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MQVTGWVPHLRLARGAMVLAATAALALAGCSTTVAGTALPAANLGHAPTTTTRAAPRIVAAAALEGALLT QQQVVALVGGTNMSLVGAITGTADGSKVVDDPTCLRLASIGDTSVYANSGWVAMRGNQMTSPNVVQADVT QLLTSFPVAADAAALLQRARQDWQGCANRRYGFHSSNGNHSYFNTGPVIASGSRIEVLLRQQEDPRWTCS HAMALQDSVLAEARVCLMSKNTTSALENLIDQVISRIPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4151 | - | - | 100% (249) | lipoprotein |
| M. ulcerans Agy99 | MUL_4150 | lppH | 2e-19 | 26.01% (223) | lipoprotein LppH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3607 | lppH | 2e-19 | 27.73% (238) | lipoprotein LppH |
| M. gilvum PYR-GCK | Mflv_2235 | - | 2e-15 | 25.85% (205) | putative lipoprotein LppH |
| M. tuberculosis H37Rv | Rv3576 | lppH | 2e-19 | 27.73% (238) | lipoprotein LppH |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5075 | - | 1e-138 | 99.20% (249) | lipoprotein |
| M. avium 104 | MAV_1417 | - | 5e-12 | 25.89% (197) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_4554 | - | 2e-15 | 26.29% (232) | serine/threonine-protein kinase PknH, putative |
| M. thermoresistible (build 8) | TH_3756 | - | 4e-20 | 27.72% (202) | PUTATIVE putative conserved lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_4738 | - | 7e-19 | 27.17% (254) | putative lipoprotein LppH |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4151|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5075|M.marinum_M --------------------------------------------------
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4151|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5075|M.marinum_M --------------------------------------------------
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4151|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5075|M.marinum_M --------------------------------------------------
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4151|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5075|M.marinum_M --------------------------------------------------
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4151|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5075|M.marinum_M --------------------------------------------------
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK ----------------------------------MRRAVAIAGIAIMVTG
TH_3756|M.thermoresistible__bu -------------------------------------------MGVLVAG
Mvan_4738|M.vanbaalenii_PYR-1 -------------------------------MREHTAALTVAATCVLVAA
Mb3607|M.bovis_AF2122/97 ------------------------------MGKQLAALAALVGACMLAAG
Rv3576|M.tuberculosis_H37Rv ------------------------------MGKQLAALAALVGACMLAAG
MUL_4151|M.ulcerans_Agy99 ---------------------MQVTGWVPHLRLARGAMVLAATAALALAG
MMAR_5075|M.marinum_M ---------------------MQVTGWVPHLRLARGAMALAATAALALAG
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
MSMEG_4554|M.smegmatis_MC2_155 -------------------------MTPGRRWTRLCTAGAAAAVMCLLSG
:.
Mflv_2235|M.gilvum_PYR-GCK CASTS-------------SAESAEPP--TRTMIPR---------------
TH_3756|M.thermoresistible__bu CGSTG-------------HAESTTAPSTTKTLIPR---------------
Mvan_4738|M.vanbaalenii_PYR-1 CGGGGNEGATSTTPSTLLSPTTSAPAPPTTSTPPP---------------
Mb3607|M.bovis_AF2122/97 CTNVVDG--------------TAVAADKSGPLHQD---------------
Rv3576|M.tuberculosis_H37Rv CTNVVDG--------------TAVAADKSGPLHQD---------------
MUL_4151|M.ulcerans_Agy99 CSTTVAG-------TALPAANLGHAPTTTTRAAPR---------------
MMAR_5075|M.marinum_M CSTTVAG-------TALPAANLGHAPTTTTRAAPR---------------
MAV_1417|M.avium_104 QRDAGASTVLAPPPAVNTRQPGSAASQAGRGWTPESGPIPAAGQPGPPYY
MSMEG_4554|M.smegmatis_MC2_155 CVTVVGG----------------TATRDPAAPPPG---------------
..
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4151|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5075|M.marinum_M --------------------------------------------------
MAV_1417|M.avium_104 QGGNANWAAAPAQFAGPPPWGRPPPKRRVWPIVAAVVAVLVVIAGGVGVW
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK -------------PLVEREIGEVLLSPEEIAALMGVPAMTVIEAQTSLSD
TH_3756|M.thermoresistible__bu -------------PLVERELPGLLLSPEQVNAAMGTTDMAIISSQTSLSD
Mvan_4738|M.vanbaalenii_PYR-1 -------------PVAESALDGLLLSPAEIDTVVGATGMAVAGTSTSLAE
Mb3607|M.bovis_AF2122/97 -------------PIPVSALEGLLLDLSQINAALGATSMKVWFNAKAMWD
Rv3576|M.tuberculosis_H37Rv -------------PIPVSALEGLLLDLSQINAALGATSMKVWFNAKAMWD
MUL_4151|M.ulcerans_Agy99 -------------IVAAAALEGALLTQQQVVALVGGTNMSLVGAITGTAD
MMAR_5075|M.marinum_M -------------IVAAAALEGALLTQQQVVALVGGTNMSLVGAITGTAD
MAV_1417|M.avium_104 LVIRPKPEPPQAAPLTSDRLGALLLSASEVNAVMGSSTMEPGKPITATDS
MSMEG_4554|M.smegmatis_MC2_155 ------------AAVTEVDLDNLLLPVTELGDIVGSDDLTVTVELDQFND
: : ** :: :* : .
