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DIFDEWHRGGTTFSWTSTTPANGGAQVDVFARRTGTPGAPALVCVHGFPTAGVDYHALTRELADDFDIYV LDFPGYGLSGKPPHPYVYSLYDDARLLVHAITDVWGLETFRMVTHDRGSSIGMIALGLLDDIGRRPLDLF MTNANIYLPLANLTAFQVALLDDDTGRATAAATTPEMLAAGLGAATFMPRRTLQDPEIAALAHCFAHNDG IRVLPDTVRYLHERAADETGWLERLSTIPVDTTVIWGLHDAVAPLRVANHVWQTYVKPKPGRNHYWVVPT ADHYVQCDAPAELAQIIRMTADGADIDLQTLGNRPDGAVLVDRSDGDRL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2749 | - | - | 100% (330) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_4848 | - | 2e-08 | 30.85% (94) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_1960 | - | 2e-07 | 31.78% (107) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1865 | - | 3e-19 | 28.52% (298) | hydrolase |
| M. tuberculosis H37Rv | Rv1834 | - | 4e-19 | 28.52% (298) | hydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4300 | - | 3e-14 | 24.82% (274) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3449 | - | 1e-142 | 73.25% (329) | hydrolase |
| M. avium 104 | MAV_2139 | - | 1e-144 | 74.15% (325) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2777 | - | 6e-09 | 24.36% (275) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_4027 | - | 3e-19 | 30.87% (230) | PUTATIVE hydrolase |
| M. ulcerans Agy99 | MUL_2723 | - | 1e-142 | 73.25% (329) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3788 | - | 1e-156 | 78.96% (328) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1865|M.bovis_AF2122/97 MTSPSVREWRDGG---RWLPTAVG------KVFVR-SGPGDTPTMLLLHG
Rv1834|M.tuberculosis_H37Rv MTSPSVREWRDGG---RWLPTAVG------KVFVR-SGPGDTPTMLLLHG
TH_4027|M.thermoresistible__bu -----VARWRAEG---RWIRTGVG------SVFVR-SASGRGSPVVLLHG
Mflv_2749|M.gilvum_PYR-GCK --MDIFDEWHRGGTTFSWTSTTPANGGAQVDVFARRTGTPGAPALVCVHG
Mvan_3788|M.vanbaalenii_PYR-1 --MDIFTDWQRDGTHFTWTSTTAANAGTEVEVFSRRCGTPGAPALVCVHG
MMAR_3449|M.marinum_M MVLDIFAEWQSGASTLRWRSTTAANADAEVTVFTRRCGTPDAPALVLVHG
MUL_2723|M.ulcerans_Agy99 --MDIFAEWQSGASTLRWRSTTAANADAEVTVFTRRCGTPDAPALVLVHG
MAV_2139|M.avium_104 --MDIFAQWQGGGTELRWRSTTAANDGREVGVFSRRCGTPGAPALVLVHG
MAB_4300|M.abscessus_ATCC_1997 -MDAELEEWKAAGHYFDYLGFDIF-------YRVE----GSGPPLLLIHG
MSMEG_2777|M.smegmatis_MC2_155 -MHDELQRWKDAGQYFDYLGFDIF-------YRVDGVAPGTGPNLLLIHG
. *: . : . :: :**
Mb1865|M.bovis_AF2122/97 YPSSSFDFRAVIPHLT-GQAWVTMDFLGFGLSDKPR-PHRYSLLEQAHLV
Rv1834|M.tuberculosis_H37Rv YPSSSFDFRAVIPHLT-GQAWVTMDFLGFGLSDKPR-PHRYSLLEQAHLV
TH_4027|M.thermoresistible__bu YPSSSYDYRAVLPELG-DRGWVTFDFLGFGLSDKPR-PHRYSLFEQADLV
Mflv_2749|M.gilvum_PYR-GCK FPTAGVDYHALTRELADDFDIYVLDFPGYGLSGKPPHPYVYSLYDDARLL
Mvan_3788|M.vanbaalenii_PYR-1 FPTSGIDYSALARELAAEFDIYVLDFPGYGLSGKPPSPYVYSLYDDARLL
MMAR_3449|M.marinum_M FPTSSIDYFALARELGSEFDIYVLDFPGYGLSDKPRQPYVYSLYDDARLL
MUL_2723|M.ulcerans_Agy99 FPTSSIDYFALARELGSEFDIYVLDFPGYGLSDKPRQPYVYSLYDDARLL
MAV_2139|M.avium_104 FPTSSIDYFALAGELSRDFDIHLIDFPGYGLSDKPPEPYVYSLYDDARLL
MAB_4300|M.abscessus_ATCC_1997 YPFNSWDWALIWPTLVERFTVIAPDMIGMGFSDKPV-QYGYSVLDHADMH
MSMEG_2777|M.smegmatis_MC2_155 YPFNSWDWSLIWPTLTQRFTVIAPDMIGMGFSDKPV-AYEYRVTDHADIH
:* . *: : * *: * *:*.** : * : :.* :
Mb1865|M.bovis_AF2122/97 ETVVAHTVTG-AVVVLAHDMGTSVTTELLARDLDGRLP---FDLRRAVLS
Rv1834|M.tuberculosis_H37Rv ETVVAHTVTG-AVVVLAHDMGTSVTTELLARDLDGRLP---FDLRRAVLS
TH_4027|M.thermoresistible__bu QTVVRSVTDE-PVLLIAHDMGTSVATELMARDLQGQLP---FRLQRVVLS
Mflv_2749|M.gilvum_PYR-GCK VHAITDVWGLETFRMVTHDRGSSIGMIALGLLDDIG-----RRPLDLFMT
Mvan_3788|M.vanbaalenii_PYR-1 VHAVTERWRLTDYRMITHDRGSSVGMIALGMLAESG-----STPVDVFIT
MMAR_3449|M.marinum_M VHAIRRVWKLTEFRMLTHDRGSSVGMIALGMLAAEDPP---ALPIDLIIT
MUL_2723|M.ulcerans_Agy99 VHAIRRVWKLTEFRMLTHDRGSSVGMIALGMLAAEDPP---ALPIDLIIT
MAV_2139|M.avium_104 VHAITEVWRLSDYRMLTHDRGSSVGMIASGMLAALDPP---AAPVDLILT
MAB_4300|M.abscessus_ATCC_1997 EALLS-YLGIERFHLLTHDLGNSVGQEMLARFEFEQQSRGRVPIDSVTWL
MSMEG_2777|M.smegmatis_MC2_155 EALLA-HLGITSTHILAHDLGDSVGQEMLARHEFGGQAYGGFQIESVTWL
: :::** * *: .
Mb1865|M.bovis_AF2122/97 NGSVILERASLRPIQKVLR-SPLGPVAARLVSRGG--FTRG--FGRIFSP
Rv1834|M.tuberculosis_H37Rv NGSVILERASLRPIQKVLR-SPLGPVAARLVSRGG--FTRG--FGRIFSP
TH_4027|M.thermoresistible__bu NGSVLLDRASLRPIQKVLR-GRFGPVVSQLVNEPM--FIRG--LGKVFSK
Mflv_2749|M.gilvum_PYR-GCK NANIYLPLANLTAFQVALL-DDDTGRATAAATTPE--MLAAGLGAATFMP
Mvan_3788|M.vanbaalenii_PYR-1 NGNIYLPLANLTAFQVALL-DEATGRATAAATTPA--MLAAGLGASTFMP
MMAR_3449|M.marinum_M NANIYLPLSNLTAFQTALL-DPATARATAAATTPE--LLAAGLGASTFMP
MUL_2723|M.ulcerans_Agy99 NANIYLPLSNLTAFQTALL-DPATARATAAATTPE--LLAAGLGASTFMP
MAV_2139|M.avium_104 NANIYLPLANLTAFQSALL-DPSTARATAAATTPE--LLAAGMGASTFMP
MAB_4300|M.abscessus_ATCC_1997 NGGLFIEAYRPRIAQTLMSRTPLGDLVSRFQGTPVTRRIMDAAVSEMFGP
MSMEG_2777|M.smegmatis_MC2_155 NGGLFNEAYRPRLMQKVMSRTPLGDILSPLQGSPLSRRVFESTLDQMFGV
*..: * : : *
Mb1865|M.bovis_AF2122/97 AHPLSAQEAQAQWELLCYNDGNRIPHLLISYLDERIRHAQRWHGAVRDWP
Rv1834|M.tuberculosis_H37Rv AHPLSAQEAQAQWELLCYNDGNRIPHLLISYLDERIRHAQRWHGAVRDWP
TH_4027|M.thermoresistible__bu QRPLSAAEGAAQWALMSYHDGHRIMHLLTAYLNERVRYADRWHGAVADWP
Mflv_2749|M.gilvum_PYR-GCK RRTLQDPEIAALAHCFAHNDGIRVLPDTVRYLHERAADETGWLERLSTIP
Mvan_3788|M.vanbaalenii_PYR-1 RRSPQDDEIAALAQCFAHNDGISVLPDTVRYLHERAADETGWLERLSTID
MMAR_3449|M.marinum_M RRALEDPEITALARCFAHNDGIQALPDTVQYLHERAAGETHWLESLSTIT
MUL_2723|M.ulcerans_Agy99 RRALEDPEITALARCFAHNDGIQALPDTVQYLHERAAGETHWLESLSTIT
MAV_2139|M.avium_104 RRTLDDPEIAALAKCFAHNDGIRVLPDTIQYLNERAADETRWLEALSTSD
MAB_4300|M.abscessus_ATCC_1997 DTKPSPRLLSLFQQVLEYNDGARVTHQVGRFINDRYDNRSRWVRAMRETA
MSMEG_2777|M.smegmatis_MC2_155 NTKPSREMIEKFHQILDHNDGKRVLHKVGRFVTDRYTHRNRWVRAMRETS
. : ::** :: :* * :
Mb1865|M.bovis_AF2122/97 KPLGFVWGLDDPVATTNVLNGLRELRP-----SAAVVELPGLGHYPQAEA
Rv1834|M.tuberculosis_H37Rv KPLGFVWGLDDPVATTNVLNGLRELRP-----SAAVVELPGLGHYPQVEA
TH_4027|M.thermoresistible__bu KPLGLLWGTDDPVATTDVLAGLRELRS-----DAEVIELAGVGHYPQIEV
Mflv_2749|M.gilvum_PYR-GCK VDTTVIWGLHDAVAPLRVANHVWQTYVKPKPGRNHYWVVPTADHYVQCDA
Mvan_3788|M.vanbaalenii_PYR-1 VDTTLIWGLHDTVAPLRVANHVWEHYLKSSPGRNRYWVVPGADHYVQCDA
MMAR_3449|M.marinum_M VNTTLVWGLHDTVAPLRVPNHVWQAYLKNQPGRSRYWVVPTADHYLQCDA
MUL_2723|M.ulcerans_Agy99 VNTTLVWGLHDTVAPLRVPNHVWQAYLKNQPGRSRYWVVPTADHYLQCDA
MAV_2139|M.avium_104 VDTTMVWGLHDNVAPLRVPNHVWQTYLKTKPGRNRYWVIPGADHYLQCDA
MAB_4300|M.abscessus_ATCC_1997 VPMRMIDGPIDPNSGLHMAERYLEVIHD----PDVVLLDDNIGHWPQIEA
MSMEG_2777|M.smegmatis_MC2_155 VPMRLIDGPSDPNSGRHMAQRYLEVIPD----PDVVMLADDIAHWPQIEA
.: * * : : : *: * :.
Mb1865|M.bovis_AF2122/97 PKAYAEAA----------LSLLVD----------------
Rv1834|M.tuberculosis_H37Rv PKAYAEAA----------LSLLVD----------------
TH_4027|M.thermoresistible__bu PEVFARAA----------LELLGLNRTIG-----------
Mflv_2749|M.gilvum_PYR-GCK PAELAQIIRMTADGADIDLQTLGNRPDGAVLVDRSDGDRL
Mvan_3788|M.vanbaalenii_PYR-1 PGQLAGIIRLTAEGVPPGLPTLGDRPDGAVLVDRSDGDDG
MMAR_3449|M.marinum_M PAELAEIVRVTAAGGDVALQTLGDRADGAVLVDQCDGPA-
MUL_2723|M.ulcerans_Agy99 PAELAEIVRVTAAGGDVALQTLGDRADGAVLVDQCDGPA-
MAV_2139|M.avium_104 PAQLAEIVRLTARGEDVPLQTLGDRPDGAVLVDGGAS---
MAB_4300|M.abscessus_ATCC_1997 PEAVLTHF----------LEHIDRITP-------------
MSMEG_2777|M.smegmatis_MC2_155 PDAVLAHF----------LEHIDRVVAL------------
* * :