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QMLLVRHALPLRSEHGEGSDPVLSDTGVAQVSRLPEALSRFPITRVISSPQRRAVQTAESVATARGLAID IDDRFAEYDRDLPHYIPVEQIRTEKPQEWARMAQGKLPSAVDEDAFRARVRAVVDDVVSAAGSDDTVAVF SHGGVINVVLHEILGTARLLSFPIDYASITRLLFSRTGQATVATVNSTEHVWDLLPRNQRW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4380 | - | - | 100% (202) | hypothetical protein MUL_4380 |
| M. ulcerans Agy99 | MUL_1324 | - | 1e-08 | 27.00% (200) | bifunctional RNase H/acid phosphatase |
| M. ulcerans Agy99 | MUL_0624 | - | 8e-06 | 36.49% (74) | hypothetical protein MUL_0624 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2253c | - | 2e-08 | 28.50% (200) | bifunctional RNase H/acid phosphatase |
| M. gilvum PYR-GCK | Mflv_1203 | - | 1e-74 | 66.01% (203) | phosphoglycerate mutase |
| M. tuberculosis H37Rv | Rv2228c | - | 2e-08 | 28.50% (200) | bifunctional RNase H/acid phosphatase |
| M. leprae Br4923 | MLBr_01452 | - | 6e-08 | 30.63% (160) | putative phosphoglycerate mutase |
| M. abscessus ATCC 19977 | MAB_1905 | - | 8e-12 | 29.50% (200) | bifunctional RNase H/acid phosphatase |
| M. marinum M | MMAR_5305 | - | 1e-110 | 98.02% (202) | hypothetical protein MMAR_5305 |
| M. avium 104 | MAV_0314 | - | 7e-93 | 81.19% (202) | phosphoglycerate mutase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6338 | - | 1e-76 | 67.33% (202) | phosphoglycerate mutase family protein, putative |
| M. thermoresistible (build 8) | TH_1658 | - | 8e-69 | 60.50% (200) | phosphoglycerate mutase family protein, putative |
| M. vanbaalenii PYR-1 | Mvan_5604 | - | 8e-78 | 68.81% (202) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2253c|M.bovis_AF2122/97 MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
Rv2228c|M.tuberculosis_H37Rv MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
MAB_1905|M.abscessus_ATCC_1997 MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEY
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------------------
MAV_0314|M.avium_104 --------------------------------------------------
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01452|M.leprae_Br4923 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
Rv2228c|M.tuberculosis_H37Rv RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
MAB_1905|M.abscessus_ATCC_1997 RGLIAGLAEAARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAV
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------------------
MAV_0314|M.avium_104 --------------------------------------------------
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01452|M.leprae_Br4923 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 ALASQFRRINYEWVPRARNTYADRLANDAMD-AAAQSAAADADPAKIVAT