Mflv_2235|M.gilvum_PYR-GCK HSDI-----MAPIE---CLAIDGAGELQVYANSDYRASRDQSLN----DG
TH_3756|M.thermoresistible__bu HSNT-----MAPPE---CLALDGAGEADVYADSGYRAARDHSLN----NG
Mvan_4738|M.vanbaalenii_PYR-1 DITVP---PDAPEEKKACVGIAGTAEAQAYAGSGSTAVRDQALRA--PND
Mb3607|M.bovis_AF2122/97 WSKS-----VADKN---CLAIDGPAQEKVYAGTGWTAMRGQRLDDSINDS
Rv3576|M.tuberculosis_H37Rv WSKS-----VADKN---CLAIDGPAQEKVYAGTGWTAMRGQRLDDSIDDS
MUL_4151|M.ulcerans_Agy99 GSKVVDDPT--------CLRLASIGDTSVYANSGWVAMRGNQMT----SP
MMAR_5075|M.marinum_M GSKVVDDPT--------CLGLASIGDTSVYANSGWVAMRGNQMT----SP
MAV_1417|M.avium_104 SSVT--------VSVPDCQGALYTTQDPVYAGSGYSAVNGLVSSE---PG
MSMEG_4554|M.smegmatis_MC2_155 SSAAMDD--------PDCLAAAFGAQERVYAGTGWTAVRDQIVRE---PG
* : .**.:. * ..
Mflv_2235|M.gilvum_PYR-GCK EGWKTYVKQAVVLFPYLEKAGEFFDASVAQWPACR-----EYTHTQSGSV
TH_3756|M.thermoresistible__bu DNFTHYAKQAVVLFPLAETARAFFEASAEQWPACH-----EYRHTQSGTK
Mvan_4738|M.vanbaalenii_PYR-1 SGATLSAGQAVVLFPTADEAATFFAESAQKWPLCR-----GYN--AGGSP
Mb3607|M.bovis_AF2122/97 KKRDHYAIQAVVGFPTAHDAEEFYSSSVQSWSSCSNRRFVEVTPGQDDAA
Rv3576|M.tuberculosis_H37Rv KKRDHYAIQAVVGFPTAHDAEEFYSSSVQSWSSCSNRRFVEVTPGQDDAA
MUL_4151|M.ulcerans_Agy99 NVVQADVTQLLTSFPVAADAAALLQRARQDWQGCANRRYGFHSSNGNHSY
MMAR_5075|M.marinum_M NVVQADVTQLLTSFPVAADAAALLQRARQDWQGCANRRYGFHSSNGNHSY
MAV_1417|M.avium_104 DNYDHWVNQAVVLFPSADKAKSFLQTSLQKWKGCAG-QTVTVTNKSKTYR
MSMEG_4554|M.smegmatis_MC2_155 SFSPHWIEQVVVLFTSDLHARDFFDQSRETWRGCVG-TLTTYDIDQMPLE
. * :. *. * : : * *
Mflv_2235|M.gilvum_PYR-GCK WNPGEITSADRTLSTVAMQRDAAAPGWGCGRALVHRNNVIVDVNTCS-AA
TH_3756|M.thermoresistible__bu WYVAELTRDGDILKAITVQRDAGHPGWGCGRALVLRNNIIGDVNTCS-AD
Mvan_4738|M.vanbaalenii_PYR-1 VTVGDVSSDNGMLVTSITIQSEDEPTL-CERALTMKNNIVIDVSTCG-GS
Mb3607|M.bovis_AF2122/97 WTVADVVNDNGMLSSSQVQEGGD--GWTCQRALTARNNVTIDIVTCAYSQ
Rv3576|M.tuberculosis_H37Rv WTVADVVNDNGMLSSSQVQEGGD--GWTCQRALTARNNVTIDIVTCAYSQ
MUL_4151|M.ulcerans_Agy99 FNTGPVIASGSRIEVLLRQQEDP--RWTCSHAMALQDSVLAEARVCLMSK
MMAR_5075|M.marinum_M FNTGPVIASGSRIEVLLRQQEDP--RWTCSHAMALQDSVLAEARVCLMSK
MAV_1417|M.avium_104 WTFAQVQGAPPKITLMDTQEGAD--GWECQRALSVANNVIVDINACG--Y
MSMEG_4554|M.smegmatis_MC2_155 WVVGEVTAEESTISQLSVPETAVR--GGCHHALSVAANLVAEAWACG--E
. : : . * :*: .: : .*
Mflv_2235|M.gilvum_PYR-GCK PGDSAVR-IAHQIADKVDAQW
TH_3756|M.thermoresistible__bu PGDSAVR-IAQQIGENVDAVW
Mvan_4738|M.vanbaalenii_PYR-1 S-DSAVR-IADQIAARVPGE-
Mb3607|M.bovis_AF2122/97 PDLVAIG-IANQIAAKVAKQ-
Rv3576|M.tuberculosis_H37Rv PDLVAIG-IANQIAAKVAKQ-
MUL_4151|M.ulcerans_Agy99 NTTSALENLIDQVISRIPQ--
MMAR_5075|M.marinum_M NTTSALENLIDQVISRIPQ--
MAV_1417|M.avium_104 RITDQGDQIADKIVAKIDNE-
MSMEG_4554|M.smegmatis_MC2_155 GVEDQASEIVDQIVANIE---
: .:: .: