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VQLLLVRHALPLRSEPGQGSDPSLSPEGVEQARRLPDALARFPITRLVSSPQVRAIETGQPVADKLGLTI EVDDRLAEYDRDLPHYIPIEQIAKENPEELQRLVDGHLPSSVDETQFLARISAGIDDLVASADRDDTVVV FSHGGVINVLLHQILGTERLLSFHVDYASVTRLLWSASRERLAVACVNGTEHVWDLLPRNHRW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1203 | - | - | 100% (203) | phosphoglycerate mutase |
| M. gilvum PYR-GCK | Mflv_3044 | - | 2e-08 | 29.17% (192) | phosphoglycerate mutase |
| M. gilvum PYR-GCK | Mflv_2892 | - | 1e-06 | 30.17% (179) | bifunctional RNase H/acid phosphatase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2253c | - | 7e-09 | 32.40% (179) | bifunctional RNase H/acid phosphatase |
| M. tuberculosis H37Rv | Rv2228c | - | 7e-09 | 32.40% (179) | bifunctional RNase H/acid phosphatase |
| M. leprae Br4923 | MLBr_01298 | - | 3e-08 | 32.89% (149) | hypothetical protein MLBr_01298 |
| M. abscessus ATCC 19977 | MAB_1905 | - | 1e-07 | 30.73% (179) | bifunctional RNase H/acid phosphatase |
| M. marinum M | MMAR_5305 | - | 6e-76 | 67.00% (203) | hypothetical protein MMAR_5305 |
| M. avium 104 | MAV_0314 | - | 1e-75 | 69.46% (203) | phosphoglycerate mutase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6338 | - | 2e-81 | 72.41% (203) | phosphoglycerate mutase family protein, putative |
| M. thermoresistible (build 8) | TH_1658 | - | 2e-72 | 63.00% (200) | phosphoglycerate mutase family protein, putative |
| M. ulcerans Agy99 | MUL_4380 | - | 1e-74 | 66.01% (203) | hypothetical protein MUL_4380 |
| M. vanbaalenii PYR-1 | Mvan_5604 | - | 2e-94 | 85.22% (203) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2253c|M.bovis_AF2122/97 MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
Rv2228c|M.tuberculosis_H37Rv MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
MAB_1905|M.abscessus_ATCC_1997 MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEY
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------------------
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MAV_0314|M.avium_104 --------------------------------------------------
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
MLBr_01298|M.leprae_Br4923 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
Rv2228c|M.tuberculosis_H37Rv RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
MAB_1905|M.abscessus_ATCC_1997 RGLIAGLAEAARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAV
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------------------
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MAV_0314|M.avium_104 --------------------------------------------------
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
MLBr_01298|M.leprae_Br4923 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 ALASQFRRINYEWVPRARNTYADRLANDAMD-AAAQSAAADADPAKIVAT
Rv2228c|M.tuberculosis_H37Rv ALASQFRRINYEWVPRARNTYADRLANDAMD-AAAQSAAADADPAKIVAT
MAB_1905|M.abscessus_ATCC_1997 TAAMQFESVDYTWIPRERNKHADRLANEAMDRASGIEPKKPKEIAEIKET
Mflv_1203|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5305|M.marinum_M --------------------------------------MRRGHVRGWAER
MUL_4380|M.ulcerans_Agy99 --------------------------------------------------
MAV_0314|M.avium_104 --------------------------------------------------
MSMEG_6338|M.smegmatis_MC2_155 --------------------------------------------------
TH_1658|M.thermoresistible__bu --------------------------------------------------
MLBr_01298|M.leprae_Br4923 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 ESP-TSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGN-PGLNEVGWR
Rv2228c|M.tuberculosis_H37Rv ESP-TSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGN-PGLNEVGWR
MAB_1905|M.abscessus_ATCC_1997 KPADTAPGWTGARGKPTRMLLLRHGQTELSVQRRYSGRGN-PELTELGRE
Mflv_1203|M.gilvum_PYR-GCK ----------------MQLLLVRH---ALPLRSEPGQGSD-PSLSPEGVE
Mvan_5604|M.vanbaalenii_PYR-1 ----------------MQLLLVRH---ALPLRSEPGQGSD-PSLSAEGLE
MMAR_5305|M.marinum_M PRPRAAHHTNHRMGAHMQMLLVRH---ALPLRSEHGEGSD-PVLSDTGVA
MUL_4380|M.ulcerans_Agy99 ----------------MQMLLVRH---ALPLRSEHGEGSD-PVLSDTGVA
MAV_0314|M.avium_104 ----------------MQVLLVRH---ALPLRSEHGQGSD-PDLSADGLA
MSMEG_6338|M.smegmatis_MC2_155 ----------------MQLLLIRH---ALPLRSEPGQGSD-PVLSEIGLQ
TH_1658|M.thermoresistible__bu ----------------VQLILVRH---ALPRRSEPGQGAD-PDLSEVGLE
MLBr_01298|M.leprae_Br4923 ----------------MTVILLRHGRSTSNTAGVLAGRADGVDLDDRGRE
::*:** . .: * *
Mb2253c|M.bovis_AF2122/97 QVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDDDLVET
Rv2228c|M.tuberculosis_H37Rv QVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDDDLVET
MAB_1905|M.abscessus_ATCC_1997 QAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPLTVDDDLIET
Mflv_1203|M.gilvum_PYR-GCK QARRLPDALARFP-ITRLVSSPQVRAIETGQPVADKLGLTIEVDDRLAEY
Mvan_5604|M.vanbaalenii_PYR-1 QAKRLPDALARFP-ITRLVSSPQVRAIETGQPVADALGLPIEVDDRLAEY
MMAR_5305|M.marinum_M QVSRLPEALSRFP-ITRVISSPQRRAVQTAEPVATARGLAIDIDDRFAEY
MUL_4380|M.ulcerans_Agy99 QVSRLPEALSRFP-ITRVISSPQRRAVQTAESVATARGLAIDIDDRFAEY
MAV_0314|M.avium_104 QIERLPKALERFP-ISRVVSSPQRRAVQTAAPVAADRGLSVEIDDRFAEY
MSMEG_6338|M.smegmatis_MC2_155 QAVRLPDALKRFP-VTRVVSSPQRRAVQTGEPLAGALGLPVEIDERLAEY
TH_1658|M.thermoresistible__bu QARRLPAALERFP-IARVISSPQRRAVQTAEPVADALGLPVHIDERFAEY
MLBr_01298|M.leprae_Br4923 QAVGLIDRIAELP-IRAVVCSPLLRCRRTINPLAETLCLEPFIDDRLSEV
* : : ::.** *. * . * : :*: : *
Mb2253c|M.bovis_AF2122/97 DFGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRVRRGR-
Rv2228c|M.tuberculosis_H37Rv DFGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRVRRGR-
MAB_1905|M.abscessus_ATCC_1997 DFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRVRRAR-
Mflv_1203|M.gilvum_PYR-GCK DRDLPHYIPIEQIAKENPEELQRLVDG---HLPSSVDETQFLARISAGI-
