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MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWFKHAVFYEVLVRAFFDASADGSGDLRG LIDRLDYLQWLGIDCIWLPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMN HTSESHPWFQESRRDPDGPYGDYYVWSDTSERYTDARIIFVDTEESNWSFDPVRRQFYWHRFFSHQPDLN YDNPAVQEAMIDVIRFWLGLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAE ANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIAQTPPIPDMAQWGIFLRNHD ELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYGDEIGM GDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLA VRRRHPAFAVGAFQELGGSNPSVLAYVRQVAGDDGDTVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHV EFPRIGQVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0126 | treS | - | 100% (601) | TREHALOSE SYNTHASE TRES |
| M. tuberculosis H37Rv | Rv2471 | aglA | 2e-56 | 33.20% (509) | alpha-glucosidase AglA |
| M. tuberculosis H37Rv | Rv1562c | treZ | 5e-09 | 32.37% (139) | maltooligosyltrehalose trehalohydrolase TreZ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0131 | treS | 0.0 | 100.00% (601) | trehalose synthase TRES |
| M. gilvum PYR-GCK | Mflv_3723 | - | 1e-106 | 38.76% (547) | alpha amylase, catalytic region |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1565c | - | 3e-51 | 30.42% (526) | Alpha-amylase family protein |
| M. marinum M | MMAR_0325 | treS | 0.0 | 91.20% (591) | trehalose synthase TreS |
| M. avium 104 | MAV_5186 | treS | 0.0 | 90.82% (588) | trehalose synthase |
| M. smegmatis MC2 155 | MSMEG_6515 | treS | 0.0 | 85.79% (577) | trehalose synthase |
| M. thermoresistible (build 8) | TH_1780 | treS | 0.0 | 84.14% (599) | trehalose synthase |
| M. ulcerans Agy99 | MUL_4797 | treS | 0.0 | 90.52% (591) | trehalose synthase TreS |
| M. vanbaalenii PYR-1 | Mvan_2546 | - | 2e-50 | 29.69% (512) | alpha amylase, catalytic region |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0126|M.tuberculosis_H37Rv ---MNEAEHSVEHPPVQGSHVEGG----VVEHPDAKDFGSAAALPADPTW
Mb0131|M.bovis_AF2122/97 ---MNEAEHSVEHPPVQGSHVEGG----VVEHPDAKDFGSAAALPADPTW
MMAR_0325|M.marinum_M --MMNEATNTIEHNPAEGSHVEGG----VVEHPDAKDFGNAAALPADPTW
MUL_4797|M.ulcerans_Agy99 MELMNEATNTIEHNPAEGSHVEGG----MVEHPDAKDFGNAAPLPADPTW
MAV_5186|M.avium_104 ---MNDAREAVEHHPEEGSHVQDG----VVEHPEAEDFDNAAALPTDPTW
MSMEG_6515|M.smegmatis_MC2_155 ----------MEEH-TQGSHVEAG----IVEHPNAEDFGHARTLPTDTNW
TH_1780|M.thermoresistible__bu MESTSEPDRRTEHHRSEGSHVEHGPAGSVVEHPTADDFGQARVLPEDPTW
Mflv_3723|M.gilvum_PYR-GCK ----------------------------------------MRTIETGDLW
MAB_1565c|M.abscessus_ATCC_199 -------------------------------------MTAAYLGQHDDPW
Mvan_2546|M.vanbaalenii_PYR-1 -----------------------------MRKRLRTVWRSSPVAPEESPW
*
Rv0126|M.tuberculosis_H37Rv FKHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYD
Mb0131|M.bovis_AF2122/97 FKHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYD
MMAR_0325|M.marinum_M FKHAVFYEVLVRAFYDGTADGSGDLRGLMQRLDYLQWLGIDCIWLPPFYD
MUL_4797|M.ulcerans_Agy99 FKHAVFYEVLVRAFYDGTADGSGDLRGLMQRLDYLQWLGIDCIWLPPFYD
MAV_5186|M.avium_104 FKHAVFYEVLVRAFFDANADGAGDLRGLLAQLDYLQWLGIDCIWLPPFYD
MSMEG_6515|M.smegmatis_MC2_155 FKHAVFYEVLVRAFYDSNADGIGDLRGLTEKLDYIKWLGVDCLWLPPFYD
TH_1780|M.thermoresistible__bu YKHAVFYEVLVRAFYDSNADGIGDLRGLTEQLDYLKWLGVDCLWLPPFYD
Mflv_3723|M.gilvum_PYR-GCK WKNAVVYCADIETFYDWNGDGCGDIRGMTERIEYLADLGITCLWLMPFYP
MAB_1565c|M.abscessus_ATCC_199 WSRAVFYQIYPRSFGDSDGDGVGDIDGISAKLGYLDLLGVEGIWLNPVTR
Mvan_2546|M.vanbaalenii_PYR-1 WQTAVVYQVYIRSFADGNGDGVGDIAGLRARLPYLARLGVDAMWINPWYP
:. **.* .:* * .** **: *: :: *: **: :*: *
Rv0126|M.tuberculosis_H37Rv SPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTS
Mb0131|M.bovis_AF2122/97 SPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTS
MMAR_0325|M.marinum_M SPLRDGGYDIRDFYKVLPEFGTVGDFVALVDAAHRRGIRVITDLVMNHTS
MUL_4797|M.ulcerans_Agy99 SPLRDGGYDIRDFYKVLPEFGTVGDFVALVDAAHRRGIRVITDLVMNHTS
MAV_5186|M.avium_104 SPLRDGGYDIRDFYKVLPEFGTVEDFVALLNAAHERGIRVITDLVMNHTS
MSMEG_6515|M.smegmatis_MC2_155 SPLRDGGYDIRDFYKVLPEFGTVDDFVTLLDAAHRRGIRIITDLVMNHTS
TH_1780|M.thermoresistible__bu SPLRDGGYDIRDFYKVLPEFGTVDDFVNLLDAAHRRGIRIITDLVMNHTS
Mflv_3723|M.gilvum_PYR-GCK TARKDDGYDITDFFGVDERLGNLGDFVELIRTAGSHGIRVIVDFVMNHTS
MAB_1565c|M.abscessus_ATCC_199 SPMADHGYDVSNPREIDPLFGGSIAMHRLIASAHRHNIKVIMDLVPNHTS
Mvan_2546|M.vanbaalenii_PYR-1 SPMADAGYDVADYRDIEPAYGTLEDARALIAEAHALGIRVILDIVPNHTS
:. * ***: : : * *: * .*::* *:* ****
Rv0126|M.tuberculosis_H37Rv ESHPWFQESRRDPDGP-YGDYYVWSDTSERY-----TDARIIFVDTEESN
Mb0131|M.bovis_AF2122/97 ESHPWFQESRRDPDGP-YGDYYVWSDTSERY-----TDARIIFVDTEESN
MMAR_0325|M.marinum_M ESHPWFQESRHDPDGP-YGDYYVWSDSSEKY-----TDARIIFVDTEESN
MUL_4797|M.ulcerans_Agy99 ESHPWFQESRHDPDGP-YGDYYVWSDSSEKY-----TDARIIFVDTEESN
MAV_5186|M.avium_104 ESHPWFQESRHDPDGP-YGDFYVWSDTSDRY-----ADARIIFVDTEESN
MSMEG_6515|M.smegmatis_MC2_155 DQHEWFQESRHNPDGP-YGDFYVWSDTSDRY-----PDARIIFVDTEESN
TH_1780|M.thermoresistible__bu DTHPWFEESRRDPDGP-YGDFYVWSDTAEKY-----SQARIIFVDTEESN
Mflv_3723|M.gilvum_PYR-GCK DAHPWFKSARRGTDDP-YRDYYVWTATEPPD-----TSEDVVFPDQEDSL
MAB_1565c|M.abscessus_ATCC_199 SEHPWFLEALQSPPGSDARERYIFRDGKGAHGELPPNNWPSVFGGPAWTR
Mvan_2546|M.vanbaalenii_PYR-1 DQHAWFRAALAGESG--ARRRYHFLAGRGADGELPPNDWQSVFGGPAWTR
. * ** : . . * : . :* . :
Rv0126|M.tuberculosis_H37Rv WSFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGIDGFR
Mb0131|M.bovis_AF2122/97 WSFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGIDGFR
MMAR_0325|M.marinum_M WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVLRFWLGLGIDGFR
MUL_4797|M.ulcerans_Agy99 WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVLRFWLGLGIDGFR
MAV_5186|M.avium_104 WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGIDGFR
MSMEG_6515|M.smegmatis_MC2_155 WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMLDVLRFWLDLGIDGFR
TH_1780|M.thermoresistible__bu WTFDP-VRRQFYWHRFFSHQPDLNYDNPAVQEAMLDVLRFWLDLGIDGFR
Mflv_3723|M.gilvum_PYR-GCK WELDP-KTGQWYLHHFYKHQPDLNIANPQVQEEISRTLGFWLQLGVAGFR
MAB_1565c|M.abscessus_ATCC_199 VTEADGTPGQWYLHLFAPEQPDVNWDNPEVFDDFADTLRFWLDRGIDGFR
Mvan_2546|M.vanbaalenii_PYR-1 VDRGP-LEGQWYLHLFAPGQPDLNWENDEVRAEFEDILAFWFDRGVDGFR
*:* * * ***:* * * : : **: *: ***
Rv0126|M.tuberculosis_H37Rv LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
Mb0131|M.bovis_AF2122/97 LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
MMAR_0325|M.marinum_M LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
MUL_4797|M.ulcerans_Agy99 LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
MAV_5186|M.avium_104 LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRVRK
MSMEG_6515|M.smegmatis_MC2_155 LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRCRK
TH_1780|M.thermoresistible__bu LDAVP-------------------YLFEREGTNCEN-LPETHAFLKRCRK
Mflv_3723|M.gilvum_PYR-GCK VDAVP-------------------FLFARDGAPGDPGVFDPFQYLGDVRN
MAB_1565c|M.abscessus_ATCC_199 LDVAHGMAKPPGLPD---IEDTETSMLHIADEDPRFNNEGVHEYHRKIRK
Mvan_2546|M.vanbaalenii_PYR-1 IDVAHGLVKAAGLPDGAGVDAEPHTLLQVQGRHPAWDQDGVHDIYRGWRA
:*.. :: . . *
Rv0126|M.tuberculosis_H37Rv VVDDEFPGRVLLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFM
Mb0131|M.bovis_AF2122/97 VVDDEFPGRVLLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFM
MMAR_0325|M.marinum_M VVDDEFPGRVLLAEANQWPADVVEYFGEASTGGDECHMAFHFPLMPRIFM
MUL_4797|M.ulcerans_Agy99 VVDDEFPGRLLLAEANQWPADVVEYFGEASTGGDECHMAFHFPLMPRIFM
MAV_5186|M.avium_104 VVDDEFPGRVLLAEANQWPADVVEYFGDPSTGGDECHMAFHFPLMPRIFM
MSMEG_6515|M.smegmatis_MC2_155 AIDDEYPGRVLLAEANQWPADVVAYFGDPDTGGDECHMAFHFPLMPRIFM
TH_1780|M.thermoresistible__bu VVDDEYPGRVLLAEANQWPADVVAYFGDPAVGGDECHMAFHFPLMPRIFM
Mflv_3723|M.gilvum_PYR-GCK FVTRRVGDAVLLGEVNVPYKDQKAFFG--GSDGDGLNMQFDFIGMQSMYL
MAB_1565c|M.abscessus_ATCC_199 VLDQYR-DVVAVGEIWVNDNTRFAEYVR----PDELHLGFNFKLVEADFD
Mvan_2546|M.vanbaalenii_PYR-1 VADRYAPERIFIAEAWVSSNARLARYLR----PDELHTAFQFDFLRTPWR
: :.* : * : *.* : :
Rv0126|M.tuberculosis_H37Rv AVRRESRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMY
Mb0131|M.bovis_AF2122/97 AVRRESRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMY
MMAR_0325|M.marinum_M AVRRESRFPISEILAKTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMY
MUL_4797|M.ulcerans_Agy99 AVRRESRFPISEILAKTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMY
MAV_5186|M.avium_104 AVRRESRFPISEILAQTPQIPEMAQWGIFLRNHDELTLEMVTDEERDYMY
MSMEG_6515|M.smegmatis_MC2_155 AVRRESRFPISEILAQTPPIPDTAQWGIFLRNHDELTLEMVTDEERDYMY
TH_1780|M.thermoresistible__bu AVRRESRFPISEILAQTPDIPETAQWGIFLRNHDELTLEMVTDEERDYMY
Mflv_3723|M.gilvum_PYR-GCK SLARGDARPLAKALRSRPSLDVTSQWANFARNHDELTLDKLSDSERQEVF
MAB_1565c|M.abscessus_ATCC_199 ADQIR--AAIQNSLAAVDSVGATPTWTLSNHDVEREVTRYGDGQ------
Mvan_2546|M.vanbaalenii_PYR-1 AQMLR--EVIDDAIDSAASVGAPPTWVLSNHDVTRTVTRFSRSQPAHLIE
: : . : : . * :: . . ..
Rv0126|M.tuberculosis_H37Rv AEYAKDPRMKAN-VGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYG
Mb0131|M.bovis_AF2122/97 AEYAKDPRMKAN-VGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYG
MMAR_0325|M.marinum_M AEYAKDPRMKAN-VGIRRRLAPLLENDRNQIQLFNALLLSLPGSPVLYYG
MUL_4797|M.ulcerans_Agy99 AEYAKDPRMKAN-VGIRRRLAPLLENDRNQIQLFNALLLSLPGSPVLYYG
MAV_5186|M.avium_104 AEYAKDPRMKAN-VGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYG
MSMEG_6515|M.smegmatis_MC2_155 AEYAKDPRMKAN-VGIRRRLAPLLENDRNQIELFTALLLSLPGSPVLYYG
TH_1780|M.thermoresistible__bu AEYAKDPRMKAN-VGIRRRLAPLLENDRNQIELFTALLLSLPGSPVIYYG
Mflv_3723|M.gilvum_PYR-GCK DAFGPDPDMQLYDRGLRRRLPSMLGADQRRMRMVYSLAFSLPGTPVLFYG
MAB_1565c|M.abscessus_ATCC_199 -------------------------IGQWRARAMALVMLALPGTVFIYNG
Mvan_2546|M.vanbaalenii_PYR-1 TDWERGRWEDER---------PDHALGRRRARAAALVQLALPGTAYVYQG
.: : . : ::***: :: *
Rv0126|M.tuberculosis_H37Rv DEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYG
Mb0131|M.bovis_AF2122/97 DEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYG
MMAR_0325|M.marinum_M DEIGMGDVIWLGDRDGVRTPMQWTPDRNAGFSTANPGRLYLPPSQDSVYG
MUL_4797|M.ulcerans_Agy99 DEIGMGDVIWLGDRDGVRTPMQWTPDRNAGFSTANPGRLYLPPSQDSVYG
MAV_5186|M.avium_104 DEIGMGDVIWLGDRDGVRTPMQWTPDRNAGFSKANPGRLYLPPSQDPVYG
MSMEG_6515|M.smegmatis_MC2_155 DEIGMGDIIWLGDRDSVRTPMQWTPDRNAGFSKATPGRLYLPPNQDAVYG
TH_1780|M.thermoresistible__bu DEIGMGDIIWLGDRDAVRTPMQWTPDRNAGFSKANPGRLYLPVNQDPIYG
Mflv_3723|M.gilvum_PYR-GCK EEIGMAENLDVPGRFAVRTPMQWTSGTNGGFSTAPKRRLPRPLPEG-LFG
MAB_1565c|M.abscessus_ATCC_199 SELGLPNVE-LPDEALQDPVWERS-----GHTERGRDGCRVPIPWEGTDP
Mvan_2546|M.vanbaalenii_PYR-1 EELGLEEVEDLPDEARQDPTWVQS-----GFTDVGRDGCRIPLPWTETSV
.*:*: : : .. : *.: *
Rv0126|M.tuberculosis_H37Rv YQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLA
Mb0131|M.bovis_AF2122/97 YQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLA
MMAR_0325|M.marinum_M YQAVNVEAQRDTSTSLLNWTRTMLAVRRRHNAFAVGTFQELGGSNPSILA
MUL_4797|M.ulcerans_Agy99 YQAVNVEAQRDTSTSLLNWTRTMLAVRRRHNAFAVGTFQELGGSNPSILA
MAV_5186|M.avium_104 YQAVNVEAQRDTSTSLLNFTRTMLAVRRRHEAFAIGTFEELGGSNPSVLA
MSMEG_6515|M.smegmatis_MC2_155 YHSVNVEAQLDSSSSLLNWTRNMLAVRSRHDAFAVGTFRELGGSNPSVLA
TH_1780|M.thermoresistible__bu YQSVNVEAQRDSSTSLLNWTRKMLAVRRRHRAFAVGDFRELGGSNPSVLA
Mflv_3723|M.gilvum_PYR-GCK PDRVNVADQRRDHRSFWWFVRDLIYTYRQQPEIGWSTVEILKQPHTAVLA
MAB_1565c|M.abscessus_ATCC_199 PYGFSSN-----AQTWLPMPHGWAEYTVERQLEHTDSMLSLYRRAIELRK
Mvan_2546|M.vanbaalenii_PYR-1 PYGFAAHP---AAVTWLPQPEHWAEHSVEAQERDPGSTLNLYRSALELRP
. : . . . * :
Rv0126|M.tuberculosis_H37Rv YVRQVAG------DDGDTVLCVNNLSRFPQPIELDLQQWT-NYTPVELT-
Mb0131|M.bovis_AF2122/97 YVRQVAG------DDGDTVLCVNNLSRFPQPIELDLQQWT-NYTPVELT-
MMAR_0325|M.marinum_M YVREAPGP---AGEDGDVVLCVNNLSRFPQPIELNLQQWN-SYTPVELT-
MUL_4797|M.ulcerans_Agy99 YVREAPGP---AGEDGDVVLCVNNLSRFPQPIELNLQQWN-SYTPVELT-
MAV_5186|M.avium_104 FVRQVSN-------DGDTVLCVNNLSRFPQPIELNLQHWS-GCIPVELT-
MSMEG_6515|M.smegmatis_MC2_155 YIREVTRQQGDGGAKTDAVLCVNNLSRFPQPIELNLQQWA-GYIPVEMT-
TH_1780|M.thermoresistible__bu FIRELEE---DG--QKDTVLCVNNLSRFPQPIELQLQNWS-GYTPVEMT-
Mflv_3723|M.gilvum_PYR-GCK HVCRESS--------GWAMVGLHNFGADGCLVPLTLGDLPEGSRLVDLLD
MAB_1565c|M.abscessus_ATCC_199 SRKEFTGT------SLEWYGSPPGALAFRVKGGGLTCALNVSSDLVDLP-
Mvan_2546|M.vanbaalenii_PYR-1 TMWRDTG-------DVKWLEVASDIAAFER--GGAQCWVNTGDAGVPLP-
. . . * :
Rv0126|M.tuberculosis_H37Rv GHVEFPRIGQVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
Mb0131|M.bovis_AF2122/97 GHVEFPRIGQVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
MMAR_0325|M.marinum_M GQVEFPKIGHLPYLLTLPGHGFYWFQLSASEE--------ER--
MUL_4797|M.ulcerans_Agy99 GQVEFRKIGHLPYLLTLPGHGFYWFQLSASEE--------ER--
MAV_5186|M.avium_104 GHVEFPRIGHLPYLLTLPGHGFYWFQLTACEEDT----------
MSMEG_6515|M.smegmatis_MC2_155 GYVEFPSIGQLPYLLTLPGHGFYWFQLREPDPEP-----GAQQ-
TH_1780|M.thermoresistible__bu GYVEFPRIGQLPYLLTLPGHGFYWFQLREPEPEV-----GEQP-
Mflv_3723|M.gilvum_PYR-GCK GRAEFPVDARGGIELSLEGYGYRWLRLLRPDDPPII--------
MAB_1565c|M.abscessus_ATCC_199 EGE-VILTSGPLVNGKLPRNTAAWIV------------------
Mvan_2546|M.vanbaalenii_PYR-1 AGAAVVLASEPGVDGMLPPDTAVWLR------------------
. . * *: