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VSRILMTLVSVVALGMTGAGYWVAHGALTGITISQALTAEDPRSTGNNMNILLIGLDSRKDQEGNDLPWS ILKHLHAGDSDQGGYNTNTLILVHVSADGKVVAFSIPRDDWVPFTGVPGYNHIKIKEAYGLTKQYVAQEL IDQGVTSQRELETRGREAGRAATLRAVRALTGVPIDYFAEVNLAGFYDLAQALGGVEVCLNHAVDDSYSG ADFPAGRQRLDAAQALAFVRQRHGLDNGDLDRTHRQQVFLSSVMRDLQDSGTFTNLDRLDSLMAVARKDL VLSGGWDEDLVRRMGELAGADIEFRTLPVVRYDNIDGQDVNIVDPAAIKAEVAAAIGSTSTAATATTTPA KPSPSTVVDVVNAGSISGLASQVSNALRKRGYTTDQVRDRKSGDPAATTIKYGPGAQADAMNLGTLLGID APKQPDASIEPGHIQVTVDTNFSMPAPDDSDDDTTVYPKPNAYYNGGDDSSSYPAPDHGQPIDGGGVPCV N
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4040 | cpsA | - | 100% (491) | membrane protein CpsA |
| M. ulcerans Agy99 | MUL_2613 | - | 1e-63 | 36.62% (456) | hypothetical protein MUL_2613 |
| M. ulcerans Agy99 | MUL_5013 | - | 2e-23 | 26.70% (352) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3514 | cpsA | 0.0 | 79.44% (496) | hypothetical protein Mb3514 |
| M. gilvum PYR-GCK | Mflv_4737 | - | 8e-62 | 34.22% (453) | cell envelope-related transcriptional attenuator |
| M. tuberculosis H37Rv | Rv3484 | cpsA | 0.0 | 79.44% (496) | hypothetical protein Rv3484 |
| M. leprae Br4923 | MLBr_02247 | cpsA | 0.0 | 72.43% (497) | hypothetical protein MLBr_02247 |
| M. abscessus ATCC 19977 | MAB_0560 | - | 1e-152 | 57.20% (493) | hypothetical protein MAB_0560 |
| M. marinum M | MMAR_4966 | cpsA | 0.0 | 98.98% (491) | membrane protein CpsA |
| M. avium 104 | MAV_0673 | - | 0.0 | 75.90% (498) | cell envelope-related function transcriptional attenuator |
| M. smegmatis MC2 155 | MSMEG_0107 | - | 4e-84 | 38.18% (516) | cell envelope-related function transcriptional attenuator |
| M. thermoresistible (build 8) | TH_3471 | - | 1e-62 | 33.94% (495) | PUTATIVE cell envelope-related transcriptional attenuator |
| M. vanbaalenii PYR-1 | Mvan_1726 | - | 8e-63 | 34.33% (501) | cell envelope-related transcriptional attenuator |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4040|M.ulcerans_Agy99 ----------------------------MSRILMTLVSVVALGMTGAGYW
MMAR_4966|M.marinum_M -MGRT---KARHRAVRKPSP----IRRRVSRTLMTLVSVVALGMTGAGYW
Mb3514|M.bovis_AF2122/97 -MARSEGNRPRHRAVPQPSR----IRKRLSRGVMTLVSVVALLMTGAGYW
Rv3484|M.tuberculosis_H37Rv -MARSEGNRPRHRAVPQPSR----IRKRLSRGVMTLVSVVALLMTGAGYW
MAV_0673|M.avium_104 MMARSGGAHRRHRAVRQPSR----FRKGLTRTLGALVSVAAIGLTGAGYY
MLBr_02247|M.leprae_Br4923 -MARSHNPRHRHRAIHKPSR----IRIALTRSFMTLTSFVAVLLTGAGYW
MAB_0560|M.abscessus_ATCC_1997 -MSRDTGRRRPKHALPKSNKRWSVSKTAAARTIFALLACGSLVVTGAGWQ
MSMEG_0107|M.smegmatis_MC2_155 --MNSPAHALTKPRRRTPRR----AVRLARRALVGLTAAAILAGTGMGWV
Mflv_4737|M.gilvum_PYR-GCK -----------------------MPAAHMLRAVSVALAVAIVIGTGVAWG
Mvan_1726|M.vanbaalenii_PYR-1 -----------------------MPAAHLVRAISVAMAVVVVLGTGIAWG
TH_3471|M.thermoresistible__bu ------------------------VPARLIRALAVATAVVIVLSTGVAWS
* . : : ** .:
MUL_4040|M.ulcerans_Agy99 VAHGALTGITISQALTAEDPRSTGNNMNILLIGLDSRKDQEGNDLPWSIL
MMAR_4966|M.marinum_M VAHGALTGITISQALTAEDPRSTGNNMNILLIGLDSRKDQEGNDLPWSIL
Mb3514|M.bovis_AF2122/97 VAHGALGGITISQALTPEDPRSSGNNMNILLIGLDSRKDQEGNDLPWSVL
Rv3484|M.tuberculosis_H37Rv VAHGALGGITISQALTPEDPRSSGNNMNILLIGLDSRKDQEGNDLPWSVL
MAV_0673|M.avium_104 VAHGALGGITVSNALQPDDPRSSGDNMNILLIGLDSRKDQDGNDLPYSIL
MLBr_02247|M.leprae_Br4923 VAHRALEDITVSQALTTDDPRSTDNNINILLIGLDSRKDQQGNDLPWSIL
MAB_0560|M.abscessus_ATCC_1997 VFYKAFSHVPTSGAEAEGG-KSSDGSMNMLLIGLDSRKDQDGNDLPRAVL
MSMEG_0107|M.smegmatis_MC2_155 TYHGALDGITTSNALAGES-GSVGDTENILIMGLDSRLDQHGNPLPEDVY
Mflv_4737|M.gilvum_PYR-GCK KIRSFEAGINHINPIALGGEGEDG-AIDILLVGSDSRTDAHGNPLSDQER
Mvan_1726|M.vanbaalenii_PYR-1 KIRSFESGINHINPVALGEGGEDG-AIDILLVGSDSRTDAHGNPLSDEER
TH_3471|M.thermoresistible__bu RIRAFEAGISQISSPLLGQGGEDG-AVDILLVGMDSRTDAHGNPLSAEEL
: . . . ::*::* *** * .** *.
MUL_4040|M.ulcerans_Agy99 KHLHAGDSDQGGYNTNTLILVHVSADG-KVVAFSIPRDDWVPFTGVP-GY
MMAR_4966|M.marinum_M KHLHAGDSDQGGYNTNTLILVHVSADG-KVVAFSIPRDDWVPFTGVP-GY
Mb3514|M.bovis_AF2122/97 KQLHAGDSDDGGYNTNTLILVHVGADG-KVVAFSIPRDDWVPFTGVP-GY
Rv3484|M.tuberculosis_H37Rv KQLHAGDSDDGGYNTNTLILVHVGADG-KVVAFSIPRDDWVPFTGVP-GY
MAV_0673|M.avium_104 KHLHAGDSDDGGYNTNTLILVHVSADN-KVVAFSIPRDDWVPFSGVP-GY
MLBr_02247|M.leprae_Br4923 KQLHAGDSNDGGYNTNTLILVHVGADN-KAVAFSIPRDDWVPFSDVP-GY
MAB_0560|M.abscessus_ATCC_1997 NQLHAGDSDAGGYNTNTLILVHVGADN-KVTAFSIPRDDWVPAEGIP-GY
MSMEG_0107|M.smegmatis_MC2_155 QALHAGDETVGGYNANVLIVVHLPGDGGPATAFSIPRDDYVDLAGCPSGI
Mflv_4737|M.gilvum_PYR-GCK AMLRAG--DEVSTNTDTIILIRIPNNGESATAISIPRDSYVEAPGIG---
Mvan_1726|M.vanbaalenii_PYR-1 AMLRAG--DEVSTNTDTIILIRIPNNGQSATAISIPRDSYVESPGIG---
TH_3471|M.thermoresistible__bu AALRAG--NDVATNTDTIVLVRIPNNGRSATAISIPRDSYVEAPGRG---
*:** . *::.:::::: :. ..*:*****.:* .
MUL_4040|M.ulcerans_Agy99 NHIKIKEAYGLTKQYVAQELIDQGVTSQRELETRGREAGRAATLRAVRAL
MMAR_4966|M.marinum_M NHIKIKEAYGLTKQYVAQELIDQGVTSQRELETRGREAGRAATLRAVRAL
Mb3514|M.bovis_AF2122/97 NHIKIKEAYGLTKQYVAEQLANQGVSDRKELETRGREAARAATLRAVRSL
Rv3484|M.tuberculosis_H37Rv NHIKIKEAYGLTKQYVAEQLANQGVSDRKELETRGREAARAATLRAVRSL
MAV_0673|M.avium_104 NHIKIKEAYGLTKQYVAQKLANQGTSSQKELETKGREAGRAATLRAVRNL
MLBr_02247|M.leprae_Br4923 NHIKIKEAYGLTKQYVTQKLIDQGVTDQKELETQGREAGRAATLRIVRSL
MAB_0560|M.abscessus_ATCC_1997 KHIKIKEAYGLTKANEADKLVNEGITDQATLEQQSREAGRRATLNAVHRL
MSMEG_0107|M.smegmatis_MC2_155 CKGKVKQAYGFAYQAEMEATESE-EEDPATREQKAREAGRKAEIATVRNL
Mflv_4737|M.gilvum_PYR-GCK -KMKINGVYGSVHLEEMKELVEQQGVDPAEAEPEAQAAGREELIKTVANL
Mvan_1726|M.vanbaalenii_PYR-1 -KLKINGVYGSVHLEKMKELVEEQGVDPAVAEPEAQAAGREQLIKTVANL
TH_3471|M.thermoresistible__bu -KMKINGVYGEVKFETMKQLVEVQGMDPEVAEPLAVQDARGALIETVAEL
: *:: .** . . . . * . .* : * *
MUL_4040|M.ulcerans_Agy99 TGVPIDYFAEVNLAGFYDLAQALGGVEVCLNHAVDDSYSGADFPAGRQRL
MMAR_4966|M.marinum_M TGVPIDYFAEVNLAGFYDLAQALGGVEVCLNHAVDDSYSGADFPAGRQRL
Mb3514|M.bovis_AF2122/97 TGVPIDYFAEINLAGFYDLAQTLGGVDVCLNHAVYDSYSGADFPAGRQRL
Rv3484|M.tuberculosis_H37Rv TGVPIDYFAEINLAGFYDLAQTLGGVDVCLNHAVYDSYSGADFPAGRQRL
MAV_0673|M.avium_104 TGVPIDYFAEVNLAGFYDLAQTLGGVEVCLNHPVYDSYSGADFPAGRQRL
MLBr_02247|M.leprae_Br4923 TGVSIDYFAEVNLAGFYDLTHTLGGVEVCLNHAVYDSYSGADFPAGRQRL
MAB_0560|M.abscessus_ATCC_1997 TGQPIDYFAEVNLVGFYDLASELGGITVCLNNAVYDSYSGANFPAGEQTL
MSMEG_0107|M.smegmatis_MC2_155 LGIPIDHFVEVTLGAFFEIAKAVAPITVCLNDDTSDPYSGADFRKGVQQI
Mflv_4737|M.gilvum_PYR-GCK TGVTVDHYAEIGLLGFALITDALGGVDVCLNAPVYEPLSGADFPAGWQKL
Mvan_1726|M.vanbaalenii_PYR-1 TGVTVDHYAEIGLLGFALITDALGGVNVCLNAPVYEPLSGADFPAGWQKL
TH_3471|M.thermoresistible__bu TGVTVDHYAEIGLLGFALITDALGGVEVCLKNPVYEPLSGADFPAGWQRL
* .:*::.*: * .* :: :. : ***: . :. ***:* * * :
MUL_4040|M.ulcerans_Agy99 DAAQALAFVRQRHGLDNG---DLDRTHRQQVFLSSVMRDLQDSGTFTNLD
MMAR_4966|M.marinum_M DAAQALAFVRQRHGLDNG---DLDRTHRQQAFLSSVMRDLQDSGTFTNLD
Mb3514|M.bovis_AF2122/97 NAAQALAFVRQRHGLDNG---DLDRTHRQQAFLSSVMRELQDSGTFTNLD
Rv3484|M.tuberculosis_H37Rv NAAQALAFVRQRHGLDNG---DLDRTHRQQAFLSSVMRELQDSGTFTNLD
MAV_0673|M.avium_104 DASEALSFVRQRHGLDNG---DLDRTHRQQAFISSVMQELQAAGTFTNID
MLBr_02247|M.leprae_Br4923 DASEALAFVRQRHGLDNG---DLDRTHRQQAFISSVMRELGDTGTFTNLD
MAB_0560|M.abscessus_ATCC_1997 NASQALAFVRQRHGLENG---DLDRTHRQQAFLISVMQQLRNAGTLTDIT
MSMEG_0107|M.smegmatis_MC2_155 DAAQAMAFVRQRRDINDENFTDLDRTRRQQAFLAALVSALRQSGALSSPS
Mflv_4737|M.gilvum_PYR-GCK NGTQALSFVRQRHDLPRG---DLDRVARQQAAMASMAHEVISSKTLSSPS
Mvan_1726|M.vanbaalenii_PYR-1 NGTQALSFVRQRHDLPRG---DLDRVARQQAVMASMAHEVISSKTLSSPT
TH_3471|M.thermoresistible__bu DGAQALSFVRQRQDLPRG---DLDRVTRQQTVMASLAREVISSKTLSSPA
:.::*::*****:.: ****. ***. : :: : : :::.
MUL_4040|M.ulcerans_Agy99 RLDSLMAVARKDLVLSGGWD-EDLVRRMGELAG----ADIEFRTLPVVRY
MMAR_4966|M.marinum_M RLDSLMAVARKDLVLSGGWD-EDLIRRMGELAG----ADIEFRTLPVVRY
Mb3514|M.bovis_AF2122/97 RLDNLMAVARKDVVLSAGWD-EDLFRRMGDLAG----GNVEFRTLPVVRY
Rv3484|M.tuberculosis_H37Rv RLDNLMAVARKDVVLSAGWD-EDLFRRMGDLAG----GNVEFRTLPVVRY
MAV_0673|M.avium_104 KLKNLMAVARKDVVLSAGWT-DDMIQRLGGLAG----GNIEFRTLPVVRY
MLBr_02247|M.leprae_Br4923 KLRSLMAVARKDVVLSAGWN-EDLIQRLGTLANDVGENRTQFRTLPVVRY
MAB_0560|M.abscessus_ATCC_1997 KLNGLMNVVHKDVVLSKGWT-EKQFQRLGQIAD----GNVNFQTLPVVRY
MSMEG_0107|M.smegmatis_MC2_155 KLRGLLDVTKQNVALDAGFDLASFTKRASALTD----APPTLYTLPIKEF
Mflv_4737|M.gilvum_PYR-GCK TLSALESAVQRSVVLSEGWDIMDFVEQLQKLAA----GNVAFATIPILEE
Mvan_1726|M.vanbaalenii_PYR-1 TLNNLEDAVQRSVVLSDGWNIMDFVEQLQKLAG----GNIAFATIPIVEE
TH_3471|M.thermoresistible__bu TLDRLQRAIQRSVVLSDGWDVMEFVEQLQGLAA----GNIAFATIPIVRE
* * . ::.:.*. *: . .: :: : *:*: .
MUL_4040|M.ulcerans_Agy99 ---DNIDGQDVNIVDPAAIKAEVAAAIGSTSTAATATTTPAKPSPS---T
MMAR_4966|M.marinum_M ---DNIDGQDVNIVDPAAIKAEVAAAIGTTSTAATATTTPAKPSPS---T
Mb3514|M.bovis_AF2122/97 ---DNIDGQDVNIIDPTAIRAEVAAAFG-SAPPTSQTAAAAKPNPS---T
Rv3484|M.tuberculosis_H37Rv ---DNIDGQDVNIIDPTAIRAEVAAAFG-SAPPTSQTAAAAKPNPS---T
MAV_0673|M.avium_104 ---DNIDGQDVNIVDPAAIKAEVAAAIGADAPTSAPTSTSVAPDPS---T
MLBr_02247|M.leprae_Br4923 ---DNINGQAVNIIDPVAIKAEVASTIG---TASPATATPSKPNPS---T
MAB_0560|M.abscessus_ATCC_1997 ---DNINGADVNIVDPVAIRAKVAAAFK----GEDAAPASAATTPT---S
MSMEG_0107|M.smegmatis_MC2_155 G--QNAYGEDINIIDVPTIRKIVHDLVS-KDDPATTTATPDKPELNGHGA
Mflv_4737|M.gilvum_PYR-GCK AGWSDDGMQSVVRVDPKEVKDWVTSLLNDQDQGKTEELAYSNDKTT----
Mvan_1726|M.vanbaalenii_PYR-1 AGWSDDGMQSVVRVDPAAVKDWVTGLLHDQDEGKTEELTYSNDKTT----
TH_3471|M.thermoresistible__bu DGWSDDGMQSVVRVDPQQVRDWVSSLLEEQDEGKTEEIAYSRDKTT----
.: : :* :: * . : .
MUL_4040|M.ulcerans_Agy99 VVDVVNAGSISGLASQVSNALRKRGYTTDQVRDRKSGDPAATTIKYGPGA
MMAR_4966|M.marinum_M VVDVVNAGSISGLASQVSNALRKRGYTTDQVRDRKSGDPAATTIKYGPGA
Mb3514|M.bovis_AF2122/97 VVDVVNAGSISGLASQVSGALLKRGYTAGQVRDRESGDPFTTAIEYGAGA
Rv3484|M.tuberculosis_H37Rv VVDVVNAGSISGLASQVSGALLKRGYTAGQVRDRESGDPFTTAIEYGAGA
MAV_0673|M.avium_104 VVDVVNSGSMSGLASEVSHALKKRGYTTGQVRDRESGDPAATTIEYGAGA
MLBr_02247|M.leprae_Br4923 VVDVINAGRLTGLASEVFQTLKKHGYTAGQVRDRSSGEPTTTSIQYGAGA
MAB_0560|M.abscessus_ATCC_1997 TVDVVNATSTSGLASTVSSALVSRGYTKGDVRDPLSGESTGTAIDYGVGA
MSMEG_0107|M.smegmatis_MC2_155 TLDVINGSTYTGLAAKLQTTFAADNFTEGQIGDAEALEP-ATTIDYGPGA
Mflv_4737|M.gilvum_PYR-GCK -VEVYNDSDVNGLAAAVAHVLTGKGFTQGNVGNNEGPKVTGSQVRAAKVD
Mvan_1726|M.vanbaalenii_PYR-1 -VEVVNDTDINGLAAAVSHVLSGKGFTKGNVGNNDGAKVTASQVQAAKTD
TH_3471|M.thermoresistible__bu -VEVLNGTDINGLAAAVSHVLTSNGFSPGPVGNAEDGPADRTEVRVAKQD
::* * .***: : .: .:: . : : : : .
MUL_4040|M.ulcerans_Agy99 QADAMNLGTLLGIDAPKQPDASIEPGHIQVTVDTNFS--------MPAPD
MMAR_4966|M.marinum_M QADAMNLGTLLGIDAPKQPDASIEPGHIQVTVDTNFS--------MPAPD
Mb3514|M.bovis_AF2122/97 ETDAQNVADLLGIDAPNHPDPAVAPGHIRVTVDTNFS--------LPAPD
Rv3484|M.tuberculosis_H37Rv ETDAQNVADLLGIDAPNHPDPAVAPGHIRVTVDTNFS--------LPAPD
MAV_0673|M.avium_104 QNDARNLANLLSLDAPNQPSPSIAPGHIRLTVDTNFT--------MPTTD
MLBr_02247|M.leprae_Br4923 DTDAQNVATLLSIDAPNQADPKLASGHIRVIVDTNYS--------LPADE
MAB_0560|M.abscessus_ATCC_1997 DADAKAMSTMLGIETEPVADPTLAPGRIRVMLGTGYS--------APSDV
MSMEG_0107|M.smegmatis_MC2_155 DAAAHSLATELGVTAT--PSDWVLADTVRLTIGTDFPGTDYLGADMFTST
Mflv_4737|M.gilvum_PYR-GCK DMGAQAVALDLG-GLEVVEDSSVPPDTVRVVLADDYTG--------PGAG
Mvan_1726|M.vanbaalenii_PYR-1 DLGAQAVAQELG-GLPVVENAQVPQGSVRVVLAADYTG--------PGAG
TH_3471|M.thermoresistible__bu DRGAREVADQLG-DLPIVEDRTVAPGFVRVVLADDYTG--------PGSG
: * :. *. . : . ::: : .:.
MUL_4040|M.ulcerans_Agy99 D-------SDDDTTVYPKPNAYYNGGDDSSSYPAPDHGQPIDGG--GVPC
MMAR_4966|M.marinum_M D-------SDDDTTTYPKPNAYYNGGDDSSSYPAPDHGQPIDGG--GVPC
Mb3514|M.bovis_AF2122/97 E-------ATAAATSTETSTYPLYGGG-TTTDPTPDQGAPIDGG--GVPC
Rv3484|M.tuberculosis_H37Rv E-------ATAAATSTETSTYPLYGGG-TTTDPTPDQGAPIDGG--GVPC
MAV_0673|M.avium_104 DTQLDDTTSTSSTTTSSKAKTYYYNGT-TTTYPTPDQGKPIDGG--GVPC
MLBr_02247|M.leprae_Br4923 DS------TMDETITSQKVGTYPPYSYNTSPYPTPDQGKPIDGG--GIPC
MAB_0560|M.abscessus_ATCC_1997 LS------AEDSGTASSMSSSSSSGAS--GDYAPPDSGKPVVSSNSGVPC
MSMEG_0107|M.smegmatis_MC2_155 TSGASESESYGPSETAELTPITTVAATATGTYTPAPTDLSQMTAS-GIPC
Mflv_4737|M.gilvum_PYR-GCK LD--------GSDVTLMGADPSTSGVVSDTGAAVPAPSPIITAGSDDPKC
Mvan_1726|M.vanbaalenii_PYR-1 LD--------GSDVTLMGADPSTSGVVTDTGATVPAPPPILTAGSNDPEC
TH_3471|M.thermoresistible__bu LD--------GTDPTVTTLQQS-SATVGQTVEAAPPPPQIITAGADDPKC
. . . . *
MUL_4040|M.ulcerans_Agy99 VN
MMAR_4966|M.marinum_M VN
Mb3514|M.bovis_AF2122/97 VN
Rv3484|M.tuberculosis_H37Rv VN
MAV_0673|M.avium_104 VN
MLBr_02247|M.leprae_Br4923 VN
MAB_0560|M.abscessus_ATCC_1997 VN
MSMEG_0107|M.smegmatis_MC2_155 VK
Mflv_4737|M.gilvum_PYR-GCK VN
Mvan_1726|M.vanbaalenii_PYR-1 VN
TH_3471|M.thermoresistible__bu VN
*: