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SYLLVTPELLTSAATDLEGIASALSTANLAAAVPTTGVLAAGADEVSAAVASLFAGYGQAYQSISLQANA FQAQFIQAINGAGGAYAAAEAASTSPLQAFEDTVLGVINAPTQTLLGRPLIGDGAAGTAANPNGGAGGFL YGNGGNGFSQTTAGVAGGSGGAAGLIGNGGMGGAGGAGAAGGAGGTGGWWFGNGGVGGAGGAGTAGAVGF NGVSGGAGGAGGAAGWWGAGGAGGQGGTGGMAGGYDNVNSVYGTTAGNGGDGGAGGRGGWLFGDAGAGGQ GGLGGDGNYAGQGSYGGVGGAGGAGGAAGMFGSGGSGGAGGEGGAFGDGNAGGSGSGGHGGNGGNGGWLY GDAGAGGQGGNAAPGAYSDNLGTIQYGNTSGNGGAGGNGGVAGMIGTGGAGGAGGAGGVNVYDSGGGGGG GGTGGNGGWLYGNAGSGGQGGAGGDGSFLWDSPPNTNVYIGDAGGAGGVGGHGGSAGLIGSGGAGGAGGV GGTGGYPAGNGGAGGDGGRAGLLFGSAGVGGQGGDGGGNYIAFTSNGNPNYNDGDAAGSGGAGGNGGAAG LFGAGAAGGAGGAGGLSGYRSAGNGGAGGAGGAGGVLGGDGGAGGDGGAAGNGVNDPVTGAVEGDGGIGG NGGTGGAALGWFGNGGAGGDGGAGGASQEFGDSGGNGGNGGAGGASGALIGAGGVGGSGGGGGAGVVGPP AGNPGNDGLDGVTGASGLLFGG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_5321 | - | - | 100% (723) | PE-PGRS family protein |
M. marinum M | MMAR_1208 | - | 0.0 | 55.14% (769) | PE-PGRS family protein |
M. marinum M | MMAR_3316 | - | 0.0 | 54.82% (768) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1116 | PE_PGRS21 | 0.0 | 51.46% (785) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-131 | 41.52% (778) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3388 | PE_PGRS52 | 0.0 | 53.68% (760) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 1e-11 | 36.46% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 2e-46 | 35.56% (450) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 9e-22 | 44.68% (141) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-118 | 41.26% (715) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 4e-39 | 35.57% (357) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4399 | - | 0.0 | 86.05% (516) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-127 | 41.18% (760) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_5321|M.marinum_M -------------------------------------------------- MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv3388|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5321|M.marinum_M -------------------------------------------------- MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- Mb1116|M.bovis_AF2122/97 -------------------------------------------------- Rv3388|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_5321|M.marinum_M ------------------------------------------MSYLLVTP MUL_4399|M.ulcerans_Agy99 ------------------------------------------MSYLLVAP Mb1116|M.bovis_AF2122/97 ------------------------------------------MSFVVVAP Rv3388|M.tuberculosis_H37Rv ------------------------------------------MSFVIANP Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------------------------MNIVLGVSMAP MMAR_5321|M.marinum_M ----------------------------------------ELLTSAATDL MUL_4399|M.ulcerans_Agy99 ----------------------------------------ELLTSAATDL Mb1116|M.bovis_AF2122/97 ----------------------------------------EVLAAAASDL Rv3388|M.tuberculosis_H37Rv ----------------------------------------EMLAAAATDL Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------VEAASYVADP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------------------------SSIQMVVLEG MMAR_5321|M.marinum_M EG----------------------IASALS-----------TANLAAAVP MUL_4399|M.ulcerans_Agy99 EG----------------------IASALS-----------TANLAAAVP Mb1116|M.bovis_AF2122/97 AG----------------------IGSTLA-----------QANAAALAP Rv3388|M.tuberculosis_H37Rv AG----------------------IRSAIS-----------AATAAAAAP Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------EAALAN----------AGLSAVSAA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 EY---------------------------------------ADGATVEED MMAR_5321|M.marinum_M TTG-------VLAAGADEVSAAVASLFAGYGQAYQSISLQANAFQAQFIQ MUL_4399|M.ulcerans_Agy99 TTG-------MLAAGADEVSAAVASLFAGYGQAYQSISLQANAFQAQFIQ Mb1116|M.bovis_AF2122/97 TTA-------VLAAGADEVSAAIASLFGAHGQAYQAVSAQMSAFHAQFMQ Rv3388|M.tuberculosis_H37Rv TIQ-------VAAAGADEVSLAISALFGQHAQAYQALSAQATIFHDQFVQ Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MAB_4284c|M.abscessus_ATCC_199 QVG-------AVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA MMAR_5321|M.marinum_M AINGAGGAYAAAEAASTSPLQAFEDTVLGVINAPTQTLLGRPLIGDGAAG MUL_4399|M.ulcerans_Agy99 AINGAGGAYVAAEAASTSPLQAFEDTVLGVINAPTQTLLGRPLIGDGAAG Mb1116|M.bovis_AF2122/97 ALTGAGGAYAAAEAVNVSAAQSVEQDLLAAINARFERIFGRPLIGDGANG Rv3388|M.tuberculosis_H37Rv ALTSGGNLYAAAES------HTVEQMVLNAINAPTQTLFGRPLIGDGANG Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRG--------------------------GDGGDG MAB_4284c|M.abscessus_ATCC_199 QPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSF MLBr_01183|M.leprae_Br4923 ----------------------------------------MPLFLNAEPQ MAV_4827|M.avium_104 AALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTA MMAR_5321|M.marinum_M TAANPNGGAGG--FLYGNGGNGFSQTTAGVAGGSG--------------- MUL_4399|M.ulcerans_Agy99 TVANPNGGAGG--FLYGNGGNGFSQTTAGVAGGAG--------------- Mb1116|M.bovis_AF2122/97 GPGQ-DGGPGG--LLYGNGGNGGTSTTVGMAGGNG--------------- Rv3388|M.tuberculosis_H37Rv TAENPDGQNGG--LLFGNGGNGFTQTTAGVAGGNG--------------- Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT TH_3810|M.thermoresistible__bu GLGGNGGHGGG-------TGIISLLSLAGNGGNGG--------------- MAB_4284c|M.abscessus_ATCC_199 NRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNS--------------- MLBr_01183|M.leprae_Br4923 ALTAAANTLEG-----------LSAATVASNAAAA--------------- MAV_4827|M.avium_104 TLAVVETSDGS-----IPDVYKQQIRAESYGDAAG--------------- . . MMAR_5321|M.marinum_M -GAAGLIGNGGMGGAGG------AGAAGGAGGTGG--WWFGNGG------ MUL_4399|M.ulcerans_Agy99 -GAAGLIGNGGMGGAGG------AGAAGGAGGTGG--WWFGNGG------ Mb1116|M.bovis_AF2122/97 -GAAGLIGNGGFGGGGG------PGAAGGNGGAGG--WLFGNGG------ Rv3388|M.tuberculosis_H37Rv -GSAGLIGNGGAGGGGG------AGAAGGLGGNGG--WLYGNGG------ Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------ Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------ MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH TH_3810|M.thermoresistible__bu -NGYRTTDNNALDGGHG-----------GNGGNVG---FFSLFN------ MAB_4284c|M.abscessus_ATCC_199 GPIASGQGSTAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTN----- MLBr_01183|M.leprae_Br4923 -QLTTEIAPPAADDVSI------------LLAHFF--------------- MAV_4827|M.avium_104 QLSAMVAGLEKLESLPG------GLLLVGSGVDVAP-------------- . MMAR_5321|M.marinum_M -VGGAGG-----AGTA-GAVGFNGVSG-------GAGGAGGAAG----WW MUL_4399|M.ulcerans_Agy99 -VGGAGG-----AGTA-GAVGFNGVSG-------GAGGAGGAAG----WW Mb1116|M.bovis_AF2122/97 -AGGAGG-----LGVAPGVPGGAGGAG-------GAGGVGGPAG----LW Rv3388|M.tuberculosis_H37Rv -AGGIGG-----AGTGTGGHGGAGGAGGR-AWLWGTGGAGGAGGDGGWLF Mflv_5091|M.gilvum_PYR-GCK -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG Mvan_1264|M.vanbaalenii_PYR-1 -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS TH_3810|M.thermoresistible__bu -LGGAGG------------WGGSGVDG--------VDVVGGNPD------ MAB_4284c|M.abscessus_ATCC_199 -VSGHGSADIDKSVTVVDDHSQRNTTNIN---DSFNTDRSTNIGSGNTTN MLBr_01183|M.leprae_Br4923 --SGHGR-----------QYQAHASQG--------ATNHQDLIQS--LLT MAV_4827|M.avium_104 -LKQVLQTTTFLDVSVAEEPETALARG--------AALAAANAPLFASST . MMAR_5321|M.marinum_M GAGGAGGQGGTG----------------------GMAGGYDNVNSVYGT- MUL_4399|M.ulcerans_Agy99 GAGGAGGQGGTG----------------------GMAGGYDNVNGVFGI- Mb1116|M.bovis_AF2122/97 GHGGAGGAGGAGV---------------------AGAGGFEGTIGAGGAG Rv3388|M.tuberculosis_H37Rv GDGGAGGTGGNGGSGF--------NSLTSSVGGAGGAGGHAGLFGAGGTG Mflv_5091|M.gilvum_PYR-GCK ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG Mvan_1264|M.vanbaalenii_PYR-1 ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY TH_3810|M.thermoresistible__bu --GGTPGAHGES----------------------HTPGVYTDRQGEDGED MAB_4284c|M.abscessus_ATCC_199 TEIGSHNQANIG--------------------TSTSAGGSAAVGGNAGLA MLBr_01183|M.leprae_Br4923 SSSAYAG---------------------------TETANHDSL------- MAV_4827|M.avium_104 AALAYAQDPGTG-----------------------AVDQYSLPDYLYVPV MMAR_5321|M.marinum_M -----------TAGNGG--------------------------------- MUL_4399|M.ulcerans_Agy99 -----------TAGNGG--------------------------------- Mb1116|M.bovis_AF2122/97 ----------GVGGAGG--------------------------------- Rv3388|M.tuberculosis_H37Rv ----------GTGGIGGQNTET---------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------STGAVGG-------VGGKG----IQGGQG----------- Mvan_1264|M.vanbaalenii_PYR-1 ----------ATGGAGG-------VGGKG----IQGGQG----------- MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA TH_3810|M.thermoresistible__bu -----------GTGTG---------------------------------- MAB_4284c|M.abscessus_ATCC_199 G----------NAGLAG--------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 DPEPGDDE------------------------------------------ MMAR_5321|M.marinum_M ---------DGGAGGRGG------------------------WLFGDAGA MUL_4399|M.ulcerans_Agy99 ---------DGGAGGRGG------------------------WLFGDAGA Mb1116|M.bovis_AF2122/97 ---------VGGAGGAGG------------------------WLYGDAGA Rv3388|M.tuberculosis_H37Rv -GPAASNGGAGGAGGGGG------------------------YLVGDGGA Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV TH_3810|M.thermoresistible__bu ---------IGGRGGNGG------------------------------SS MAB_4284c|M.abscessus_ATCC_199 ---------NAGLAGNAG-------------------------LAGNAGL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------LAYSAVGEED-------------------------AESPTVV MMAR_5321|M.marinum_M GGQGGLGGDG---------------------NYAGQGSY----------- MUL_4399|M.ulcerans_Agy99 GGQGGLGGDG---------------------NYAGQGSY----------- Mb1116|M.bovis_AF2122/97 GGDGGVGGAGGTGG---------------LGNRGGAGGA----------- Rv3388|M.tuberculosis_H37Rv GGTGGAGGKN---------------------SSGGATLT----------- Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD----------- Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN----------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP TH_3810|M.thermoresistible__bu SGTHPMAEDG---------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAG------------------NAGLAGN----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 IEKLFLPEDSEPRRR--------------PVLLVGSG------------- MMAR_5321|M.marinum_M -----------GGVGGAGGAGGAAG-MFGSGGSGG--------------- MUL_4399|M.ulcerans_Agy99 -----------GGVGGAGGAGGAAG-MFGSGGSGG--------------- Mb1116|M.bovis_AF2122/97 -----------GGAGGVGGAGGAAG-LWGGGGAGG--------------- Rv3388|M.tuberculosis_H37Rv -----------GGTGGTGGAGGAAGWLYGSGGAGG--------------- Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG--------------- MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ TH_3810|M.thermoresistible__bu -----------EHVKALDGRPGLDG---GNGSHGG--------------- MAB_4284c|M.abscessus_ATCC_199 -----------AGLAGNAGLAGNAG-LAGNAGLAG--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------LAVVGISAVLALEIALAIGIRTTG--------------- MMAR_5321|M.marinum_M --AGGEGG----------------AFGDGNAGGSGSGGHGGNGGNGG--W MUL_4399|M.ulcerans_Agy99 --AGGEGG----------------AFGDGNAGGSGSGGHGGNGGNGG--W Mb1116|M.bovis_AF2122/97 --VGGTGGGAGLGAQSVTFSSSLSGLSGGDGGAGGAGGAGGAGGTGG--W Rv3388|M.tuberculosis_H37Rv --AGGAGG-----------------LNNAGGATGGTGGTGGAGGSGA--W Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGG------------AGSTGGTGGTGGTGGTGGTGGTG---G Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGG------------AGSTGGTGGTGGTGGTGGTGGTG---G MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGG------------DGGTFVNAGANGNGGAGGAGGVSE--G TH_3810|M.thermoresistible__bu --NGGHGG------------------RGGFLGIGGSGGWGGHGGNGG--D MAB_4284c|M.abscessus_ATCC_199 --NAGLAGNAG---------------LAGNAGLAGNAGLAGNAGLAGNAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --TVALQPTPN---------------QHLIVPTEQAPAPPPVQASAPQPK MMAR_5321|M.marinum_M LYGDAGAGGQGGNAAPGAYSDNLGTI----QYGNTSGNGGAGGNG----- MUL_4399|M.ulcerans_Agy99 LYGDAGAGGQGGNAAPGAYSDNLGTF----QSSYTSGNGGAGGNG----- Mb1116|M.bovis_AF2122/97 LYGGGGAAGSGGDGGTGGQGGAGGAG----VFSLFGSGGGPGGNG----- Rv3388|M.tuberculosis_H37Rv LYGNGGAAGAGGNGGNNTSAGTGG----------VGASGGTGGNA----- Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTGGKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG----- Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGTGGKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG----- MSMEG_0868|M.smegmatis_MC2_155 EGGTGGHGGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVD TH_3810|M.thermoresistible__bu TDADGGNGGDGGNGGSAGRGGTGGLR---------GVFGINGGNG----- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAGLAGNAAVAG----NAAVAGNAAVAGNA----- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ISVPEPVAAPKPLSPPVAAPLPAAPP--------PAAPPLPEAPP----- MMAR_5321|M.marinum_M ----GVAGMIGTGGAG------------GAGGAGGVN------VYDSGGG MUL_4399|M.ulcerans_Agy99 ----GVAGMIGTGGAG------------GAGGAGGVN------AFDSGGG Mb1116|M.bovis_AF2122/97 ----GVGGVGGVGGAGG------RAGLFGVGGLGGAGG----DAGDSGEG Rv3388|M.tuberculosis_H37Rv ----GLIGAGGHGGAG------------GAGGNQTGG------VGNGGAG Mflv_5091|M.gilvum_PYR-GCK ----GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQG Mvan_1264|M.vanbaalenii_PYR-1 ----GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQG MSMEG_0868|M.smegmatis_MC2_155 PSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKG TH_3810|M.thermoresistible__bu -----RAGLGGRGXXX------------XGGGVGAAVR-----SGNGVFS MAB_4284c|M.abscessus_ATCC_199 ----AVGGVLNTGVSG------------AIGGSSHVGG-----AINESLG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----IPAAPPVVPVP-----------VVVPPVPVPVPVRIPVPDPVSPP MMAR_5321|M.marinum_M GGGGGTG-------------------GNGGWLYGNAGSG----------- MUL_4399|M.ulcerans_Agy99 GGGG---------------------------------------------- Mb1116|M.bovis_AF2122/97 GFGGP---------------------GLAGGLFGNPGNG----------- Rv3388|M.tuberculosis_H37Rv GNGGAG--------------------GAGGQLYGNGGDG----------- Mflv_5091|M.gilvum_PYR-GCK GQGG-----------------TGGTGGQGG-LGGGGGTG----------- Mvan_1264|M.vanbaalenii_PYR-1 GQGG-----------------TGGTGGQGG-LGGVGGTG----------- MSMEG_0868|M.smegmatis_MC2_155 GDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVV TH_3810|M.thermoresistible__bu GGGG---------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GSGSVG-------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 QLLAPP-------------------------------------------- MMAR_5321|M.marinum_M ------------GQGGAGGDGSFLWDSPPNTNV-YI-GDAGGAGGVGGHG MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- Mb1116|M.bovis_AF2122/97 ------------GVGGIGGDAAAGGAGGAGGNGGWL-FGNGGAGGSGGDG Rv3388|M.tuberculosis_H37Rv ------------GNGGAGGANIAGGNGS-----------DGGAAGHGGAG Mflv_5091|M.gilvum_PYR-GCK ------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAG Mvan_1264|M.vanbaalenii_PYR-1 ------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAG MSMEG_0868|M.smegmatis_MC2_155 QANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------GSTAVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------------------------RLSVPQ MMAR_5321|M.marinum_M GSAGLIGSGGAGGAGGVGG-TGGYPAGNGGAGGDGGRAGLLFGSA-GVGG MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- Mb1116|M.bovis_AF2122/97 GAAGRGGAGNLGSAGGINA-PAGNPGSGSVGIGGAGGAGGTAGLF-GDGG Rv3388|M.tuberculosis_H37Rv GSARLIGAGGHGGDGGAGGNTAGRRADAIAGTGGDGGNGGNGGLLSGNAG Mflv_5091|M.gilvum_PYR-GCK GDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGL Mvan_1264|M.vanbaalenii_PYR-1 GDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGL MSMEG_0868|M.smegmatis_MC2_155 GDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PVQPPVRVPQPPSPPQVGGTVPQSPPQHQTPPGEGTPPKPDGPGNYGGGH MMAR_5321|M.marinum_M QG----GDGGGNYIAFTSNGNPNYNDGDAAGSGGAGGNGGAAGLFGAGAA MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- Mb1116|M.bovis_AF2122/97 AG----GAGAAG--GFGGISAATPSAGSEGAMGGAGGVGGNARLLGTGGA Rv3388|M.tuberculosis_H37Rv AG----GHGGAGGSSTATTTTGTPPTGATGGNGGNGGAGGTAGFTGSGGI Mflv_5091|M.gilvum_PYR-GCK FG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGAT Mvan_1264|M.vanbaalenii_PYR-1 FG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGAT MSMEG_0868|M.smegmatis_MC2_155 GGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GG-----VSTGVGVGSHVGGGISESLGGSGSVGGSTAVGG---------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VP----TPGAGGSGGSGGGHVPTPGAGGSGGSGGGHVPTP---------- MMAR_5321|M.marinum_M GGAGGAGGLSGYRSAGNGGAGGAGGAGGVLGGDGG-----------AGGD MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- Mb1116|M.bovis_AF2122/97 GGVGGGGGAGGDGGRGGVATPGGQGGDAGDGGAGG-----------AGGN Rv3388|M.tuberculosis_H37Rv GGNGGAGG-----------TGGNAGVALSVGSTGG-----------LGGN Mflv_5091|M.gilvum_PYR-GCK G-ATGAAGKAG--------ATGAAGAAGAAGSAG-----------TTGAQ Mvan_1264|M.vanbaalenii_PYR-1 G-ATGASGAQG--------SAGSAGSAGVAGSAG-----------TTGAQ MSMEG_0868|M.smegmatis_MC2_155 GVATGNTATGG--------DGGAATTAGATGGAGGFSNIAAIHGAITDST TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------------GAH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------------------------------------GT MMAR_5321|M.marinum_M GGAAGNGVNDPVTGAVEGDGGIGGNGGTGGAA--------LGWFGNGGAG MUL_4399|M.ulcerans_Agy99 -------------------------------------------------- Mb1116|M.bovis_AF2122/97 GGGGASGAGGWLLG-TGGAGGAGGNGGNGGKAGFSPGPTNFGLNGAGGGG Rv3388|M.tuberculosis_H37Rv GGSGGLGGGGGSLFGNGGAGGVGATGGNGGSG--------IGPASVGGNG Mflv_5091|M.gilvum_PYR-GCK GSAGTNGA-NGANGSQGAAGKAGATGTTGATG-------------AAGED Mvan_1264|M.vanbaalenii_PYR-1 GSAGTNGA-NGANGSQGAAGKAGATGTTGATG-------------AAGDA MSMEG_0868|M.smegmatis_MC2_155 AISGHGGAGNGGNGGKGADGWVQAYDPAGPVGS-----KIANSSAVAGNG TH_3810|M.thermoresistible__bu -------------------------------------------------T MAB_4284c|M.abscessus_ATCC_199 TGVGGGVNTGVGVGSHVGGGISESLGGSGSVGG------------STAVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GGPGGTGGSGGGHVPTPGAGTPGGSGGGHLPFP-------------GAGS MMAR_5321|M.marinum_M GDGGAGGASQEFGDSGGNGGN-----------------GGAGGASG---- MUL_4399|M.ulcerans_Agy99 ----------------GNGGN-----------------GGAGGASG---- Mb1116|M.bovis_AF2122/97 GVGGNGATGPWLFGDGGAGGG-----------------GGAGGIGGDGGP Rv3388|M.tuberculosis_H37Rv GKGGVGAAGG-LAGQIGNGGS-----------------GGSGGAGG---- Mflv_5091|M.gilvum_PYR-GCK GDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE Mvan_1264|M.vanbaalenii_PYR-1 GDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE MSMEG_0868|M.smegmatis_MC2_155 GDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSE TH_3810|M.thermoresistible__bu PSAGFGVPTTIQFPAGSCTSR----------------------------- MAB_4284c|M.abscessus_ATCC_199 GGAHTSAINDALGGSGSVGGS-----------------TAVGGGAHTSAI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TPGGSGGGHLPTPGAGTPGG-------------------GLGGFGG---- MMAR_5321|M.marinum_M ------ALIGAGGVGGSGGGG---GAGVVGPPAGNPGNDGLDGVTGASGL MUL_4399|M.ulcerans_Agy99 ------ALIEAGGVGGSGGGG---GAGVVGPPAGNPGNDGLDGVTGASGL Mb1116|M.bovis_AF2122/97 T----PGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGGAGGLSGL Rv3388|M.tuberculosis_H37Rv -------NGGTGDTAGNGGNG---GAGAVGGNAQLIGNGGNGGGGGNGGT Mflv_5091|M.gilvum_PYR-GCK --------GGAGGGGGAGGSG--AGGAG--GAGGSGGSGGSGGSGGSGGA Mvan_1264|M.vanbaalenii_PYR-1 --------GGAGGSGGAGGSG--TGGAG--GAGGSGGSGGSGGAGGSGGA MSMEG_0868|M.smegmatis_MC2_155 PGPGGNGAGGAGGNGGTGGTT--AGGSGNGGNGGNGGNGGADGTPGTAGT TH_3810|M.thermoresistible__bu ---------AVSREGIMPSSR---AASARAGAACASSTSRSRRSFCCSRA MAB_4284c|M.abscessus_ATCC_199 NESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------GHAPAPGGGLGGG---GGHAPAPGGGLGGFGGGHSGGGLGGL MMAR_5321|M.marinum_M LFGG----- MUL_4399|M.ulcerans_Agy99 LFGG----- Mb1116|M.bovis_AF2122/97 LFGEPGANG Rv3388|M.tuberculosis_H37Rv GADGT---- Mflv_5091|M.gilvum_PYR-GCK AGDSDD--- Mvan_1264|M.vanbaalenii_PYR-1 AGDSD---- MSMEG_0868|M.smegmatis_MC2_155 TGANNP--- TH_3810|M.thermoresistible__bu --------- MAB_4284c|M.abscessus_ATCC_199 TLPGAEHH- MLBr_01183|M.leprae_Br4923 --------- MAV_4827|M.avium_104 GGGHK----