Rv2228c|M.tuberculosis_H37Rv ALASQFRRINYEWVPRARNTYADRLANDAMD-AAAQSAAADADPAKIVAT
MAB_1905|M.abscessus_ATCC_1997 TAAMQFESVDYTWIPRERNKHADRLANEAMDRASGIEPKKPKEIAEIKET
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------MRRGHVRGWAER
MAV_0314|M.avium_104 --------------------------------------------------
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01452|M.leprae_Br4923 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 ESP-TSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLNEVGWRQ
Rv2228c|M.tuberculosis_H37Rv ESP-TSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLNEVGWRQ
MAB_1905|M.abscessus_ATCC_1997 KPADTAPGWTGARGKPTRMLLLRHGQTELSVQRRYSGRGNPELTELGREQ
MUL_4380|M.ulcerans_Agy99 ----------------MQMLLVRH---ALPLRSEHGEGSDPVLSDTGVAQ
MMAR_5305|M.marinum_M PRPRAAHHTNHRMGAHMQMLLVRH---ALPLRSEHGEGSDPVLSDTGVAQ
MAV_0314|M.avium_104 ----------------MQVLLVRH---ALPLRSEHGQGSDPDLSADGLAQ
MSMEG_6338|M.smegmatis_MC2_155 ----------------MQLLLIRH---ALPLRSEPGQGSDPVLSEIGLQQ
TH_1658|M.thermoresistible__bu ----------------VQLILVRH---ALPRRSEPGQGADPDLSEVGLEQ
Mflv_1203|M.gilvum_PYR-GCK ----------------MQLLLVRH---ALPLRSEPGQGSDPSLSPEGVEQ
Mvan_5604|M.vanbaalenii_PYR-1 ----------------MQLLLVRH---ALPLRSEPGQGSDPSLSAEGLEQ
MLBr_01452|M.leprae_Br4923 -------------MRTRRLVMLRHGQTDFNLGGRMQGQLDTELSELGRAQ
:::::** : . :. *. * *
Mb2253c|M.bovis_AF2122/97 VGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDDDLVETD
Rv2228c|M.tuberculosis_H37Rv VGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDDDLVETD
MAB_1905|M.abscessus_ATCC_1997 AARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPLTVDDDLIETD
MUL_4380|M.ulcerans_Agy99 VSRLPEALSRFP-ITRVISSPQRRAVQTAESVATARGLAIDIDDRFAEYD
MMAR_5305|M.marinum_M VSRLPEALSRFP-ITRVISSPQRRAVQTAEPVATARGLAIDIDDRFAEYD
MAV_0314|M.avium_104 IERLPKALERFP-ISRVVSSPQRRAVQTAAPVAADRGLSVEIDDRFAEYD
MSMEG_6338|M.smegmatis_MC2_155 AVRLPDALKRFP-VTRVVSSPQRRAVQTGEPLAGALGLPVEIDERLAEYD
TH_1658|M.thermoresistible__bu ARRLPAALERFP-IARVISSPQRRAVQTAEPVADALGLPVHIDERFAEYD
Mflv_1203|M.gilvum_PYR-GCK ARRLPDALARFP-ITRLVSSPQVRAIETGQPVADKLGLTIEVDDRLAEYD
Mvan_5604|M.vanbaalenii_PYR-1 AKRLPDALARFP-ITRLVSSPQVRAIETGQPVADALGLPIEVDDRLAEYD
MLBr_01452|M.leprae_Br4923 AVAVAEVLGKLQ-PLRIVSSDLRRAYDTAIKLGERTGLKIWVDDRLREAH
. * ::** ** :*. . .: : :*: : * .
Mb2253c|M.bovis_AF2122/97 FGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRVRRGRDR
Rv2228c|M.tuberculosis_H37Rv FGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRVRRGRDR
MAB_1905|M.abscessus_ATCC_1997 FGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRVRRARNR
MUL_4380|M.ulcerans_Agy99 RDLPHYIPVEQIRTEKPQEWARMAQG---KLPSAVDEDAFRARVRAVVDD
MMAR_5305|M.marinum_M RDLPHYIPVEQIRTENPQEWARMAQG---KLPSAVDEDAFRARVRAVVDD
MAV_0314|M.avium_104 RDLPVYIPVEQIRDEMPEEWARLAQG---HLPSAVDEDAFRARVRAAVDD
MSMEG_6338|M.smegmatis_MC2_155 RDMSHYVPIEQIAQENPAELARLAGG---HLPSGVDEEEFAGRIGAAFDD
TH_1658|M.thermoresistible__bu RGLAHYVPIEEVARENPEQLERLLNG---ELPGAVDPDEFQDRVAAALDE
Mflv_1203|M.gilvum_PYR-GCK RDLPHYIPIEQIAKENPEELQRLVDG---HLPSSVDETQFLARISAGIDD
Mvan_5604|M.vanbaalenii_PYR-1 RDLAHYIPIEQIAAERPEELQRLIDG---HLPSAVDEAAFLARVTAGIED
MLBr_01452|M.leprae_Br4923 LGDWQGLTHSQIDADAPGARLAWREDATWAPHSGESRVDVAARSLPVVTE
. :. : * . . . . *
Mb2253c|M.bovis_AF2122/97 IIV-------GYEG-ATVLVVSHVTPIKMLLRLALDAGSG-VLYRLHLDL
Rv2228c|M.tuberculosis_H37Rv IIV-------GYEG-ATVLVVSHVTPIKMLLRLALDAGSG-VLYRLHLDL
MAB_1905|M.abscessus_ATCC_1997 IIA-------EYGG-ATVLVVSHVTPIKTLLRLALDAGPS-VLYRLHLDL
MUL_4380|M.ulcerans_Agy99 VVS-------AAGSDDTVAVFSHGGVINVVLHEILGTAR---LLSFPIDY
MMAR_5305|M.marinum_M VVS-------AAGSDDTVAVFSHGGLINVVLHEILGTAR---LLSFPIDY
MAV_0314|M.avium_104 LVA-------AAEPEDTVAVFSHGGVINVLLHEILGTAR---LLSFPVDY
MSMEG_6338|M.smegmatis_MC2_155 LVA-------AGNHEDTVAVFSHGGVINVALHGILKTER---LLSFHIDY
TH_1658|M.thermoresistible__bu VVA-------TSAHTDTVAVFSHGGVINAILHRIARTER---LITFHIDY
Mflv_1203|M.gilvum_PYR-GCK LVA-------SADRDDTVVVFSHGGVINVLLHQILGTER---LLSFHVDY
Mvan_5604|M.vanbaalenii_PYR-1 LVT-------GAGHDDTVAVFSHGGVINVLLHHVLRTER---LLSFHVDY
MLBr_01452|M.leprae_Br4923 VVSGAPEWGDCHEPDRPVVLVAHGGLITALSAALLRLPVANWSILGSMGN
:: .* :.:* *. :.
Mb2253c|M.bovis_AF2122/97 ASLSIAEFYADG-ASSVRLVNQTGYL------------------------
Rv2228c|M.tuberculosis_H37Rv ASLSIAEFYADG-ASSVRLVNQTGYL------------------------
MAB_1905|M.abscessus_ATCC_1997 ASLSIAEFYSDG-PASVRLVNETSYLT-----------------------
MUL_4380|M.ulcerans_Agy99 ASITRLLFSRTG-QATVATVNSTEHVWDLLPRN--QRW------------
MMAR_5305|M.marinum_M ASVTRLLFSRTG-QATVATVNSTEHVWDLLPRN--QRW------------
MAV_0314|M.avium_104 ASVTRLLFSRSG-QATVAAVNTTEHVWDLLPRI--QRW------------
MSMEG_6338|M.smegmatis_MC2_155 ASVTRVLASRSG-RLSVASVNSTEHVWDLLPRN--ARW------------
TH_1658|M.thermoresistible__bu ASVTRVLASRSG-RLSIGGINTVEHVWDLLPRNRDGRLQGTAAVSDNKEV
Mflv_1203|M.gilvum_PYR-GCK ASVTRLLWSASRERLAVACVNGTEHVWDLLPRN--HRW------------
Mvan_5604|M.vanbaalenii_PYR-1 ASVTRLLSSRTG-RLAVAGVNGTEHVWDLLPRN--QRW------------
MLBr_01452|M.leprae_Br4923 ASWVQLSGHSDESDSELDLIQWRLDVWNASVQVSNDVL------------
** : :: :
Mb2253c|M.bovis_AF2122/97 -----------
Rv2228c|M.tuberculosis_H37Rv -----------
MAB_1905|M.abscessus_ATCC_1997 -----------
MUL_4380|M.ulcerans_Agy99 -----------
MMAR_5305|M.marinum_M -----------
MAV_0314|M.avium_104 -----------
MSMEG_6338|M.smegmatis_MC2_155 -----------
TH_1658|M.thermoresistible__bu IDNGRDLPRRT
Mflv_1203|M.gilvum_PYR-GCK -----------
Mvan_5604|M.vanbaalenii_PYR-1 -----------
MLBr_01452|M.leprae_Br4923 -----------