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SVQLTPHFGNVQAHYDLSDDFFRLFLDPSQTYSCAYFERDDMTLEQAQIAKIDLALGKLNLEPGMTLLDI GCGWGATMRRAIEKYDVNVVGLTLSENQAAHVQQMFDQIDTSRSRRVLLEGWEKFDEPVDRIVSIGAFEH FGRLRYAHFFKMAYQALPADGIMLLHTIARPTFKEARAKGLTLTHEIVHFSQFILAEIFPGGWLPTIPTV EEHATAAGFKVTRVQSLQLHYARTLEIWAAALEAKKEEAIAIQSQKVYDRYMKYLTGCAKLFRQGYTDID QFTLEK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4539 | pcaA | - | 100% (287) | mycolic acid synthase PcaA |
| M. ulcerans Agy99 | MUL_3772 | mmaA5 | e-121 | 72.13% (287) | methoxy mycolic acid synthase 5 MmaA5 |
| M. ulcerans Agy99 | MUL_0730 | mmaA3 | e-105 | 65.34% (277) | methoxy mycolic acid synthase 3, MmaA3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0479c | pcaA | 1e-148 | 86.41% (287) | mycolic acid synthase pcaA (cyclopropane synthase) |
| M. gilvum PYR-GCK | Mflv_3304 | - | 1e-118 | 69.58% (286) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv0470c | pcaA | 1e-148 | 86.41% (287) | mycolic acid synthase pcaA (cyclopropane synthase) |
| M. leprae Br4923 | MLBr_02459 | umaA2 | 1e-148 | 85.02% (287) | Mycolic acid synthase |
| M. abscessus ATCC 19977 | MAB_3881 | - | 1e-104 | 64.44% (284) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. marinum M | MMAR_0796 | pcaA | 1e-167 | 100.00% (287) | mycolic acid synthase PcaA |
| M. avium 104 | MAV_4679 | - | 1e-142 | 83.86% (285) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_3538 | - | 1e-117 | 69.47% (285) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. thermoresistible (build 8) | TH_3139 | - | 1e-124 | 74.20% (283) | PUTATIVE Cyclopropane-fatty-acyl-phospholipid synthase |
| M. vanbaalenii PYR-1 | Mvan_3025 | - | 1e-119 | 71.33% (286) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3304|M.gilvum_PYR-GCK MSDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLDPTQTYSCAYFERDDMT
Mvan_3025|M.vanbaalenii_PYR-1 MPETTSGSADLQPHFEDVQSHYDLSDDFYRLFLDPTQTYSCAYFERDDMT
MSMEG_3538|M.smegmatis_MC2_155 --------MALQPHFEDVQSHYDLSDEFFRLFLDPTQTYSCAYFERDDMT
TH_3139|M.thermoresistible__bu ----------LTPHFEEVQAHYDLSDDFFRLFLDPSQTYSCAYFERDDMT
MUL_4539|M.ulcerans_Agy99 ------MSVQLTPHFGNVQAHYDLSDDFFRLFLDPSQTYSCAYFERDDMT
MMAR_0796|M.marinum_M ------MSVQLTPHFGNVQAHYDLSDDFFRLFLDPSQTYSCAYFERDDMT
Mb0479c|M.bovis_AF2122/97 ------MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
Rv0470c|M.tuberculosis_H37Rv ------MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
MLBr_02459|M.leprae_Br4923 ------MSVQLTPHFRNVQAHYDLSDDFFRLFLDPTLTYSCAYFERDDMT
MAV_4679|M.avium_104 --------MQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
MAB_3881|M.abscessus_ATCC_1997 -------MSKLTPKFSDVQAHYDLSDDFFALFLDPSRTYSCAYFEPETLT
* *:* :**:******:*: *****: ******** : :*
Mflv_3304|M.gilvum_PYR-GCK LEEAQRAKIDLALGKLGLEPGMTLLDIGCGWGGTLLRALEKYDVNVIGLT
Mvan_3025|M.vanbaalenii_PYR-1 LEEAQIAKIDLSLGKLGLQPGMTLLDIGCGWGATLLRALDKYDVNVIGLT
MSMEG_3538|M.smegmatis_MC2_155 LEEAQLAKIDLSLGKLGLQPGMKLLDIGCGWGATLRRALSRYDVDVVGLT
TH_3139|M.thermoresistible__bu LEEAQLAKIDLSLGKLDLKPGMTLLDIGCGWGATIKRAVEKYDVNVVGLT
MUL_4539|M.ulcerans_Agy99 LEQAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
MMAR_0796|M.marinum_M LEQAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
Mb0479c|M.bovis_AF2122/97 LQEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
Rv0470c|M.tuberculosis_H37Rv LQEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
MLBr_02459|M.leprae_Br4923 LEEAQLAKVDLALGKLKLEPGMTLLDIGCGWGATMKRAIEIYDVNVIGLT
MAV_4679|M.avium_104 LEEAQIAKIDLALGKLKLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLT
MAB_3881|M.abscessus_ATCC_1997 LEQAQQAKIDLALGKLNLEPGMTLLDVGCGWGSTMKRALEHYDVNVIGLT
*::** **:**:**** *:***.***:*****.*: **:. ***:*:***
Mflv_3304|M.gilvum_PYR-GCK LSRNQQAHVQKVLDEHDSPRSKTVLLQGWEQFDQPVDRIVSIGAFEHFGS
Mvan_3025|M.vanbaalenii_PYR-1 LSRNQQAHVQKRLDAHGSGRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGR
MSMEG_3538|M.smegmatis_MC2_155 LSKNQQAHVERSFAETDTERSRRVLLQGWEQFDEPVDRIVSIGAFEHFGA
TH_3139|M.thermoresistible__bu LSRNQQAHVQQVLDEMDSTRSRRVLLQGWEQFREPVDRIVSIGAFEHFGR
MUL_4539|M.ulcerans_Agy99 LSENQAAHVQQMFDQIDTSRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGR
MMAR_0796|M.marinum_M LSENQAAHVQQMFDQIDTSRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGR
Mb0479c|M.bovis_AF2122/97 LSENQAGHVQKMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGH
Rv0470c|M.tuberculosis_H37Rv LSENQAGHVQKMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGH
MLBr_02459|M.leprae_Br4923 LSENQAAHVQKTFDELDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFGR
MAV_4679|M.avium_104 LSENQAEHVQKTFDAMDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFGR
MAB_3881|M.abscessus_ATCC_1997 LSKNQFAYVNTLLDSAGSSRNYEVRLAGWEEFEGTVDRIVSIGAFEHFGH
**.** :*: : .: *. * * ***:* .**************
Mflv_3304|M.gilvum_PYR-GCK DRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEFAERKLPLTMTKLKFFKF
Mvan_3025|M.vanbaalenii_PYR-1 DRYDEFFKKAYQVLPDGGVMMLHTIIKPTDEEFADRGLKLTMSIVRFSKF
MSMEG_3538|M.smegmatis_MC2_155 DRYDDFFRMAHTALPDDGVMLLHTIVKPSGDEMSQRGLPLTMRKLRFFKF
TH_3139|M.thermoresistible__bu DRYEEFFKMAYEVLPADGIMMLHTIIKPSDEEFAARELPITMRYLRFFKF
MUL_4539|M.ulcerans_Agy99 LRYAHFFKMAYQALPADGIMLLHTIARPTFKEARAKGLTLTHEIVHFSQF
MMAR_0796|M.marinum_M LRYAHFFKMAYQALPADGIMLLHTIARPTFKEARAKGLTLTHEIVHFSQF
Mb0479c|M.bovis_AF2122/97 QRYHHFFEVTHRTLPADGKMLLHTIVRPTFKEGREKGLTLTHELVHFTKF
Rv0470c|M.tuberculosis_H37Rv QRYHHFFEVTHRTLPADGKMLLHTIVRPTFKEGREKGLTLTHELVHFTKF
MLBr_02459|M.leprae_Br4923 QRYARFFKMAHEVLPADSVMLLHTIVRPTFKDARARGMTLTHEIVHFTQF
MAV_4679|M.avium_104 QRYGRFFRMAYDVLPPGGIMLLHTIVRPSFKDARAKGMKLTHEIVEFSRF
MAB_3881|M.abscessus_ATCC_1997 ERYDSFFAMAHRVLPSDGKMLLHTIVSHHPDEWKRMGIPLLMSRVRFIYF
** ** :: .** .. *:**** .: : : :.* *
Mflv_3304|M.gilvum_PYR-GCK IMDEIFPGGMLPKVDDVEKHATKASFKVNRIQPLRLHYARTLQIWAASLE
Mvan_3025|M.vanbaalenii_PYR-1 IMDEIFPGGDLPKPTTVAEHATKAGFRLTREQRLREHYAKTLDIWADALR
MSMEG_3538|M.smegmatis_MC2_155 IMDEIFPGGELPYVAQVSEHAQRAGFRVDRVQSLRPHYAKTLDIWAETLR
TH_3139|M.thermoresistible__bu IMDEIFPGGDLPQAKVVEEHATRAGFTVAHTQPLRLHYARTLDHWSSALE
MUL_4539|M.ulcerans_Agy99 ILAEIFPGGWLPTIPTVEEHATAAGFKVTRVQSLQLHYARTLEIWAAALE
MMAR_0796|M.marinum_M ILAEIFPGGWLPTIPTVEEHATAAGFKVTRVQSLQLHYARTLEIWAAALE
Mb0479c|M.bovis_AF2122/97 ILAEIFPGGWLPSIPTVHEYAEKVGFRVTAVQSLQLHYARTLDMWATALE
Rv0470c|M.tuberculosis_H37Rv ILAEIFPGGWLPSIPTVHEYAEKVGFRVTAVQSLQLHYARTLDMWATALE
MLBr_02459|M.leprae_Br4923 ILAEIFPGGWLPTVPTVEEHATAAGFKFTRIQSLQLHYAKTLDLWAARLE
MAV_4679|M.avium_104 ILAEIFPGGWLPTPQTVGEYGVTAGFDLTRVQSLQLHYARTLDLWAQALE
MAB_3881|M.abscessus_ATCC_1997 IGTEIFPGGRLPSVPMVDKHAALAGFHITRHHSLQPHYARTLDCWATNLA
* ****** ** * ::. ..* . : *: ***:**: *: *
Mflv_3304|M.gilvum_PYR-GCK SRRDDAIAIQSEEVYDRYMKYLTGCAELFTEGYTDVCQFTLAK-------
Mvan_3025|M.vanbaalenii_PYR-1 KREDDAVAIQSREDYDRYMKYLTGCADLFRDGYTDICQFTLEK-------
MSMEG_3538|M.smegmatis_MC2_155 GRKDEAIAVQSEEMYERYMKYLTGCADLFREGYTDVCQFTLVKA------
TH_3139|M.thermoresistible__bu ARKDEAIAIQSEEVYERYMKYLTGCADLFRKGYTDVCQFTLKK-------
MUL_4539|M.ulcerans_Agy99 AKKEEAIAIQSQKVYDRYMKYLTGCAKLFRQGYTDIDQFTLEK-------
MMAR_0796|M.marinum_M AKKEEAIAIQSQKVYDRYMKYLTGCAKLFRQGYTDIDQFTLEK-------
Mb0479c|M.bovis_AF2122/97 ANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQGYTDVDQFTLEK-------
Rv0470c|M.tuberculosis_H37Rv ANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQGYTDVDQFTLEK-------
MLBr_02459|M.leprae_Br4923 ANKNKAIAIQSEEVYDRYMKYLTGCAKLFRDGYTDVDQFTLEKQPATARR
MAV_4679|M.avium_104 ANREQAIAIQSQEVYDRYMKYLTGCAKLFREGYTDVNQFTMEKK------
MAB_3881|M.abscessus_ATCC_1997 AHEDEAISVQSQEVYDRYIKYLTGCAEGFREGWIDVVQFTCEK-------
..:.*:::**. *:**:*******. * .*: *: *** *
Mflv_3304|M.gilvum_PYR-GCK -
Mvan_3025|M.vanbaalenii_PYR-1 -
MSMEG_3538|M.smegmatis_MC2_155 -
TH_3139|M.thermoresistible__bu -
MUL_4539|M.ulcerans_Agy99 -
MMAR_0796|M.marinum_M -
Mb0479c|M.bovis_AF2122/97 -
Rv0470c|M.tuberculosis_H37Rv -
MLBr_02459|M.leprae_Br4923 H
MAV_4679|M.avium_104 -
MAB_3881|M.abscessus_ATCC_1997 -