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MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRV MVADVWVGSIRAIKLKNWVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPDPSPVPLKDGDTI PLKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDIT RAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDL QALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFLTGTGFSGAL RALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0173 | lprK | - | 100% (390) | POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY LIPOPROTEIN MCE1E) |
| M. tuberculosis H37Rv | Rv0593 | lprL | e-139 | 65.67% (367) | MCE-family lipoprotein LprL |
| M. tuberculosis H37Rv | Rv1970 | lprM | 2e-71 | 40.16% (371) | MCE-family lipoprotein LprM |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 0.0 | 100.00% (390) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0707 | - | 1e-135 | 62.04% (382) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02593 | lprK | 1e-172 | 76.35% (389) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 5e-54 | 35.87% (329) | MCE-family protein LprN |
| M. marinum M | MMAR_0416 | lprK | 1e-170 | 75.98% (383) | MCE family lipoprotein LprK |
| M. avium 104 | MAV_5011 | - | 1e-180 | 77.72% (386) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0138 | - | 1e-138 | 66.03% (368) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3924 | - | 1e-134 | 63.27% (373) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1066 | lprK | 1e-168 | 75.46% (383) | MCE family lipoprotein LprK |
| M. vanbaalenii PYR-1 | Mvan_0138 | - | 1e-135 | 63.32% (368) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0707|M.gilvum_PYR-GCK -------------------------MS--RLGTLAKRAVALGAAALVLTS
Mvan_0138|M.vanbaalenii_PYR-1 -------------------------MG--KWTRLARRTVALAAAAVVLTS
MSMEG_0138|M.smegmatis_MC2_155 ----------------MRLLKGFPKMR--NWTRVGRRTAVLAAVALVLTS
Rv0173|M.tuberculosis_H37Rv ------------------MMSVLARMR--VMRHRAWQGLVLLVLALLLSS
Mb0179|M.bovis_AF2122/97 ------------------MMSVLARMR--VMRHRAWQGLVLLVLALLLSS
MLBr_02593|M.leprae_Br4923 ------------------MRRAMSVVHTSRVRHQTWRGLVMLVAALLLSS
MAV_5011|M.avium_104 ----------------------MGALR--VIRRRSWQGLTLLVAAMVLTS
MMAR_0416|M.marinum_M MRRGVSVMGAIGKSKQSAARRGVGAMR--AVSRRAWQGLALLMVALVLSS
MUL_1066|M.ulcerans_Agy99 -------MGAIGKSKQSTARRGVGAMR--AVSRRAWQGLALLMVALVLSS
TH_3924|M.thermoresistible__bu ----------------------MSALR------RAARLLAALSVIVALTS
MAB_4149c|M.abscessus_ATCC_199 ------------------------------MSRNVLRAAVMGVGVAVVVS
: . : *
Mflv_0707|M.gilvum_PYR-GCK CGSWKGIANIPLPGGPGTGSERTTIYVQMPDTLALNVNSRVRVADVYVGR
Mvan_0138|M.vanbaalenii_PYR-1 CGSWKGISNVPLPGGPGSGSERTTIYVQMPDTLALNVNSRVRVADVYVGR
MSMEG_0138|M.smegmatis_MC2_155 CGQWRGIANVPLPGGPGTESGSMTLYVQMPETLALNANSRVRVRDVFVGR
Rv0173|M.tuberculosis_H37Rv CG-WRGISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGS
Mb0179|M.bovis_AF2122/97 CG-WRGISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGS
MLBr_02593|M.leprae_Br4923 CG-WRGISNVSIPGGPGSGKGAYTIYVQVPDTLAINGNSKVMVADVTVGS
MAV_5011|M.avium_104 CG-WKGISNVSIPGGPGSGPNSYNIYVQVPDTLAINGNSKVMVADVFVGS
MMAR_0416|M.marinum_M CG-WRGISNVAIPGAPGTGKGSYTVYVQVPDTLAINGNSKVMVADVPVGS
MUL_1066|M.ulcerans_Agy99 CG-WRGISNVAIPGAPGTGKGSYTVYVQVPDTLAINGNSKVMVADVPVGS
TH_3924|M.thermoresistible__bu CGSWRGIANVPLPSGPGTGPGSYTVYVQVEDALALNVNSRVRVADVYVGT
MAB_4149c|M.abscessus_ATCC_199 GCQFNGLNSLNLPGTAGHGSRSYTVTVELPDVTTLPQNSPVMVDDVTVGS
:.*: .: :*. .* .: *:: :. :: ** * * ** **
Mflv_0707|M.gilvum_PYR-GCK VRAIELRN-----WVATLTLDLEPNIALPVNTQAKIGQTSLLGSQHVQLD
Mvan_0138|M.vanbaalenii_PYR-1 VRAIELKN-----WIATLTLDLEPSVQLPVNTLARIGQTSLLGSQHVQLD
MSMEG_0138|M.smegmatis_MC2_155 VRKIELIN-----WVPTLTVDVEPGIKLPKNTLAKIGQTSLLGSQHVELN
Rv0173|M.tuberculosis_H37Rv IRAIKLKN-----WVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELA
Mb0179|M.bovis_AF2122/97 IRAIKLKN-----WVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELA
MLBr_02593|M.leprae_Br4923 IRAINLKN-----WVATLTLGLNKDVQLPKNTTAKIGQTSLLGSQHVELA
MAV_5011|M.avium_104 IKAIQLKN-----WIATLTLGINKNVKLPKNATAKIGQTSLLGSQHVELA
MMAR_0416|M.marinum_M IRNIQLKN-----WVATLTLGIDQGVKLPKNALAKIGQTSLLGSQHVELA
MUL_1066|M.ulcerans_Agy99 IRNIQLKN-----WVATLTLGIDQGVKLPKNALAKIGQTSLLGSQHVELA
TH_3924|M.thermoresistible__bu VRSIDLVD-----WVGTLTISLDPAVRLPRNATAKIGQTSLLGTQHVELA
MAB_4149c|M.abscessus_ATCC_199 VSGIDAFQKPDGSWYAGVKVSLEPEVHLPANAVAKVAQTSLLGSQHIELA
: *. : * :.:.:. : ** *: *::.******:**::*
Mflv_0707|M.gilvum_PYR-GCK LPP-DPSPQRLESGDTITLENASAFPTTERVLASIASILTGGGVANLETI
Mvan_0138|M.vanbaalenii_PYR-1 LPP-DPSPQKLKSGDVIPLANASAFPTTERVLASISSILTGGGVANLETI
MSMEG_0138|M.smegmatis_MC2_155 PPE-DPSSELLRDGDTIPLAQSSAYPTIERTLAGISGILTGGGIPNIEVI
Rv0173|M.tuberculosis_H37Rv APP-DPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGI
Mb0179|M.bovis_AF2122/97 APP-DPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGI
MLBr_02593|M.leprae_Br4923 APA-NPSLELLKNGDTIPLKNSSVFPTTEQTLASLSLILRGGGIPNLETL
MAV_5011|M.avium_104 APP-NPSPELLKDGDTIPLKNSSSYPTTEQTLASLSLILRGGGIPNLEVL
MMAR_0416|M.marinum_M APP-NPSSQLLKNGDTIPLKNSSAYPNTEQTLASISLILRGGGIPNLEVL
MUL_1066|M.ulcerans_Agy99 APP-NPSSQLLKNGDTIPLKNSSAYPNTEQTLASISLILRGGGIPNLEVL
TH_3924|M.thermoresistible__bu APA-EPAPEPLRDGDTIPLRHTSAFPTTERTLAGIATVLRGGGVGNLEYL
MAB_4149c|M.abscessus_ATCC_199 APVGEPAVGKLTGGATIPLSRTGKYPSTEEVLSALSVVVNKGNLGALQDI
* :*: * .* .*.* .:. :*. *..*:.:: :: *.: :: :
Mflv_0707|M.gilvum_PYR-GCK QSEVYNVLNGRADQIRDFLNQLDTFTAELNQQRDDITRAIDSTNRLLTIV
Mvan_0138|M.vanbaalenii_PYR-1 QTEIYNVLNGRADQIREFLGRLDTFTEELNRQRDDITRAIDSTNRLLAIV
MSMEG_0138|M.smegmatis_MC2_155 QTEVFNILNGRADQIREFLNQLDTFTDELNQQREEITRAIDSTNRLLNIV
Rv0173|M.tuberculosis_H37Rv QQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYV
Mb0179|M.bovis_AF2122/97 QQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYV
MLBr_02593|M.leprae_Br4923 TNEVFNIFHGRADQIHAFLTKLDTFASQLNQQRDDITHAIDSTNRLLTYV
MAV_5011|M.avium_104 QNEVYNIFNGRGEAIRALLGKLDTFTNQLNQQRDDITHAIDSTNRLLTYV
MMAR_0416|M.marinum_M QNEVYDIFHGRGDQIRGFLTRLDTFTRQLNEQRDDITHAIDSTNRLMAYV
MUL_1066|M.ulcerans_Agy99 QNEVYDIFHGRGDQIRGFLTRLDTFTRQLNEQRDDITHAIDSTNRLMAYV
TH_3924|M.thermoresistible__bu QNEVHAMLSGNAEQIGEFLDRLAVFTASLNDQIDQIDRAISSTRRLAGVV
MAB_4149c|M.abscessus_ATCC_199 TDETYNLFKGRTGNLTQVLPKLATLISSLNSQRDDIISAIEGIDKFSRVL
* :. *. : .* :* .: .** * ::* **.. :: :
Mflv_0707|M.gilvum_PYR-GCK AQRNETLDAVLTEFPPLIKHFADTRDLFGDAIESLGRISNAAVAALEPAN
Mvan_0138|M.vanbaalenii_PYR-1 GQRNQTLDAVLTEFPPLIQHFADTRDLFADAVESLGRISNAAVDALAPAS
MSMEG_0138|M.smegmatis_MC2_155 SQRNDTLDRVLTEFPPLIQHFAETRDLFADAVTALGRLSAAADETLSGSN
Rv0173|M.tuberculosis_H37Rv GGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAAR
Mb0179|M.bovis_AF2122/97 GGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAAR
MLBr_02593|M.leprae_Br4923 GGRSDVLDQILTDIPPLIKHFADTKNLLINAVGSVGQLSQAVDQYLSEAR
MAV_5011|M.avium_104 GGRADVVDRLLTDVPPLIKHFADTKQLLINAVDSVGRLSQAADQYLSEAR
MMAR_0416|M.marinum_M GGRADVVDRALTDLPPLIKHFADTRDLLINAVNSVGQLSDVTGRYLSEAR
MUL_1066|M.ulcerans_Agy99 GGRADVVDRALTDLPPLIKHFADTRDLLINAVNSVGQLSDVTGRYLSEAR
TH_3924|M.thermoresistible__bu AERSATLERVLTEVPPLIEHFAAQRELFVDGMEALGRFAHITDEALTAAR
MAB_4149c|M.abscessus_ATCC_199 AEHKESLGRAIDSIEPALKVLNENRANIIEAFRSVGNLAKITDRVLRTTK
. : : : .. * :: : : : :. ::*.:: . * :
Mflv_0707|M.gilvum_PYR-GCK GDMNQNLQNLQRPLRELGKSGPYLLGALKIFLTAPYSIENLPKAIRGDYV
Mvan_0138|M.vanbaalenii_PYR-1 DDINTNLANLQRPLRELGKSGPYLLGALKIFLTAPYNIENVPKAIRGDYI
MSMEG_0138|M.smegmatis_MC2_155 ANLHTNLQNLQRPLKQLGRAAPYLVGALKLILTVPFNIDNIPKAIRGDYI
Rv0173|M.tuberculosis_H37Rv GDLHQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYM
Mb0179|M.bovis_AF2122/97 GDLHQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYM
MLBr_02593|M.leprae_Br4923 GPLHTDLQALACPLRELGRGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQ
MAV_5011|M.avium_104 GPLHTDLQALQCPLKELGKASPYLIGALKLILTQPFDIDTVPKIFRGDYI
MMAR_0416|M.marinum_M GNLHTDLQSLQCPLKELGRGSQYLIGALKLILTQPFDIDAVPKIFRGDYQ
MUL_1066|M.ulcerans_Agy99 GNLHTDLQSLQCPLKELGRGSQYLIGALKLILTQPFDIDAVPKIFRGDYQ
TH_3924|M.thermoresistible__bu ADLHTNLRLLQRPLRELARAAPYLPEALQLLLTLPFTIDNVDKVVRGDYI
MAB_4149c|M.abscessus_ATCC_199 DDIVADLKGLYPVVRALAENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYL
: :* * :: * . : ::.:: * *: . : : .****
Mflv_0707|M.gilvum_PYR-GCK NVSLTVDLTLSAIDNGFFSGTGISGMLRALEQAWGRDPATMIPDVR----
Mvan_0138|M.vanbaalenii_PYR-1 NVSLTVDLTLSAIDNGFFSGTGISGMLRALEQAWGRDPATMIPDVR----
MSMEG_0138|M.smegmatis_MC2_155 NVSLKLDLTLSSVDNAFLSGTGVSGMLRALEQAWGRDPATMIPDVR----
Rv0173|M.tuberculosis_H37Rv NLSLTLDLTYSAIDNAFLTGTGFSGALRALEQSFGRDPETMIPDIR----
Mb0179|M.bovis_AF2122/97 NLSLTLDLTYSAIDNAFLTGTGFSGALRALEQSFGRDPETMIPDIR----
MLBr_02593|M.leprae_Br4923 NVSLTLDVTYSAMDNAVLTGTGLSGALRALEQSFGRDPETMIPDVR----
MAV_5011|M.avium_104 NISLTLDLTYSAVDNAFLTGTGLSGALRALEQSYGRDPETMIPDVR----
MMAR_0416|M.marinum_M NVSATLDVTFSAMDNAVLTGTGFSGALRALEQSFGRDPETMIPDVR----
MUL_1066|M.ulcerans_Agy99 NVSAALDVTFSAMDNAVLTGTGFSGALRALEQSFGLDPETMIPDVR----
TH_3924|M.thermoresistible__bu NLSGTFDLTLSTLDNGFLTGTGFSGALRALEQSWGRDPDTMLPDIR----
MAB_4149c|M.abscessus_ATCC_199 NVFVTFDLTARRLGETLFTTSFFDPNMQHFNDVVN-PPEWLIGSMANLNG
*: .*:* :.: .:: : .. :: ::: . * :: .:
Mflv_0707|M.gilvum_PYR-GCK FTPNPNSAPNGPLIERSE--------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 FTPNPNSVPGGPLIERSE--------------------------------
MSMEG_0138|M.smegmatis_MC2_155 FTPNPHDAPGGPLVERGE--------------------------------
Rv0173|M.tuberculosis_H37Rv YTPNPNDAPGGPLVERGNRQC-----------------------------
Mb0179|M.bovis_AF2122/97 YTPNPNDAPGGPLVERGNRQC-----------------------------
MLBr_02593|M.leprae_Br4923 YTTNPNDAPGGPLVERADRRC-----------------------------
MAV_5011|M.avium_104 YTPNPNDAPGGPLVERGDRNCDSLRPTPTGRLRDPDRHLAARARHLLPAD
MMAR_0416|M.marinum_M YTPNPNDAPGGPLVERGDRQC-----------------------------
MUL_1066|M.ulcerans_Agy99 YTPNPNDAPGGPLVERGDRQC-----------------------------
TH_3924|M.thermoresistible__bu FTPNPLDAPGGPLIERAE--------------------------------
MAB_4149c|M.abscessus_ATCC_199 KETSPFDLPAPAAPQGGGR-------------------------------
..* . * . : .
Mflv_0707|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0138|M.smegmatis_MC2_155 --------------------------------------------------
Rv0173|M.tuberculosis_H37Rv --------------------------------------------------
Mb0179|M.bovis_AF2122/97 --------------------------------------------------
MLBr_02593|M.leprae_Br4923 --------------------------------------------------
MAV_5011|M.avium_104 PELGGDRPVHAQGRAAGVGRPVPDGQRHLSRHHHRQGHRRRAHRARRRGD
MMAR_0416|M.marinum_M --------------------------------------------------
MUL_1066|M.ulcerans_Agy99 --------------------------------------------------
TH_3924|M.thermoresistible__bu --------------------------------------------------
MAB_4149c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0707|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0138|M.smegmatis_MC2_155 --------------------------------------------------
Rv0173|M.tuberculosis_H37Rv --------------------------------------------------
Mb0179|M.bovis_AF2122/97 --------------------------------------------------
MLBr_02593|M.leprae_Br4923 --------------------------------------------------
MAV_5011|M.avium_104 HEHRQPLQDPDRRGGQRALGVGGRRAVPGPGVERKPGQVPVVRADHHQGH
MMAR_0416|M.marinum_M --------------------------------------------------
MUL_1066|M.ulcerans_Agy99 --------------------------------------------------
TH_3924|M.thermoresistible__bu --------------------------------------------------
MAB_4149c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0707|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0138|M.smegmatis_MC2_155 --------------------------------------------------
Rv0173|M.tuberculosis_H37Rv --------------------------------------------------
Mb0179|M.bovis_AF2122/97 --------------------------------------------------
MLBr_02593|M.leprae_Br4923 --------------------------------------------------
MAV_5011|M.avium_104 GAGRDRAGPGHREPRAGGAAQGEDRPVARRDGAVRRRVGPQPAAAGRRHP
MMAR_0416|M.marinum_M --------------------------------------------------
MUL_1066|M.ulcerans_Agy99 --------------------------------------------------
TH_3924|M.thermoresistible__bu --------------------------------------------------
MAB_4149c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0707|M.gilvum_PYR-GCK -------------------------------
Mvan_0138|M.vanbaalenii_PYR-1 -------------------------------
MSMEG_0138|M.smegmatis_MC2_155 -------------------------------
Rv0173|M.tuberculosis_H37Rv -------------------------------
Mb0179|M.bovis_AF2122/97 -------------------------------
MLBr_02593|M.leprae_Br4923 -------------------------------
MAV_5011|M.avium_104 GHRRRLQEPDHRRQRHHRALRAGDRQPGQIR
MMAR_0416|M.marinum_M -------------------------------
MUL_1066|M.ulcerans_Agy99 -------------------------------
TH_3924|M.thermoresistible__bu -------------------------------
MAB_4149c|M.abscessus_ATCC_199 -------------------------------