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QLLLIRHALPLRSEPGQGSDPVLSEIGLQQAVRLPDALKRFPVTRVVSSPQRRAVQTGEPLAGALGLPVE IDERLAEYDRDMSHYVPIEQIAQENPAELARLAGGHLPSGVDEEEFAGRIGAAFDDLVAAGNHEDTVAVF SHGGVINVALHGILKTERLLSFHIDYASVTRVLASRSGRLSVASVNSTEHVWDLLPRNARW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6338 | - | - | 100% (202) | phosphoglycerate mutase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_4305 | - | 1e-08 | 29.85% (201) | bifunctional RNase H/acid phosphatase |
| M. smegmatis MC2 155 | MSMEG_4193 | - | 2e-06 | 29.09% (165) | phosphoglycerate mutase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2253c | - | 7e-09 | 30.85% (201) | bifunctional RNase H/acid phosphatase |
| M. gilvum PYR-GCK | Mflv_1203 | - | 1e-81 | 72.41% (203) | phosphoglycerate mutase |
| M. tuberculosis H37Rv | Rv2228c | - | 7e-09 | 30.85% (201) | bifunctional RNase H/acid phosphatase |
| M. leprae Br4923 | MLBr_01637 | - | 1e-07 | 27.45% (204) | bifunctional RNase H/acid phosphatase |
| M. abscessus ATCC 19977 | MAB_1905 | - | 2e-10 | 29.85% (201) | bifunctional RNase H/acid phosphatase |
| M. marinum M | MMAR_5305 | - | 4e-78 | 68.32% (202) | hypothetical protein MMAR_5305 |
| M. avium 104 | MAV_0314 | - | 1e-75 | 70.30% (202) | phosphoglycerate mutase family protein, putative |
| M. thermoresistible (build 8) | TH_1658 | - | 3e-81 | 70.85% (199) | phosphoglycerate mutase family protein, putative |
| M. ulcerans Agy99 | MUL_4380 | - | 6e-77 | 67.33% (202) | hypothetical protein MUL_4380 |
| M. vanbaalenii PYR-1 | Mvan_5604 | - | 6e-86 | 73.27% (202) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------------------
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MAV_0314|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
Rv2228c|M.tuberculosis_H37Rv MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
MLBr_01637|M.leprae_Br4923 MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEY
MAB_1905|M.abscessus_ATCC_1997 MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEY
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------------------
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MAV_0314|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
Rv2228c|M.tuberculosis_H37Rv RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
MLBr_01637|M.leprae_Br4923 RALIAGLDDAVKMGATEAEVLMDSKLVVEQMSGRWKVKHPDLIELYVHAQ
MAB_1905|M.abscessus_ATCC_1997 RGLIAGLAEAARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAV
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------------MRRGHV
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MAV_0314|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 ALASQFRRINYEWVPRARNTYADRLANDAMDAA-------AQSAAADADP
Rv2228c|M.tuberculosis_H37Rv ALASQFRRINYEWVPRARNTYADRLANDAMDAA-------AQSAAADADP
MLBr_01637|M.leprae_Br4923 TLASRLASVSYTWIPRTRNSRADRLANEAMDAASCAEGRVDQAATQLAQS
MAB_1905|M.abscessus_ATCC_1997 TAAMQFESVDYTWIPRERNKHADRLANEAMDRAS------GIEPKKPKEI
MSMEG_6338|M.smegmatis_MC2_155 ----------------------MQLLLIRH---ALPLRSEPGQGSDPVLS
TH_1658|M.thermoresistible__bu ----------------------VQLILVRH---ALPRRSEPGQGADPDLS
Mflv_1203|M.gilvum_PYR-GCK ----------------------MQLLLVRH---ALPLRSEPGQGSDPSLS
Mvan_5604|M.vanbaalenii_PYR-1 ----------------------MQLLLVRH---ALPLRSEPGQGSDPSLS
MMAR_5305|M.marinum_M RGWAERPRPRAAHHTNHRMGAHMQMLLVRH---ALPLRSEHGEGSDPVLS
MUL_4380|M.ulcerans_Agy99 ----------------------MQMLLVRH---ALPLRSEHGEGSDPVLS
MAV_0314|M.avium_104 ----------------------MQVLLVRH---ALPLRSEHGQGSDPDLS
Mb2253c|M.bovis_AF2122/97 AKIVATE-SPTSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLN
Rv2228c|M.tuberculosis_H37Rv AKIVATE-SPTSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLN
MLBr_01637|M.leprae_Br4923 TKAVAKE-SQTAPGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALN
MAB_1905|M.abscessus_ATCC_1997 AEIKETKPADTAPGWTGARGKPTRMLLLRHGQTELSVQRRYSGRGNPELT
:::*:** *. : . . .:* *.
MSMEG_6338|M.smegmatis_MC2_155 EIGLQQAVRLPDALKRFP-VTRVVSSPQRRAVQTGEPLAGALGLPVEIDE
TH_1658|M.thermoresistible__bu EVGLEQARRLPAALERFP-IARVISSPQRRAVQTAEPVADALGLPVHIDE
Mflv_1203|M.gilvum_PYR-GCK PEGVEQARRLPDALARFP-ITRLVSSPQVRAIETGQPVADKLGLTIEVDD
Mvan_5604|M.vanbaalenii_PYR-1 AEGLEQAKRLPDALARFP-ITRLVSSPQVRAIETGQPVADALGLPIEVDD
MMAR_5305|M.marinum_M DTGVAQVSRLPEALSRFP-ITRVISSPQRRAVQTAEPVATARGLAIDIDD
MUL_4380|M.ulcerans_Agy99 DTGVAQVSRLPEALSRFP-ITRVISSPQRRAVQTAESVATARGLAIDIDD
MAV_0314|M.avium_104 ADGLAQIERLPKALERFP-ISRVVSSPQRRAVQTAAPVAADRGLSVEIDD
Mb2253c|M.bovis_AF2122/97 EVGWRQVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDD
Rv2228c|M.tuberculosis_H37Rv EVGWRQVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDD
MLBr_01637|M.leprae_Br4923 NVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADLLGANLTVDD
MAB_1905|M.abscessus_ATCC_1997 ELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPLTVDD
* * . : :: ::*** ** :*. . * . : :*:
MSMEG_6338|M.smegmatis_MC2_155 RLAEYDRDMSHYVPIEQIAQENPAELARLAGG---HLPSGVDEEEFAGRI
TH_1658|M.thermoresistible__bu RFAEYDRGLAHYVPIEEVARENPEQLERLLNG---ELPGAVDPDEFQDRV
Mflv_1203|M.gilvum_PYR-GCK RLAEYDRDLPHYIPIEQIAKENPEELQRLVDG---HLPSSVDETQFLARI
Mvan_5604|M.vanbaalenii_PYR-1 RLAEYDRDLAHYIPIEQIAAERPEELQRLIDG---HLPSAVDEAAFLARV
MMAR_5305|M.marinum_M RFAEYDRDLPHYIPVEQIRTENPQEWARMAQG---KLPSAVDEDAFRARV
MUL_4380|M.ulcerans_Agy99 RFAEYDRDLPHYIPVEQIRTEKPQEWARMAQG---KLPSAVDEDAFRARV
MAV_0314|M.avium_104 RFAEYDRDLPVYIPVEQIRDEMPEEWARLAQG---HLPSAVDEDAFRARV
Mb2253c|M.bovis_AF2122/97 DLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRV
Rv2228c|M.tuberculosis_H37Rv DLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRV
MLBr_01637|M.leprae_Br4923 DLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGRV
MAB_1905|M.abscessus_ATCC_1997 DLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRV
: * * . :.. : . * . * . . . *:
MSMEG_6338|M.smegmatis_MC2_155 GAAFDDLVAAGNHEDTVAVFSHGGVINVALHGILKTER--LLSFHIDYAS
TH_1658|M.thermoresistible__bu AAALDEVVATSAHTDTVAVFSHGGVINAILHRIARTER--LITFHIDYAS