Mvan_5604|M.vanbaalenii_PYR-1 DRDLAHYIPIEQIAAERPEELQRLIDG---HLPSAVDEAAFLARVTAGI-
MMAR_5305|M.marinum_M DRDLPHYIPVEQIRTENPQEWARMAQG---KLPSAVDEDAFRARVRAVV-
MUL_4380|M.ulcerans_Agy99 DRDLPHYIPVEQIRTEKPQEWARMAQG---KLPSAVDEDAFRARVRAVV-
MAV_0314|M.avium_104 DRDLPVYIPVEQIRDEMPEEWARLAQG---HLPSAVDEDAFRARVRAAV-
MSMEG_6338|M.smegmatis_MC2_155 DRDMSHYVPIEQIAQENPAELARLAGG---HLPSGVDEEEFAGRIGAAF-
TH_1658|M.thermoresistible__bu DRGLAHYVPIEEVARENPEQLERLLNG---ELPGAVDPDEFQDRVAAAL-
MLBr_01298|M.leprae_Br4923 DYGEWTGRSIGDLAKEPLWQVVQAHPS-AAVFPSGEGLAQVQVRAVAAIR
* . .. : . : . * . . . *
Mb2253c|M.bovis_AF2122/97 ---DRIIVGYEG-ATVLVVSHVTPIKMLLRLALDAGSGVLYRLHLDLASL
Rv2228c|M.tuberculosis_H37Rv ---DRIIVGYEG-ATVLVVSHVTPIKMLLRLALDAGSGVLYRLHLDLASL
MAB_1905|M.abscessus_ATCC_1997 ---NRIIAEYGG-ATVLVVSHVTPIKTLLRLALDAGPSVLYRLHLDLASL
Mflv_1203|M.gilvum_PYR-GCK ---DDLVASADRDDTVVVFSHGGVINVLLHQILGTER--LLSFHVDYASV
Mvan_5604|M.vanbaalenii_PYR-1 ---EDLVTGAGHDDTVAVFSHGGVINVLLHHVLRTER--LLSFHVDYASV
MMAR_5305|M.marinum_M ---DDVVSAAGSDDTVAVFSHGGLINVVLHEILGTAR--LLSFPIDYASV
MUL_4380|M.ulcerans_Agy99 ---DDVVSAAGSDDTVAVFSHGGVINVVLHEILGTAR--LLSFPIDYASI
MAV_0314|M.avium_104 ---DDLVAAAEPEDTVAVFSHGGVINVLLHEILGTAR--LLSFPVDYASV
MSMEG_6338|M.smegmatis_MC2_155 ---DDLVAAGNHEDTVAVFSHGGVINVALHGILKTER--LLSFHIDYASV
TH_1658|M.thermoresistible__bu ---DEVVATSAHTDTVAVFSHGGVINAILHRIARTER--LITFHIDYASV
MLBr_01298|M.leprae_Br4923 EYDRRFTSEHGGDTLWVACTHGDVIKAVIADAFGMHLDSFQRVIADPGSV
. . :* *: : : . * .*:
Mb2253c|M.bovis_AF2122/97 SIAEFYADG-ASSVRLVNQTGYL---------------------------
Rv2228c|M.tuberculosis_H37Rv SIAEFYADG-ASSVRLVNQTGYL---------------------------
MAB_1905|M.abscessus_ATCC_1997 SIAEFYSDG-PASVRLVNETSYLT--------------------------
Mflv_1203|M.gilvum_PYR-GCK TRLLWSASRERLAVACVNGTEHVWDLLPRNH--RW---------------
Mvan_5604|M.vanbaalenii_PYR-1 TRLLSSRTG-RLAVAGVNGTEHVWDLLPRNQ--RW---------------
MMAR_5305|M.marinum_M TRLLFSRTG-QATVATVNSTEHVWDLLPRNQ--RW---------------
MUL_4380|M.ulcerans_Agy99 TRLLFSRTG-QATVATVNSTEHVWDLLPRNQ--RW---------------
MAV_0314|M.avium_104 TRLLFSRSG-QATVAAVNTTEHVWDLLPRIQ--RW---------------
MSMEG_6338|M.smegmatis_MC2_155 TRVLASRSG-RLSVASVNSTEHVWDLLPRNA--RW---------------
TH_1658|M.thermoresistible__bu TRVLASRSG-RLSIGGINTVEHVWDLLPRNRDGRLQGTAAVSDNKEVIDN
MLBr_01298|M.leprae_Br4923 SVIRYTQLR--PFVLHVNHTGAQLSSALRAAMKPSGESHSDSCGERSGEI
: : :* .
Mb2253c|M.bovis_AF2122/97 --------------------
Rv2228c|M.tuberculosis_H37Rv --------------------
MAB_1905|M.abscessus_ATCC_1997 --------------------
Mflv_1203|M.gilvum_PYR-GCK --------------------
Mvan_5604|M.vanbaalenii_PYR-1 --------------------
MMAR_5305|M.marinum_M --------------------
MUL_4380|M.ulcerans_Agy99 --------------------
MAV_0314|M.avium_104 --------------------
MSMEG_6338|M.smegmatis_MC2_155 --------------------
TH_1658|M.thermoresistible__bu GRDLPRRT------------
MLBr_01298|M.leprae_Br4923 RNEPDAAVPSGDAVLGGSAD