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M. ulcerans Agy99 MUL_4400 (-)

annotation: PE-PGRS family protein
coordinates: 4881794 - 4883275
length: 493

PHIAVAPDLVASAANQLERIGSALSAANLTAAAPTTTVMAAGADEVSTAVAALFGGHAQEYQALVARAEA
FHQQFVQLMTTGAGSYAAAEAANTTPLQAVGQELLAAINGPTQAIFGRPLIGDGAAGTATDPNGGAGGLL
YGNGGNGYSETTAGVAGGAGGAAGLISNGGSGGNGGIGAAGGAGGSGGWLCGNGGAGGQGGAGAAAVDGL
GVGNGGSGGVGGAAGVFGSGGAGGSGGVGGLNAGAQGVFDISAGDGGAGGHGGHGGLLYGSGGTGGQGGG
GGDGFLATNADGATGVVDFMGGSAAAGSAGNGGAGGAAGLFGASGAGGAGGIGGLAGPTDNGDFIIASSS
STITIGSLFGTGGTGGDGGIGGHGGWLFGNAGAGGPGGSGGAGTYISPSGRLTVVEFGGGVGGGGGAGGG
AGVFGNGGAGGLGGAGGVSGDHSGGNGGEGGNGGDAQFAGHGGAGGPGGTGGGGTADDGVAGSNGSPGLF
FG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_4400--100% (493)PE-PGRS family protein
M. ulcerans Agy99MUL_4399-e-15154.79% (511) PE-PGRS family protein
M. ulcerans Agy99MUL_3507-e-13050.48% (517) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1116PE_PGRS211e-13853.23% (526) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-7e-7644.63% (419) triple helix repeat-containing collagen
M. tuberculosis H37RvRv1087PE_PGRS211e-13953.74% (521) PE-PGRS family protein
M. leprae Br4923MLBr_01183-9e-1337.93% (87) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-1e-3835.31% (371) hypothetical protein MAB_4284c
M. marinum MMMAR_5322-0.096.75% (493) PE-PGRS family protein
M. avium 104MAV_4827-7e-2243.10% (174) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-3e-7040.09% (459) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-7e-3739.54% (306) PUTATIVE -
M. vanbaalenii PYR-1Mvan_1264-6e-7441.48% (499) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


MUL_4400|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5322|M.marinum_M               --------------------------------------------------
Mb1116|M.bovis_AF2122/97            --------------------------------------------------
Rv1087|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5322|M.marinum_M               --------------------------------------------------
Mb1116|M.bovis_AF2122/97            --------------------------------------------------
Rv1087|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5322|M.marinum_M               --------------------------------------------------
Mb1116|M.bovis_AF2122/97            --------------------------------------------------
Rv1087|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5322|M.marinum_M               --------------------------------------------------
Mb1116|M.bovis_AF2122/97            --------------------------------------------------
Rv1087|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           ------------------------------------MPHIAVAPDLVASA
MMAR_5322|M.marinum_M               ------------------------------------MPHIAVAPDLVASA
Mb1116|M.bovis_AF2122/97            ------------------------------------MSFVVVAPEVLAAA
Rv1087|M.tuberculosis_H37Rv         ------------------------------------MSFVVVAPEVLAAA
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------MSIIDFILNLFRDP
MAV_4827|M.avium_104                ------------------------------------------MNIVLGVS
                                                                                      

MUL_4400|M.ulcerans_Agy99           ANQLERIGSALSAANLTAAAPTTTVMAAGADEVSTAVAALFGGHAQEYQA
MMAR_5322|M.marinum_M               ANQLERIGSALSAANLTAAAPTTTVMAAGADEVSTAVAALFGGHAQEYQA
Mb1116|M.bovis_AF2122/97            ASDLAGIGSTLAQANAAALAPTTAVLAAGADEVSAAIASLFGAHGQAYQA
Rv1087|M.tuberculosis_H37Rv         ASDLAGIGSTLAQANAAALAPTTAVLAAGADEVSAAIASLFGAHGQAYQA
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
TH_3810|M.thermoresistible__bu      ------------------------------------------------VD
MLBr_01183|M.leprae_Br4923          -------MPLFLNAEPQALTAAANTLEG----LSAATVASNAAAAQLTTE
MAB_4284c|M.abscessus_ATCC_199      VEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVN
MAV_4827|M.avium_104                MAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGT
                                                                                      

MUL_4400|M.ulcerans_Agy99           LVARAEAFHQQFVQLMTTGAGSYAAAEAANTTPLQAVGQELLAAINGPTQ
MMAR_5322|M.marinum_M               LVARAEAFHQQFVQLMTTGAGSYAAAEAANTTPLQAVGQELLAAINGPTQ
Mb1116|M.bovis_AF2122/97            VSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVEQDLLAAINARFE
Rv1087|M.tuberculosis_H37Rv         VSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVEQDLLAAINARFE
Mflv_5091|M.gilvum_PYR-GCK          GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1       GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155      LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
TH_3810|M.thermoresistible__bu      GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGGGTG
MLBr_01183|M.leprae_Br4923          IAPPAADDVSILLAHFFSGHGRQYQAH-------------ASQGATNHQD
MAB_4284c|M.abscessus_ATCC_199      TGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHN
MAV_4827|M.avium_104                REGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAA
                                                                                      

MUL_4400|M.ulcerans_Agy99           AIFGRPLIGDGAAGTATDPNGGAGGLLYGNGGNGY---------------
MMAR_5322|M.marinum_M               AIFGRPLIGDGAAGTATDPNGGAGGLLYGNGGNGY---------------
Mb1116|M.bovis_AF2122/97            RIFGRPLIGDGANG-GPGQDGGPGGLLYGNGGNGG---------------
Rv1087|M.tuberculosis_H37Rv         RIFGRPLIGDGANG-GPGQDGGPGGLLYGNGGNGG---------------
Mflv_5091|M.gilvum_PYR-GCK          VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1       VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155      GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
TH_3810|M.thermoresistible__bu      IIS--------------------LLSLAGNGGNGG---------------
MLBr_01183|M.leprae_Br4923          LIQS---------------------LLTSSSAYAG---------------
MAB_4284c|M.abscessus_ATCC_199      PIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGN---------------
MAV_4827|M.avium_104                LAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGS-------------IP
                                                                     .                

MUL_4400|M.ulcerans_Agy99           -SETTAGVAGGAGGAAG-----LISNGGSGGNGG----------------
MMAR_5322|M.marinum_M               -SETTAGVAGGAGGAAG-----LIGNGGSGGNGG----------------
Mb1116|M.bovis_AF2122/97            -TSTTVGMAGGNGGAAG-----LIGNGGFGGGGG----------------
Rv1087|M.tuberculosis_H37Rv         -TSTTVGMAGGNGGAAG-----LIGNGGFGGGGG----------------
Mflv_5091|M.gilvum_PYR-GCK          VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----------------
Mvan_1264|M.vanbaalenii_PYR-1       VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----------------
MSMEG_0868|M.smegmatis_MC2_155      VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
TH_3810|M.thermoresistible__bu      NGYRTTDNNALDGGHGG---------------------------------
MLBr_01183|M.leprae_Br4923          --TETANHDSL---------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --RDTTAIGDGAVAVGG------SNSGPIASGQG----------------
MAV_4827|M.avium_104                DVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPG----------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           ----------------IGAAGGAGGSG----------------GWLCGNG
MMAR_5322|M.marinum_M               ----------------IGAAGGAGGSG----------------GWLCGNG
Mb1116|M.bovis_AF2122/97            ----------------PGAAGGNGGAG----------------GWLFGNG
Rv1087|M.tuberculosis_H37Rv         ----------------PGAAGGNGGAG----------------GWLFGNG
Mflv_5091|M.gilvum_PYR-GCK          AVGAAGAAG------TVGTAGATGGTG---------------TGANGGAG
Mvan_1264|M.vanbaalenii_PYR-1       AIGTAGVAG------AAGTAGATGGTG---------------VGGNGGAG
MSMEG_0868|M.smegmatis_MC2_155      AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
TH_3810|M.thermoresistible__bu      ------------------------------------------NGGNVGFF
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------STAVNGDVRDSNIIN----------ADHGSNVGVD
MAV_4827|M.avium_104                -----------------GLLLVGSGVD---------------VAPLKQVL
                                                                                      

MUL_4400|M.ulcerans_Agy99           GAGGQGGAGAAA--------------VDGLGVGNGGSGGVGGAAGVFGS-
MMAR_5322|M.marinum_M               GAGGQGGAGAAA--------------VDGLGVGNGGSGGVGGAAGLFGS-
Mb1116|M.bovis_AF2122/97            GAGGAGGLGVAPG-------------VPGGAGGAGGAGGVGGPAGLWGH-
Rv1087|M.tuberculosis_H37Rv         GAGGAGGLGVAPG-------------VPGGAGGAGGAGGVGGPAGLWGH-
Mflv_5091|M.gilvum_PYR-GCK          GVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGGQ-
Mvan_1264|M.vanbaalenii_PYR-1       QAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGGQ-
MSMEG_0868|M.smegmatis_MC2_155      TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
TH_3810|M.thermoresistible__bu      SLFNLGG--------------------AGGWGGSGVDG------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      QSQTRVGGDYTN---------------VSGHGSADIDKSVTVVDDHSQRN
MAV_4827|M.avium_104                QTTTFLDVSVAEE--------------PETALARGAALAAANAPLFASS-
                                                                                      

MUL_4400|M.ulcerans_Agy99           ----GGAGGSGGVGGLNAG-AQGVFDIS----------------------
MMAR_5322|M.marinum_M               ----GGAGGSGGIGGLNAG-AQGVFDIS----------------------
Mb1116|M.bovis_AF2122/97            ----GGAGGAGGAGVAGAGGFEGTIGAGG---------------------
Rv1087|M.tuberculosis_H37Rv         ----GGAGGAGGAGVAGAGGFEGTIGAGG---------------------
Mflv_5091|M.gilvum_PYR-GCK          -GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG-----------
Mvan_1264|M.vanbaalenii_PYR-1       -GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG-----------
MSMEG_0868|M.smegmatis_MC2_155      SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
TH_3810|M.thermoresistible__bu      ---------VDVVGGNP---------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TTNINDSFNTDRSTNIGSGNTTNTEIGSHN--------------------
MAV_4827|M.avium_104                ------TAALAYAQDPGTGAVDQYSLPDY---------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           -------AGDGGAGGHGGHGGLLY------------------GSGGTGGQ
MMAR_5322|M.marinum_M               -------AGAGGAGGHGGHGGLLY------------------GSGGTGGQ
Mb1116|M.bovis_AF2122/97            ---AGGVGGAGGVGGAGGAGGWLYGDA---------------GAGGDGGV
Rv1087|M.tuberculosis_H37Rv         ---AGGVGGAGGVGGAGGAGGWLYGDA---------------GAGGDGGV
Mflv_5091|M.gilvum_PYR-GCK          --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK
Mvan_1264|M.vanbaalenii_PYR-1       --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK
MSMEG_0868|M.smegmatis_MC2_155      KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV
TH_3810|M.thermoresistible__bu      ---------DGGTPG------------------------------AHGES
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      QANIGTSTSAGGSAAVGGNAGLAGNAG----------------LAGNAGL
MAV_4827|M.avium_104                --------LYVPVDPEPGDDELAYS--------------------AVGEE
                                                                                      

MUL_4400|M.ulcerans_Agy99           GGGGGDGFLATN--------------------------------------
MMAR_5322|M.marinum_M               GGGGGDGFLATN--------------------------------------
Mb1116|M.bovis_AF2122/97            GGAGGTGGLGNRGGAGGAGGA-----------------------------
Rv1087|M.tuberculosis_H37Rv         GGAGGTGGLGNRGGAGGAGGA-----------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGNGGNGGRGGLFG---------------KGGNAGNGAD-----------
Mvan_1264|M.vanbaalenii_PYR-1       GGNGGNGGRGSLFG---------------RGGNAGNGGN-----------
MSMEG_0868|M.smegmatis_MC2_155      GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP
TH_3810|M.thermoresistible__bu      HTPGVYTDRQ----------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AGNAGLAGNAGLAG------------------------------------
MAV_4827|M.avium_104                DAESPTVVIEKLFLP-----------------------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           ----------ADGATGVVDFMGGSAAAGSAGNGG----------------
MMAR_5322|M.marinum_M               ----------ADGATGVVEFMGGSATAGSAGNGG----------------
Mb1116|M.bovis_AF2122/97            --------GGVGGAGGAAGLWGGGGAGGVGGTGGGAGLGAQSVTFSSSLS
Rv1087|M.tuberculosis_H37Rv         --------GGVGGAGGAAGLWGGGGAGGVGGTGGGAGLGAQSVTFSSSLS
Mflv_5091|M.gilvum_PYR-GCK          -----------GGTGGAGGAGGTGG-TGGAGGTGG---------------
Mvan_1264|M.vanbaalenii_PYR-1       -----------GGTGGNGGNGGTGG-TGGNGGTGG---------------
MSMEG_0868|M.smegmatis_MC2_155      AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ
TH_3810|M.thermoresistible__bu      ---------------GEDGEDGTGTGIGGRGGNGG---------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------NAGLAGNAGLAGNAGLAGNAGLAGNAG-------------
MAV_4827|M.avium_104                ----------EDSEPRRRPVLLVGSGLAVVGISAVLA-------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           --AGGAAGLFGAS---------GAGGAGGIG-------GLAGPTDNGDFI
MMAR_5322|M.marinum_M               --AGGAAGLFGAG---------GAGGAGGIG-------GLAGPTDNGDFI
Mb1116|M.bovis_AF2122/97            GLSGGDGGAGGAG---------GAGGAGGTGGWLYGGGGAAGSGGDGGTG
Rv1087|M.tuberculosis_H37Rv         GLSGGDGGAGGAG---------GAGGAGGTGGWLYGGGGAAGSGGDGGTG
Mflv_5091|M.gilvum_PYR-GCK          --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
Mvan_1264|M.vanbaalenii_PYR-1       --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
MSMEG_0868|M.smegmatis_MC2_155      TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG
TH_3810|M.thermoresistible__bu      -SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSHGGNGGHG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --LAGNAGLAGNAG------LAGNAGLAGNAGLAGNAGLAGNAGLAGNAG
MAV_4827|M.avium_104                LEIALAIGIRTTG-------TVALQPTPNQHLIVPTEQAPAPPPVQASAP
                                                                                      

MUL_4400|M.ulcerans_Agy99           IASSSSTITIGS----LFGTGG-TGGDGGIG-------------------
MMAR_5322|M.marinum_M               TVSSSSTITIAS----LFGIGG-TGGDGGIG-------------------
Mb1116|M.bovis_AF2122/97            GQGGAGGAGVFS----LFGSGGGPGGNGGVGGV------GGVGGAGGRAG
Rv1087|M.tuberculosis_H37Rv         GQGGAGGAGVFS----LFGSGGGPGGNGGVGGV------GGVGGAGGRAG
Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155      GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGG
TH_3810|M.thermoresistible__bu      GRGGFLGIGGSG-------GWGGHGGNGGD-----------TDADGGNGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LAGNAGLAGNAG-----LAGNAGLAGNAGLAGN--------AAVAGNAAV
MAV_4827|M.avium_104                QPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAP-------PLPEAPPIPA
                                                                                      

MUL_4400|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5322|M.marinum_M               --------------------------------------------------
Mb1116|M.bovis_AF2122/97            LFGVGGLGGAGGDAGDSGEGGFGGPGLAGGLFGNPGNGGVGGIGGDAAAG
Rv1087|M.tuberculosis_H37Rv         LFGVGGLGGAGGDAGDSGEGGFGGPGLAGGLFGNPGNGGVGGIGGDAAAG
Mflv_5091|M.gilvum_PYR-GCK          AG-----------DGTGGTGGTGG----TGGQGGQGGQGG----------
Mvan_1264|M.vanbaalenii_PYR-1       AG-----------DGLGGTGGTGG----TGGFGGQGGQGG----------
MSMEG_0868|M.smegmatis_MC2_155      AGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIG
TH_3810|M.thermoresistible__bu      DG---------------GNGGSAG--------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AG----------NAAVAGNAAVGG--------------------------
MAV_4827|M.avium_104                APPVVPVPVVVPPVPVPVPVRIPVP-------------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           ------------GHGGWLFGNAGAG-------------------------
MMAR_5322|M.marinum_M               ------------GHGGWLFGNAGAG-------------------------
Mb1116|M.bovis_AF2122/97            GAG------GAGGNGGWLFGNGGAG-------------------------
Rv1087|M.tuberculosis_H37Rv         GAGGAGGNGGAGGNGGWLFGNGGAG-------------------------
Mflv_5091|M.gilvum_PYR-GCK          -------TGGTGGQGG-LGGGGGTG-----------------------GQ
Mvan_1264|M.vanbaalenii_PYR-1       -------TGGTGGQGG-LGGVGGTG-----------------------GT
MSMEG_0868|M.smegmatis_MC2_155      SNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGH
TH_3810|M.thermoresistible__bu      -------RGGTGGLRGVFGINGGNG------------------------R
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------VLNTGVSGAIGGSSHVG-------------------------
MAV_4827|M.avium_104                ----------DPVSPPQLLAPPRLS-------------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           -GPGGSG------GAGTYISPS--------------GRLTVVEFGG----
MMAR_5322|M.marinum_M               -GPGGSG------GAGTYISPS--------------GRLTVEEFAG----
Mb1116|M.bovis_AF2122/97            -GSGGDGGAAGRGGAGNLGSAG--------------GINAPAGNPGSGSV
Rv1087|M.tuberculosis_H37Rv         -GSGGDGGAAGRGGAGNLGSAG--------------GINAPAGNPGSGSV
Mflv_5091|M.gilvum_PYR-GCK          GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGS
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGV
MSMEG_0868|M.smegmatis_MC2_155      GGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGD
TH_3810|M.thermoresistible__bu      AGLGGRGXXXXGGGVGAAVRSG---------------NGVFSGGGGTPSA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --GAINESLGGSGSVGGSTAVG---------------GGAHTGVGGGVST
MAV_4827|M.avium_104                -VPQPVQPPVRVPQPPSPPQVG---------------GTVPQSPPQHQTP
                                                                                      

MUL_4400|M.ulcerans_Agy99           GVGGGGGAGGGAGVFGNGGAGGLG--------------------------
MMAR_5322|M.marinum_M               GVGGGGGAGGGAGVFGNGGAGGLG--------------------------
Mb1116|M.bovis_AF2122/97            GIGGAGGAGGTAGLFGDGGAGGAG--------AAGGFGGISAATPSAGSE
Rv1087|M.tuberculosis_H37Rv         GIGGAGGAGGTAGLFGDGGAGGAGG-----AGAAGGFGGISAATPSAGSE
Mflv_5091|M.gilvum_PYR-GCK          GGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKA
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTA
MSMEG_0868|M.smegmatis_MC2_155      GVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTL
TH_3810|M.thermoresistible__bu      GFGVPTTIQFPAGSCTSRAVSREG------------------------IM
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GVGVGSHVGGGISESLGGSGSVGG--------------------------
MAV_4827|M.avium_104                PGEGTPPKPDGPGNYGGGHVPTPG--------------------------
                                                                                      

MUL_4400|M.ulcerans_Agy99           ----GAGGVSG-------------DHSGGNGGEGGNGGDAQFAGHGG---
MMAR_5322|M.marinum_M               ----GAGGVTG-------------AHSGGNGGDGGNGGDAQFAGHGG---
Mb1116|M.bovis_AF2122/97            GAMGGAGGVGGNARLLGTGGAGGVGGGGGAGGDGGRGGVATPGGQGGDAG
Rv1087|M.tuberculosis_H37Rv         GAMGGAGGVGGNARLLGTGGAGGVGGGGGAGGDGGRGGVATPGGQGGDAG
Mflv_5091|M.gilvum_PYR-GCK          GATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATG
Mvan_1264|M.vanbaalenii_PYR-1       GVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAG
MSMEG_0868|M.smegmatis_MC2_155      GGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGG
TH_3810|M.thermoresistible__bu      PSSRAASARAG---------------------------AACASSTSRSRR
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      STAVGGGAHTG------VGGGVSTGVGVGSHVGGGISESLGGSGSVGGST
MAV_4827|M.avium_104                --AGGSGGSGG----------------GHVPTPGAGGSGGSGGGHVPTPG
                                                                                      

MUL_4400|M.ulcerans_Agy99           ---AGGPGGTGGG----------GTADDGVAGSNG--------SPG----
MMAR_5322|M.marinum_M               ---AGGPGGTGGG----------GTADDGVAGSNG--------SPG----
Mb1116|M.bovis_AF2122/97            DGGAGGAGGNGGGGASGAGGWLLGTGGAGGAGGNGGNGGKAGFSPGPTNF
Rv1087|M.tuberculosis_H37Rv         DGGAGGAGGNGGG-ASGAGGWLLGTGGAGGAGGNGGNGGKAGFSPGPTNF
Mflv_5091|M.gilvum_PYR-GCK          AAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA
Mvan_1264|M.vanbaalenii_PYR-1       SAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKA
MSMEG_0868|M.smegmatis_MC2_155      AATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWV
TH_3810|M.thermoresistible__bu      SFCCSRA-------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AVGGGAHTGVGGG---------VNTGVGVGSHVGGGISESLGGSGSVGGS
MAV_4827|M.avium_104                TGGPGGTGGSGGG----------HVPTPGAGTPGGSGGGHLPFPGAGSTP
                                                                                      

MUL_4400|M.ulcerans_Agy99           ---------------------------------LFFG-------------
MMAR_5322|M.marinum_M               ---------------------------------LFFG-------------
Mb1116|M.bovis_AF2122/97            GLNGAG--------------GGGGVGGNGATGPWLFGDGGAGGGGGAGGI
Rv1087|M.tuberculosis_H37Rv         GLNGAG--------------GGGGVGGNGATGPWLFGDG-----------
Mflv_5091|M.gilvum_PYR-GCK          GATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-------
Mvan_1264|M.vanbaalenii_PYR-1       GATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-------
MSMEG_0868|M.smegmatis_MC2_155      QAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKS
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      TAVGGG-------------------AHTSAINDALGGSGSVGG-------
MAV_4827|M.avium_104                GGSGGG------------------HLPTPGAGTPGGGLGGFGG-------
                                                                                      

MUL_4400|M.ulcerans_Agy99           --------------------------------------------------
MMAR_5322|M.marinum_M               --------------------------------------------------
Mb1116|M.bovis_AF2122/97            GGDGGPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGGAGGLS
Rv1087|M.tuberculosis_H37Rv         ----GPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGGAGGLS
Mflv_5091|M.gilvum_PYR-GCK          ----AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG-
Mvan_1264|M.vanbaalenii_PYR-1       ----AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG-
MSMEG_0868|M.smegmatis_MC2_155      GGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGN
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------STAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAG
MAV_4827|M.avium_104                ----GHAPAPGGGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK--
                                                                                      

MUL_4400|M.ulcerans_Agy99           ---------------------------
MMAR_5322|M.marinum_M               ---------------------------
Mb1116|M.bovis_AF2122/97            GLLFGEPGANG----------------
Rv1087|M.tuberculosis_H37Rv         GLLFGEPGANG----------------
Mflv_5091|M.gilvum_PYR-GCK          -GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1       -GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155      GGNGGNGGNGGADGTPGTAGTTGANNP
TH_3810|M.thermoresistible__bu      ---------------------------
MLBr_01183|M.leprae_Br4923          ---------------------------
MAB_4284c|M.abscessus_ATCC_199      TGFEAQGHAQGHASETAHTTLPGAEHH
MAV_4827|M.avium_104                ---------------------------