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VSKPTWVQHAIWWQVYPLGFVGAFPANQPPNPGEHRLRRLVGWFDHAVELGASGVALGPIFDSRTHGYDT TDHFRIDPRLGDEGDFDHLVAEAHRRGLRVLLDGVFNHVGVDFHSYRHAADDPSSAGWFRGRAGNFRTFE GHSGLITLNHANPEVADYVVDVMAHWLQRGADGWRLDAAYAVPQQFWAKVLPRVRDRYPQAWFVGEIIHG DYAAAVQGAGFDSVTQYELWKAIWSGLNDGNFFELDWALQRHNEFVASFAPLTFIGNHDVTRIASRLERP EHLAHALVILMTVGGIPSIYAGDEFGWRAVKEERCGGDDAIRPEFGSPPFELTHDQASVWALHQYLVGLR RRYPWLHTASTSALRLRNRQYVYQTRSADNALVVILNADDEPLRMSLPDLGIPHAEVLAGSAAPPQEVTD EVLVEGHGWRILQPASRFSCASVSGSSRRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3001 | treS_1 | - | 100% (450) | trehalose synthase TreS_1 |
| M. ulcerans Agy99 | MUL_4797 | treS | 3e-19 | 35.12% (205) | trehalose synthase TreS |
| M. ulcerans Agy99 | MUL_3935 | - | 7e-10 | 24.05% (262) | glycosidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0131 | treS | 6e-18 | 30.24% (205) | trehalose synthase TRES |
| M. gilvum PYR-GCK | Mflv_3333 | - | 1e-180 | 66.59% (434) | alpha amylase, catalytic region |
| M. tuberculosis H37Rv | Rv0126 | treS | 7e-18 | 30.24% (205) | trehalose synthase TRES |
| M. leprae Br4923 | MLBr_02045 | - | 3e-29 | 65.88% (85) | hypothetical protein MLBr_02045 |
| M. abscessus ATCC 19977 | MAB_1565c | - | 9e-13 | 23.40% (376) | Alpha-amylase family protein |
| M. marinum M | MMAR_2753 | treS_1 | 0.0 | 97.90% (429) | trehalose synthase TreS_1 |
| M. avium 104 | MAV_2842 | - | 0.0 | 74.26% (439) | alpha-amylase 3 |
| M. smegmatis MC2 155 | MSMEG_3576 | - | 0.0 | 68.74% (435) | alpha-amylase 3 |
| M. thermoresistible (build 8) | TH_2297 | - | 1e-176 | 66.37% (443) | alpha-amylase 3 |
| M. vanbaalenii PYR-1 | Mvan_3059 | - | 0.0 | 68.43% (434) | alpha amylase, catalytic region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0131|M.bovis_AF2122/97 MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWFKHAVFY
Rv0126|M.tuberculosis_H37Rv MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWFKHAVFY
MUL_3001|M.ulcerans_Agy99 -------------------------------------MSKPTWVQHAIWW
MMAR_2753|M.marinum_M -------------------------------------------MQHAIWW
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MAV_2842|M.avium_104 -------------------------------------MTGPDWVQHVIWW
MSMEG_3576|M.smegmatis_MC2_155 -------------------------------------MTMPDWVTHAIWW
TH_2297|M.thermoresistible__bu -------------------------------------VTGPDWVRHTIWW
Mflv_3333|M.gilvum_PYR-GCK -------------------------------------MSDPAWVEHVLWW
Mvan_3059|M.vanbaalenii_PYR-1 -------------------------------------MTEPDWVDHVVWW
MAB_1565c|M.abscessus_ATCC_199 ------------------------------MTAAYLGQHDDPWWSRAVFY
Mb0131|M.bovis_AF2122/97 EVLVRAFFDASA----------DGSGDLRGLIDRLDYLQWLGIDCIWLPP
Rv0126|M.tuberculosis_H37Rv EVLVRAFFDASA----------DGSGDLRGLIDRLDYLQWLGIDCIWLPP
MUL_3001|M.ulcerans_Agy99 QVYPLGFVGAFP---ANQ-PPNPGEHRLRRLVGWFDHAVELGASGVALGP
MMAR_2753|M.marinum_M QVYPLGFVGAFP---ANQ-PPDPGEHRLRRLVGWFDHAVELGASGVALGP
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MAV_2842|M.avium_104 QVYPLGFVGAYPLPQSSE-PPQPEHHRLRRLVDWFDHAIELGASGIALGP
MSMEG_3576|M.smegmatis_MC2_155 QIYPLGFVGAHP-ADP---PPGPEEHRLRRIVEWLDHAVELGASGLALGP
TH_2297|M.thermoresistible__bu QIYPLGFVGAHPWTDPTTGPPGPDEHRLRRVLDWLDHVVDLGASGLALGP
Mflv_3333|M.gilvum_PYR-GCK QVYPLGFVGVHP-ADT---APEPGEHRLRRIVDWLDYAVELGASGVALGP
Mvan_3059|M.vanbaalenii_PYR-1 QVYPLGFVGAYP-ADP---PPPPGEHRLRRIVDWLDYAIELGASGLALGP
MAB_1565c|M.abscessus_ATCC_199 QIYPRSFGDSDG----------DGVGDIDGISAKLGYLDLLGVEGIWLNP
Mb0131|M.bovis_AF2122/97 FYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMN
Rv0126|M.tuberculosis_H37Rv FYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMN
MUL_3001|M.ulcerans_Agy99 IFDS--RTHGYDTTDHFRIDPRLGDEGDFDHLVAEAHRRGLRVLLDGVFN
MMAR_2753|M.marinum_M IFDS--RTHGYDTTDHFRIDPRLGDEGDFDHLVAEAHRRGLRVLLDGVFN
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MAV_2842|M.avium_104 IFTS--RTHGYDTTDHYRIDPRLGDDADFDHLIAQAHRRGLRVLLDGVFN
MSMEG_3576|M.smegmatis_MC2_155 VFAS--RTHGYDTTDHLRIDPRLGDDADFDHVVAEAHRRGLRVLLDGVFN
TH_2297|M.thermoresistible__bu VFAS--RSHGYDTTDHYRIDPRLGTDADFDELVEQAHRRGLRVLLDGVFH
Mflv_3333|M.gilvum_PYR-GCK VFHS--RTHGYDTIDHYRVDPRLGDDSDFDHLIEESHSRGLRVLLDGVFN
Mvan_3059|M.vanbaalenii_PYR-1 VFAS--RTHGYDTTDHYRIDPRLGEDGDFDHLVAEARDRGLRILLDGVFN
MAB_1565c|M.abscessus_ATCC_199 VTRSPMADHGYDVSNPREIDPLFGGSIAMHRLIASAHRHNIKVIMDLVPN
Mb0131|M.bovis_AF2122/97 HTSESHPWFQESRRDP-DGPYGDYYVWSDTSERYTDARIIFVDTEES---
Rv0126|M.tuberculosis_H37Rv HTSESHPWFQESRRDP-DGPYGDYYVWSDTSERYTDARIIFVDTEES---
MUL_3001|M.ulcerans_Agy99 HVGVDFHSYRHAAD---DPSSAGWFRGRAGNFRTFEG-------------
MMAR_2753|M.marinum_M HVGMDFHRYRHAAD---DPSSAGWFRGRAGNFRTFEG-------------
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MAV_2842|M.avium_104 HVGVDFPRYRAAIDSD-DHAAARWFRGSRGRFHTFEG-------------
MSMEG_3576|M.smegmatis_MC2_155 HVGTDFARYRQALGGD-ADSAA-WFRHRDGKFEVFEG-------------
TH_2297|M.thermoresistible__bu HVGTDFARYRDAAAG---GSSG-WFRRRGDRFETFEG-------------
Mflv_3333|M.gilvum_PYR-GCK HVGTEFPRYREAVDG---GDRS-WFATRGDDFATFEG-------------
Mvan_3059|M.vanbaalenii_PYR-1 HVGTDFPRYRDAAAG---GDSA-WFRRRGGDFATFEG-------------
MAB_1565c|M.abscessus_ATCC_199 HTSSEHPWFLEALQSPPGSDARERYIFRDGKGAHGELPPNNWPSVFGGPA
Mb0131|M.bovis_AF2122/97 ---NWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGID
Rv0126|M.tuberculosis_H37Rv ---NWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGID
MUL_3001|M.ulcerans_Agy99 -------------------HSGLITLNHANPEVADYVVDVMAHWLQRGAD
MMAR_2753|M.marinum_M -------------------HSELITLNHANPEVADYVVDVMAHWLQRGAD
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MAV_2842|M.avium_104 -------------------HDGLITLNHDNPEVVDYTVDVMAHWLGRGAD
MSMEG_3576|M.smegmatis_MC2_155 -------------------HGELIALNHDNPEVVNYTAGVMRHWLGRGAD
TH_2297|M.thermoresistible__bu -------------------HDELIALDHDNPEVAAYTVDVLRHWLNRGAD
Mflv_3333|M.gilvum_PYR-GCK -------------------HEGLITLDHDNADVVDYTVDVMSHWLARGAD
Mvan_3059|M.vanbaalenii_PYR-1 -------------------HGDLIALDHRSAEVVDYTVDVMSHWLGRGAD
MAB_1565c|M.abscessus_ATCC_199 WTRVTEADGTPGQWYLHLFAPEQPDVNWDNPEVFDDFADTLRFWLDRGID
Mb0131|M.bovis_AF2122/97 GFRLDAVP---------YLFEREGTNCENLPETHAFLKRVRKVVDDEFPG
Rv0126|M.tuberculosis_H37Rv GFRLDAVP---------YLFEREGTNCENLPETHAFLKRVRKVVDDEFPG
MUL_3001|M.ulcerans_Agy99 GWRLDAAY---------AVPQQ-------------FWAKVLPRVRDRYP-
MMAR_2753|M.marinum_M GWRLDAAY---------AVPQQ-------------FWAKVLPRVRDRYP-
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MAV_2842|M.avium_104 GWRLDAAY---------AVPET-------------FWAATLPRVRDRYP-
MSMEG_3576|M.smegmatis_MC2_155 GWRLDAAY---------AVPDR-------------FWAQVLPIVRSDFG-
TH_2297|M.thermoresistible__bu GWRLDAAY---------AVPDR-------------FWARVLPDVRRSHP-
Mflv_3333|M.gilvum_PYR-GCK GWRLDAAY---------AVPDR-------------FWAQVLPRVRQAHP-
Mvan_3059|M.vanbaalenii_PYR-1 GWRLDAAY---------AVPDS-------------FWAGVLPRVRERHP-
MAB_1565c|M.abscessus_ATCC_199 GFRLDVAHGMAKPPGLPDIEDTETSMLHIADEDPRFNNEGVHEYHRKIRK
Mb0131|M.bovis_AF2122/97 RVLLAEANQWPGDVVEYF---GDPNTGGDECHMAFHFPLMPRIFMAVRRE
Rv0126|M.tuberculosis_H37Rv RVLLAEANQWPGDVVEYF---GDPNTGGDECHMAFHFPLMPRIFMAVRRE
MUL_3001|M.ulcerans_Agy99 ------QAWFVGEIIHGD---YAAAVQGAGFDSVTQYELWKAIWSGLNDG
MMAR_2753|M.marinum_M ------RAWFVGEIIHGD---YAAAVQGAGFDSVTQYELWKAIWSGLNDG
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MAV_2842|M.avium_104 ------QAWFVGELIHGD---YAAVVRAAGFDSATQYELWKAIWSSLNDG
MSMEG_3576|M.smegmatis_MC2_155 ------DAWFVGEVIHGD---YAATVAASTFDSVTQYELWKAVWSALNDG
TH_2297|M.thermoresistible__bu ------EAWFVGEVIHGD---YAATVSAASFDSVTQYELWKAVWSSLNDG
Mflv_3333|M.gilvum_PYR-GCK ------AAWFVGEVIHGD---YVARVRDSGFDSVTQYELWKAVWSSINDA
Mvan_3059|M.vanbaalenii_PYR-1 ------QAWFVGEVIHGD---YPARVRDSGFDSVTQYELWKAIWSSLNDG
MAB_1565c|M.abscessus_ATCC_199 VLDQYRDVVAVGEIWVNDNTRFAEYVRPDELHLGFNFKLVEADFDADQIR
Mb0131|M.bovis_AF2122/97 SRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAK
Rv0126|M.tuberculosis_H37Rv SRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAK
MUL_3001|M.ulcerans_Agy99 NFFELDWALQRHNEFVASFAPLTFIGNHDVTRIASRLE------------
MMAR_2753|M.marinum_M NFFELDWALQRHNEFVASFAPLTFIGNHDVTRIASRLE------------
MLBr_02045|M.leprae_Br4923 -----------------------------MSRIASQLG------------
MAV_2842|M.avium_104 NFYELDWALQRHNAFLGRFSPLTFIGNHDVTRIASQLN------------
MSMEG_3576|M.smegmatis_MC2_155 NFHELDWALQRHNDFLASFVPMTFVGNHDVTRIASQLS------------
TH_2297|M.thermoresistible__bu NFFELDWALQRHNDFLAVFTPLTFIGNHDVTRIASRLA------------
Mflv_3333|M.gilvum_PYR-GCK NFHELDWALTRHNEFLDTFVPLTFIGNHDVTRIASRLT------------
Mvan_3059|M.vanbaalenii_PYR-1 NFHELDWALTRHDEFLDTFVPMTFVGNHDVTRIASQLT------------
MAB_1565c|M.abscessus_ATCC_199 AAIQNSLAAVDSVGATPTWTLSNHDVEREVTRYGDGQIG-----------
Mb0131|M.bovis_AF2122/97 DPRMKANVGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYGDEIGMG
Rv0126|M.tuberculosis_H37Rv DPRMKANVGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYGDEIGMG
MUL_3001|M.ulcerans_Agy99 --------------------RPEHLAHALVILMTVGGIPSIYAGDEF---
MMAR_2753|M.marinum_M --------------------RPEHLAHALVILMTVGGIPSIYAGDEF---
MLBr_02045|M.leprae_Br4923 --------------------QPEHLTHALIILLTVAGVPSVYAGDEF---
MAV_2842|M.avium_104 --------------------NPAHLAHALVLLLTVGGVPSVYAGDEL---
MSMEG_3576|M.smegmatis_MC2_155 --------------------DARHLEHALVILFTTGGIPSVYAGDEW---
TH_2297|M.thermoresistible__bu --------------------DRRHVEHAVVLLLTVGGVPSIYAGDEA---
Mflv_3333|M.gilvum_PYR-GCK --------------------DPAHVEHALVVLLTTGGTPSVYAGDEV---
Mvan_3059|M.vanbaalenii_PYR-1 --------------------DPTHVEHALVLLMTVGGTPSVYAGDEV---
MAB_1565c|M.abscessus_ATCC_199 ---------------------QWRARAMALVMLALPGTVFIYNGSELG--
: :::: * :* *.*
Mb0131|M.bovis_AF2122/97 DVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYGYQAVN-
Rv0126|M.tuberculosis_H37Rv DVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYGYQAVN-
MUL_3001|M.ulcerans_Agy99 -----------------------GWRAVKEERCGGDDAIRPEFGSPP---
MMAR_2753|M.marinum_M -----------------------GWRAVKEERYGGDDAIRPEFGSPP---
MLBr_02045|M.leprae_Br4923 -----------------------GFRGLKEERYGVDDAVLPEFFSPP---
MAV_2842|M.avium_104 -----------------------GFRGVKEERFGGDDAVRPEFGSPP---
MSMEG_3576|M.smegmatis_MC2_155 -----------------------GHQGVKEERRGGDDAVRPEFGERP---
TH_2297|M.thermoresistible__bu -----------------------GYLGVKEERFSGDDAIRPEFGSPPIVS
Mflv_3333|M.gilvum_PYR-GCK -----------------------AYRGVKEERFGGDDAVRPEFRSPF---
Mvan_3059|M.vanbaalenii_PYR-1 -----------------------AYRGVKEERFGGDDAVRPEFGSPF---
MAB_1565c|M.abscessus_ATCC_199 -------------------LPNVELPDEALQDPVWERSGHTERGRDGCRV
: .
Mb0131|M.bovis_AF2122/97 VEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLAYVRQV
Rv0126|M.tuberculosis_H37Rv VEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLAYVRQV
MUL_3001|M.ulcerans_Agy99 -FELTHDQASVWALHQYLVGLRRRYPWLHTASTSALRLRNR---QYVYQT
MMAR_2753|M.marinum_M -LQLTHDQASVWALHQYLVGLRRRYPWLHTASTSALRLRNR---QYVYQT
MLBr_02045|M.leprae_Br4923 -MQLDVFGVHAWALHQYLIGLRRRHP------------------------
MAV_2842|M.avium_104 -IPLDDFGTEVWRLHQYLIGLRRRHPWLHAATTTALLLQNR---HYVYET
MSMEG_3576|M.smegmatis_MC2_155 --GPDAPGADVLRLHQYLIGLRRRHPWLHSATTTPLLLTNT---QYVYRS
TH_2297|M.thermoresistible__bu GAGENTVAADLVRLHQHLIGLRRRNPWLHTATTAPLHLTNT---QYVYES
Mflv_3333|M.gilvum_PYR-GCK -DGVGEQGHQMFRSHQHLIGLRRRHPWLHEARTTALSVTNT---GYVYIT
Mvan_3059|M.vanbaalenii_PYR-1 -EGVGEHGHQVFRSHQHLIGLRRRNPWLHTARTTPLRVTNR---GYVYTT
MAB_1565c|M.abscessus_ATCC_199 PIPWEGTDPPYGFSSNAQTWLPMPHGWAEYTVERQLEHTDSMLSLYRRAI
. :
Mb0131|M.bovis_AF2122/97 AGDDGD---TVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIGQ
Rv0126|M.tuberculosis_H37Rv AGDDGD---TVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIGQ
MUL_3001|M.ulcerans_Agy99 RSADNA---LVVILN---ADDEPLRMSLPDLGIPHAEVLAGSAAPP--QE
MMAR_2753|M.marinum_M RSADNA---LVVILN---ADDEPLRMSLPDLGIPRAEVLAGSAAPP--QE
MLBr_02045|M.leprae_Br4923 --------------------------------------------------
MAV_2842|M.avium_104 RSGDEA---LLIVLN---IGDEPLRVSLDELGGRRGRVIGGSAAPP--PE
MSMEG_3576|M.smegmatis_MC2_155 AGAAGA---LVVALN---LDDAPLRVALPELGLASGVVVAGSKAPP--QE
TH_2297|M.thermoresistible__bu RSGEHA---LVVALN---IDTAPLPLRLSEIGLGAGRVVAGSGAPP--AA
Mflv_3333|M.gilvum_PYR-GCK RSGDDA---LVVALN---VADEPLPVALSGLGLGHAEIVAGSGAPP--AE
Mvan_3059|M.vanbaalenii_PYR-1 RHGDDA---LVVALN---IDDDAMPVSLAEFGLARAEVVAGSGAPP--AQ
MAB_1565c|M.abscessus_ATCC_199 ELRKSRKEFTGTSLEWYGSPPGALAFRVKGGGLTCALNVSSDLVDLPEGE
Mb0131|M.bovis_AF2122/97 VPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
Rv0126|M.tuberculosis_H37Rv VPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
MUL_3001|M.ulcerans_Agy99 VTDEVLVEGHGWRILQPASRFSCASVSGSSRRA-
MMAR_2753|M.marinum_M VTDEVLVEGHGWRILQPA----------------
MLBr_02045|M.leprae_Br4923 ----------------------------------
MAV_2842|M.avium_104 VLDTVVVEPQGWRILSPI----------------
MSMEG_3576|M.smegmatis_MC2_155 QIEVTEVPPHGWLVIEPR----------------
TH_2297|M.thermoresistible__bu DLTNVDVAPHGWLIIEPAR---------------
Mflv_3333|M.gilvum_PYR-GCK VVPDIVVPPHGWVILNPR----------------
Mvan_3059|M.vanbaalenii_PYR-1 VVADTVVPAHGWLILAPR----------------
MAB_1565c|M.abscessus_ATCC_199 VILTSGPLVNGKLPRNTAAWIV------------