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QTLRTPDERFAQLPEFPYAPMYCDIDDGEGGRLRVAWVEDGPAHAEPVLLLHGEPSWSFLYRKMIPILVA AGHRVICPDLVGFGRSDKPTRIEDHTYARHVEWMRSLVFDALDLRKVTLVGQDWGGLIGLRLAAEHPDRF ANIVVANTGLPTGDIPMPDIWWQFRNAIQKAPKVDVGRFVASGCRRPLSDGVIAAYDAPFPDDSYCAGPR AMPGLVPTSPDDPAAEANRAAWKVLRASKTPMLVAFSDGDPITGGMAPIFKKEMRGAHGIEHPVISGAGH FLQEDAGEDLASAVVEFLRDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6314 | - | - | 100% (302) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_0117 | - | 2e-18 | 30.96% (281) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_6837 | - | 2e-15 | 26.99% (289) | haloalkane dehalogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2318 | - | 1e-81 | 53.00% (300) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4004 | - | 5e-31 | 54.03% (124) | haloalkane dehalogenase |
| M. tuberculosis H37Rv | Rv2296 | - | 2e-81 | 53.00% (300) | haloalkane dehalogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-05 | 25.26% (95) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 7e-14 | 35.65% (115) | epoxide hydrolase EphA |
| M. marinum M | MMAR_3472 | - | 4e-78 | 49.66% (298) | haloalkane dehalogenase |
| M. avium 104 | MAV_0357 | - | 1e-137 | 73.67% (300) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_1615 | linB | 9e-18 | 27.11% (284) | POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE |
| M. ulcerans Agy99 | MUL_3052 | - | 1e-18 | 28.76% (306) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 5e-94 | 57.86% (299) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6314|M.smegmatis_MC2_155 MQTLRTPDERFAQLPEFPYAPMYCDIDDGEGGRLRVAWVEDGPAHAEPVL
MAV_0357|M.avium_104 MHTLRTPDDRFHTVPDFPYPPRYCEVSDDDGGALRVAWVEDGPAGADPVL
Mb2318|M.bovis_AF2122/97 MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIV
Rv2296|M.tuberculosis_H37Rv MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPGDGPPIV
MMAR_3472|M.marinum_M MDVVRTPDARFQNLVGYPFAAHYVDVAATDTPHLRMHYIDEGPADGPPIV
Mflv_4004|M.gilvum_PYR-GCK MDVLRTPYERFTDLPGFPFDPHYVEVGG-----LRMHYLDEGPAGGDVVL
Mvan_2384|M.vanbaalenii_PYR-1 MDILRTPDERFADLPDFPFAPHYVEVDG-----LRMHYLDEGPADGPVVL
MUL_3052|M.ulcerans_Agy99 MGRQFTP-DFTPDPKLYPFASRWFDSSRG-----RLHYIDE--SDGPPIL
TH_1615|M.thermoresistible__bu -----MPGSKPYG------EPRFREIKNK-----RMAYIDEG--EGDAIV
MAB_0528c|M.abscessus_ATCC_199 -------------MTDAAVDIRERDIATNG---VHLRIVEAGEPGQPAVI
MLBr_00862|M.leprae_Br4923 ---------MPATQSIHKVPHQFVESPDG----VRLAIYQSGQPEGPAIV
: :: : ::
MSMEG_6314|M.smegmatis_MC2_155 LLHGEPSWSFLYRKMIPILVAAGHRVICPDLVGFGRSD--KPTRIEDHTY
MAV_0357|M.avium_104 MLHGEPSWSYLYRKMIPVLAGAGHRVVCPDLVGFGRSD--KPTRREDHSY
Mb2318|M.bovis_AF2122/97 LLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSD--KPTRIEDYTY
Rv2296|M.tuberculosis_H37Rv LLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSD--KPTRIEDYTY
MMAR_3472|M.marinum_M LLHGEPTWSYLYRTMIPPLAAGGYRVLAPDLIGFGRSD--KPTRIADYTY
Mflv_4004|M.gilvum_PYR-GCK LLHGEPSWSYLYRTMIPVLVDAGLRAVAIDLVGFGRSD--KPADRADYTY
Mvan_2384|M.vanbaalenii_PYR-1 LLHGEPSWSYLYRRMIPVLVDAGLRAVAIDLVGFGRSD--KPTRREDYTY
MUL_3052|M.ulcerans_Agy99 LCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSE--HPGTFG-YKV
TH_1615|M.thermoresistible__bu FQHGNPTSSYLWRNVLPHLEGLGRLVAC-DLIGMGGSEKLSPSGPDRYHY
MAB_0528c|M.abscessus_ATCC_199 LSHGFPELAYSWRHQIPALAAAGYHVIAPDQRGYGRSS--MPAHIDDYNI
MLBr_00862|M.leprae_Br4923 LVHGFPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSS--VPKPVSAYTM
: ** * : : * * * * *. * :
MSMEG_6314|M.smegmatis_MC2_155 ARHVEWMRSLVFDALDLRKVTLVGQDWG--GLIGLRLAAEHPDRFANIVV
MAV_0357|M.avium_104 ARHVEWMRAVAFDVLDLHNVTLVGQDWG--GLIGLRLAAEHPERFARMVV
Mb2318|M.bovis_AF2122/97 LRHVEWVTS-WFENLDLHDVTLFVQDWG--SLIGLRIAAEHGDRIARLVV
Rv2296|M.tuberculosis_H37Rv LRHVEWVTS-WFENLDLHDVTLFVQDWG--SLIGLRIAAEHGDRIARLVV
MMAR_3472|M.marinum_M LRHVEWVKS-WFEELRLAEATLFVQDWG--SLIGLRVAAEHGDAIARLVV
Mflv_4004|M.gilvum_PYR-GCK QAHVDWTWG-AVAALGLADITLVCQD------------------------
Mvan_2384|M.vanbaalenii_PYR-1 QAHVDWTWA-AIEAIGLTGITLVCQDWG--GLIGLRLVGEHPDRFARVVA
MUL_3052|M.ulcerans_Agy99 DEHAQVVGE-FVDHLGLDNYLTMGQDWG--GPISMAVAVERAERVRGIVL
TH_1615|M.thermoresistible__bu GEHRDYLFALWEELELGDRVVLVLHDWG--SVLGFDWANHHRDRVQGIAH
MAB_0528c|M.abscessus_ATCC_199 EALSDDLLG-ILDDVGAGKATFVGHDWG--AVVTWHTALAVPERVSGVVG
MLBr_00862|M.leprae_Br4923 TRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTS
: . :*
MSMEG_6314|M.smegmatis_MC2_155 ANTGLPTG-----DIPMPDIW-----------------------------
MAV_0357|M.avium_104 ANTGLPNG-----DQPMADVW-----------------------------
Mb2318|M.bovis_AF2122/97 ANGFLPAA-----QGRTPLPF-----------------------------
Rv2296|M.tuberculosis_H37Rv ANGFLPAA-----QGRTPLPF-----------------------------
MMAR_3472|M.marinum_M ANGFLPTA-----RGRTPTAF-----------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 ANTTLPTG-----DQRPGEAF-----------------------------
MUL_3052|M.ulcerans_Agy99 GNTWFWPA-----DTLTMKAF-----------------------------
TH_1615|M.thermoresistible__bu MESIVTPLTWADWEDPARSVF-----------------------------
MAB_0528c|M.abscessus_ATCC_199 LSVPFTRRSQVPPTQAWNKLFGDNFFY-----------------------
MLBr_00862|M.leprae_Br4923 VSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPM
MSMEG_6314|M.smegmatis_MC2_155 -WQFR-----NAIQKAPKVDVGRFVASGCRRPLSDGVIAAYDAPFPDD-S
MAV_0357|M.avium_104 -WRFR-----EAITSAPQLNIGAFVQGGCRRRLSDAERAGYDAPFPSD-E
Mb2318|M.bovis_AF2122/97 -YVWR-----AFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDK-T
Rv2296|M.tuberculosis_H37Rv -YVWR-----AFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDK-T
MMAR_3472|M.marinum_M -HIWR-----AFARYSPVLPAGRLVAAGTVRKVPPAVRAGYDAPFPDK-S
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 -LAWQ-----RFSQETPDFAVGHIVNGGCVSTLAPEVIAAYDAPFPDD-S
MUL_3052|M.ulcerans_Agy99 -STVMSSLPMQYAILHHNFFVERLIPAGTTHRPSSAVMEHYRGVQPTA-S
TH_1615|M.thermoresistible__bu -QGLRTP-EGERMVLEENIFVEAMLPRGVHRTLSDEEMAHYREPFRDRGE
MAB_0528c|M.abscessus_ATCC_199 ILYFQEPGVADADLNRDPATTMRRMMAGMARIDGATMIAPGPAGFVERMP
MLBr_00862|M.leprae_Br4923 VLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFS
MSMEG_6314|M.smegmatis_MC2_155 YCAGPRAMPGL---------------------------------------
MAV_0357|M.avium_104 YCAGPRAMPTL---------------------------------------
Mb2318|M.bovis_AF2122/97 YQAGARAFPRL---------------------------------------
Rv2296|M.tuberculosis_H37Rv YQAGARAFPRL---------------------------------------
MMAR_3472|M.marinum_M YQAGARAFPQL---------------------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 YKAGARQFPTL---------------------------------------
MUL_3052|M.ulcerans_Agy99 ARVGVAEMPKQ---------------------------------------
TH_1615|M.thermoresistible__bu GRRPTLTWPRN---------------------------------------
MAB_0528c|M.abscessus_ATCC_199 DPGELPEWLSQ---------------------------------------
MLBr_00862|M.leprae_Br4923 GRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGH
MSMEG_6314|M.smegmatis_MC2_155 --VPTSPDDPAAEAN----------------RAAWKVLRAS-KTPMLVAF
MAV_0357|M.avium_104 --VPTSPEDPAAAAN----------------KAAWAKLAVS-PTPMLVAF
Mb2318|M.bovis_AF2122/97 --VPTSPDDPAVPAN----------------RAAWEALGRW-DKPFLAIF
Rv2296|M.tuberculosis_H37Rv --VPTSPDDPAVPAN----------------RAAWEALGRW-DKPFLAIF
MMAR_3472|M.marinum_M --VPISPDDPAVAAN----------------RAAWDALGRW-EKPFLAIF
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --VPTSPDDPAAPAN----------------RAAWEVLRTF-DRPFLCAF
MUL_3052|M.ulcerans_Agy99 --ILAARPLLARLAS----------------EVPAQLG----TKPALLVW
TH_1615|M.thermoresistible__bu --VPIDGEPADVAAI----------------VADYAVWLAEGDVPKLFVN
MAB_0528c|M.abscessus_ATCC_199 --DELDHYITEFARTGFTGGLNWYRNFDRNWALTERLAGANVVVPSLFIA
MLBr_00862|M.leprae_Br4923 FSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVT
MSMEG_6314|M.smegmatis_MC2_155 SDGDPITGGMAPIFKK----------EMRGAHGIEHPVISGAGHFLQEDA
MAV_0357|M.avium_104 SDSDPITGPMAAIFQR----------EMRGAQGIDHPLIRGAGHFLQEDA
Mb2318|M.bovis_AF2122/97 GYRDPILGQADGPLIK----------HIPGAAGQPHARIKAS-HFIQEDS
Rv2296|M.tuberculosis_H37Rv GYRDPILGQADGPLIK----------HIPGAAGQPHARIKAS-HFIQEDS
MMAR_3472|M.marinum_M GERDPLLGRADRPLIK----------HIPGAAGQPHARINAN-HFIQEDS
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 SDSDPITRGADAPLRK----------FIPGAQGRPEVTIAGGGHFLQEDK
MUL_3052|M.ulcerans_Agy99 GMKDFAFR-PEPMLAR----------MRAVFADHILVELPEAKHLIQEDA
TH_1615|M.thermoresistible__bu AEPGAIVRGRVRDFVR----------SWP----NQTEITVAGRHYIQEDS
MAB_0528c|M.abscessus_ATCC_199 GAADPVLGFTDHAGSA----------KYR-TDNRGDLLIDGAGHWIQQER
MLBr_00862|M.leprae_Br4923 GAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYAL
MSMEG_6314|M.smegmatis_MC2_155 GEDLASAVVEFLRDR-----------------------------------
MAV_0357|M.avium_104 GAELAGHIVEFLRR------------------------------------
Mb2318|M.bovis_AF2122/97 GTELAERMLSWQQAT-----------------------------------
Rv2296|M.tuberculosis_H37Rv GTELAERMLSWQQAT-----------------------------------
MMAR_3472|M.marinum_M GPELAERIISWQ--------------------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 GPELAAVVVDFIAANPV---------------------------------
MUL_3052|M.ulcerans_Agy99 PDEIAAAIIARFG-------------------------------------
TH_1615|M.thermoresistible__bu PDEIGAAIADFVRKLRG---------------------------------
MAB_0528c|M.abscessus_ATCC_199 PLEVNAALLAFLREVVH---------------------------------
MLBr_00862|M.leprae_Br4923 DVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLA
MSMEG_6314|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0357|M.avium_104 --------------------------------------------------
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3472|M.marinum_M --------------------------------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAA
MSMEG_6314|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0357|M.avium_104 --------------------------------------------------
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3472|M.marinum_M --------------------------------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 TYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDR
MSMEG_6314|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0357|M.avium_104 --------------------------------------------------
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3472|M.marinum_M --------------------------------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 RGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLP
MSMEG_6314|M.smegmatis_MC2_155 ------------
MAV_0357|M.avium_104 ------------
Mb2318|M.bovis_AF2122/97 ------------
Rv2296|M.tuberculosis_H37Rv ------------
MMAR_3472|M.marinum_M ------------
Mflv_4004|M.gilvum_PYR-GCK ------------
Mvan_2384|M.vanbaalenii_PYR-1 ------------
MUL_3052|M.ulcerans_Agy99 ------------
TH_1615|M.thermoresistible__bu ------------
MAB_0528c|M.abscessus_ATCC_199 ------------
MLBr_00862|M.leprae_Br4923 QVLRSTARIRVI