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GKRGDQPSLPDQLSPPVEAVQSHYDRSNEFFKLFLDPSMTYSCAYFERPDMTLEQAQYAKRKLSLDKLNL EPGMTLLDIGCGWGSTMRHAIEEYDVNVIGLTLSENQLVHDERKFADMDSPRHKEVRLQSWEQFDEPVDR IVSLGAFEHFADGAGDASWERYDRFFKMCYNVLPDDGRMLLHTIIVPDAKEAKELGLTAPMSLMRFIKFI LTEIFPGGRLPQIPQIDEYSSRAGFKVERYHRIGSNYVPTLNSWAQALQANQEKAIELQGQEVYDIYMHY LTGCSDLFRDHYTDVCQFTMVK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4575 | cmaA2 | - | 100% (303) | cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 |
| M. ulcerans Agy99 | MUL_4539 | pcaA | 8e-99 | 60.82% (291) | mycolic acid synthase PcaA |
| M. ulcerans Agy99 | MUL_3772 | mmaA5 | 6e-94 | 56.90% (290) | methoxy mycolic acid synthase 5 MmaA5 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0515c | cmaA2 | 1e-145 | 79.87% (303) | cyclopropane-fatty-acyl-phospholipid synthase 2 CMAA2 |
| M. gilvum PYR-GCK | Mflv_3304 | - | 1e-97 | 56.38% (298) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv0503c | cmaA2 | 1e-145 | 79.87% (303) | cyclopropane-fatty-acyl-phospholipid synthase 2 CMAA2 |
| M. leprae Br4923 | MLBr_02426 | cmaA2 | 1e-143 | 80.95% (294) | cyclopropane mycolic acid synthase |
| M. abscessus ATCC 19977 | MAB_3881 | - | 1e-91 | 56.36% (291) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. marinum M | MMAR_0831 | cmaA2 | 1e-180 | 99.67% (303) | cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 |
| M. avium 104 | MAV_4647 | - | 1e-125 | 71.23% (292) | cyclopropane-fatty-acyl-phospholipid synthase 2 |
| M. smegmatis MC2 155 | MSMEG_3538 | - | 1e-101 | 60.00% (290) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. thermoresistible (build 8) | TH_2761 | - | 2e-99 | 61.27% (284) | PUTATIVE cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. vanbaalenii PYR-1 | Mvan_3025 | - | 7e-96 | 57.93% (290) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0515c|M.bovis_AF2122/97 MTSQGDT---TSGTQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCAYFE
Rv0503c|M.tuberculosis_H37Rv MTSQGDT---TSGTQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCAYFE
MAV_4647|M.avium_104 MTSQGE-------TQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCGYWE
MUL_4575|M.ulcerans_Agy99 MGKRGDQPSLP--DQLSPPVEAVQSHYDRSNEFFKLFLDPSMTYSCAYFE
MMAR_0831|M.marinum_M MGKRGDQPSLP--DQLSPPVEAVQSHYDRSNEFFKLFLDPSMTYSCAYFE
MLBr_02426|M.leprae_Br4923 MVPSQSHPAKTPRKQLKPPIEAVQSHYDRSNEFFKLWLDPSMTYSCAYFE
TH_2761|M.thermoresistible__bu ----------------------VRSHYDLSNEFFRLWQDPTQTYSCAYFE
Mflv_3304|M.gilvum_PYR-GCK -----MSDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLDPTQTYSCAYFE
Mvan_3025|M.vanbaalenii_PYR-1 -----MPETTSGSADLQPHFEDVQSHYDLSDDFYRLFLDPTQTYSCAYFE
MSMEG_3538|M.smegmatis_MC2_155 -------------MALQPHFEDVQSHYDLSDEFFRLFLDPTQTYSCAYFE
MAB_3881|M.abscessus_ATCC_1997 ------------MSKLTPKFSDVQAHYDLSDDFFALFLDPSRTYSCAYFE
*::*** *::*: *: **: ****.*:*
Mb0515c|M.bovis_AF2122/97 RPDMTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEYDVN
Rv0503c|M.tuberculosis_H37Rv RPDMTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEYDVN
MAV_4647|M.avium_104 EGAKTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVEEYDVD
MUL_4575|M.ulcerans_Agy99 RPDMTLEQAQYAKRKLSLDKLNLEPGMTLLDIGCGWGSTMRHAIEEYDVN
MMAR_0831|M.marinum_M RPDMTLEQAQYAKRKLSLDKLNLEPGMTLLDIGCGWGSTMRHAIEEYDVN
MLBr_02426|M.leprae_Br4923 RPDLTLEEAQRAKRDLALSKLGLEPGMTLLDIGCGWGSTMLHAIEKYDVN
TH_2761|M.thermoresistible__bu RDDMTLEEAQLAKVDLALGKLGLRPGMTLLDIGCGWGSTIMRAVDEHDVD
Mflv_3304|M.gilvum_PYR-GCK RDDMTLEEAQRAKIDLALGKLGLEPGMTLLDIGCGWGGTLLRALEKYDVN
Mvan_3025|M.vanbaalenii_PYR-1 RDDMTLEEAQIAKIDLSLGKLGLQPGMTLLDIGCGWGATLLRALDKYDVN
MSMEG_3538|M.smegmatis_MC2_155 RDDMTLEEAQLAKIDLSLGKLGLQPGMKLLDIGCGWGATLRRALSRYDVD
MAB_3881|M.abscessus_ATCC_1997 PETLTLEQAQQAKIDLALGKLNLEPGMTLLDVGCGWGSTMKRALEHYDVN
***:** ** .*:*.**.*.***.***:*****.*: :*: .:**:
Mb0515c|M.bovis_AF2122/97 VIGLTLSENQYAHDKAM-FDEVDSP---RRKEVRIQGWEEF-DEPVDRIV
Rv0503c|M.tuberculosis_H37Rv VIGLTLSENQYAHDKAM-FDEVDSP---RRKEVRIQGWEEF-DEPVDRIV
MAV_4647|M.avium_104 VIGLTLSENQYAHCVAE-FDKMDSP---RRKEVRIQGWEEFPDEPIDRIV
MUL_4575|M.ulcerans_Agy99 VIGLTLSENQLVHDERK-FADMDSP---RHKEVRLQSWEQF-DEPVDRIV
MMAR_0831|M.marinum_M VIGLTLSENQLVHDERK-FADMDSP---RHKEVRLQGWEQF-DEPVDRIV
MLBr_02426|M.leprae_Br4923 VIGLTLSANQLAHNKLK-FAEIDHTRTDRTKDVRLQGWEQF-DEPVDRII
TH_2761|M.thermoresistible__bu VIGLTLSENQRRHIEEHWFANSDSP---RRKEVRLQGWEDF-DEPVDRIV
Mflv_3304|M.gilvum_PYR-GCK VIGLTLSRNQQAHVQKV-LDEHDSP---RSKTVLLQGWEQF-DQPVDRIV
Mvan_3025|M.vanbaalenii_PYR-1 VIGLTLSRNQQAHVQKR-LDAHGSG---RSKRVLLAGWEQF-DEPVDRIV
MSMEG_3538|M.smegmatis_MC2_155 VVGLTLSKNQQAHVERS-FAETDTE---RSRRVLLQGWEQF-DEPVDRIV
MAB_3881|M.abscessus_ATCC_1997 VIGLTLSKNQFAYVNTL-LDSAGSS---RNYEVRLAGWEEF-EGTVDRIV
*:***** ** : : . * * : .**:* : .:***:
Mb0515c|M.bovis_AF2122/97 SLGAFEHFADGAGDAGFERYDTFFKKFYNLTPDDGRMLLHTITIPDKEEA
Rv0503c|M.tuberculosis_H37Rv SLGAFEHFADGAGDAGFERYDTFFKKFYNLTPDDGRMLLHTITIPDKEEA
MAV_4647|M.avium_104 SLGAFEHFADGAGDAGYERYATFFKKYYDLLPDDGRMLLHSIVVPTREEG
MUL_4575|M.ulcerans_Agy99 SLGAFEHFADGAGDASWERYDRFFKMCYNVLPDDGRMLLHTIIVPDAKEA
MMAR_0831|M.marinum_M SLGAFEHFADGAGDASWERYDRFFKMCYNVLPDDGRMLLHTIIVPDAKEA
MLBr_02426|M.leprae_Br4923 SLGAFEHFADGAGDAGFERYDSFFKMCYDVLPDDGRMLLHTIIVPDAKET
TH_2761|M.thermoresistible__bu SIGAFEHFG-------FDNYDFYFKKTYDLLPDDGVMLLHTIVSTSREEV
Mflv_3304|M.gilvum_PYR-GCK SIGAFEHFG-------SDRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEF
Mvan_3025|M.vanbaalenii_PYR-1 SIGAFEHFG-------RDRYDEFFKKAYQVLPDGGVMMLHTIIKPTDEEF
MSMEG_3538|M.smegmatis_MC2_155 SIGAFEHFG-------ADRYDDFFRMAHTALPDDGVMLLHTIVKPSGDEM
MAB_3881|M.abscessus_ATCC_1997 SIGAFEHFG-------HERYDSFFAMAHRVLPSDGKMLLHTIVSHHPDEW
*:******. :.* :* : *..* *:**:* .*
Mb0515c|M.bovis_AF2122/97 QELGLTSPMSLLRFIKFILTEIFPGGRLPRISQVDYYSSNAGWKVERYHR
Rv0503c|M.tuberculosis_H37Rv QELGLTSPMSLLRFIKFILTEIFPGGRLPRISQVDYYSSNAGWKVERYHR
MAV_4647|M.avium_104 NAMGLKVNMTLLRFISFILKEIYPGGKLPQVNLVDKYATDAGFKIERHHF
MUL_4575|M.ulcerans_Agy99 KELGLTAPMSLMRFIKFILTEIFPGGRLPQIPQIDEYSSRAGFKVERYHR
MMAR_0831|M.marinum_M KELGLTAPMSLMRFIKFILTEIFPGGRLPQIPQIDEYSSRAGFKVERYHR
MLBr_02426|M.leprae_Br4923 KELGLTTPMSLLRFIKFILTEIFPGGRLPKISQVDHYSSNAGFTVERYHR
TH_2761|M.thermoresistible__bu AELGLPTTMSLLRFFKFIVDEIYPGGRIPLIAQVEDAATNAGFRITQKQR
Mflv_3304|M.gilvum_PYR-GCK AERKLPLTMTKLKFFKFIMDEIFPGGMLPKVDDVEKHATKASFKVNRIQP
Mvan_3025|M.vanbaalenii_PYR-1 ADRGLKLTMSIVRFSKFIMDEIFPGGDLPKPTTVAEHATKAGFRLTREQR
MSMEG_3538|M.smegmatis_MC2_155 SQRGLPLTMRKLRFFKFIMDEIFPGGELPYVAQVSEHAQRAGFRVDRVQS
MAB_3881|M.abscessus_ATCC_1997 KRMGIPLLMSRVRFIYFIGTEIFPGGRLPSVPMVDKHAALAGFHITRHHS
: * ::* ** **:*** :* : : *.: : : :
Mb0515c|M.bovis_AF2122/97 IGANYVPTLNAWADALQAHKDEAIALKGQETYDIYMHYLRGCSDLFRDKY
Rv0503c|M.tuberculosis_H37Rv IGANYVPTLNAWADALQAHKDEAIALKGQETYDIYMHYLRGCSDLFRDKY
MAV_4647|M.avium_104 IGKNYVPTLTAWGDALEAHKEEAIALKGQETYDIYLKYLRGCAELFRDGY
MUL_4575|M.ulcerans_Agy99 IGSNYVPTLNSWAQALQANQEKAIELQGQEVYDIYMHYLTGCSDLFRDHY
MMAR_0831|M.marinum_M IGSNYVPTLNSWAQALQANQEKAIELQGQEVYDIYMHYLTGCSDLFRDHY
MLBr_02426|M.leprae_Br4923 IGSHYVPTLNAWAAALEAHKDEAIALQGRQIYDTYMHYLTGCSDLFRDRY
TH_2761|M.thermoresistible__bu LRPHYVKTLDAWAANLEANRRAAIEITSEEVYDRYLRYLTGCSDLFAKGY
Mflv_3304|M.gilvum_PYR-GCK LRLHYARTLQIWAASLESRRDDAIAIQSEEVYDRYMKYLTGCAELFTEGY
Mvan_3025|M.vanbaalenii_PYR-1 LREHYAKTLDIWADALRKREDDAVAIQSREDYDRYMKYLTGCADLFRDGY
MSMEG_3538|M.smegmatis_MC2_155 LRPHYAKTLDIWAETLRGRKDEAIAVQSEEMYERYMKYLTGCADLFREGY
MAB_3881|M.abscessus_ATCC_1997 LQPHYARTLDCWATNLAAHEDEAISVQSQEVYDRYIKYLTGCAEGFREGW
: :*. ** *. * .. *: : ..: *: *::** **:: * . :
Mb0515c|M.bovis_AF2122/97 TDVCQFTLVK--
Rv0503c|M.tuberculosis_H37Rv TDVCQFTLVK--
MAV_4647|M.avium_104 TNVCQFTMVK--
MUL_4575|M.ulcerans_Agy99 TDVCQFTMVK--
MMAR_0831|M.marinum_M TDVCQFTMVK--
MLBr_02426|M.leprae_Br4923 TDVCQFTLVK--
TH_2761|M.thermoresistible__bu TDVCQFTCRKGQ
Mflv_3304|M.gilvum_PYR-GCK TDVCQFTLAK--
Mvan_3025|M.vanbaalenii_PYR-1 TDICQFTLEK--
MSMEG_3538|M.smegmatis_MC2_155 TDVCQFTLVKA-
MAB_3881|M.abscessus_ATCC_1997 IDVVQFTCEK--
:: *** *