For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SIGIGGMVGGGIFSVLGLTVQIADAGAYLSFVAGGVIAALTGRSYSLLSVRIRSRGGTAFFLDKCFGTAI GGPLNVLLWLSYFVMLGLYAVAFGSYGAVLLGADPDGPWRRVLASAVVVAFAALNLAGAQIVGRAESFLV YGKLAILLLFCVAGLAFVDGSRFSPAHYPSFGVIVYAGALIFLGYEGFELIANAAEDARNPRRSLLLAYL ISIGVVIVLYVLVAFVAVGNLDVAQIDHDRDYAPAVAARPFLGSAGFELIGIAAVISTASAINATLYGTG KFTYLMARNGELPVALGKPVWDRPIGGLLATTAGTLVVVNAVDIEGISLMGSAGFLLIFAAVNLAVLRLR ITRLTRVLAVTGAVACVASFAAMTVYVAATTPAHLCVLGGFLVGAIVVEGLVRLRGRHVSHPPMRPEH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3182 | potE | - | 100% (419) | amino acid transporter PotE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 1e-24 | 26.27% (373) | cationic amino acid transport integral membrane protein RocE |
| M. ulcerans Agy99 | MUL_2597 | - | 2e-20 | 23.57% (403) | cationic amino acid transport integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 2e-24 | 25.69% (436) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_0187 | - | 1e-23 | 26.46% (412) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 2e-24 | 25.69% (436) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 1e-18 | 24.56% (395) | putative permease |
| M. abscessus ATCC 19977 | MAB_3842 | - | 3e-24 | 24.14% (435) | cationic amino acid transport integral membrane protein |
| M. marinum M | MMAR_2579 | potE | 0.0 | 98.33% (419) | amino acid transporter PotE |
| M. avium 104 | MAV_2087 | - | 4e-22 | 24.39% (369) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_1412 | - | 1e-23 | 24.58% (419) | amino acid permease |
| M. thermoresistible (build 8) | TH_0471 | - | 1e-20 | 24.16% (389) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. vanbaalenii PYR-1 | Mvan_0718 | - | 1e-25 | 26.62% (402) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3182|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2579|M.marinum_M --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
MAB_3842|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1412|M.smegmatis_MC2_155 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mflv_0187|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0718|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MUL_3182|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2579|M.marinum_M -------------------MTAPASPPAKGSRDSPAGRQ-----------
Mb2347c|M.bovis_AF2122/97 ---------------MPTTSMSLRELMLRRRPVSGAPVA-----------
Rv2320c|M.tuberculosis_H37Rv ---------------MPTTSMSLRELMLRRRPVSGAPVA-----------
MAV_2087|M.avium_104 -------------------------------------MA-----------
MAB_3842|M.abscessus_ATCC_1997 ---------------MAPSSPSLAQQLLRRRPTSGAPTA-----------
MSMEG_1412|M.smegmatis_MC2_155 ---------------MSAPPTSMAGQMMRRRPVIGAPVA-----------
TH_0471|M.thermoresistible__bu ----------------------MTDRLRVKSVEQSIADT-----------
Mflv_0187|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0718|M.vanbaalenii_PYR-1 -------------------------------------MS-----------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MUL_3182|M.ulcerans_Agy99 -----------------MSIGIGGMVGGGIFSVLGLTVQ-IADAGAYLSF
MMAR_2579|M.marinum_M -RAGGQPEGGELGVSALVSIGIGGMVGGGIFSVLGLTVQ-IADAGAYLSF
Mb2347c|M.bovis_AF2122/97 -SGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVP-EAGPGVIVSF
Rv2320c|M.tuberculosis_H37Rv -SGASGNLKRSFGTFQLTMFGVGATIGTGIFFVLAQAVP-EAGPGVIVSF
MAV_2087|M.avium_104 -PGTADHLRRGIGTFQLTMFGVGSTIGTGIFFVMSQAVP-EAGPAVIVSF
MAB_3842|M.abscessus_ATCC_1997 -HGAGGHLKQSMGTFQLTMIGVGATVGTGIFFILAESVP-KAGPAVMASF
MSMEG_1412|M.smegmatis_MC2_155 -HGASDHLKRSIGTFQLTLFGVGATVGTGIFLVLQEAVP-EAGPAVLVSF
TH_0471|M.thermoresistible__bu -DEPDSRLRKDLSWWDLTVFGVSVVIGAGIFTVTASTAGNITGPAISVSF
Mflv_0187|M.gilvum_PYR-GCK -------MRRRLGTFDTVTLGLGSMIGAGIFVALAPAAA-AAGTGLLVGL
Mvan_0718|M.vanbaalenii_PYR-1 -SPGGSTLDRRLGVFDTVTIGLGSMIGAGIFVALAPAAA-AAGSGLLIGL
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPGEVIK-IAGPFAPIAY
:*:. :* *** :.. .
MUL_3182|M.ulcerans_Agy99 VAGGVIAALTGRSYSLLSVRIRSRGGTAFFLDKCFGTAIGGPLNVLLWLS
MMAR_2579|M.marinum_M VAGGVIAALTGRSYSLLSVRIRSRGGTAFFLDKCFGTAIGGPLNVLLWLS
Mb2347c|M.bovis_AF2122/97 IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
Rv2320c|M.tuberculosis_H37Rv IIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLLE
MAV_2087|M.avium_104 LLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLE
MAB_3842|M.abscessus_ATCC_1997 LVAGLAAGLAALCYAELASAVPVSGSSFSYAYTTLGELAAMVVAACLLLE
MSMEG_1412|M.smegmatis_MC2_155 VLAGVAAGLSALCYAEMASAVPVSGSTYSYAYTTMGEFVAMGVAACLLLE
TH_0471|M.thermoresistible__bu IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
Mflv_0187|M.gilvum_PYR-GCK AVAALIAVCNAMSSARLAARYPESGGTYVYGRERLGPFWGHTAGWSFIVG
Mvan_0718|M.vanbaalenii_PYR-1 AVAAVVAVCNAMSSARLAARYPQSGGTYVYGRERLGPFWGHAAGWSFIVG
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
..: . . : : *.: : :* . :
MUL_3182|M.ulcerans_Agy99 YFVMLGLYAVAFGSYGAVLLG------------ADPDG--------PWRR
MMAR_2579|M.marinum_M YFVMLGLYAVAFGSYGAVLLG------------ADPDG--------PWRR
Mb2347c|M.bovis_AF2122/97 YGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHP-----GWVN
Rv2320c|M.tuberculosis_H37Rv YGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHP-----GWVN
MAV_2087|M.avium_104 YGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQP-----GYVN
MAB_3842|M.abscessus_ATCC_1997 YGVSAAAVAVGWSQYLDKLLVNLFGWHLPHAISAAPWDSADPAAPHPWLN
MSMEG_1412|M.smegmatis_MC2_155 YGVSMSATSIGWGGYLNQLLDDVFGFRIPQALTSAPWGENP-----GIMN
TH_0471|M.thermoresistible__bu FSVAAAVVAKGWSSYLGEVFE----------FAGATTRLGP-----ITLD
Mflv_0187|M.gilvum_PYR-GCK KTASCAAMALTVG------------------YYVWP----------AYAN
Mvan_0718|M.vanbaalenii_PYR-1 KTASCAAMALTVG------------------FYAWP----------EYAN
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLRVAFP-------EKIWADNDELIS------VKT
. :
MUL_3182|M.ulcerans_Agy99 VLASAVVVAFAALNLAGAQIVGRAESFLVYGKLAILLLFCVAGLAFVDGS
MMAR_2579|M.marinum_M VLASAVVVAFAALNLAGAQIVGRAESFLVYGKLAILLLFCVAGLAFVDGS
Mb2347c|M.bovis_AF2122/97 LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
Rv2320c|M.tuberculosis_H37Rv LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
MAB_3842|M.abscessus_ATCC_1997 LPAVLLIIMCAILLIRGTSESALVNTVMVLLKLAVLSVFAIIAFTAFHAG
MSMEG_1412|M.smegmatis_MC2_155 LTATLLIVMCGLLLIRGASESALVNTIMVIIKLAVLALFVAVAFTAFTTD
TH_0471|M.thermoresistible__bu WGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAA
Mflv_0187|M.gilvum_PYR-GCK AVAVGSVVALTAVSYAGVQRSATLTRVIVALVLGVLAMVVVVVFGSGDVD
Mvan_0718|M.vanbaalenii_PYR-1 AVAVASVVALTAVGYAGVQRSAALTRIIVALVLAVLAMVVVVLLGFGGAD
MLBr_01974|M.leprae_Br4923 LTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQ
: : * . : : :.
MUL_3182|M.ulcerans_Agy99 RFSPAHYPSFGVIVYAG---------------------------ALIFLG
MMAR_2579|M.marinum_M RVSPAHYPSFGVIVYAG---------------------------ALIFLG
Mb2347c|M.bovis_AF2122/97 HLKDFVPFGVAG--------------IGSAAGT-------------IFFS
Rv2320c|M.tuberculosis_H37Rv HLKDFVPFGVAG--------------IGSAAGT-------------IFFS
MAV_2087|M.avium_104 HLDDFAPFGVAG--------------VGTAAGT-------------IFFS
MAB_3842|M.abscessus_ATCC_1997 NFSDFAPFGVSG--------------IGAAAGT-------------IFFT
MSMEG_1412|M.smegmatis_MC2_155 HFAGFWDKGFAG--------------ITAAAGS-------------IFFT
TH_0471|M.thermoresistible__bu NYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFFA
Mflv_0187|M.gilvum_PYR-GCK ASRLALGPDVDAYGVLQAAGL-------------------------LFFA
Mvan_0718|M.vanbaalenii_PYR-1 TSRLALGDDVTVYGVLQAAGL-------------------------LFFA
MLBr_01974|M.leprae_Br4923 HVNNYVTSRSAYQPTTYSLLGVTEIGKSTAASMT-------LATIVALYA
:
MUL_3182|M.ulcerans_Agy99 YEGFELIANAAEDARNPRRSLLLAYLISIGVVIVLYVLVAFVAVGNLDVA
MMAR_2579|M.marinum_M YEGFELIANAAEDARNPRRSLPLAYLISIGVVIVLYVLVAFVAVGNLDVA
Mb2347c|M.bovis_AF2122/97 YIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQ
Rv2320c|M.tuberculosis_H37Rv YIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQPWQ
MAV_2087|M.avium_104 YIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQ
MAB_3842|M.abscessus_ATCC_1997 YVGLDTVSTAGEEVKDPQRTMPRALIAALLIVTAFYLVVALAALGAQPWK
MSMEG_1412|M.smegmatis_MC2_155 FIGLDAVSTAGDEVKNPQKTMPRAILGALVVVASVYILVAFAGLGTQSAD
TH_0471|M.thermoresistible__bu FIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHYT
Mflv_0187|M.gilvum_PYR-GCK FAGYARIATLGEEVRDPARTIPRAIGLALVIALLTYAVVAVAVLAQLGST
Mvan_0718|M.vanbaalenii_PYR-1 FAGYARIATLGEEVRDPARTIPRAVALALVIALMVYAVVAVAVVSELGVA
MLBr_01974|M.leprae_Br4923 FTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDK
: * ::. .:: * : : . :: . * . ..
MUL_3182|M.ulcerans_Agy99 QID----HDRDYAPAVAARPFLGSAGFELIGIAAVISTASAINATLYGTG
MMAR_2579|M.marinum_M QID----HDRDYALAAAARPFLGSAGFELIGIAAVISTASAINATLYGTG
Mb2347c|M.bovis_AF2122/97 DF--AEQETAGLAIILDNVTHG-EWASTILAAGAVVSIFTVTLVTMYGQT
Rv2320c|M.tuberculosis_H37Rv DF--AEQETAGLAIILDNVTHG-EWASTILAAGAVVSIFTVTLVTMYGQT
MAV_2087|M.avium_104 DF--GGQQEAGLATILDHVTHG-SWASTILAAGAVISIFSVTLVTMYGIT
MAB_3842|M.abscessus_ATCC_1997 EF--EGQ-SAGLALILDKVTGS-TSASTFLAAGAVISIFSITLVSMYGQT
MSMEG_1412|M.smegmatis_MC2_155 EFGSEEQSEAGLAVILTNILHGQTWASTILSFGAVISIFSVTLVVMYGQT
TH_0471|M.thermoresistible__bu ELR-AAGENANLATAFA--ANGIDWAAKVISIGALAGLTTVVIVLVLGQT
Mflv_0187|M.gilvum_PYR-GCK GLA-----TADAPLADAVRAAGLPALAPVVAVGAALAALGALLALLLGVS
Mvan_0718|M.vanbaalenii_PYR-1 GLA-----SATAPLSDAVRAAGFPGLTPVVNVGAAIAALGALLALLLGVS
MLBr_01974|M.leprae_Br4923 IVA-------TNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAP
. .: .* . . *
MUL_3182|M.ulcerans_Agy99 KFTYLMARNGELPVALG--KPVWDRPIGGLLATTAGTLVVVNAVDIE--G
MMAR_2579|M.marinum_M KFTYLMARNGELPAALG--KPVWDRPIGGLLATTAGTLVVVNAVDIE--G
Mb2347c|M.bovis_AF2122/97 RILFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLD--S
Rv2320c|M.tuberculosis_H37Rv RILFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLD--S
MAV_2087|M.avium_104 RILFAMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAATLAAFIPLQ--N
MAB_3842|M.abscessus_ATCC_1997 RILFAIGRDGLLPSVFAQVNPRTLTPVNNTIIVAVVVGFMAAFVPLD--S
MSMEG_1412|M.smegmatis_MC2_155 RILFAMGRDGLLPSMFARVNSHTMTPINNTIVVALVTGTLAGFVPLD--Y
TH_0471|M.thermoresistible__bu RVLFAMSRDGLLPRPLSKTGPR-GTPVRITVLVGALVAIAASVFPVG--N
Mflv_0187|M.gilvum_PYR-GCK RTTLAMARDRHLPHPLAHVHPGHGTPQRAEVAVGVVVAVVAAVVDVR--S
Mvan_0718|M.vanbaalenii_PYR-1 RTTLAMARDRYLPAGLAAVHPKHGTPHHAEVAVGLVVAVVAAFVDLR--G
MLBr_01974|M.leprae_Br4923 RLWTALSDGRILPTRLSS-KNRFGVPIVAFGITAFLTLAFPLSLRFDSLN
: :. . ** :. * . . . .
MUL_3182|M.ulcerans_Agy99 ISLMGSAGFLLIFAAVNLAVLRLRITR----LTRVLAVTGAVACVASFAA
MMAR_2579|M.marinum_M ISLMGSAGFLLIFAAVNLAVLRLRITR----LTRVLAVTGAVACVASFAA
Mb2347c|M.bovis_AF2122/97 LADMVSIGTLTAFSVVAVGVIVLRVREPD--LPRGFKVPGYPVTPVLSVL
Rv2320c|M.tuberculosis_H37Rv LADMVSIGTLTAFSVVAVGVIVLRVREPD--LPRGFKVPGYPVTPVLSVL
MAV_2087|M.avium_104 LADMVSIGTLTAFVVVSVGVIVLRVREPD--LPRGFRVPGYPVTPVLSIM
MAB_3842|M.abscessus_ATCC_1997 LANMVSIGTLTAFIVVSIGVIILRVREPE--LPRAFRVPGYPVTPVLSVI
MSMEG_1412|M.smegmatis_MC2_155 LWDLVSIGTLVAFIVVSAGVVLLRVREPD--LPRSFKVPGYPVTPVLSII
TH_0471|M.thermoresistible__bu LEEMVNIGTLFAFALVSAGVIVLRRTRPD--LKRGFRVPFVPWLPLAAIA
Mflv_0187|M.gilvum_PYR-GCK AIGFSSFGVLLYYAVANASAWTLTAT------------PRARLVPAVGLI
Mvan_0718|M.vanbaalenii_PYR-1 AIGFSSFGVLLYYAIANASAWTLG----------------ARLIPAIGLV
MLBr_01974|M.leprae_Br4923 LTGLAVIARFIQFIIVPIALFALARSRTTNSVYVKRNVFTDKVLPITAVV
: . : : . . *
MUL_3182|M.ulcerans_Agy99 MTVYVAATTPAHLCVLGGF---LVGAIVVEGLVRLRGRHVSHP-------
MMAR_2579|M.marinum_M MTVYAAATTPAHLWVLGGF---LVGAIVVEGLVRLRGRHVSHP-------
Mb2347c|M.bovis_AF2122/97 ACGYILASLHWYTWLAFSG---WVAVAVIFYLMWGRHHSALNE-------
Rv2320c|M.tuberculosis_H37Rv ACGYILASLHWYTWLAFSG---WVAVAVIFYLMWGRHHSALNE-------
MAV_2087|M.avium_104 ACGYILASLHWYTWIAFSG---WVLLALIFYFVWGRHHSALND-------
MAB_3842|M.abscessus_ATCC_1997 ACGYILFSLPWITWIAFGA---WVAIVLVFYLVWGRHHSALND-------
MSMEG_1412|M.smegmatis_MC2_155 ACLFVLYGLPAVTWLWFSV---WVGAVLLFYLLWGRRHSALNDGGDGYIP
TH_0471|M.thermoresistible__bu ACLWLMLNLTGLTWVRFLG---WMALGLVLYFFYGRHHSMLGR-------
Mflv_0187|M.gilvum_PYR-GCK GCVVLAFTLPPVSVLAGAA---VVLVGMLAYTTGGALRRGV---------
Mvan_0718|M.vanbaalenii_PYR-1 GCLVLAFTLPLTSVLAGAA---VVLVGMIAYTIGGTR-------------
MLBr_01974|M.leprae_Br4923 VSAGLMVSFDYRSIFLTRGGPNYFSISLIAITFIGIPAVAYLH-------
. . ::
MUL_3182|M.ulcerans_Agy99 --PMRPEH----------
MMAR_2579|M.marinum_M --PMRPEH----------
Mb2347c|M.bovis_AF2122/97 -EVP--------------
Rv2320c|M.tuberculosis_H37Rv -EVP--------------
MAV_2087|M.avium_104 -AAVDPSGQER-------
MAB_3842|M.abscessus_ATCC_1997 -LPSDPAELSEKEPV---
MSMEG_1412|M.smegmatis_MC2_155 GAAAGEDDVMTGHPEDRA
TH_0471|M.thermoresistible__bu -GMTDISARRTG------
Mflv_0187|M.gilvum_PYR-GCK ------------------
Mvan_0718|M.vanbaalenii_PYR-1 ------------------
MLBr_01974|M.leprae_Br4923 --YYRTSGIK--------