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KVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEYRGLIAGLDDAVKLGATEAAVL MDSKLVVEQMSGRWKVKHPDLLKLYVQAQALASQFRRINYEWVPRARNTYADRLANDAMDAAAQSAAADA DPAKIVATESPTSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLNEVGWRQVGAAAGYLARRGG IAAVVSSPLQRAYDTAVTAARALALDVVVDDDLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPG GESFDDVLRRVRRGRDRIIVGYEGATVLVVSHVTPIKMLLRLALDAGSGVLYRLHLDLASLSIAEFYADG ASSVRLVNQTGYL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2228c | - | - | 100% (364) | hypothetical protein Rv2228c |
| M. tuberculosis H37Rv | Rv2419c | - | 8e-19 | 42.97% (128) | phosphoglycerate mutase (phosphoglyceromutase) |
| M. tuberculosis H37Rv | Rv0525 | - | 9e-12 | 31.79% (195) | hypothetical protein Rv0525 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2253c | - | 0.0 | 100.00% (364) | bifunctional RNase H/acid phosphatase |
| M. gilvum PYR-GCK | Mflv_2892 | - | 1e-146 | 70.60% (364) | bifunctional RNase H/acid phosphatase |
| M. leprae Br4923 | MLBr_01637 | - | 1e-162 | 77.09% (371) | bifunctional RNase H/acid phosphatase |
| M. abscessus ATCC 19977 | MAB_1905 | - | 1e-145 | 71.58% (366) | bifunctional RNase H/acid phosphatase |
| M. marinum M | MMAR_3304 | - | 1e-173 | 81.55% (374) | hypothetical protein MMAR_3304 |
| M. avium 104 | MAV_2211 | - | 1e-161 | 74.67% (383) | bifunctional RNase H/acid phosphatase |
| M. smegmatis MC2 155 | MSMEG_4305 | - | 1e-150 | 71.82% (369) | bifunctional RNase H/acid phosphatase |
| M. thermoresistible (build 8) | TH_1467 | - | 1e-150 | 72.68% (366) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1324 | - | 1e-173 | 81.28% (374) | bifunctional RNase H/acid phosphatase |
| M. vanbaalenii PYR-1 | Mvan_3618 | - | 1e-142 | 69.38% (369) | bifunctional RNase H/acid phosphatase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2892|M.gilvum_PYR-GCK MKVIVECDGGSRGNPGPAGYGAVVWSADRESVLAEARSAIGTATNNVAEY
Mvan_3618|M.vanbaalenii_PYR-1 MRVVVEADGGSRGNPGPAGYGAVVVSADRVSVLAETSSAIGTATNNVAEY
TH_1467|M.thermoresistible__bu VKVIVEADGGSRGNPGPAGYGAVVYSADSGEVLAETKQSIGRATNNVAEY
MSMEG_4305|M.smegmatis_MC2_155 MKVLVEADGGSRGNPGPAGYGAVVYDADHATVLAERKEAIGRATNNVAEY
MAB_1905|M.abscessus_ATCC_1997 MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEY
Rv2228c|M.tuberculosis_H37Rv MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
Mb2253c|M.bovis_AF2122/97 MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
MMAR_3304|M.marinum_M MKVIIEADGGSRGNPGPAGYGAVVWTADRSTVLAESKQAIGRATNNVAEY
MUL_1324|M.ulcerans_Agy99 MKVIIEADGGSRGNPGPAGYGAVVWTADRSTVLAESKQAIGRATNNVAEY
MLBr_01637|M.leprae_Br4923 MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEY
MAV_2211|M.avium_104 MKVVIEADGGSRGNPGPAGYGAVVWTPDRGTVLAENKQAIGRATNNVAEY
::*::*.********* ******* .* ** * .:** ********
Mflv_2892|M.gilvum_PYR-GCK RGLIAGLESAAQTGATEVEVRMDSKLIVEQMAGRWRVKHPDLAALHRQAA
Mvan_3618|M.vanbaalenii_PYR-1 RGLIAGLEAAAELGATEVEVLMDSKLVVEQMSGRWRVRHPSLAPLHQQAR
TH_1467|M.thermoresistible__bu RGLIAGLEQAARVGATEVEVRMDSKLVVEQMAGRWRVKHPDLQPLSQQAK
MSMEG_4305|M.smegmatis_MC2_155 RGLIAGLEAAAETGATEVAVSMDSKLVIEQMCGRWRVKHPDLIELQRRAA
MAB_1905|M.abscessus_ATCC_1997 RGLIAGLAEAARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAV
Rv2228c|M.tuberculosis_H37Rv RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
Mb2253c|M.bovis_AF2122/97 RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
MMAR_3304|M.marinum_M RGLIAGLDDAVKLGATEVSVLMDSKLVVEQMCGRWKVKHPDLVELHGQAR
MUL_1324|M.ulcerans_Agy99 RGLIAGLDDAVKLGATEVSVLMDSKLVVEQMCGRWKVKHPDLVELHGQAR
MLBr_01637|M.leprae_Br4923 RALIAGLDDAVKMGATEAEVLMDSKLVVEQMSGRWKVKHPDLIELYVHAQ
MAV_2211|M.avium_104 RGLIAGLDDALKLGATEAEVYLDSKLLVEQMSGRWKVKHPDLIELHAQAR
*.***** * . ****. * :****::***.***:*:**.* * :*
Mflv_2892|M.gilvum_PYR-GCK DLARRFEHITYSWIPREQNSYADRLANEAMDAAAG---------------
Mvan_3618|M.vanbaalenii_PYR-1 DLERRFQRVSYRWVPRAQNSRADRLANEAMDAAGGGS-------------
TH_1467|M.thermoresistible__bu TLAARFGRVSYRWVPRAENSRADRLANEAMDAAAEGE-------------
MSMEG_4305|M.smegmatis_MC2_155 ALAAGFDHVDYTWIPRERNSHADRLANEAMDAAAGIA-------------
MAB_1905|M.abscessus_ATCC_1997 TAAMQFESVDYTWIPRERNKHADRLANEAMDRASGIE-------------
Rv2228c|M.tuberculosis_H37Rv ALASQFRRINYEWVPRARNTYADRLANDAMDAAAQS--------------
Mb2253c|M.bovis_AF2122/97 ALASQFRRINYEWVPRARNTYADRLANDAMDAAAQS--------------
MMAR_3304|M.marinum_M ELAGQFRRISYAWIPRARNAHADRLANEAMDAAVRTNRRGEP--------
MUL_1324|M.ulcerans_Agy99 ELAGQFRRISYAWIPRARNAHADQLANEAMDAAVRTNRRGEP--------
MLBr_01637|M.leprae_Br4923 TLASRLASVSYTWIPRTRNSRADRLANEAMDAASCAEGR-----------
MAV_2211|M.avium_104 GLAARFDRISYSWIPRERNSHADRLANEAMDAAAAATGTAEKPEPAEKPG
: : * *:** .* **:***:*** *
Mflv_2892|M.gilvum_PYR-GCK --EATP----------TEVVTNPAGWTGAKGAPTRLLLLRHGQTPLSVER
Mvan_3618|M.vanbaalenii_PYR-1 -MDAAGGGSMDAAGGGSEVVTNPAGWTGAKGAPTRLLLLRHGQTELSVQR
TH_1467|M.thermoresistible__bu -PEPGK------QAGNGGTGTNPAGWTGARGEPTRFLLLRHGQTELSRER
MSMEG_4305|M.smegmatis_MC2_155 -VPDKAS----ESDDPPAPAKNSVGWSGVTGAPTRLFLLRHGQTELSVDR
MAB_1905|M.abscessus_ATCC_1997 -PKKPKE---IAEIKETKPADTAPGWTGARGKPTRMLLLRHGQTELSVQR
Rv2228c|M.tuberculosis_H37Rv -----AAADADPAKIVATESPTSPGWTGARGTPTRLLLLRHGQTELSEQR
Mb2253c|M.bovis_AF2122/97 -----AAADADPAKIVATESPTSPGWTGARGTPTRLLLLRHGQTELSEQR
MMAR_3304|M.marinum_M -GTVAVAAVADPANTAPVQTPAAPGWTGRRDTATRLLLLRHGQTELSVQR
MUL_1324|M.ulcerans_Agy99 -GTVAVAAVADPANTAPVQTPAAPGWTGRRDTATRLLLLRHGQTELSVQR
MLBr_01637|M.leprae_Br4923 -VDQAATQLAQSTKAVAKESQTAPGWTGARGTPTRLLLLRHGQTELSVQR
MAV_2211|M.avium_104 RAEQSDPTAVDAGKTAAAPSPAAPGWTGARGTPTRLLLLRHGQTELSVQR
. **:* . .**::******* ** :*
Mflv_2892|M.gilvum_PYR-GCK RYSGRGNPELTELGSRQAGAAAKYLGDRGGIDAVIASPLQRAYDTAAAAA
Mvan_3618|M.vanbaalenii_PYR-1 RYSGRGNPELTELGIQQADAAARYLGQKGGIDAVISSPLQRAHDTAAAAS
TH_1467|M.thermoresistible__bu RYSGRGNPALTDLGRRQAEAAAQYLAARGGIDAVISSPLQRAYDTAAAAA
MSMEG_4305|M.smegmatis_MC2_155 RYSGRGNPALTEEGRRQADAAARYLGERGGISAVVTSPLQRAYDTAAAAA
MAB_1905|M.abscessus_ATCC_1997 RYSGRGNPELTELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAA
Rv2228c|M.tuberculosis_H37Rv RYSGRGNPGLNEVGWRQVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAA
Mb2253c|M.bovis_AF2122/97 RYSGRGNPGLNEVGWRQVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAA
MMAR_3304|M.marinum_M RYSGRGNPALNEVGWRQAGLAARYIAHRGGIAAVVSSPLQRAYDTATTAA
MUL_1324|M.ulcerans_Agy99 RYSGRGNPALNEVGWRQAGLAARYIAHRGGIAAVVSSPLQRAYDTATTAA
MLBr_01637|M.leprae_Br4923 RYSGRGNPALNNVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVA
MAV_2211|M.avium_104 RYSGRGNPALTETGRRQADAAARYLAARGGISAVFASPLQRAYDTAAVAA
******** *.: * .*. ** *:. :*** .*.:***.** :**...:
Mflv_2892|M.gilvum_PYR-GCK STLGRDVVVDDDLIETDFGAWEGLTFSEASQRDPELHRRWLKDTSVPPPG
Mvan_3618|M.vanbaalenii_PYR-1 KAMGLDVEVDDDLIETDFGAWEGLTFQEAAQRDPELHLRWLRDTSVPPPG
TH_1467|M.thermoresistible__bu KALGLDVTVDDDLIETDFGAWEGLTFADAAARDPELHRRWLRDTSVQPPG
MSMEG_4305|M.smegmatis_MC2_155 KALGLDVTVDDDLIETDFGAWEGLTFAEAAQRDPDVHRRWLRDTSVEPPG
MAB_1905|M.abscessus_ATCC_1997 GALGVPLTVDDDLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPE
Rv2228c|M.tuberculosis_H37Rv RALALDVVVDDDLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPG
Mb2253c|M.bovis_AF2122/97 RALALDVVVDDDLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPG
MMAR_3304|M.marinum_M RALGLDVTVDEDLVETDFGDWEGMTFAEAANRDPDLHHRWLNDTSITPPG
MUL_1324|M.ulcerans_Agy99 RALGLDVTVDEDLVETDFGDWEGMTFAEAANRDPDLHHRWLNDTSITPPG
MLBr_01637|M.leprae_Br4923 DLLGANLTVDDDLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPG
MAV_2211|M.avium_104 KALGLDVTVDDDLIETDFGAWEGLTFGEAAERDPGLHRRWLRDTSTAPPG
:. : **:**:* *** ***:** :*: *** :* ** **: **
Mflv_2892|M.gilvum_PYR-GCK GESFDAVATRVHRAQRRIVEEHAGQTVLIVSHVTPIKTLLRLALDAGPAM
Mvan_3618|M.vanbaalenii_PYR-1 GESFDAVAARVSRAQQRLIAKHPGQTLLLVSHVTPIKTLLRMALDAGPAI
TH_1467|M.thermoresistible__bu GESFDAVAQRVRRASDRIIAEHRASTVLVVSHVTPIKSVLRVALDAGAGL
MSMEG_4305|M.smegmatis_MC2_155 GESFDAVAHRVRRARNRIIAEHGASTVLVVSHVTPIKTILRLALDAGEGI
MAB_1905|M.abscessus_ATCC_1997 GESFDTVHHRVRRARNRIIAEYGGATVLVVSHVTPIKTLLRLALDAGPSV
Rv2228c|M.tuberculosis_H37Rv GESFDDVLRRVRRGRDRIIVGYEGATVLVVSHVTPIKMLLRLALDAGSGV
Mb2253c|M.bovis_AF2122/97 GESFDDVLRRVRRGRDRIIVGYEGATVLVVSHVTPIKMLLRLALDAGSGV
MMAR_3304|M.marinum_M GESFDEVLRRVRRGRDRMISRYEGTTVLVVSHVTPIKMLLRLALDVGSEV
MUL_1324|M.ulcerans_Agy99 GESFDEVLRRVRRGRDRMISRYEGTTVLVVSHVTPIKMLLRLALDVGSEV
MLBr_01637|M.leprae_Br4923 GESFDDVLGRVCSARARIIAEYQGETVLVVSHVTPIKMLLRLALDAGAGI
MAV_2211|M.avium_104 GESFDSVAERVSRVRQKIIAAQQGSTVLVVSHVTPIKMLLREALDAGPGI
***** * ** ::: . *:*:******** :** ***.* :
Mflv_2892|M.gilvum_PYR-GCK LYRLHLDLASLSIAEFYPDGAASVRLVNQTAYL--
Mvan_3618|M.vanbaalenii_PYR-1 LYRLHLDLASLSIAEFYPDGAASVRLVNQTTYL--
TH_1467|M.thermoresistible__bu LYRLHLDLASLSIAEFYPDGVASVRLVNQTDYLRG
MSMEG_4305|M.smegmatis_MC2_155 LYRLHLDLASLSIAEFYADGGSAVRLVNQTAYL--
MAB_1905|M.abscessus_ATCC_1997 LYRLHLDLASLSIAEFYSDGPASVRLVNETSYLT-
Rv2228c|M.tuberculosis_H37Rv LYRLHLDLASLSIAEFYADGASSVRLVNQTGYL--
Mb2253c|M.bovis_AF2122/97 LYRLHLDLASLSIAEFYADGASSVRLVNQTGYL--
MMAR_3304|M.marinum_M LYRLHLDLASLSIAEFYADGASSVRLVNQTGYL--
MUL_1324|M.ulcerans_Agy99 LYRLHLDLASLSIAEFYADGASSVRLVNQTGYL--
MLBr_01637|M.leprae_Br4923 LYRLHLDLGSLSIAEFYPDGASSVRLVNQTGYL--
MAV_2211|M.avium_104 LYRLHLDLASLSIAEFYSDGAASVRLVNQTGYL--
********.********.** ::*****:* **