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DIFAQWQGGGTELRWRSTTAANDGREVGVFSRRCGTPGAPALVLVHGFPTSSIDYFALAGELSRDFDIHL IDFPGYGLSDKPPEPYVYSLYDDARLLVHAITEVWRLSDYRMLTHDRGSSVGMIASGMLAALDPPAAPVD LILTNANIYLPLANLTAFQSALLDPSTARATAAATTPELLAAGMGASTFMPRRTLDDPEIAALAKCFAHN DGIRVLPDTIQYLNERAADETRWLEALSTSDVDTTMVWGLHDNVAPLRVPNHVWQTYLKTKPGRNRYWVI PGADHYLQCDAPAQLAEIVRLTARGEDVPLQTLGDRPDGAVLVDGGAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2139 | - | - | 100% (329) | hydrolase, alpha/beta fold family protein, putative |
| M. avium 104 | MAV_3609 | - | 5e-10 | 24.44% (270) | hydrolase |
| M. avium 104 | MAV_0868 | - | 2e-06 | 24.83% (290) | proline imino-peptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1865 | - | 2e-23 | 31.67% (300) | hydrolase |
| M. gilvum PYR-GCK | Mflv_2749 | - | 1e-144 | 74.15% (325) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1834 | - | 2e-23 | 31.67% (300) | hydrolase |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-06 | 31.96% (97) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4300 | - | 7e-15 | 25.26% (285) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3449 | - | 1e-157 | 80.62% (325) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_2777 | - | 1e-11 | 24.92% (297) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_4027 | - | 4e-20 | 29.83% (295) | PUTATIVE hydrolase |
| M. ulcerans Agy99 | MUL_2723 | - | 1e-157 | 80.62% (325) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3788 | - | 1e-145 | 76.00% (325) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1865|M.bovis_AF2122/97 ---------MTSPSVREWRDGGRWLPTAVGKVFVRSG---PGDTPTMLLL
Rv1834|M.tuberculosis_H37Rv ---------MTSPSVREWRDGGRWLPTAVGKVFVRSG---PGDTPTMLLL
TH_4027|M.thermoresistible__bu --------------VARWRAEGRWIRTGVGSVFVRSA---SGRGSPVVLL
MAB_4300|M.abscessus_ATCC_1997 ----------MDAELEEWKAAGHYFDYLGFDIFYRVE----GSGPPLLLI
MSMEG_2777|M.smegmatis_MC2_155 ----------MHDELQRWKDAGQYFDYLGFDIFYRVDGVAPGTGPNLLLI
MMAR_3449|M.marinum_M MVLDIFAEWQSGASTLRWRSTTAANADAEVTVFTRRCG--TPDAPALVLV
MUL_2723|M.ulcerans_Agy99 --MDIFAEWQSGASTLRWRSTTAANADAEVTVFTRRCG--TPDAPALVLV
MAV_2139|M.avium_104 --MDIFAQWQGGGTELRWRSTTAANDGREVGVFSRRCG--TPGAPALVLV
Mflv_2749|M.gilvum_PYR-GCK --MDIFDEWHRGGTTFSWTSTTPANGGAQVDVFARRTG--TPGAPALVCV
Mvan_3788|M.vanbaalenii_PYR-1 --MDIFTDWQRDGTHFTWTSTTAANAGTEVEVFSRRCG--TPGAPALVCV
MLBr_00862|M.leprae_Br4923 ----------MPATQSIHKVPHQFVESPDGVRLAIYQS-GQPEGPAIVLV
: . :: :
Mb1865|M.bovis_AF2122/97 HGYPSSSFDFRAVIPHLTGQA-WVTMDFLGFGLSDKPR-PHRYSLLEQAH
Rv1834|M.tuberculosis_H37Rv HGYPSSSFDFRAVIPHLTGQA-WVTMDFLGFGLSDKPR-PHRYSLLEQAH
TH_4027|M.thermoresistible__bu HGYPSSSYDYRAVLPELGDRG-WVTFDFLGFGLSDKPR-PHRYSLFEQAD
MAB_4300|M.abscessus_ATCC_1997 HGYPFNSWDWALIWPTLVERFTVIAPDMIGMGFSDKPV-QYGYSVLDHAD
MSMEG_2777|M.smegmatis_MC2_155 HGYPFNSWDWSLIWPTLTQRFTVIAPDMIGMGFSDKPV-AYEYRVTDHAD
MMAR_3449|M.marinum_M HGFPTSSIDYFALARELGSEFDIYVLDFPGYGLSDKPRQPYVYSLYDDAR
MUL_2723|M.ulcerans_Agy99 HGFPTSSIDYFALARELGSEFDIYVLDFPGYGLSDKPRQPYVYSLYDDAR
MAV_2139|M.avium_104 HGFPTSSIDYFALAGELSRDFDIHLIDFPGYGLSDKPPEPYVYSLYDDAR
Mflv_2749|M.gilvum_PYR-GCK HGFPTAGVDYHALTRELADDFDIYVLDFPGYGLSGKPPHPYVYSLYDDAR
Mvan_3788|M.vanbaalenii_PYR-1 HGFPTSGIDYSALARELAAEFDIYVLDFPGYGLSGKPPSPYVYSLYDDAR
MLBr_00862|M.leprae_Br4923 HGFPDSHVLWDGVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFAD
**:* : : * * * * *. * * : *
Mb1865|M.bovis_AF2122/97 LVETVVAHTV-TGAVVVLAHDMGTSVTTELLARDLDGRLP---FDLRR--
Rv1834|M.tuberculosis_H37Rv LVETVVAHTV-TGAVVVLAHDMGTSVTTELLARDLDGRLP---FDLRR--
TH_4027|M.thermoresistible__bu LVQTVVRSVT-DEPVLLIAHDMGTSVATELMARDLQGQLP---FRLQR--
MAB_4300|M.abscessus_ATCC_1997 MHEALLSYLG-IERFHLLTHDLGNSVGQEMLARFEFEQQSRGRVPIDS--
MSMEG_2777|M.smegmatis_MC2_155 IHEALLAHLG-ITSTHILAHDLGDSVGQEMLARHEFGGQAYGGFQIES--
MMAR_3449|M.marinum_M LLVHAIRRVWKLTEFRMLTHDRGSSVG--MIALGMLAAEDPPALPID---
MUL_2723|M.ulcerans_Agy99 LLVHAIRRVWKLTEFRMLTHDRGSSVG--MIALGMLAAEDPPALPID---
MAV_2139|M.avium_104 LLVHAITEVWRLSDYRMLTHDRGSSVG--MIASGMLAALDPPAAPVD---
Mflv_2749|M.gilvum_PYR-GCK LLVHAITDVWGLETFRMVTHDRGSSIG--MIALGLLDDIG--RRPLD---
Mvan_3788|M.vanbaalenii_PYR-1 LLVHAVTERWRLTDYRMITHDRGSSVG--MIALGMLAESG--STPVD---
MLBr_00862|M.leprae_Br4923 DFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPS
: :::** * :: :
Mb1865|M.bovis_AF2122/97 ------------------------------------------------AV
Rv1834|M.tuberculosis_H37Rv ------------------------------------------------AV
TH_4027|M.thermoresistible__bu ------------------------------------------------VV
MAB_4300|M.abscessus_ATCC_1997 ------------------------------------------------VT
MSMEG_2777|M.smegmatis_MC2_155 ------------------------------------------------VT
MMAR_3449|M.marinum_M ------------------------------------------------LI
MUL_2723|M.ulcerans_Agy99 ------------------------------------------------LI
MAV_2139|M.avium_104 ------------------------------------------------LI
Mflv_2749|M.gilvum_PYR-GCK ------------------------------------------------LF
Mvan_3788|M.vanbaalenii_PYR-1 ------------------------------------------------VF
MLBr_00862|M.leprae_Br4923 QDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIA
Mb1865|M.bovis_AF2122/97 LSNGSVILERASLRPIQKVLR-SPLGPVAARLVS----------------
Rv1834|M.tuberculosis_H37Rv LSNGSVILERASLRPIQKVLR-SPLGPVAARLVS----------------
TH_4027|M.thermoresistible__bu LSNGSVLLDRASLRPIQKVLR-GRFGPVVSQLVN----------------
MAB_4300|M.abscessus_ATCC_1997 WLNGGLFIEAYRPRIAQTLMSRTPLGDLVSRFQGTPVT------------
MSMEG_2777|M.smegmatis_MC2_155 WLNGGLFNEAYRPRLMQKVMSRTPLGDILSPLQGSPLS------------
MMAR_3449|M.marinum_M ITNANIYLPLSNLTAFQTALLDPATARATAAATT----------------
MUL_2723|M.ulcerans_Agy99 ITNANIYLPLSNLTAFQTALLDPATARATAAATT----------------
MAV_2139|M.avium_104 LTNANIYLPLANLTAFQSALLDPSTARATAAATT----------------
Mflv_2749|M.gilvum_PYR-GCK MTNANIYLPLANLTAFQVALLDDDTGRATAAATT----------------
Mvan_3788|M.vanbaalenii_PYR-1 ITNGNIYLPLANLTAFQVALLDEATGRATAAATT----------------
MLBr_00862|M.leprae_Br4923 LSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRG
.. : : . :
Mb1865|M.bovis_AF2122/97 ---------------------------------RGGFTRGFGR-IFSPAH
Rv1834|M.tuberculosis_H37Rv ---------------------------------RGGFTRGFGR-IFSPAH
TH_4027|M.thermoresistible__bu ---------------------------------EPMFIRGLGK-VFSKQR
MAB_4300|M.abscessus_ATCC_1997 ---------------------------------RRIMDAAVSE-MFGPDT
MSMEG_2777|M.smegmatis_MC2_155 ---------------------------------RRVFESTLDQ-MFGVNT
MMAR_3449|M.marinum_M ---------------------------------PELLAAGLGASTFMPRR
MUL_2723|M.ulcerans_Agy99 ---------------------------------PELLAAGLGASTFMPRR
MAV_2139|M.avium_104 ---------------------------------PELLAAGMGASTFMPRR
Mflv_2749|M.gilvum_PYR-GCK ---------------------------------PEMLAAGLGAATFMPRR
Mvan_3788|M.vanbaalenii_PYR-1 ---------------------------------PAMLAAGLGASTFMPRR
MLBr_00862|M.leprae_Br4923 KGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMS
. *
Mb1865|M.bovis_AF2122/97 PLSAQEAQAQWELLCYNDGNRIPHLLISYLDERIRHAQ------------
Rv1834|M.tuberculosis_H37Rv PLSAQEAQAQWELLCYNDGNRIPHLLISYLDERIRHAQ------------
TH_4027|M.thermoresistible__bu PLSAAEGAAQWALMSYHDGHRIMHLLTAYLNERVRYAD------------
MAB_4300|M.abscessus_ATCC_1997 KPSPRLLSLFQQVLEYNDGARVTHQVGRFINDRYDNRS------------
MSMEG_2777|M.smegmatis_MC2_155 KPSREMIEKFHQILDHNDGKRVLHKVGRFVTDRYTHRN------------
MMAR_3449|M.marinum_M ALEDPEITALARCFAHNDGIQALPDTVQYLHERAAGET------------
MUL_2723|M.ulcerans_Agy99 ALEDPEITALARCFAHNDGIQALPDTVQYLHERAAGET------------
MAV_2139|M.avium_104 TLDDPEIAALAKCFAHNDGIRVLPDTIQYLNERAADET------------
Mflv_2749|M.gilvum_PYR-GCK TLQDPEIAALAHCFAHNDGIRVLPDTVRYLHERAADET------------
Mvan_3788|M.vanbaalenii_PYR-1 SPQDDEIAALAQCFAHNDGISVLPDTVRYLHERAADET------------
MLBr_00862|M.leprae_Br4923 HP-QVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGS
** *
Mb1865|M.bovis_AF2122/97 --RWHGAVRDWPKPLGFVWGLDDPVATT----NVLNG-------------
Rv1834|M.tuberculosis_H37Rv --RWHGAVRDWPKPLGFVWGLDDPVATT----NVLNG-------------
TH_4027|M.thermoresistible__bu --RWHGAVADWPKPLGLLWGTDDPVATT----DVLAG-------------
MAB_4300|M.abscessus_ATCC_1997 --RWVRAMRETAVPMRMIDGPIDPNSGL----HMAER-------------
MSMEG_2777|M.smegmatis_MC2_155 --RWVRAMRETSVPMRLIDGPSDPNSGR----HMAQR-------------
MMAR_3449|M.marinum_M --HWLESLSTITVNTTLVWGLHDTVAPLRVPNHVWQA-------------
MUL_2723|M.ulcerans_Agy99 --HWLESLSTITVNTTLVWGLHDTVAPLRVPNHVWQA-------------
MAV_2139|M.avium_104 --RWLEALSTSDVDTTMVWGLHDNVAPLRVPNHVWQT-------------
Mflv_2749|M.gilvum_PYR-GCK --GWLERLSTIPVDTTVIWGLHDAVAPLRVANHVWQT-------------
Mvan_3788|M.vanbaalenii_PYR-1 --GWLERLSTIDVDTTLIWGLHDTVAPLRVANHVWEH-------------
MLBr_00862|M.leprae_Br4923 GIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSD
: .: . * : .:
Mb1865|M.bovis_AF2122/97 ----------------LRELRPSAAVVELPG-LGHYPQAEAPKAYAEAAL
Rv1834|M.tuberculosis_H37Rv ----------------LRELRPSAAVVELPG-LGHYPQVEAPKAYAEAAL
TH_4027|M.thermoresistible__bu ----------------LRELRSDAEVIELAG-VGHYPQIEVPEVFARAAL
MAB_4300|M.abscessus_ATCC_1997 ----------------YLEVIHDPDVVLLDDNIGHWPQIEAPEAVLTHFL
MSMEG_2777|M.smegmatis_MC2_155 ----------------YLEVIPDPDVVMLADDIAHWPQIEAPDAVLAHFL
MMAR_3449|M.marinum_M ----------------YLKNQPGRSRYWVVPTADHYLQCDAPAELAEIVR
MUL_2723|M.ulcerans_Agy99 ----------------YLKNQPGRSRYWVVPTADHYLQCDAPAELAEIVR
MAV_2139|M.avium_104 ----------------YLKTKPGRNRYWVIPGADHYLQCDAPAQLAEIVR
Mflv_2749|M.gilvum_PYR-GCK ----------------YVKPKPGRNHYWVVPTADHYVQCDAPAELAQIIR
Mvan_3788|M.vanbaalenii_PYR-1 ----------------YLKSSPGRNRYWVVPGADHYVQCDAPGQLAGIIR
MLBr_00862|M.leprae_Br4923 AAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLG
. . . :
Mb1865|M.bovis_AF2122/97 SLLVD---------------------------------------------
Rv1834|M.tuberculosis_H37Rv SLLVD---------------------------------------------
TH_4027|M.thermoresistible__bu ELLGLNRTIG----------------------------------------
MAB_4300|M.abscessus_ATCC_1997 EHIDRITP------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 EHIDRVVAL-----------------------------------------
MMAR_3449|M.marinum_M VTAAGGDVALQTLGDRADGAVLVDQCDGPA--------------------
MUL_2723|M.ulcerans_Agy99 VTAAGGDVALQTLGDRADGAVLVDQCDGPA--------------------
MAV_2139|M.avium_104 LTARGEDVPLQTLGDRPDGAVLVDGGAS----------------------
Mflv_2749|M.gilvum_PYR-GCK MTADGADIDLQTLGNRPDGAVLVDRSDGDRL-------------------
Mvan_3788|M.vanbaalenii_PYR-1 LTAEGVPPGLPTLGDRPDGAVLVDRSDGDDG-------------------
MLBr_00862|M.leprae_Br4923 GVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMF
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3449|M.marinum_M --------------------------------------------------
MUL_2723|M.ulcerans_Agy99 --------------------------------------------------
MAV_2139|M.avium_104 --------------------------------------------------
Mflv_2749|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3788|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQL
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3449|M.marinum_M --------------------------------------------------
MUL_2723|M.ulcerans_Agy99 --------------------------------------------------
MAV_2139|M.avium_104 --------------------------------------------------
Mflv_2749|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3788|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLR
Mb1865|M.bovis_AF2122/97 --------
Rv1834|M.tuberculosis_H37Rv --------
TH_4027|M.thermoresistible__bu --------
MAB_4300|M.abscessus_ATCC_1997 --------
MSMEG_2777|M.smegmatis_MC2_155 --------
MMAR_3449|M.marinum_M --------
MUL_2723|M.ulcerans_Agy99 --------
MAV_2139|M.avium_104 --------
Mflv_2749|M.gilvum_PYR-GCK --------
Mvan_3788|M.vanbaalenii_PYR-1 --------
MLBr_00862|M.leprae_Br4923 STARIRVI