Mflv_1203|M.gilvum_PYR-GCK SAGIDDLVASADRDDTVVVFSHGGVINVLLHQILGTER--LLSFHVDYAS
Mvan_5604|M.vanbaalenii_PYR-1 TAGIEDLVTGAGHDDTVAVFSHGGVINVLLHHVLRTER--LLSFHVDYAS
MMAR_5305|M.marinum_M RAVVDDVVSAAGSDDTVAVFSHGGLINVVLHEILGTAR--LLSFPIDYAS
MUL_4380|M.ulcerans_Agy99 RAVVDDVVSAAGSDDTVAVFSHGGVINVVLHEILGTAR--LLSFPIDYAS
MAV_0314|M.avium_104 RAAVDDLVAAAEPEDTVAVFSHGGVINVLLHEILGTAR--LLSFPVDYAS
Mb2253c|M.bovis_AF2122/97 RRGRDRIIVGYEG-ATVLVVSHVTPIKMLLRLALDAGSGVLYRLHLDLAS
Rv2228c|M.tuberculosis_H37Rv RRGRDRIIVGYEG-ATVLVVSHVTPIKMLLRLALDAGSGVLYRLHLDLAS
MLBr_01637|M.leprae_Br4923 CSARARIIAEYQG-ETVLVVSHVTPIKMLLRLALDAGAGILYRLHLDLGS
MAB_1905|M.abscessus_ATCC_1997 RRARNRIIAEYGG-ATVLVVSHVTPIKTLLRLALDAGPSVLYRLHLDLAS
:: ** *.** *: *: : * : :* .*
MSMEG_6338|M.smegmatis_MC2_155 VTRVLASRSG-RLSVASVNSTEHVWDLLPRN--ARW--------------
TH_1658|M.thermoresistible__bu VTRVLASRSG-RLSIGGINTVEHVWDLLPRNRDGRLQGTAAVSDNKEVID
Mflv_1203|M.gilvum_PYR-GCK VTRLLWSASRERLAVACVNGTEHVWDLLPRN--HRW--------------
Mvan_5604|M.vanbaalenii_PYR-1 VTRLLSSRTG-RLAVAGVNGTEHVWDLLPRN--QRW--------------
MMAR_5305|M.marinum_M VTRLLFSRTG-QATVATVNSTEHVWDLLPRN--QRW--------------
MUL_4380|M.ulcerans_Agy99 ITRLLFSRTG-QATVATVNSTEHVWDLLPRN--QRW--------------
MAV_0314|M.avium_104 VTRLLFSRSG-QATVAAVNTTEHVWDLLPRI--QRW--------------
Mb2253c|M.bovis_AF2122/97 LSIAEFYADG-ASSVRLVNQTGYL--------------------------
Rv2228c|M.tuberculosis_H37Rv LSIAEFYADG-ASSVRLVNQTGYL--------------------------
MLBr_01637|M.leprae_Br4923 LSIAEFYPDG-ASSVRLVNQTGYL--------------------------
MAB_1905|M.abscessus_ATCC_1997 LSIAEFYSDG-PASVRLVNETSYLT-------------------------
:: :: :* . ::
MSMEG_6338|M.smegmatis_MC2_155 ---------
TH_1658|M.thermoresistible__bu NGRDLPRRT
Mflv_1203|M.gilvum_PYR-GCK ---------
Mvan_5604|M.vanbaalenii_PYR-1 ---------
MMAR_5305|M.marinum_M ---------
MUL_4380|M.ulcerans_Agy99 ---------
MAV_0314|M.avium_104 ---------
Mb2253c|M.bovis_AF2122/97 ---------
Rv2228c|M.tuberculosis_H37Rv ---------
MLBr_01637|M.leprae_Br4923 ---------
MAB_1905|M.abscessus_ATCC_1997 ---------