------------------------ MSMEG_5670|M.smegmatis_MC2_155 ------------------------ MAV_1387|M.avium_104 ------------------------ TH_3965|M.thermoresistible__bu ------------------------ Mvan_4014|M.vanbaalenii_PYR-1 ------------------------ MAB_1396|M.abscessus_ATCC_1997 ------------------------ Mb3755|M.bovis_AF2122/97 ------------------------ Rv3728|M.tuberculosis_H37Rv ------------------------ MMAR_2964|M.marinum_M ------------------------ MUL_3590|M.ulcerans_Agy99 AGQTTGRAIDRSARALRTDARRPA MLBr_01562|M.leprae_Br4923 ------------------------