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PHIAVAPDLVASAANQLERIGSALSAANLTAAAPTTTVMAAGADEVSTAVAALFGGHAQEYQALVARAEA FHQQFVQLMTTGAGSYAAAEAANTTPLQAVGQELLAAINGPTQAIFGRPLIGDGAAGTATDPNGGAGGLL YGNGGNGYSETTAGVAGGAGGAAGLISNGGSGGNGGIGAAGGAGGSGGWLCGNGGAGGQGGAGAAAVDGL GVGNGGSGGVGGAAGVFGSGGAGGSGGVGGLNAGAQGVFDISAGDGGAGGHGGHGGLLYGSGGTGGQGGG GGDGFLATNADGATGVVDFMGGSAAAGSAGNGGAGGAAGLFGASGAGGAGGIGGLAGPTDNGDFIIASSS STITIGSLFGTGGTGGDGGIGGHGGWLFGNAGAGGPGGSGGAGTYISPSGRLTVVEFGGGVGGGGGAGGG AGVFGNGGAGGLGGAGGVSGDHSGGNGGEGGNGGDAQFAGHGGAGGPGGTGGGGTADDGVAGSNGSPGLF FG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_4400 | - | - | 100% (493) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_4399 | - | e-151 | 54.79% (511) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_3507 | - | e-130 | 50.48% (517) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1116 | PE_PGRS21 | 1e-138 | 53.23% (526) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 7e-76 | 44.63% (419) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1087 | PE_PGRS21 | 1e-139 | 53.74% (521) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 9e-13 | 37.93% (87) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-38 | 35.31% (371) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_5322 | - | 0.0 | 96.75% (493) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 7e-22 | 43.10% (174) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 3e-70 | 40.09% (459) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 7e-37 | 39.54% (306) | PUTATIVE - |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 6e-74 | 41.48% (499) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MUL_4400|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5322|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv1087|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4400|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5322|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv1087|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4400|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5322|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv1087|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4400|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5322|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv1087|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MUL_4400|M.ulcerans_Agy99 ------------------------------------MPHIAVAPDLVASA MMAR_5322|M.marinum_M ------------------------------------MPHIAVAPDLVASA Mb1116|M.bovis_AF2122/97 ------------------------------------MSFVVVAPEVLAAA Rv1087|M.tuberculosis_H37Rv ------------------------------------MSFVVVAPEVLAAA Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MAV_4827|M.avium_104 ------------------------------------------MNIVLGVS MUL_4400|M.ulcerans_Agy99 ANQLERIGSALSAANLTAAAPTTTVMAAGADEVSTAVAALFGGHAQEYQA MMAR_5322|M.marinum_M ANQLERIGSALSAANLTAAAPTTTVMAAGADEVSTAVAALFGGHAQEYQA Mb1116|M.bovis_AF2122/97 ASDLAGIGSTLAQANAAALAPTTAVLAAGADEVSAAIASLFGAHGQAYQA Rv1087|M.tuberculosis_H37Rv ASDLAGIGSTLAQANAAALAPTTAVLAAGADEVSAAIASLFGAHGQAYQA Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MLBr_01183|M.leprae_Br4923 -------MPLFLNAEPQALTAAANTLEG----LSAATVASNAAAAQLTTE MAB_4284c|M.abscessus_ATCC_199 VEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVN MAV_4827|M.avium_104 MAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGT MUL_4400|M.ulcerans_Agy99 LVARAEAFHQQFVQLMTTGAGSYAAAEAANTTPLQAVGQELLAAINGPTQ MMAR_5322|M.marinum_M LVARAEAFHQQFVQLMTTGAGSYAAAEAANTTPLQAVGQELLAAINGPTQ Mb1116|M.bovis_AF2122/97 VSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVEQDLLAAINARFE Rv1087|M.tuberculosis_H37Rv VSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVEQDLLAAINARFE Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGGGTG MLBr_01183|M.leprae_Br4923 IAPPAADDVSILLAHFFSGHGRQYQAH-------------ASQGATNHQD MAB_4284c|M.abscessus_ATCC_199 TGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHN MAV_4827|M.avium_104 REGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAA MUL_4400|M.ulcerans_Agy99 AIFGRPLIGDGAAGTATDPNGGAGGLLYGNGGNGY--------------- MMAR_5322|M.marinum_M AIFGRPLIGDGAAGTATDPNGGAGGLLYGNGGNGY--------------- Mb1116|M.bovis_AF2122/97 RIFGRPLIGDGANG-GPGQDGGPGGLLYGNGGNGG--------------- Rv1087|M.tuberculosis_H37Rv RIFGRPLIGDGANG-GPGQDGGPGGLLYGNGGNGG--------------- Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT TH_3810|M.thermoresistible__bu IIS--------------------LLSLAGNGGNGG--------------- MLBr_01183|M.leprae_Br4923 LIQS---------------------LLTSSSAYAG--------------- MAB_4284c|M.abscessus_ATCC_199 PIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGN--------------- MAV_4827|M.avium_104 LAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGS-------------IP . MUL_4400|M.ulcerans_Agy99 -SETTAGVAGGAGGAAG-----LISNGGSGGNGG---------------- MMAR_5322|M.marinum_M -SETTAGVAGGAGGAAG-----LIGNGGSGGNGG---------------- Mb1116|M.bovis_AF2122/97 -TSTTVGMAGGNGGAAG-----LIGNGGFGGGGG---------------- Rv1087|M.tuberculosis_H37Rv -TSTTVGMAGGNGGAAG-----LIGNGGFGGGGG---------------- Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------------- Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------------- MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH TH_3810|M.thermoresistible__bu NGYRTTDNNALDGGHGG--------------------------------- MLBr_01183|M.leprae_Br4923 --TETANHDSL--------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --RDTTAIGDGAVAVGG------SNSGPIASGQG---------------- MAV_4827|M.avium_104 DVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPG---------------- MUL_4400|M.ulcerans_Agy99 ----------------IGAAGGAGGSG----------------GWLCGNG MMAR_5322|M.marinum_M ----------------IGAAGGAGGSG----------------GWLCGNG Mb1116|M.bovis_AF2122/97 ----------------PGAAGGNGGAG----------------GWLFGNG Rv1087|M.tuberculosis_H37Rv ----------------PGAAGGNGGAG----------------GWLFGNG Mflv_5091|M.gilvum_PYR-GCK AVGAAGAAG------TVGTAGATGGTG---------------TGANGGAG Mvan_1264|M.vanbaalenii_PYR-1 AIGTAGVAG------AAGTAGATGGTG---------------VGGNGGAG MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS TH_3810|M.thermoresistible__bu ------------------------------------------NGGNVGFF MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------STAVNGDVRDSNIIN----------ADHGSNVGVD MAV_4827|M.avium_104 -----------------GLLLVGSGVD---------------VAPLKQVL MUL_4400|M.ulcerans_Agy99 GAGGQGGAGAAA--------------VDGLGVGNGGSGGVGGAAGVFGS- MMAR_5322|M.marinum_M GAGGQGGAGAAA--------------VDGLGVGNGGSGGVGGAAGLFGS- Mb1116|M.bovis_AF2122/97 GAGGAGGLGVAPG-------------VPGGAGGAGGAGGVGGPAGLWGH- Rv1087|M.tuberculosis_H37Rv GAGGAGGLGVAPG-------------VPGGAGGAGGAGGVGGPAGLWGH- Mflv_5091|M.gilvum_PYR-GCK GVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGGQ- Mvan_1264|M.vanbaalenii_PYR-1 QAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGGQ- MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY TH_3810|M.thermoresistible__bu SLFNLGG--------------------AGGWGGSGVDG------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 QSQTRVGGDYTN---------------VSGHGSADIDKSVTVVDDHSQRN MAV_4827|M.avium_104 QTTTFLDVSVAEE--------------PETALARGAALAAANAPLFASS- MUL_4400|M.ulcerans_Agy99 ----GGAGGSGGVGGLNAG-AQGVFDIS---------------------- MMAR_5322|M.marinum_M ----GGAGGSGGIGGLNAG-AQGVFDIS---------------------- Mb1116|M.bovis_AF2122/97 ----GGAGGAGGAGVAGAGGFEGTIGAGG--------------------- Rv1087|M.tuberculosis_H37Rv ----GGAGGAGGAGVAGAGGFEGTIGAGG--------------------- Mflv_5091|M.gilvum_PYR-GCK -GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG----------- Mvan_1264|M.vanbaalenii_PYR-1 -GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG----------- MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA TH_3810|M.thermoresistible__bu ---------VDVVGGNP--------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TTNINDSFNTDRSTNIGSGNTTNTEIGSHN-------------------- MAV_4827|M.avium_104 ------TAALAYAQDPGTGAVDQYSLPDY--------------------- MUL_4400|M.ulcerans_Agy99 -------AGDGGAGGHGGHGGLLY------------------GSGGTGGQ MMAR_5322|M.marinum_M -------AGAGGAGGHGGHGGLLY------------------GSGGTGGQ Mb1116|M.bovis_AF2122/97 ---AGGVGGAGGVGGAGGAGGWLYGDA---------------GAGGDGGV Rv1087|M.tuberculosis_H37Rv ---AGGVGGAGGVGGAGGAGGWLYGDA---------------GAGGDGGV Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV TH_3810|M.thermoresistible__bu ---------DGGTPG------------------------------AHGES MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 QANIGTSTSAGGSAAVGGNAGLAGNAG----------------LAGNAGL MAV_4827|M.avium_104 --------LYVPVDPEPGDDELAYS--------------------AVGEE MUL_4400|M.ulcerans_Agy99 GGGGGDGFLATN-------------------------------------- MMAR_5322|M.marinum_M GGGGGDGFLATN-------------------------------------- Mb1116|M.bovis_AF2122/97 GGAGGTGGLGNRGGAGGAGGA----------------------------- Rv1087|M.tuberculosis_H37Rv GGAGGTGGLGNRGGAGGAGGA----------------------------- Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD----------- Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN----------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP TH_3810|M.thermoresistible__bu HTPGVYTDRQ---------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAG------------------------------------ MAV_4827|M.avium_104 DAESPTVVIEKLFLP----------------------------------- MUL_4400|M.ulcerans_Agy99 ----------ADGATGVVDFMGGSAAAGSAGNGG---------------- MMAR_5322|M.marinum_M ----------ADGATGVVEFMGGSATAGSAGNGG---------------- Mb1116|M.bovis_AF2122/97 --------GGVGGAGGAAGLWGGGGAGGVGGTGGGAGLGAQSVTFSSSLS Rv1087|M.tuberculosis_H37Rv --------GGVGGAGGAAGLWGGGGAGGVGGTGGGAGLGAQSVTFSSSLS Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG--------------- MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ TH_3810|M.thermoresistible__bu ---------------GEDGEDGTGTGIGGRGGNGG--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------NAGLAGNAGLAGNAGLAGNAGLAGNAG------------- MAV_4827|M.avium_104 ----------EDSEPRRRPVLLVGSGLAVVGISAVLA------------- MUL_4400|M.ulcerans_Agy99 --AGGAAGLFGAS---------GAGGAGGIG-------GLAGPTDNGDFI MMAR_5322|M.marinum_M --AGGAAGLFGAG---------GAGGAGGIG-------GLAGPTDNGDFI Mb1116|M.bovis_AF2122/97 GLSGGDGGAGGAG---------GAGGAGGTGGWLYGGGGAAGSGGDGGTG Rv1087|M.tuberculosis_H37Rv GLSGGDGGAGGAG---------GAGGAGGTGGWLYGGGGAAGSGGDGGTG Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG TH_3810|M.thermoresistible__bu -SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSHGGNGGHG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --LAGNAGLAGNAG------LAGNAGLAGNAGLAGNAGLAGNAGLAGNAG MAV_4827|M.avium_104 LEIALAIGIRTTG-------TVALQPTPNQHLIVPTEQAPAPPPVQASAP MUL_4400|M.ulcerans_Agy99 IASSSSTITIGS----LFGTGG-TGGDGGIG------------------- MMAR_5322|M.marinum_M TVSSSSTITIAS----LFGIGG-TGGDGGIG------------------- Mb1116|M.bovis_AF2122/97 GQGGAGGAGVFS----LFGSGGGPGGNGGVGGV------GGVGGAGGRAG Rv1087|M.tuberculosis_H37Rv GQGGAGGAGVFS----LFGSGGGPGGNGGVGGV------GGVGGAGGRAG Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGG TH_3810|M.thermoresistible__bu GRGGFLGIGGSG-------GWGGHGGNGGD-----------TDADGGNGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAG-----LAGNAGLAGNAGLAGN--------AAVAGNAAV MAV_4827|M.avium_104 QPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAP-------PLPEAPPIPA MUL_4400|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5322|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 LFGVGGLGGAGGDAGDSGEGGFGGPGLAGGLFGNPGNGGVGGIGGDAAAG Rv1087|M.tuberculosis_H37Rv LFGVGGLGGAGGDAGDSGEGGFGGPGLAGGLFGNPGNGGVGGIGGDAAAG Mflv_5091|M.gilvum_PYR-GCK AG-----------DGTGGTGGTGG----TGGQGGQGGQGG---------- Mvan_1264|M.vanbaalenii_PYR-1 AG-----------DGLGGTGGTGG----TGGFGGQGGQGG---------- MSMEG_0868|M.smegmatis_MC2_155 AGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIG TH_3810|M.thermoresistible__bu DG---------------GNGGSAG-------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AG----------NAAVAGNAAVGG-------------------------- MAV_4827|M.avium_104 APPVVPVPVVVPPVPVPVPVRIPVP------------------------- MUL_4400|M.ulcerans_Agy99 ------------GHGGWLFGNAGAG------------------------- MMAR_5322|M.marinum_M ------------GHGGWLFGNAGAG------------------------- Mb1116|M.bovis_AF2122/97 GAG------GAGGNGGWLFGNGGAG------------------------- Rv1087|M.tuberculosis_H37Rv GAGGAGGNGGAGGNGGWLFGNGGAG------------------------- Mflv_5091|M.gilvum_PYR-GCK -------TGGTGGQGG-LGGGGGTG-----------------------GQ Mvan_1264|M.vanbaalenii_PYR-1 -------TGGTGGQGG-LGGVGGTG-----------------------GT MSMEG_0868|M.smegmatis_MC2_155 SNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGH TH_3810|M.thermoresistible__bu -------RGGTGGLRGVFGINGGNG------------------------R MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------VLNTGVSGAIGGSSHVG------------------------- MAV_4827|M.avium_104 ----------DPVSPPQLLAPPRLS------------------------- MUL_4400|M.ulcerans_Agy99 -GPGGSG------GAGTYISPS--------------GRLTVVEFGG---- MMAR_5322|M.marinum_M -GPGGSG------GAGTYISPS--------------GRLTVEEFAG---- Mb1116|M.bovis_AF2122/97 -GSGGDGGAAGRGGAGNLGSAG--------------GINAPAGNPGSGSV Rv1087|M.tuberculosis_H37Rv -GSGGDGGAAGRGGAGNLGSAG--------------GINAPAGNPGSGSV Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGS Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGV MSMEG_0868|M.smegmatis_MC2_155 GGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGD TH_3810|M.thermoresistible__bu AGLGGRGXXXXGGGVGAAVRSG---------------NGVFSGGGGTPSA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --GAINESLGGSGSVGGSTAVG---------------GGAHTGVGGGVST MAV_4827|M.avium_104 -VPQPVQPPVRVPQPPSPPQVG---------------GTVPQSPPQHQTP MUL_4400|M.ulcerans_Agy99 GVGGGGGAGGGAGVFGNGGAGGLG-------------------------- MMAR_5322|M.marinum_M GVGGGGGAGGGAGVFGNGGAGGLG-------------------------- Mb1116|M.bovis_AF2122/97 GIGGAGGAGGTAGLFGDGGAGGAG--------AAGGFGGISAATPSAGSE Rv1087|M.tuberculosis_H37Rv GIGGAGGAGGTAGLFGDGGAGGAGG-----AGAAGGFGGISAATPSAGSE Mflv_5091|M.gilvum_PYR-GCK GGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKA Mvan_1264|M.vanbaalenii_PYR-1 GGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTA MSMEG_0868|M.smegmatis_MC2_155 GVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTL TH_3810|M.thermoresistible__bu GFGVPTTIQFPAGSCTSRAVSREG------------------------IM MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GVGVGSHVGGGISESLGGSGSVGG-------------------------- MAV_4827|M.avium_104 PGEGTPPKPDGPGNYGGGHVPTPG-------------------------- MUL_4400|M.ulcerans_Agy99 ----GAGGVSG-------------DHSGGNGGEGGNGGDAQFAGHGG--- MMAR_5322|M.marinum_M ----GAGGVTG-------------AHSGGNGGDGGNGGDAQFAGHGG--- Mb1116|M.bovis_AF2122/97 GAMGGAGGVGGNARLLGTGGAGGVGGGGGAGGDGGRGGVATPGGQGGDAG Rv1087|M.tuberculosis_H37Rv GAMGGAGGVGGNARLLGTGGAGGVGGGGGAGGDGGRGGVATPGGQGGDAG Mflv_5091|M.gilvum_PYR-GCK GATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATG Mvan_1264|M.vanbaalenii_PYR-1 GVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAG MSMEG_0868|M.smegmatis_MC2_155 GGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGG TH_3810|M.thermoresistible__bu PSSRAASARAG---------------------------AACASSTSRSRR MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 STAVGGGAHTG------VGGGVSTGVGVGSHVGGGISESLGGSGSVGGST MAV_4827|M.avium_104 --AGGSGGSGG----------------GHVPTPGAGGSGGSGGGHVPTPG MUL_4400|M.ulcerans_Agy99 ---AGGPGGTGGG----------GTADDGVAGSNG--------SPG---- MMAR_5322|M.marinum_M ---AGGPGGTGGG----------GTADDGVAGSNG--------SPG---- Mb1116|M.bovis_AF2122/97 DGGAGGAGGNGGGGASGAGGWLLGTGGAGGAGGNGGNGGKAGFSPGPTNF Rv1087|M.tuberculosis_H37Rv DGGAGGAGGNGGG-ASGAGGWLLGTGGAGGAGGNGGNGGKAGFSPGPTNF Mflv_5091|M.gilvum_PYR-GCK AAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA Mvan_1264|M.vanbaalenii_PYR-1 SAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA MSMEG_0868|M.smegmatis_MC2_155 AATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWV TH_3810|M.thermoresistible__bu SFCCSRA------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AVGGGAHTGVGGG---------VNTGVGVGSHVGGGISESLGGSGSVGGS MAV_4827|M.avium_104 TGGPGGTGGSGGG----------HVPTPGAGTPGGSGGGHLPFPGAGSTP MUL_4400|M.ulcerans_Agy99 ---------------------------------LFFG------------- MMAR_5322|M.marinum_M ---------------------------------LFFG------------- Mb1116|M.bovis_AF2122/97 GLNGAG--------------GGGGVGGNGATGPWLFGDGGAGGGGGAGGI Rv1087|M.tuberculosis_H37Rv GLNGAG--------------GGGGVGGNGATGPWLFGDG----------- Mflv_5091|M.gilvum_PYR-GCK GATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG------- Mvan_1264|M.vanbaalenii_PYR-1 GATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG------- MSMEG_0868|M.smegmatis_MC2_155 QAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKS TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TAVGGG-------------------AHTSAINDALGGSGSVGG------- MAV_4827|M.avium_104 GGSGGG------------------HLPTPGAGTPGGGLGGFGG------- MUL_4400|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5322|M.marinum_M -------------------------------------------------- Mb1116|M.bovis_AF2122/97 GGDGGPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGGAGGLS Rv1087|M.tuberculosis_H37Rv ----GPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGGAGGLS Mflv_5091|M.gilvum_PYR-GCK ----AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG- Mvan_1264|M.vanbaalenii_PYR-1 ----AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG- MSMEG_0868|M.smegmatis_MC2_155 GGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------STAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAG MAV_4827|M.avium_104 ----GHAPAPGGGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK-- MUL_4400|M.ulcerans_Agy99 --------------------------- MMAR_5322|M.marinum_M --------------------------- Mb1116|M.bovis_AF2122/97 GLLFGEPGANG---------------- Rv1087|M.tuberculosis_H37Rv GLLFGEPGANG---------------- Mflv_5091|M.gilvum_PYR-GCK -GAGGSGGSGGSGGSGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 -GAGGSGGSGGSGGAGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGNGGADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu --------------------------- MLBr_01183|M.leprae_Br4923 --------------------------- MAB_4284c|M.abscessus_ATCC_199 TGFEAQGHAQGHASETAHTTLPGAEHH MAV_4827|M.avium_104 ---------------------------